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  1. Article ; Online: Patterns and assessment of spastic hemiplegic gait.

    Li, Sheng

    Muscle & nerve

    2024  Volume 69, Issue 5, Page(s) 516–522

    Abstract: Hemiparetic gait disorders are common in stroke survivors. A circumductory gait is often considered the typical hemiparetic gait. In clinical practice, a wide spectrum of abnormal gait patterns is observed, depending on the severity of weakness and ... ...

    Abstract Hemiparetic gait disorders are common in stroke survivors. A circumductory gait is often considered the typical hemiparetic gait. In clinical practice, a wide spectrum of abnormal gait patterns is observed, depending on the severity of weakness and spasticity, and the anatomical distribution of spasticity. Muscle strength is the key determinant of gait disorders in hemiparetic stroke survivors. Spasticity and its associated involuntary activation of synergistic spastic muscles often alter posture of involved joint(s) and subsequently the alignment of hip, knee, and ankle joints, resulting in abnormal gait patterns. Due to combinations of various levels of muscle weakness and spasticity and their interactions with ground reaction force, presentations of gait disorders are variable. From a neuromechanical perspective, a stepwise visual gait analysis approach is proposed to identify primary underlying causes. In this approach, the pelvic and hip joint movement is examined first. The pelvic girdle constitutes three kinematic determinants. Its abnormality determines the body vector and compensatory kinetic chain reactions in the knee and ankle joints. The second step is to assess the ankle and foot complex abnormality. The last step is to examine abnormality of the knee joint. Assessment of muscle strength and spasticity of hip, knee, and ankle/foot joints needs to be performed before these steps. Lidocaine nerve blocks can be a useful diagnostic tool. Recognizing different patterns and identifying the primary causes are critical to developing clinical interventions to improve gait functions.
    MeSH term(s) Humans ; Muscle Spasticity/diagnosis ; Muscle Spasticity/etiology ; Gait/physiology ; Knee Joint ; Stroke/complications ; Ankle Joint ; Gait Disorders, Neurologic/diagnosis ; Gait Disorders, Neurologic/etiology ; Movement Disorders ; Biomechanical Phenomena
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.28052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exploring the clinical capabilities and limitations of ChatGPT: a cautionary tale for medical applications.

    Li, Sheng

    International journal of surgery (London, England)

    2023  Volume 109, Issue 9, Page(s) 2865–2867

    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: ChatGPT has made the field of surgery full of opportunities and challenges.

    Li, Sheng

    International journal of surgery (London, England)

    2023  Volume 109, Issue 8, Page(s) 2537–2538

    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Stroke Recovery Is a Journey: Prediction and Potentials of Motor Recovery after a Stroke from a Practical Perspective.

    Li, Sheng

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 10

    Abstract: Stroke recovery is a journey. Stroke survivors can face many consequences that may last the rest of their lives. Assessment of initial impairments allows reasonable prediction of biological spontaneous recovery at 3 to 6 months for a majority of ... ...

    Abstract Stroke recovery is a journey. Stroke survivors can face many consequences that may last the rest of their lives. Assessment of initial impairments allows reasonable prediction of biological spontaneous recovery at 3 to 6 months for a majority of survivors. In real-world clinical practice, stroke survivors continue to improve their motor function beyond the spontaneous recovery period, but management plans for maximal recovery are not well understood. A model within the international classification of functioning (ICF) theoretical framework is proposed to systematically identify opportunities and potential barriers to maximize and realize the potentials of functional recovery from the acute to chronic stages and to maintain their function in the chronic stages. Health conditions of individuals, medical and neurological complications can be optimized under the care of specialized physicians. This permits stroke survivors to participate in various therapeutic interventions. Sufficient doses of appropriate interventions at the right time is critical for stroke motor rehabilitation. It is important to highlight that combining interventions is likely to yield better clinical outcomes. Caregivers, including family members, can assist and facilitate targeted therapeutic exercises for these individuals and can help stroke survivors comply with medical plans (medications, visits), and provide emotional support. With health optimization, comprehensive rehabilitation, support from family and caregivers and a commitment to a healthy lifestyle, many stroke survivors can overcome barriers and achieve potentials of maximum recovery and maintain their motor function in chronic stages. This ICF recovery model is likely to provide a guidance through the journey to best achieve stroke recovery potentials.
    Language English
    Publishing date 2023-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13102061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stiff Knee Gait Disorders as Neuromechanical Consequences of Spastic Hemiplegia in Chronic Stroke.

    Li, Sheng

    Toxins

    2023  Volume 15, Issue 3

    Abstract: Stiff knee gait (SKG) is defined as decreased knee flexion during the swing phase. It is one of the most common gait disorders following stroke. Knee extensor spasticity is commonly accepted as the primary cause. Clinical management has focused on the ... ...

    Abstract Stiff knee gait (SKG) is defined as decreased knee flexion during the swing phase. It is one of the most common gait disorders following stroke. Knee extensor spasticity is commonly accepted as the primary cause. Clinical management has focused on the reduction in knee extensor spasticity. Recent advances in understanding of post-stroke hemiplegic gait suggest that SKG can present as mechanical consequences between muscle spasticity, weakness, and their interactions with ground reactions during walking. Various underlying mechanisms are presented through sample cases in this article. They include ankle plantar flexor spasticity, knee extensor spasticity, knee flexor and extensor coactivation, and hip flexor spasticity. Careful and thorough clinical assessment is advised to determine the primary cause for each patient. Understanding of these various presentations of SKG is helpful to guide clinical assessment and select appropriate target muscles for interventions.
    MeSH term(s) Humans ; Hemiplegia/etiology ; Quadriceps Muscle ; Gait ; Walking/physiology ; Stroke/complications ; Muscle Spasticity/etiology ; Biomechanical Phenomena
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15030204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Inferring the Cancer Cellular Epigenome Heterogeneity via DNA Methylation Patterns.

    Li, Sheng

    Cancer treatment and research

    2023  Volume 190, Page(s) 375–393

    Abstract: Tumor cells evolve through space and time, generating genetically and phenotypically diverse cancer cell populations that are continually subjected to the selection pressures of their microenvironment and cancer treatment. ...

    Abstract Tumor cells evolve through space and time, generating genetically and phenotypically diverse cancer cell populations that are continually subjected to the selection pressures of their microenvironment and cancer treatment.
    MeSH term(s) Humans ; DNA Methylation ; Epigenome ; Epigenesis, Genetic ; Neoplasms/genetics
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-031-45654-1_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Electromyography (EMG) Techniques for the Assessment and Rehabilitation of Motor Impairment Following Stroke

    Klein, Cliff S. / Li, Sheng / Hu, Xiaogang / Li, Xiaoyan

    2019  

    Keywords Medicine ; Neurology & clinical neurophysiology ; electromyography ; MUSC ; motor ; rehabilitation ; stroke
    Size 1 electronic resource (205 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229838
    ISBN 9782889458530 ; 2889458539
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Physical activity and the risk of ischemic stroke: A population-based longitudinal follow-up study in Taiwan (KCIS no. 43).

    Lu, Ching-Yu / Li-Sheng Chen, Sam / Pan, Shin-Liang

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2024  Volume 121, Page(s) 18–22

    Abstract: Lack of exercise is a leading risk factor for stroke, and it has been demonstrated that increasing physical activity (PA) can prevent ischemic stroke. However, there has been limited research on the relationship between ischemic stroke and PA, especially ...

    Abstract Lack of exercise is a leading risk factor for stroke, and it has been demonstrated that increasing physical activity (PA) can prevent ischemic stroke. However, there has been limited research on the relationship between ischemic stroke and PA, especially among Asian populations. This study therefore investigates whether the level of PA in the Taiwanese population affects its risk of first-ever ischemic stroke, utilizing screening data on 58,857 individuals collected by the Keelung Health Bureau between 2005 and 2012. These subjects were divided into three groups based on their weekly exercise frequency and duration, i.e., 1) a no PA (NPA) group, 2) a low PA (LPA) group (less than 90 min of exercise per week), and 3) a high PA (HPA) group (90 min or more of exercise per week). The results showed that, as compared to the NPA group, the adjusted hazard ratio for ischemic stroke in the LPA group was 0.86 (95 % CI, 0.78-0.95, p < 0.0001); and that in the HPA group, it was also 0.86 (95 % CI, 0.79-0.94, p < 0.0001). In other words, even engaging in PA for less than 90 min per week may lower the risk of first-ever ischemic stroke. Importantly, LPA is more accessible, more sustainable, and easier to promote for the general population than the 150 min per week recommended by the World Health Organization.
    MeSH term(s) Humans ; Follow-Up Studies ; Ischemic Stroke ; Taiwan/epidemiology ; Exercise ; Stroke/epidemiology ; Risk Factors
    Language English
    Publishing date 2024-02-06
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2024.01.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Deconstructing media narratives of the Indo-Pacific strategy

    Zhou Li / Li Sheng

    Humanities & Social Sciences Communications, Vol 10, Iss 1, Pp 1-

    Exploring India’s ontological security and national identity in the Times of India

    2023  Volume 10

    Abstract: Abstract India’s attempt to forge a distinct role for itself in the global order started soon after independence in 1947. Since this watershed event, India’s policymakers have gradually recast their initial strategy of nonalignment, as they realized that ...

    Abstract Abstract India’s attempt to forge a distinct role for itself in the global order started soon after independence in 1947. Since this watershed event, India’s policymakers have gradually recast their initial strategy of nonalignment, as they realized that Nehruvian “soft” power was not adequate for creating an especially dynamic presence in an increasingly volatile international environment. In response to this realization, India embarked on a journey of transforming its diplomatic benchmarks. In 2017, to counter China’s assertiveness across the region, India joined then-U.S. President Donald Trump’s advocacy in launching the Indo-Pacific strategy. Transforming the nation’s diplomatic benchmarks while maintaining a coherent narrative of national identity was the main challenge. This paper examines the role that media narratives play in maintaining that coherent national identity. To do so, we analyzed 47 reports by the Times of India (TOI) on the Indo-Pacific strategy in order to reveal how elite media strategically framed the nation’s regional policy, thereby ensuring its ontological security—its sense of continuity and order—while conveying its global aspirations.
    Keywords History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
    Subject code 950
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Springer Nature
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Ankle and Foot Spasticity Patterns in Chronic Stroke Survivors with Abnormal Gait.

    Li, Sheng

    Toxins

    2020  Volume 12, Issue 10

    Abstract: Chronic stroke survivors with spastic hemiplegia have various clinical presentations of ankle and foot muscle spasticity patterns. They are mechanical consequences of interactions between spasticity and weakness of surrounding muscles during walking. ... ...

    Abstract Chronic stroke survivors with spastic hemiplegia have various clinical presentations of ankle and foot muscle spasticity patterns. They are mechanical consequences of interactions between spasticity and weakness of surrounding muscles during walking. Four common ankle and foot spasticity patterns are described and discussed through sample cases. The patterns discussed are equinus, varus, equinovarus, and striatal toe deformities. Spasticity of the primary muscle(s) for each deformity is identified. However, it is emphasized that clinical presentation depends on the severity of spasticity and weakness of these muscles and their interactions. Careful and thorough clinical assessment of the ankle and foot deformities is needed to determine the primary cause of each deformity. An understanding of common ankle and foot spasticity patterns can help guide clinical assessment and selection of target spastic muscles for botulinum toxin injection or nerve block.
    MeSH term(s) Acetylcholine Release Inhibitors/administration & dosage ; Adult ; Aged ; Ankle/innervation ; Botulinum Toxins/administration & dosage ; Female ; Foot/innervation ; Gait ; Gait Analysis ; Gait Disorders, Neurologic/diagnosis ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology ; Gait Disorders, Neurologic/therapy ; Humans ; Injections ; Male ; Middle Aged ; Muscle Spasticity/diagnosis ; Muscle Spasticity/etiology ; Muscle Spasticity/physiopathology ; Muscle Spasticity/therapy ; Nerve Block ; Recovery of Function ; Stroke/complications ; Stroke/diagnosis ; Stroke/physiopathology ; Stroke/therapy ; Treatment Outcome
    Chemical Substances Acetylcholine Release Inhibitors ; Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2020-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins12100646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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