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Article ; Online: The Panel Spatial Econometric Analysis for Development of Green Intensive Agriculture Based on Edge Computing and Internet of Things.

Li, Qiubo / Shi, Hongyu

Journal of environmental and public health

2022 Volume 2022, Page(s) 2811119

Abstract: To further promote the modernization of agriculture and the prosperity of green industry, the analyses are made on the intensive level of agriculture by using spatial econometric model under the Internet of Things (IoT), and the optimal defense strategy ... ...

Abstract	To further promote the modernization of agriculture and the prosperity of green industry, the analyses are made on the intensive level of agriculture by using spatial econometric model under the Internet of Things (IoT), and the optimal defense strategy is adopted for edge network equipment to ensure the security of agricultural information. Initially, the present work introduces the related concepts of agricultural intensive development and analyzes the important role of IoT in the development process of agricultural modernization. Next, it briefly explains the spatial econometric analysis method, introduces two basic spatial analysis models-spatial lag model (SLM) and spatial error model (SEM), and explains their principles in detail. Then, it signifies the characteristics of IoT and edge computing (EC) and designs the optimal defense strategy of edge network equipment from the perspective of IoT. Finally, the simulation experiment is carried out based on the edge network defense strategy, and the spatial econometric analysis is carried out by taking the agricultural intensive development of counties in a Chinese province as an example. The experimental results show that with the increase of the number of edge network devices, the optimal strategy of edge network defense can be adopted while consuming certain computing resources. The agricultural technology input and intensive level in the jurisdiction have high spatial correlation, so it is necessary to establish a spatial econometric model for analysis. Additionally, the statistics of SLM is higher than that of SEM, which shows that SLM can better reflect the technology investment and spatial correlation than SEM does. Both industrial and agricultural division of labor and agricultural production link division of labor can promote the level of intensification, among which the promotion of industrial and agricultural division of labor is not very significant, while the promotion of agricultural production link division of labor is very significant.
MeSH term(s)	Agriculture ; Computer Simulation ; Internet of Things ; Spatial Analysis
Language	English
Publishing date	2022-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/2811119
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Article: Asymptomatic hyperuricaemia in chronic kidney disease: mechanisms and clinical implications.

Anders, Hans-Joachim / Li, Qiubo / Steiger, Stefanie

Clinical kidney journal

2023 Volume 16, Issue 6, Page(s) 928–938

Abstract: Asymptomatic hyperuricaemia (HU) is considered a pathogenic factor in multiple disease contexts, but a causative role is only proven for the crystalline form of uric acid in gouty arthritis and urate nephropathy. Epidemiological studies document a robust ...

Abstract	Asymptomatic hyperuricaemia (HU) is considered a pathogenic factor in multiple disease contexts, but a causative role is only proven for the crystalline form of uric acid in gouty arthritis and urate nephropathy. Epidemiological studies document a robust association of HU with hypertension, cardiovascular disease (CVD) and CKD progression, but CKD-related impaired uric acid (UA) clearance and the use of diuretics that further impair UA clearance likely accounts for these associations. Interpreting the available trial evidence is further complicated by referring to xanthine oxidase inhibitors as urate-lowering treatment, although these drugs inhibit other substrates, so attributing their effects only to HU is problematic. In this review we provide new mechanistic insights into the biological effects of soluble and crystalline UA and discuss clinical evidence on the role of asymptomatic HU in CKD, CVD and sterile inflammation. We identify research areas with gaps in experimental and clinical evidence, specifically on infectious complications that represent the second common cause of death in CKD patients, referred to as secondary immunodeficiency related to kidney disease. In addition, we address potential therapeutic approaches on how and when to treat asymptomatic HU in patients with kidney disease and where further interventional studies are required.
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfad006
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Article ; Online: MiR-200c-3p and miR-485-5p overexpression elevates cisplatin sensitivity and suppresses the malignant phenotypes of non-small cell lung cancer cells through targeting RRM2.

Liu, Ying / Zhang, Yong / Li, Qiubo / Xu, Ruiqi / Huang, Nian

Thoracic cancer

2022 Volume 13, Issue 13, Page(s) 1974–1985

Abstract: Background: This study intended to investigate the potential mechanism of microRNA-200c-3p (miR-200c-3p) and miR-485-5p in mediating the cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC).: Methods: Quantitative real-time polymerase ... ...

Abstract	Background: This study intended to investigate the potential mechanism of microRNA-200c-3p (miR-200c-3p) and miR-485-5p in mediating the cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to measure the expression of miR-200c-3p, miR-485-5p, and ribonucleotide reductase regulatory subunit M2 (RRM2) messenger RNA (mRNA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to analyze the DDP resistance and the proliferation of NSCLC cells. Colony formation assay was used to assess cell proliferation. Transwell assays were used to evaluate cell migration and invasion. The target relationship between RRM2 and miR-200c-3p or miR-485-5p was verified using dual-luciferase reporter assay. The protein level of RRM2 was measured using Western blot assay. Animal experiments were conducted to analyze the roles of miR-200c-3p and miR-485-5p in the DDP resistance of xenograft tumors in vivo. Results: MiR-200c-3p and miR-485-5p were both downregulated in DDP-resistant NSCLC tissues and cell lines. Overexpressing miR-200c-3p or miR-485-5p suppressed the DDP resistance and malignant behaviors of NSCLC cells. MiR-200c-3p played a synergistic role with miR-485-5p in regulating the chemo-resistance and biological behaviors NSCLC cells. RRM2 was confirmed as a target of miR-200c-3p and miR-485-5p. RRM2 silencing restrained the DDP resistance and progression of NSCLC. RRM2 overexpression partly reversed miR-200c-3p or miR-485-5p-induced influences in NSCLC cells. The overexpression of miR-200c-3p or miR-485-5p aggravated DDP-mediated suppressive effect on tumor growth in vivo. Conclusion: MiR-200c-3p or miR-485-5p enhanced the DDP sensitivity and suppressed the malignant behaviors of NSCLC cells partly through targeting RRM2.
MeSH term(s)	Animals ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Proliferation ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Phenotype
Chemical Substances	MIRN485 microRNA, human ; MicroRNAs ; Oxidoreductases (EC 1.-) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-05-22
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14475
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Article ; Online: Research Progress in Liquid Phase Growth of GaN Crystals.

Sun, Defu / Liu, Lei / Wang, Guodong / Yu, Jiaoxian / Li, Qiubo / Tian, Ge / Wang, Benfa / Xu, Xiangang / Zhang, Lei / Wang, Shouzhi

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 17, Page(s) e202303710

Abstract: As a wide band gap semiconductor, gallium nitride (GaN) has high breakdown voltage, excellent structural stability and mechanical properties, giving it unique advantages in applications such as high frequency, high power, and high temperature. As a ... ...

Abstract	As a wide band gap semiconductor, gallium nitride (GaN) has high breakdown voltage, excellent structural stability and mechanical properties, giving it unique advantages in applications such as high frequency, high power, and high temperature. As a result, it has broad application prospects in optoelectronics and microelectronics. However, the lack of high-quality, large-size GaN crystal substrates severely limit the improvement of electronic device performance. To solve this problem, liquid phase growth of GaN has attracted much attention because it can produce higher quality GaN crystals compared to traditional vapor phase growth methods. This review introduces two main methods of liquid phase growth of GaN: the flux method and ammonothermal method, as well as their advantages and challenges. It reviews the research history and recent advances of these two methods, including the effects of different solvents and mineralizers on the growth quality and performance of GaN crystals, as well as various technical improvements. This review aims to outline the principles, characteristics, and development trends of liquid phase growth of GaN, to provide more inspiration for future research on liquid phase growth, and to achieve further breakthroughs in its development and commercial application.
Language	English
Publishing date	2024-01-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303710
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Article ; Online: Circ_0011292 knockdown mitigates progression and drug resistance in PTX-resistant non-small-cell lung cancer cells by regulating miR-433-3p/CHEK1 axis.

Jin, Ming / Zhang, Fengping / Li, Qiubo / Xu, Ruiqi / Liu, Ying / Zhang, Yong

Thoracic cancer

2022 Volume 13, Issue 9, Page(s) 1276–1288

Abstract: Background: Non-small-cell lung cancer (NSCLC) is one of the most common malignant tumors on earth. Circular RNAs have been disclosed to be vital regulators in the chemoresistance and development of diverse cancers, including NSCLC. Here, we attempted ... ...

Abstract	Background: Non-small-cell lung cancer (NSCLC) is one of the most common malignant tumors on earth. Circular RNAs have been disclosed to be vital regulators in the chemoresistance and development of diverse cancers, including NSCLC. Here, we attempted to explore the function of circ_0011292 in paclitaxel (PTX)-resistant NSCLC cells. Methods: Quantitative real-time polymerase chain reaction or western blot was performed to detect the expression of circ_0011292, microRNA-433-3p (miR-433-3p), and checkpoint kinase 1 (CHEK1). Ribonuclease R (RNase R) assay was performed to assess the stability of circ_0011292. Cell Counting Kit-8 assay was conducted to evaluate the half maximal inhibitory concentration of PTX and cell viability. Cell proliferation was monitored by Edu incorporation and colony formation assays. Cell cycle and apoptosis were detected by flow cytometry. Transwell assay was implemented to assess cell migration and invasion. Western blot assay was utilized to determine the protein levels. Dual-luciferase reporter assay was carried out to verify the targeted interaction between miR-433-3p and circ_0011292 or CHEK1. Xenograft tumor model was constructed for determining the effect of circ_0011292 in NSCLC growth in vivo. Results: Circ_0011292 was upregulated in PTX-resistant NSCLC tissues and cells. Circ_0011292 or CHEK1 knockdown enhanced PTX sensitivity and cell apoptosis, and repressed cell proliferation, migration, and invasion in PTX-resistant NSCLC cells. Mechanistically, circ_0011292 was a sponge of miR-433-3p and miR-433-3p directly targeted CHEK1. Meanwhile, silencing miR-433-3p or overexpressing CHEK1 respectively abrogated the impacts of circ_0011292 deletion or miR-433-3p introduction on PTX resistance and cell progression in PTX-resistant NSCLC cells in vitro. Moreover, circ_0011292 could positively modulate CHEK1 expression through sponging miR-433-3p. In addition, circ_0011292 knockdown retarded tumor growth of NSCLC in vivo. Conclusion: Circ_0011292 could accelerate PTX resistance and cell malignant progression of NSCLC cells partially through the regulation of circ_0011292/miR-433-3p/CHEK1 axis.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Checkpoint Kinase 1 ; Drug Resistance, Neoplasm/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Paclitaxel/pharmacology
Chemical Substances	MIRN433 microRNA, human ; MicroRNAs ; CHEK1 protein, human (EC 2.7.11.1) ; Checkpoint Kinase 1 (EC 2.7.11.1) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-03-29
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14378
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Article ; Online: The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1.

Wang, Min / Gu, Yixue / Li, Qiubo / Feng, Bangzhe / Lv, Xinke / Zhang, Hao / Kong, Qingxia / Dong, Zhifang / Tian, Xin / Zhang, Yanke

Genes & diseases

2023 Volume 11, Issue 3, Page(s) 100997

Abstract: Epilepsy, one of the most common neurological disorders, is characterized by spontaneous recurrent seizures. Temporal lobe epilepsy (TLE) is one of the most common medically intractable seizure disorders. Traf2-and NcK-interacting kinase (TNIK) has ... ...

Abstract	Epilepsy, one of the most common neurological disorders, is characterized by spontaneous recurrent seizures. Temporal lobe epilepsy (TLE) is one of the most common medically intractable seizure disorders. Traf2-and NcK-interacting kinase (TNIK) has recently attracted attention as a critical modulation target of many neurological and psychiatric disorders, but its role in epilepsy remains unclear. In this study, we hypothesized the involvement of TNIK in epilepsy and investigated TNIK expression in patients with intractable TLE and in a pilocarpine-induced rat model of epilepsy by western blotting, immunofluorescence, and immunohistochemistry. A pentylenetetrazole (PTZ)-induced epilepsy rat model was used to determine the effect of the TNIK inhibitor NCB-0846 on behavioral manifestations of epilepsy. Coimmunoprecipitation (Co-IP)/mass spectrometry (MS) was used to identify the potential mechanism. Through Co-IP, we detected and confirmed the main potential TNIK interactors. Subcellular fractionation was used to establish the effect of NCB-0846 on the expression of the main interactors in postsynaptic density (PSD) fractions. We found that TNIK was primarily located in neurons and decreased significantly in epilepsy model rats and TLE patients compared with controls. NCB-0846 delayed kindling progression and decreased seizure severity. Co-IP/MS identified 63 candidate TNIK interactors in rat hippocampi, notably CaMKII. Co-IP showed that TNIK might correlate with endogenous GRIA1, SYN2, PSD-95, CaMKIV, GABRG1, and GABRG2. In addition, the significant decrease in GRIA1 in hippocampal total lysate and PSDs after NCB-0846 treatment might help modify the progression of PTZ kindling. Our results suggest that TNIK contributes to epileptic pathology and is a potential antiepileptic drug target.
Language	English
Publishing date	2023-06-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2023.03.036
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Article ; Online: Compound heterozygous mutations in the TH gene in a Chinese family with autosomal-recessive dopa-responsive dystonia: A case report.

Feng, Bangzhe / Sun, Guangfei / Kong, Qingxia / Li, Qiubo

Medicine

2018 Volume 97, Issue 44, Page(s) e12870

Abstract: Rationale: Autosomal-recessive dopa-responsive dystonia (DRD) is a rare clinical disorder presenting as bradykinesia, dystonia, tremor and even severe encephalopathy, and caused by tyrosine hydroxylase deficiency (THD). We report a case of compound ... ...

Abstract	Rationale: Autosomal-recessive dopa-responsive dystonia (DRD) is a rare clinical disorder presenting as bradykinesia, dystonia, tremor and even severe encephalopathy, and caused by tyrosine hydroxylase deficiency (THD). We report a case of compound heterozygous mutations in the TH gene in a Chinese family with autosomal-recessive DRD herein. Patient concerns: A 16-month-old Chinese boy presented with symptoms of movement disorder and growth retardation in his infant period. Diagnoses: The genetic test revealed compound heterozygous mutations in the TH gene at c.457C>T and c.698G>A, which are pathogenic of DRD. Interventions: The patient was administrated low-dose levodopa. Outcomes: The treatment resulted in the substantial improvement of dystonia. His long-term neurological outcome need follow-up for years. Lessons: Gene mutation analysis is helpful and necessary to diagnose DRD and has important guiding significance for the subsequent treatment.
MeSH term(s)	Asians/genetics ; Dystonic Disorders/congenital ; Dystonic Disorders/drug therapy ; Dystonic Disorders/genetics ; Genetic Testing ; Heterozygote ; Humans ; Infant ; Levodopa/therapeutic use ; Male ; Mutation ; Tyrosine 3-Monooxygenase/genetics
Chemical Substances	Levodopa (46627O600J) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
Language	English
Publishing date	2018-10-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000012870
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Article ; Online: Child with cerebral malformations and epilepsy.

Sun, Ying / Shen, Xuehua / Li, Qiubo / Kong, Qingxia

The International journal of neuroscience

2018 Volume 128, Issue 9, Page(s) 881–885

Abstract: Purpose: Baraitser-Winter cerebrofrontofacial syndrome (BWCFF) is a rare autosomal dominant genetic disorder involving multiple organ systems and primarily characterized by structural brain abnormalities and a distinctive facial appearance.: Methods: ...

Abstract	Purpose: Baraitser-Winter cerebrofrontofacial syndrome (BWCFF) is a rare autosomal dominant genetic disorder involving multiple organ systems and primarily characterized by structural brain abnormalities and a distinctive facial appearance. Methods: To study the clinical characteristics, gene types and seizures of BWCFF. The natural history, clinical data and peripheral blood sample were collected in the child and his patients. To screen the β-actin gene (ACTB) of a newly diagnosed child, hoping to find the gene mutation. Results: The child had left ptosis, ocular hypertelorism, arched eyebrows, only 30% of the left ear hearing, a slight hypotonia, normal muscle strength, walking instability. The seizures were difficult to control with antiepileptic drugs and presented some degree of psychomotor development delay. Genetic screening showed De Novo in ACTB gene (c.484A> G, p.Thr162Ala). Parents did not detect related gene mutations. Conclusions: Patients with typical facial features and cerebral cortical malformations associated with refractory epilepsy should be highly suspected BWCFF. Patients are advised to carry out genetic screening to confirm the diagnosis.
MeSH term(s)	Actins/genetics ; Child ; DNA Mutational Analysis ; Electroencephalography ; Epilepsy/complications ; Epilepsy/diagnostic imaging ; Epilepsy/genetics ; Humans ; Magnetic Resonance Imaging ; Models, Molecular ; Nervous System Malformations/complications ; Nervous System Malformations/diagnostic imaging ; Nervous System Malformations/genetics
Chemical Substances	Actins
Language	English
Publishing date	2018-03-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	3061-2
ISSN	1563-5279 ; 1543-5245 ; 0020-7454
ISSN (online)	1563-5279 ; 1543-5245
ISSN	0020-7454
DOI	10.1080/00207454.2018.1433177
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Article ; Online: Polo-like kinase 2 promotes chemoresistance and predicts limited survival benefit from adjuvant chemotherapy in colorectal cancer.

Xie, Yuquan / Liu, Ying / Li, Qiubo / Chen, Jianming

International journal of oncology

2018 Volume 52, Issue 5, Page(s) 1401–1414

Abstract: Colorectal cancer (CRC) is one of the most common malignances worldwide. Chemoresistance remains a major issue in the field of CRC treatment. The present study aimed to investigate the potential role of polo-like kinase 2 (Plk2) in chemoresistance in CRC. ...

Abstract	Colorectal cancer (CRC) is one of the most common malignances worldwide. Chemoresistance remains a major issue in the field of CRC treatment. The present study aimed to investigate the potential role of polo-like kinase 2 (Plk2) in chemoresistance in CRC. The associations between Plk2 and clinicopathological factors, as well as chemotherapeutic benefit were analyzed with a publicly available CRC dataset. The correlation between Plk2 expression and chemosensitivity was further confirmed in CRC cells. Moreover, knockdown and exogenous overexpression experiments of Plk2 were carried out to uncover the potential role of Plk2 in regulating the chemoresistance of CRC cells. We found that the expression of Plk2 was significantly associated with proximally located tumors. In addition, it was found that high expression ofPlk2 was associated with deficient mismatch repair status, B‑raf serine/threonine kinase proto‑oncogeneand Kirsten rat sarcoma viral oncogene homolog mutations. By contrast, tumor protein 53 mutation was correlated with a low expression level of Plk2. A higher expression level of Plk2 significantly predicted a poorer outcome in patients with CRC. However, the prognostic significance was only observed in patients who received adjuvant chemotherapy. In CRC cells, higher levels of Plk2 were associated with increased resistance to chemotherapeutic agents. Knocking down the expression of Plk2 resulted in elevated cellular apoptosis induced by oxaliplatin. By contrast, exogenous overexpression of Plk2 exerted an anti-apoptotic effect and enhanced the resistance of CRC cells to chemotherapeutic agents. In conclusion, a high expression of Plk2 was associated with chemoresistant traits of CRC through inhibiting apoptosis. These results suggested that Plk2 may serve as a predictive marker for chemoresistance and a novel target in CRC treatment.
Language	English
Publishing date	2018-03-20
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2018.4328
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Article: Multimodal Neuroimaging in Rett Syndrome With

Kong, Yu / Li, Qiu-Bo / Yuan, Zhao-Hong / Jiang, Xiu-Fang / Zhang, Gu-Qing / Cheng, Nan / Dang, Na

Frontiers in neurology

2022 Volume 13, Page(s) 838206

Abstract: Rett syndrome (RTT) is a rare neurodevelopmental disorder characterized by severe cognitive, social, and physical impairments resulting ... ...

Abstract	Rett syndrome (RTT) is a rare neurodevelopmental disorder characterized by severe cognitive, social, and physical impairments resulting from
Language	English
Publishing date	2022-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.838206
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