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  1. Article: Preparation and High-Temperature Resistance Properties of Phenolic Resin/Phosphate Hybrid Coatings.

    Li, Qinzhe / Zhang, Yu / Zhou, Lizhen / Lei, Peng / Liu, Jiangyan / Wang, Fuli / Xiang, Xueyun / Wu, Hang / Wang, Wen / Wang, Fuhui

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 9

    Abstract: In this study, a novel fabrication method was used to synthesize phenolic resin/phosphate hybrid coatings using aluminum dihydrogen phosphate (Al( ... ...

    Abstract In this study, a novel fabrication method was used to synthesize phenolic resin/phosphate hybrid coatings using aluminum dihydrogen phosphate (Al(H
    Language English
    Publishing date 2024-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17092081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adjuvanted nanoliposomes displaying six hemagglutinins and neuraminidases as an influenza virus vaccine.

    Sia, Zachary R / Roy, Jayishnu / Huang, Wei-Chiao / Song, Yiting / Zhou, Shiqi / Luo, Yuan / Li, Qinzhe / Arpin, Dominic / Kutscher, Hilliard L / Ortega, Joaquin / Davidson, Bruce A / Lovell, Jonathan F

    Cell reports. Medicine

    2024  Volume 5, Issue 3, Page(s) 101433

    Abstract: Inclusion of defined quantities of the two major surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA), could benefit seasonal influenza vaccines. Recombinant HA and NA multimeric proteins derived from three influenza serotypes, ... ...

    Abstract Inclusion of defined quantities of the two major surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA), could benefit seasonal influenza vaccines. Recombinant HA and NA multimeric proteins derived from three influenza serotypes, H1N1, H3N2, and type B, are surface displayed on nanoliposomes co-loaded with immunostimulatory adjuvants, generating "hexaplex" particles that are used to immunize mice. Protective immune responses to hexaplex liposomes involve functional antibody elicitation against each included antigen, comparable to vaccination with monovalent antigen particles. When compared to contemporary recombinant or adjuvanted influenza virus vaccines, hexaplex liposomes perform favorably in many areas, including antibody production, T cell activation, protection from lethal virus challenge, and protection following passive sera transfer. Based on these results, hexaplex liposomes warrant further investigation as an adjuvanted recombinant influenza vaccine formulation.
    MeSH term(s) Mice ; Animals ; Humans ; Influenza Vaccines ; Hemagglutinins ; Neuraminidase/genetics ; Orthomyxoviridae Infections ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Liposomes ; Influenza, Human ; Adjuvants, Immunologic ; Vaccines, Synthetic
    Chemical Substances Influenza Vaccines ; Hemagglutinins ; Neuraminidase (EC 3.2.1.18) ; Liposomes ; Adjuvants, Immunologic ; Vaccines, Synthetic
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An acidity-responsive polyoxometalate with inflammatory retention for NIR-II photothermal-enhanced chemodynamic antibacterial therapy

    Shi, Yunhao / Yin, Jiajia / Peng, Qinqin / Lv, Xinyi / Li, Qinzhe / Yang, Dongliang / Song, Xuejiao / Wang, Wenjun / Dong, Xiaochen

    Biomaterials science. 2020 Oct. 27, v. 8, no. 21

    2020  

    Abstract: Subcutaneous abscesses caused by drug-resistant pathogens pose a serious challenge to human health. To overcome this problem, herein an acidity-responsive aggregated W/Mo-based polyoxometalate (POM) was developed for photothermal-enhanced chemodynamic ... ...

    Abstract Subcutaneous abscesses caused by drug-resistant pathogens pose a serious challenge to human health. To overcome this problem, herein an acidity-responsive aggregated W/Mo-based polyoxometalate (POM) was developed for photothermal-enhanced chemodynamic antibacterial therapy in the second near-infrared (NIR) region. The POM can self-assemble into larger-sized aggregates with stronger absorption in the NIR region, making it remain in the acidic infected tissue. Furthermore, the hydrogen peroxide at the site of infection can be converted to a hydroxyl radical for chemodynamic therapy (CDT) and simultaneously the glutathione in organisms is consumed by the POM to further enhance the CDT effect. More importantly, under laser irradiation, the hyperthermia produced by the POM not only can kill drug-resistant Staphylococcus aureus, but also enhance the performance of CDT. Benefitting from the inflammatory retention and acidity-responsive photothermal-enhanced CDT properties, the POM exhibits an obvious therapeutic effect against drug-resistant bacterial infection without significant side effects under 1060 nm laser irradiation.
    Keywords Staphylococcus aureus ; absorption ; bacterial infections ; biocompatible materials ; drug resistance ; fever ; glutathione ; human health ; hydrogen peroxide ; hydroxyl radicals ; irradiation ; therapeutics
    Language English
    Dates of publication 2020-1027
    Size p. 6093-6099.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01165g
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Mitochondrial Ca

    Zhu, Jiawei / Jiao, Aihong / Li, Qinzhe / Lv, Xinyi / Wang, Xiaorui / Song, Xuejiao / Li, Buhong / Zhang, Yewei / Dong, Xiaochen

    Acta biomaterialia

    2021  Volume 137, Page(s) 252–261

    Abstract: ... The ... ...

    Abstract The Ca
    MeSH term(s) Cell Line, Tumor ; Glutathione/pharmacology ; Humans ; Mitochondria ; Nanoparticles ; Neoplasms/drug therapy ; Oxygen/pharmacology ; Photochemotherapy ; Photosensitizing Agents/pharmacology ; Porphyrins/pharmacology ; Tumor Microenvironment
    Chemical Substances Photosensitizing Agents ; Porphyrins ; Glutathione (GAN16C9B8O) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-10-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2021.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy.

    Chen, Yuang / Huang, Yixian / Li, Qinzhe / Luo, Zhangyi / Zhang, Ziqian / Huang, Haozhe / Sun, Jingjing / Zhang, LinXinTian / Sun, Runzi / Bain, Daniel J / Conway, James F / Lu, Binfeng / Li, Song

    Nature nanotechnology

    2022  Volume 18, Issue 2, Page(s) 193–204

    Abstract: Activation of scramblases is one of the mechanisms that regulates the exposure of phosphatidylserine to the cell surface, a process that plays an important role in tumour immunosuppression. Here we show that chemotherapeutic agents induce overexpression ... ...

    Abstract Activation of scramblases is one of the mechanisms that regulates the exposure of phosphatidylserine to the cell surface, a process that plays an important role in tumour immunosuppression. Here we show that chemotherapeutic agents induce overexpression of Xkr8, a scramblase activated during apoptosis, at the transcriptional level in cancer cells, both in vitro and in vivo. Based on this finding, we developed a nanocarrier for co-delivery of Xkr8 short interfering RNA and the FuOXP prodrug to tumours. Intravenous injection of our nanocarrier led to significant inhibition of tumour growth in colon and pancreatic cancer models along with increased antitumour immune response. Targeting Xkr8 in combination with chemotherapy may represent a novel strategy for the treatment of various types of cancers.
    MeSH term(s) Humans ; RNA, Small Interfering/therapeutic use ; Apoptosis ; Cell Membrane/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Nanoparticles ; Cell Line, Tumor ; Membrane Proteins/metabolism ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism
    Chemical Substances RNA, Small Interfering ; Xkr8 protein, human ; Membrane Proteins ; Apoptosis Regulatory Proteins
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/s41565-022-01266-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An acidity-responsive polyoxometalate with inflammatory retention for NIR-II photothermal-enhanced chemodynamic antibacterial therapy.

    Shi, Yunhao / Yin, Jiajia / Peng, Qinqin / Lv, Xinyi / Li, Qinzhe / Yang, Dongliang / Song, Xuejiao / Wang, Wenjun / Dong, Xiaochen

    Biomaterials science

    2020  Volume 8, Issue 21, Page(s) 6093–6099

    Abstract: Subcutaneous abscesses caused by drug-resistant pathogens pose a serious challenge to human health. To overcome this problem, herein an acidity-responsive aggregated W/Mo-based polyoxometalate (POM) was developed for photothermal-enhanced chemodynamic ... ...

    Abstract Subcutaneous abscesses caused by drug-resistant pathogens pose a serious challenge to human health. To overcome this problem, herein an acidity-responsive aggregated W/Mo-based polyoxometalate (POM) was developed for photothermal-enhanced chemodynamic antibacterial therapy in the second near-infrared (NIR) region. The POM can self-assemble into larger-sized aggregates with stronger absorption in the NIR region, making it remain in the acidic infected tissue. Furthermore, the hydrogen peroxide at the site of infection can be converted to a hydroxyl radical for chemodynamic therapy (CDT) and simultaneously the glutathione in organisms is consumed by the POM to further enhance the CDT effect. More importantly, under laser irradiation, the hyperthermia produced by the POM not only can kill drug-resistant Staphylococcus aureus, but also enhance the performance of CDT. Benefitting from the inflammatory retention and acidity-responsive photothermal-enhanced CDT properties, the POM exhibits an obvious therapeutic effect against drug-resistant bacterial infection without significant side effects under 1060 nm laser irradiation.
    MeSH term(s) Anti-Bacterial Agents ; Humans ; Hyperthermia, Induced ; Methicillin-Resistant Staphylococcus aureus ; Phototherapy ; Tungsten Compounds
    Chemical Substances Anti-Bacterial Agents ; Tungsten Compounds ; polyoxometalate I
    Language English
    Publishing date 2020-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01165g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy.

    Tang, Qianyun / Cheng, Zijin / Yang, Nan / Li, Qinzhe / Wang, Peng / Chen, Dapeng / Wang, Wenjun / Song, Xuejiao / Dong, Xiaochen

    Biomaterials

    2019  Volume 205, Page(s) 1–10

    Abstract: Developing new strategies to alleviate tumor hypoxia and enhance the therapeutic efficacy towards solid tumors is of great significance to tumor therapy. Herein, to overcome tumor hypoxia, specifically designed aza-BODIPY photosensitizer is co-loaded ... ...

    Abstract Developing new strategies to alleviate tumor hypoxia and enhance the therapeutic efficacy towards solid tumors is of great significance to tumor therapy. Herein, to overcome tumor hypoxia, specifically designed aza-BODIPY photosensitizer is co-loaded with anti-cancer drug (doxorubicin, DOX) onto the hydrangea-structured MnO
    MeSH term(s) Animals ; Boron Compounds/chemistry ; Cell Survival/drug effects ; HCT116 Cells ; Humans ; Hydrangea/chemistry ; Hydrogen Peroxide/toxicity ; Mice, Inbred BALB C ; Mice, Nude ; Multimodal Imaging ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Neoplasms/diagnosis ; Neoplasms/therapy ; Photosensitizing Agents/therapeutic use ; Spectrophotometry, Ultraviolet ; Temperature ; Tumor Hypoxia ; Tumor Microenvironment
    Chemical Substances 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Boron Compounds ; Photosensitizing Agents ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2019-03-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2019.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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