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  1. Article ; Online: Combination of omalizumab with allergen immunotherapy versus immunotherapy alone for allergic diseases: A meta-analysis of randomized controlled trials.

    Zhang, Ying-Ying / Zhang, Min / Zhang, Jia-Qi / Li, Qiu-Qi / Lu, Mei-Ping / Cheng, Lei

    International forum of allergy & rhinology

    2023  Volume 14, Issue 4, Page(s) 794–806

    Abstract: Background: Allergen immunotherapy (AIT)-associated adverse events (AEs) limit its usage in the management of allergic diseases. The monoclonal anti-IgE antibody (omalizumab) and AIT have complementary actions. However, no consensus has been reached on ... ...

    Abstract Background: Allergen immunotherapy (AIT)-associated adverse events (AEs) limit its usage in the management of allergic diseases. The monoclonal anti-IgE antibody (omalizumab) and AIT have complementary actions. However, no consensus has been reached on whether their combination could exert superior efficacy and safety.
    Objective: To evaluate whether the combination of AIT with omalizumab is superior to AIT alone in treating allergic diseases.
    Methods: The MEDLINE/PubMed, Embase, Scopus and Cochrane Library databases were searched to identify randomized control trials (RCTs) reporting the outcomes of omalizumab combined with AIT (omalizumab + AIT) versus AIT alone. A random-effect model was established to estimate outcomes with a 95% confidence interval (CI).
    Results: A total of 11 eligible RCTs (involving 901 patients) were screened out for the meta-analysis. According to a pooled analysis, omalizumab + AIT significantly increased the number of patients achieving the target maintenance dose (TMD) and sustained unresponsiveness (SU) to allergens (odds ratio [OR] = 2.43; 95% CI: 1.33-4.44; p = 0.004; I
    Conclusion: Omalizumab + AIT can significantly enhance the efficacy and safety of AIT by increasing TMD and SU to allergens, while decreasing severe systemic AEs.
    MeSH term(s) Humans ; Omalizumab/therapeutic use ; Randomized Controlled Trials as Topic ; Desensitization, Immunologic/adverse effects ; Allergens ; Hypersensitivity/etiology
    Chemical Substances Omalizumab (2P471X1Z11) ; Allergens
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23268
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  2. Article ; Online: Characterization the prognosis role and effects of snoRNAs in melanoma patients.

    Wang, Lei-Yun / Song, Jia-Nan / Chen, Yi-Xuan / Zhu, Ying / Ren, Hui-Li / Li, Qiu-Qi / Zhang, Shao-Hui

    Experimental dermatology

    2023  Volume 33, Issue 1, Page(s) e14944

    Abstract: Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable ... ...

    Abstract Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable diagnostic and prognostic markers is crucial for improving patient outcomes. In the search for biomarkers, various types of RNAs have been discovered and recognized as reliable prognostic markers. Among these, small nucleolar RNAs (snoRNAs) have emerged as a promising avenue for studying early diagnosis and prognostic markers in tumours due to their widespread presence in tissues, tumour specificity and stability. In our study, we analysed snoRNAs data from melanoma samples in the TCGA-SKCM cohort and developed a prognostic model comprising 12 snoRNAs (SNORD9, SNORA31, SNORD14E, SNORA14A, SNORA5A, SNORD83A, SNORA75, AL096855, AC007684, SNORD14A, SNORA65 and AC004839). This model exhibited unique prognostic accuracy and demonstrated a significant correlation with the immune infiltration tumour microenvironment. Additionally, analysis of the GSE213145 dataset, which explored the sensitivity and resistance of immune checkpoint inhibitors, further supported the potential of snoRNAs as prognostic markers for immunotherapy. Overall, our study contributes reliable prognostic and immune-related biomarkers for melanoma patients. These findings can offer valuable insights for the future discovery of novel melanoma treatment strategies and hold promise for improving clinical outcomes in melanoma patients.
    MeSH term(s) Humans ; Melanoma/genetics ; RNA, Small Nucleolar/genetics ; Prognosis ; Skin Neoplasms/genetics ; Biomarkers ; Tumor Microenvironment
    Chemical Substances RNA, Small Nucleolar ; Biomarkers
    Language English
    Publishing date 2023-09-29
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14944
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  3. Article ; Online: The romantic history of signaling pathway discovery in cell death: an updated review.

    Wang, Lei-Yun / Liu, Xing-Jian / Li, Qiu-Qi / Zhu, Ying / Ren, Hui-Li / Song, Jia-Nan / Zeng, Jun / Mei, Jie / Tian, Hui-Xiang / Rong, Ding-Chao / Zhang, Shao-Hui

    Molecular and cellular biochemistry

    2023  

    Abstract: Cell death is a fundamental physiological process in all living organisms. Processes such as embryonic development, organ formation, tissue growth, organismal immunity, and drug response are accompanied by cell death. In recent years with the development ...

    Abstract Cell death is a fundamental physiological process in all living organisms. Processes such as embryonic development, organ formation, tissue growth, organismal immunity, and drug response are accompanied by cell death. In recent years with the development of electron microscopy as well as biological techniques, especially the discovery of novel death modes such as ferroptosis, cuprotosis, alkaliptosis, oxeiptosis, and disulfidptosis, researchers have been promoted to have a deeper understanding of cell death modes. In this systematic review, we examined the current understanding of modes of cell death, including the recently discovered novel death modes. Our analysis highlights the common and unique pathways of these death modes, as well as their impact on surrounding cells and the organism as a whole. Our aim was to provide a comprehensive overview of the current state of research on cell death, with a focus on identifying gaps in our knowledge and opportunities for future investigation. We also presented a new insight for macroscopic intracellular survival patterns, namely that intracellular molecular homeostasis is central to the balance of different cell death modes, and this viewpoint can be well justified by the signaling crosstalk of different death modes. These concepts can facilitate the future research about cell death in clinical diagnosis, drug development, and therapeutic modalities.
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-023-04873-2
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    Zs.A 892: Show issues Location:
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  4. Article: Baicalein Exerts Neuroprotective Effects in FeCl

    Li, Qin / Li, Qiu-Qi / Jia, Ji-Ning / Sun, Qian-Yi / Zhou, Hong-Hao / Jin, Wei-Lin / Mao, Xiao-Yuan

    Frontiers in pharmacology

    2019  Volume 10, Page(s) 638

    Abstract: Posttraumatic epilepsy (PTE) is a prevalent type of acquired epilepsy secondary to traumatic brain injury, and is characterized by repeated seizures. Traditional antiepileptic drugs have minimal response in preventing posttraumatic epileptic seizures. It ...

    Abstract Posttraumatic epilepsy (PTE) is a prevalent type of acquired epilepsy secondary to traumatic brain injury, and is characterized by repeated seizures. Traditional antiepileptic drugs have minimal response in preventing posttraumatic epileptic seizures. It is essential for the development of new therapeutic strategy. Our previous work disclosed a potent neuroprotective role of baicalein, a flavonoid extracted from
    Language English
    Publishing date 2019-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.00638
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  5. Article ; Online: Targeting gap junction in epilepsy: Perspectives and challenges.

    Li, Qin / Li, Qiu-Qi / Jia, Ji-Ning / Liu, Zhao-Qian / Zhou, Hong-Hao / Mao, Xiao-Yuan

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2018  Volume 109, Page(s) 57–65

    Abstract: Gap junctions (GJs) are multiple cellular intercellular connections that allow ions to pass directly into the cytoplasm of neighboring cells. Electrical coupling mediated by GJs plays a role in the generation of highly synchronous electrical activity. ... ...

    Abstract Gap junctions (GJs) are multiple cellular intercellular connections that allow ions to pass directly into the cytoplasm of neighboring cells. Electrical coupling mediated by GJs plays a role in the generation of highly synchronous electrical activity. Accumulative investigations show that GJs in the brain are involved in the generation, synchronization and maintenance of seizure events. At the same time, GJ blockers exert potent curative potential on epilepsy in vivo or in vitro. This review aims to shed light on the role of GJs in epileptogenesis. Targeting GJs is likely to be served as a novel therapeutic approach on epileptic patients.
    MeSH term(s) Animals ; Anticonvulsants/pharmacology ; Brain/physiopathology ; Cytoplasm/metabolism ; Drug Design ; Epilepsy/drug therapy ; Epilepsy/physiopathology ; Gap Junctions/drug effects ; Gap Junctions/metabolism ; Humans ; Molecular Targeted Therapy
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2018-11-02
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2018.10.068
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  6. Article ; Online: 12/15 lipoxygenase: A crucial enzyme in diverse types of cell death.

    Li, Qiu-Qi / Li, Qin / Jia, Ji-Ning / Liu, Zhao-Qian / Zhou, Hong-Hao / Mao, Xiao-Yuan

    Neurochemistry international

    2018  Volume 118, Page(s) 34–41

    Abstract: The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. A great many of elegant studies over the last decades ... ...

    Abstract The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. A great many of elegant studies over the last decades have contributed to unraveling the mechanism how 12/15-lipoxygenase play a role in these diseases. And the way it works is mainly through apoptosis. However, recent years have found that the way 12/15-lipoxygenase works is also related to autophagy and ferroptosis, a newly defined type of cell death by Stockwell's lab in 2012. Figuring out how 12/15-lipoxygenase participate in these modes of cell death is of vital importance to understand its role in disease. The review aims to give a sight on our current knowledge on the role of this enzyme in apoptosis, autophagy and ferroptosis. And the relevant diseases that 12/15-lipoxygenase may be involved.
    MeSH term(s) Animals ; Apoptosis/physiology ; Arachidonate 12-Lipoxygenase/metabolism ; Arachidonate 15-Lipoxygenase/metabolism ; Autophagy/physiology ; Cell Death/physiology ; Humans ; Nervous System Diseases/enzymology ; Nervous System Diseases/pathology
    Chemical Substances 12-15-lipoxygenase ; Arachidonate 12-Lipoxygenase (EC 1.13.11.31) ; Arachidonate 15-Lipoxygenase (EC 1.13.11.33)
    Language English
    Publishing date 2018-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2018.04.002
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    Zs.A 1610: Show issues Location:
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  7. Article ; Online: Gap junction as an intercellular glue: Emerging roles in cancer EMT and metastasis.

    Mao, Xiao-Yuan / Li, Qiu-Qi / Gao, Yuan-Feng / Zhou, Hong-Hao / Liu, Zhao-Qian / Jin, Wei-Lin

    Cancer letters

    2016  Volume 381, Issue 1, Page(s) 133–137

    Abstract: Metastasis is a common phenomenon in the progression and dissemination of cancer. It is estimated that metastasis accounts for 90% cancer-related mortality. Although the formation of tumor metastasis is relatively well understood, the underlying ... ...

    Abstract Metastasis is a common phenomenon in the progression and dissemination of cancer. It is estimated that metastasis accounts for 90% cancer-related mortality. Although the formation of tumor metastasis is relatively well understood, the underlying molecular mechanisms responsible for the emergence of aggressive cancer phenotype are still elusive. Figuring out the mechanisms by which cancer cells evade from the tumor is beneficial for obtaining novel and effectively therapeutic approaches. Primary tumors are composed of various subpopulations of cells with heterogeneous metastatic characteristics and the occurrence of metastatic dissemination is mainly dependent upon the interactions between tumor and the surrounding microenvironment. Tumor microenvironment (TME) such as extracellular matrix, macrophages, fibroblasts, stem cells and endothelial cells can orchestrate events critical to tumor evolution toward metastasis. GJ serves as an important communication between tumor cells and stromal cells. Increased GJs coupling blocks metastatic potential in some cancer animal models such as breast cancer and melanoma. Besides, epithelial-to-mesenchymal transition (EMT) is also a crucial step in the metastatic process and there are signs that GJs contribute to cell adhesion and migration (the pathological feature of EMT) in breast cancer. Therefore, we propose that GJ serves as an intercellular glue to suppress EMT and cancer metastasis.
    MeSH term(s) Animals ; Cell Adhesion ; Cell Communication ; Cell Movement ; Connexins/metabolism ; Epithelial-Mesenchymal Transition ; Extracellular Matrix/metabolism ; Gap Junctions/metabolism ; Gap Junctions/pathology ; Humans ; Neoplasm Metastasis ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances Connexins
    Language English
    Publishing date 2016--10
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2016.07.037
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  8. Article ; Online: Sodium Valproate Ameliorates Neuronal Apoptosis in a Kainic Acid Model of Epilepsy via Enhancing PKC-Dependent GABA

    Li, Qin / Li, Qiu-Qi / Jia, Ji-Ning / Cao, Shan / Wang, Zhi-Bin / Wang, Xu / Luo, Chao / Zhou, Hong-Hao / Liu, Zhao-Qian / Mao, Xiao-Yuan

    Neurochemical research

    2018  Volume 43, Issue 12, Page(s) 2343–2352

    Abstract: GABA is a dominant inhibitory neurotransmitter in the brain and A type GABA receptor ( ... ...

    Abstract GABA is a dominant inhibitory neurotransmitter in the brain and A type GABA receptor (GABA
    MeSH term(s) Animals ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Apoptosis/drug effects ; Apoptosis/physiology ; Epilepsy/chemically induced ; Epilepsy/drug therapy ; Epilepsy/metabolism ; Kainic Acid/toxicity ; Male ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Phosphorylation/drug effects ; Phosphorylation/physiology ; Protein Kinase C/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A/metabolism ; Serine/metabolism ; Valproic Acid/pharmacology ; Valproic Acid/therapeutic use
    Chemical Substances Anticonvulsants ; Gabrg2 protein, rat ; Neuroprotective Agents ; Receptors, GABA-A ; Serine (452VLY9402) ; Valproic Acid (614OI1Z5WI) ; Protein Kinase C (EC 2.7.11.13) ; Kainic Acid (SIV03811UC)
    Language English
    Publishing date 2018-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-018-2659-8
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    Zs.A 1368: Show issues Location:
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  9. Article: XsFAD2 gene encodes the enzyme responsible for the high linoleic acid content in oil accumulated in Xanthoceras sorbifolia seeds

    Guo, Hui‐Hong / Li, Qiu‐Qi / Wang, Ting‐Ting / Hu, Qing / Deng, Wen‐Hong / Xia, Xin‐Li / Gao, Hong‐Bo

    Journal of the science of food and agriculture. 2014 Feb., v. 94, no. 3

    2014  

    Abstract: BACKGROUND: Xanthoceras sorbifolia Bunge is a valuable oilseed tree that has linoleic acid‐rich seed oil. Microsomal oleate desaturase (FAD2; EC 1.3.1.35) is responsible for the conversion of oleic acid to linoleic acid during fatty acid synthesis. In ... ...

    Abstract BACKGROUND: Xanthoceras sorbifolia Bunge is a valuable oilseed tree that has linoleic acid‐rich seed oil. Microsomal oleate desaturase (FAD2; EC 1.3.1.35) is responsible for the conversion of oleic acid to linoleic acid during fatty acid synthesis. In this study, XsFAD2 was cloned from developing embryos of X. sorbifolia. RESULTS: XsFAD2 contained three histidine boxes, a C‐terminal endoplasmic reticulum retrieval motif, and five putative transmembrane domains representing the characteristics of membrane‐bound fatty acid desaturase. XsFAD2 expression in yeast cells resulted in linoleic acid (18:2) and palmitolinoleic acid (16:2) production, confirming the biological activity of the enzyme encoded by XsFAD2. These fatty acids are not normally present in wild‐type yeast. Phylogenetic analysis indicated that XsFAD2 is located in a subgroup of FAD2 enzymes specifically or highly expressed in developing seeds. The expression level of XsFAD2 in seeds was much higher than those in leaves and petals. Furthermore, XsFAD2 expression pattern correlated well with linoleic acid accumulated in seeds. CONCLUSION: Results suggested that XsFAD2 is responsible for the high linoleic acid content in X. sorbifolia seed oil. This study provides insight on the regulation mechanism of fatty acid synthesis in X. sorbifolia seeds and a valuable gene for improving the oil quality in oilseed trees. © 2013 Society of Chemical Industry
    Keywords Xanthoceras sorbifolium ; bioactive properties ; corolla ; endoplasmic reticulum ; enzyme activity ; genes ; histidine ; leaves ; linoleic acid ; lipid content ; oilseeds ; oleic acid ; phylogeny ; seed oils ; seeds ; stearoyl-CoA desaturase ; trees ; yeasts
    Language English
    Dates of publication 2014-02
    Size p. 482-488.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.6273
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  10. Article ; Online: Two novel diacylglycerol acyltransferase genes from Xanthoceras sorbifolia are responsible for its seed oil content.

    Guo, Hui-Hong / Wang, Ting-Ting / Li, Qiu-Qi / Zhao, Na / Zhang, Yuan / Liu, Di / Hu, Qing / Li, Feng-Lan

    Gene

    2013  Volume 527, Issue 1, Page(s) 266–274

    Abstract: Xanthoceras sorbifolia is an excellent model system for studying triacylglycerol (TAG) biosynthesis in woody oilseed plants due to the high amount of seed oil, which is important for food and industrial uses. TAG is the major form of stored lipids in ... ...

    Abstract Xanthoceras sorbifolia is an excellent model system for studying triacylglycerol (TAG) biosynthesis in woody oilseed plants due to the high amount of seed oil, which is important for food and industrial uses. TAG is the major form of stored lipids in seeds and diacylglycerol acyltransferase (DGAT; EC 2. 3. 1. 20) catalyzes the final and critical step of TAG synthesis. Here, two novel DGAT genes, designated XsDGAT1 and XsDGAT2, were cloned from developing X. sorbifolia embryos. Sequence analysis showed that XsDGAT1 had little sequence homology to XsDGAT2. Heterologous expression of XsDGAT1 and XsDGAT2 in TAG-deficient yeast mutants restored TAG synthesis, confirming their biological activity. Expression of the two genes in wild-type Arabidopsis led to TAG synthesis and an increase in total seed oil in transgenic plants, with XsDGAT1 appearing to contribute to TAG synthesis at a greater level. Comparison of the expression patterns revealed that both XsDGAT1 and XsDGAT2 were expressed in the examined tissues and had similar spatiotemporal expression patterns with higher expression in embryos than in leaves and petals. The expression patterns of both XsDGAT1 and XsDGAT2 correlated with oil accumulation in developing X. sorbifolia embryos. These data suggest that XsDGAT1 and XsDGAT2 are both responsible for TAG synthesis in X. sorbifolia seeds.
    MeSH term(s) Amino Acid Sequence ; Arabidopsis ; Cloning, Molecular ; Conserved Sequence ; Diacylglycerol O-Acyltransferase/chemistry ; Diacylglycerol O-Acyltransferase/genetics ; Diacylglycerol O-Acyltransferase/metabolism ; Gene Dosage ; Molecular Sequence Data ; Phylogeny ; Plant Oils/metabolism ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Saccharomyces cerevisiae ; Sapindaceae/enzymology ; Sapindaceae/genetics ; Seeds/enzymology ; Seeds/genetics ; Sequence Analysis, DNA ; Triglycerides/biosynthesis
    Chemical Substances Plant Oils ; Plant Proteins ; Triglycerides ; Diacylglycerol O-Acyltransferase (EC 2.3.1.20)
    Language English
    Publishing date 2013-09-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2013.05.076
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