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  1. Article ; Online: Successful treatment of Langerhans cell histiocytosis in an infant with vemurafenib: a case report and literature review.

    Li, Qingqing

    The Journal of dermatological treatment

    2023  Volume 34, Issue 1, Page(s) 2279901

    Abstract: Langerhans cell histiocytosis (LCH) is a histiocytic neoplasm characterized by a mass of CD1a + CD207 + histiocytes, exhibiting a diverse range of clinical manifestations from a self-healing rash or single bone destruction to multi-organ disease with ... ...

    Abstract Langerhans cell histiocytosis (LCH) is a histiocytic neoplasm characterized by a mass of CD1a + CD207 + histiocytes, exhibiting a diverse range of clinical manifestations from a self-healing rash or single bone destruction to multi-organ disease with potentially fatal consequences. The identification of MAPK signaling pathway activation, particularly BRAF
    MeSH term(s) Humans ; Infant ; Vemurafenib/therapeutic use ; Proto-Oncogene Proteins B-raf/genetics ; Histiocytosis, Langerhans-Cell/drug therapy ; Histiocytosis, Langerhans-Cell/diagnosis ; Histiocytosis, Langerhans-Cell/genetics ; Protein Kinase Inhibitors/therapeutic use ; Treatment Outcome ; Mutation
    Chemical Substances Vemurafenib (207SMY3FQT) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2023.2279901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Advances in lung ischemia/reperfusion injury: unraveling the role of innate immunity.

    Li, Qingqing / Nie, Hanxiang

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2024  Volume 73, Issue 3, Page(s) 393–405

    Abstract: Background: Lung ischemia/reperfusion injury (LIRI) is a common occurrence in clinical practice and represents a significant complication following pulmonary transplantation and various diseases. At the core of pulmonary ischemia/reperfusion injury lies ...

    Abstract Background: Lung ischemia/reperfusion injury (LIRI) is a common occurrence in clinical practice and represents a significant complication following pulmonary transplantation and various diseases. At the core of pulmonary ischemia/reperfusion injury lies sterile inflammation, where the innate immune response plays a pivotal role. This review aims to investigate recent advancements in comprehending the role of innate immunity in LIRI.
    Methods: A computer-based online search was performed using the PubMed database and Web of Science database for published articles concerning lung ischemia/reperfusion injury, cell death, damage-associated molecular pattern molecules (DAMPs), innate immune cells, innate immunity, inflammation.
    Results: During the process of lung ischemia/reperfusion, cellular injury even death can occur. When cells are injured or undergo cell death, endogenous ligands known as DAMPs are released. These molecules can be recognized and bound by pattern recognition receptors (PRRs), leading to the recruitment and activation of innate immune cells. Subsequently, a cascade of inflammatory responses is triggered, ultimately exacerbating pulmonary injury. These steps are complex and interrelated rather than being in a linear relationship. In recent years, significant progress has been made in understanding the immunological mechanisms of LIRI, involving novel types of cell death, the ability of receptors other than PRRs to recognize DAMPs, and a more detailed mechanism of action of innate immune cells in ischemia/reperfusion injury (IRI), laying the groundwork for the development of novel diagnostic and therapeutic approaches.
    Conclusions: Various immune components of the innate immune system play critical roles in lung injury after ischemia/reperfusion. Preventing cell death and the release of DAMPs, interrupting DAMPs receptor interactions, disrupting intracellular inflammatory signaling pathways, and minimizing immune cell recruitment are essential for lung protection in LIRI.
    MeSH term(s) Humans ; Immunity, Innate ; Reperfusion Injury/metabolism ; Inflammation/complications ; Lung/metabolism ; Ischemia/complications ; Receptors, Pattern Recognition ; Lung Injury
    Chemical Substances Receptors, Pattern Recognition
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-023-01844-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 675: Show issues Location:
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  3. Article ; Online: Sensing and acting: Full circle in fat.

    Li, Qingqing / Zeng, Wenwen

    Cell metabolism

    2023  Volume 35, Issue 1, Page(s) 9–11

    Abstract: White adipose tissue (WAT) communicates with the CNS bidirectionally. In recent studies, aided by three-dimensional imaging, Wang et al. and Frei et al. have provided the organ-wide view of the afferent somatosensory network in the inguinal WAT (iWAT) ... ...

    Abstract White adipose tissue (WAT) communicates with the CNS bidirectionally. In recent studies, aided by three-dimensional imaging, Wang et al. and Frei et al. have provided the organ-wide view of the afferent somatosensory network in the inguinal WAT (iWAT) and have further delineated its critical involvement in energy balance.
    MeSH term(s) Adipose Tissue, White/metabolism ; Energy Metabolism
    Language English
    Publishing date 2023-01-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.12.010
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    Zs.A 6169: Show issues Location:
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  4. Article ; Online: A Treg-related riskscore model may improve the prognosis evaluation of colorectal cancer.

    Li, Qingqing / Chu, Yuxin / Yao, Yi / Song, Qibin

    The journal of gene medicine

    2024  Volume 26, Issue 2, Page(s) e3668

    Abstract: Background: Colorectal cancer (CRC) poses a significant health challenge. This study aims to investigate the prognostic value of a regulatory T cell (Treg)-related gene signature in CRC.: Methods: We extracted the gene expression and clinical data on ...

    Abstract Background: Colorectal cancer (CRC) poses a significant health challenge. This study aims to investigate the prognostic value of a regulatory T cell (Treg)-related gene signature in CRC.
    Methods: We extracted the gene expression and clinical data on CRC from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The gene module related to Treg was identified by weighted gene co-expression network analysis (WGCNA). The genes in the significant module were filtered by univariate Cox, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis. A riskscore model was established in terms of the key Treg-related genes. The reliability of this riskscore model was validated using the external GEO dataset. The association of riskscore with clinical features, mutation patterns and signaling pathways was explored.
    Results: Genes in the blue module showed the strongest association with Tregs. After a series of filtering cycles, seven Treg-related key genes, GDE1, GSR, HSPB1, AOC2, TBX19, TAMM41 and TIGD6, were selected to construct a riskscore model. This model performed well in evaluating the patients' survival in TCGA cohort, and was further affirmed by the GSE17536 validation cohort. For precise evaluation of the patients' survival, we established a nomogram in light of riskscore and clinical factors. Patients in different risk groups had distinct clinical features, mutation patterns and signaling pathway activities. The expression of five key genes was significantly associated with Treg infiltration in the CRC samples.
    Conclusion: We established a useful riskscore model in light of seven Treg-related genes. This model may contribute to the prognosis evaluation, direct tailored treatment, and hopefully improve clinical outcomes of the CRC patients.
    MeSH term(s) Humans ; Reproducibility of Results ; T-Lymphocytes, Regulatory ; Gene Expression Profiling ; Gene Regulatory Networks ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1458024-x
    ISSN 1521-2254 ; 1099-498X
    ISSN (online) 1521-2254
    ISSN 1099-498X
    DOI 10.1002/jgm.3668
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    Zs.A 5423: Show issues Location:
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  5. Article: Contrast-Associated Acute Kidney Injury: Advances and Challenges.

    Li, Qingqing / Pan, Shengqi

    International journal of general medicine

    2022  Volume 15, Page(s) 1537–1546

    Abstract: A decrease in renal function that follows intravascular administration of contrast medium (CM) within a few days is reported as contrast-induced acute kidney injury (CI-AKI). In clinical practice, the imaging procedure is frequently deferred when ... ...

    Abstract A decrease in renal function that follows intravascular administration of contrast medium (CM) within a few days is reported as contrast-induced acute kidney injury (CI-AKI). In clinical practice, the imaging procedure is frequently deferred when clinicians consider that the renal risks caused by CM outweigh the benefits of enhanced imaging. However, with an in-depth understanding of AKI and contrast medium, scholars have realized that the decrease in renal function after CM is caused by contrast medium factors and noncontrast medium factors (such as anemia and hemodynamic instability). Therefore, acute kidney injury caused by CM has been overestimated in the past. The term "contrast-associated acute kidney injury (CA-AKI)" has been increasingly used to indicate AKI after intravascular administration of contrast medium compared with CI-AKI. CA-AKI can increase the risk of death and chronic kidney disease. However, its pathophysiological mechanism has not been fully elucidated, and the effectiveness of various preventive and therapeutic measures have been questioned. These present challenges for us. In this article, we will review the diagnostic criteria, epidemiology, risk factors, pathophysiological mechanisms and treatment of CA-AKI to provide optimized imaging procedures in clinical practice.
    Language English
    Publishing date 2022-02-15
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S341072
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  6. Article: Gastric schwannoma misdiagnosed as gastrointestinal stromal tumor by ultrasonography before surgery: A case report.

    Li, Qing-Qing / Liu, Dong

    World journal of clinical cases

    2022  Volume 10, Issue 5, Page(s) 1667–1674

    Abstract: Background: Gastric origin tumors were diagnosed and evaluated preoperatively by gastroscopy, endoscopic ultrasonography, computed tomography (CT) or magnetic resonance imaging. Currently, transabdominal high-resolution ultrasound combined with ... ...

    Abstract Background: Gastric origin tumors were diagnosed and evaluated preoperatively by gastroscopy, endoscopic ultrasonography, computed tomography (CT) or magnetic resonance imaging. Currently, transabdominal high-resolution ultrasound combined with gastrointestinal contrast agent can be used to diagnose stomach tumors effectively and without invasive procedures or radiation. However, although an appreciable number of cases of gastric schwannoma (GS) have been reported since the first description of such in 1988, the ongoing lack of a comprehensive list of ultrasonic characteristics has limited the accuracy of preoperative ultrasound diagnosis.
    Case summary: A 64-year-old female patient presented to our hospital with dizziness and head discomfort. During an abdominal ultrasound, a hypoechoic gastric mass was found, having clear and regular boundaries and no observable blood flow. Based on these characteristics, a gastrointestinal stromal tumor was suspected. Results from an endoscopic ultrasound biopsy and accompanying immunohistochemical analysis, coupled with abdominal CT findings indicating lymph node enlargement around the stomach, led to diagnosis of GS but did not exclude malignancy. After surgical resection of the tumor, the final diagnosis of GS without lymph node metastasis was made. No recurrence has occurred in the 6 years of follow-up.
    Conclusion: A clearly defined ultrasonic characteristic profile of GS is important to improve diagnostic accuracy.
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i5.1667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms.

    Jia, Xueyan / Li, Qingqing / Xu, Mengwei / Zhang, Jie / Xu, Delin

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24341

    Abstract: Militarine is the lead member of secondary metabolites found in multiple medicinal plants of the orchid family. It acts as not only an important inhibitor on plant growth, but also functions as the quality marker for medicinal materials. In addition, ... ...

    Abstract Militarine is the lead member of secondary metabolites found in multiple medicinal plants of the orchid family. It acts as not only an important inhibitor on plant growth, but also functions as the quality marker for medicinal materials. In addition, Militarine has been shown to possess remarkably medicinal value, with a definite potential for finding widespread adoption of treating various diseases, including lung injury, brain nerve injury, cognitive impairment, aging, tumors, inflammation, peptic ulcers, and more. Thus, it can serve as a material carrier for pharmacophore upon, so much so that it probes as natural source of lead compounds in the research and development of medication. The study reported herein makes an overview on the physicochemical properties and pharmacological mechanisms of Militarine compounds, summarizes the biogenic pathways of Militarine and organically integrates the biological characteristics of Militarine with multiple omics techniques. Besides, this review also constructs a regulatory system for the biological accumulation of Militarine around its precursor compounds, characteristic gene elements, key enzymes, important metabolic products, and critical steps and links. Exceptionally, emphasis on the biosynthesis of Militarine under both abiotic and biotic stress, as well as an elaboration of the signaling pathways and critical regulatory mechanisms that govern the metabolic flow of Militarine have been represented accordingly in this paper. These findings are expected to provide reference schemes and theoretical foundations for acquiring high-quality resources of Militarine and advancing its large-scale industrial production, drug development, and clinical applications to comprehensively elucidate the biosynthetic and metabolic pathways.
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Reciprocal relationships between self-control and self-authenticity: a two-wave study.

    Li, Qingqing / Ren, Xiaomei / Zhou, Zongkui / Wang, Jing

    Frontiers in psychology

    2023  Volume 14, Page(s) 1207230

    Abstract: Both self-control and self-authenticity are critical to individuals' mental health and social adjustment, but their relationship has received little attention. Research demonstrates that exerting self-control could help individuals achieve true self and ... ...

    Abstract Both self-control and self-authenticity are critical to individuals' mental health and social adjustment, but their relationship has received little attention. Research demonstrates that exerting self-control could help individuals achieve true self and might be promoted by perceiving authenticity. Accordingly, this study utilized a longitudinal design and investigated the temporal relationship between self-control and self-authenticity in a large sample of 2,982 Chinese adolescents (
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1207230
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  9. Article: Self-concept Clarity and Subjective Well-Being: Disentangling Within- and Between-Person Associations.

    Xiang, Guangcan / Teng, Zhaojun / Li, Qingqing / Chen, Hong

    Journal of happiness studies

    2023  Volume 24, Issue 4, Page(s) 1439–1461

    Abstract: Previous research has suggested that, among adolescents, clarity about one's self-concept is closely related to subjective well-being. However, longitudinal studies are scarce, and whether a clear self-concept is the cause or effect of subjective well- ... ...

    Abstract Previous research has suggested that, among adolescents, clarity about one's self-concept is closely related to subjective well-being. However, longitudinal studies are scarce, and whether a clear self-concept is the cause or effect of subjective well-being remains unclear. This study examined the dynamic longitudinal associations between self-concept clarity and subjective well-being at the between- and within-person levels over a one-year time span among adolescents (baseline
    Language English
    Publishing date 2023-03-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2016901-2
    ISSN 1573-7780 ; 1389-4978
    ISSN (online) 1573-7780
    ISSN 1389-4978
    DOI 10.1007/s10902-023-00646-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fibrosarkomatöse Transformation eines Dermatofibrosarcoma protuberans im Gesicht mit Metastasen in Lunge und Wirbelsäule.

    Li, Qingqing / Cai, Zhen / Jiang, Zhiyuan

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 5, Page(s) 521–524

    Language German
    Publishing date 2023-02-11
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14982_g
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    Zs.A 6148: Show issues Location:
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