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  1. Article ; Online: Letter to the editor: citations for the case report on idiopathic hypertrophic pachymeningitis by Kosuke Tsuchida et al.

    Li, Shi-Jun

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2019  Volume 35, Issue 4, Page(s) 583–584

    MeSH term(s) Brain Stem ; Child ; Humans ; Meningitis
    Language English
    Publishing date 2019-01-23
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-019-04055-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2036: Show issues Location:
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  2. Article ; Online: Is Cu(iii) a necessary intermediate in Cu-mediated coupling reactions? A mechanistic point of view.

    Li, Shi-Jun / Lan, Yu

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 49, Page(s) 6609–6619

    Abstract: The mechanism of copper-mediated coupling reactions has aroused widespread interest, and it has been found to not be as simple as initially thought. In this article, we give an overview of the recent advances in this field. Notably, we focus on whether ... ...

    Abstract The mechanism of copper-mediated coupling reactions has aroused widespread interest, and it has been found to not be as simple as initially thought. In this article, we give an overview of the recent advances in this field. Notably, we focus on whether the presence of CuIII is adopted in the catalytic cycle. Attention is paid to the key CuII species, which can be generated by radical-type or single electron transfer (SET) oxidation of CuI. The CuII species can be oxidized to CuIII by SET or using a nucleophilic radical for further reductive elimination. Alternatively, radical-type substitution or bimetallic reductive elimination can avoid formation of CuIII, and coupling reactions can also be achieved.
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc01946a
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  3. Article: Is Cu(iii) a necessary intermediate in Cu-mediated coupling reactions? A mechanistic point of view

    Li, Shi-Jun / Lan, Yu

    Chemical communications. 2020 June 18, v. 56, no. 49

    2020  

    Abstract: The mechanism of copper-mediated coupling reactions has aroused widespread interest, and it has been found to not be as simple as initially thought. In this article, we give an overview of the recent advances in this field. Notably, we focus on whether ... ...

    Abstract The mechanism of copper-mediated coupling reactions has aroused widespread interest, and it has been found to not be as simple as initially thought. In this article, we give an overview of the recent advances in this field. Notably, we focus on whether the presence of Cuᴵᴵᴵ is adopted in the catalytic cycle. Attention is paid to the key Cuᴵᴵ species, which can be generated by radical-type or single electron transfer (SET) oxidation of Cuᴵ. The Cuᴵᴵ species can be oxidized to Cuᴵᴵᴵ by SET or using a nucleophilic radical for further reductive elimination. Alternatively, radical-type substitution or bimetallic reductive elimination can avoid formation of Cuᴵᴵᴵ, and coupling reactions can also be achieved.
    Keywords Lewis bases ; catalytic activity ; copper ; electron transfer ; oxidation
    Language English
    Dates of publication 2020-0618
    Size p. 6609-6619.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc01946a
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  4. Article ; Online: Tunnelling assisted hydrogen elimination mechanisms of FeCl

    Li, Shi-Jun / Fang, Wei / Richardson, Jeremy O / Fang, De-Cai

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 4, Page(s) 565–568

    Abstract: Metal-TEMPO hybrids are a family of novel and promising catalysts for aerobic oxidation of alcohols, yet the underlying mechanisms have not been understood theoretically. Using density functional theory, we probe the hydrogen abstraction mechanisms of ... ...

    Abstract Metal-TEMPO hybrids are a family of novel and promising catalysts for aerobic oxidation of alcohols, yet the underlying mechanisms have not been understood theoretically. Using density functional theory, we probe the hydrogen abstraction mechanisms of FeCl
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc06035j
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  5. Article ; Online: Palladium-Catalyzed Cascade Heck Coupling and Allylboration of Iododiboron Compounds via Diboryl Radicals.

    Wei, Yi / Xie, Xiao-Yu / Liu, Jiabin / Liu, Xiaoxiao / Zhang, Bo / Chen, Xin-Yi / Li, Shi-Jun / Lan, Yu / Hong, Kai

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 18, Page(s) e202401050

    Abstract: Geminal bis(boronates) are versatile synthetic building blocks in organic chemistry. The fact that they predominantly serve as nucleophiles in the previous reports, however, has restrained their synthetic potential. Herein we disclose the ambiphilic ... ...

    Abstract Geminal bis(boronates) are versatile synthetic building blocks in organic chemistry. The fact that they predominantly serve as nucleophiles in the previous reports, however, has restrained their synthetic potential. Herein we disclose the ambiphilic reactivity of α-halogenated geminal bis(boronates), of which the first catalytic utilization was accomplished by merging a formal Heck cross-coupling with a highly diastereoselective allylboration of aldehydes or imines, providing a new avenue for rapid assembly of polyfunctionalized boron-containing compounds. We demonstrated that this cascade reaction is highly efficient and compatible with various functional groups, and a wide range of heterocycles. In contrast to a classical Pd(0/II) scenario, mechanistic experiments and DFT calculations have provided strong evidence for a catalytic cycle involving Pd(I)/diboryl carbon radical intermediates.
    Language English
    Publishing date 2024-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202401050
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  6. Article ; Online: UV light-driven late-stage skeletal reorganization to diverse limonoid frameworks: A proof of concept for photobiosynthesis.

    Wu, Jun / Li, Shi-Jun / Jiang, Long / Ma, Xiao-Chi / Lan, Yu / Shen, Li

    Science advances

    2023  Volume 9, Issue 4, Page(s) eade2981

    Abstract: Late-stage skeletal reorganization (LSSR) is a type of fascinating organic transformation processes in natural product total synthesis. However, few facile and effective LSSR methodologies have hitherto been developed. Here, LSSR of limonoid natural ... ...

    Abstract Late-stage skeletal reorganization (LSSR) is a type of fascinating organic transformation processes in natural product total synthesis. However, few facile and effective LSSR methodologies have hitherto been developed. Here, LSSR of limonoid natural products via photochemical cascades is first reported. Starting from xyloelves A and B, nine distinct limonoid products with five unprecedented scaffolds are generated. The photocascade pathways of these natural products and mechanistic rationale via intramolecular triplet energy transfer are revealed by quantum mechanical calculations. Most notably, ultraviolet light-driven transannular and stereoselective C → C 1,4-acyl migration is first found as a photochemical approach, particularly for LSSR of natural products. This approach holds promise for designing LSSR strategies to access bioactive cage-like molecules. Besides that, our findings provide a clear proof of concept for natural product photobiosynthesis. Xyloelf A, substantially ameliorating concanavalin A-induced liver injury in mice, could be used as a unique molecular template for hepatoprotective drug discovery.
    MeSH term(s) Animals ; Mice ; Ultraviolet Rays ; Limonins/pharmacology ; Drug Discovery ; Biological Products/chemistry
    Chemical Substances Limonins ; Biological Products
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.ade2981
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  7. Article ; Online: Corrigendum to "Generation of Leydig-like cells: approaches, characterization, and challenges".

    Li, Zhao-Hui / Lu, Jun-Dong / Li, Shi-Jun / Chen, Hao-Lin / Su, Zhi-Jian

    Asian journal of andrology

    2023  Volume 25, Issue 6, Page(s) 756

    Language English
    Publishing date 2023-06-02
    Publishing country China
    Document type Journal Article ; Published Erratum
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/aja202323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Tunnelling assisted hydrogen elimination mechanisms of FeCl₃/TEMPO

    Li, Shi-Jun / Fang, Wei / Richardson, Jeremy O. / Fang, De-Cai

    Chemical communications. 2022 Jan. 6, v. 58, no. 4

    2022  

    Abstract: Metal–TEMPO hybrids are a family of novel and promising catalysts for aerobic oxidation of alcohols, yet the underlying mechanisms have not been understood theoretically. Using density functional theory, we probe the hydrogen abstraction mechanisms of ... ...

    Abstract Metal–TEMPO hybrids are a family of novel and promising catalysts for aerobic oxidation of alcohols, yet the underlying mechanisms have not been understood theoretically. Using density functional theory, we probe the hydrogen abstraction mechanisms of FeCl₃/TEMPO on two characteristic substrates, 9,10-dihydroanthracene and benzyl alcohol. We found that the low spin state of FeCl₃/TEMPO is more favourable, and that the N atom is the preferred hydrogen acceptor. Moreover, dispersion interactions assist the reaction, as well as nuclear tunnelling, which even at room temperature can speed up the process by almost two orders of magnitude. We also predict that pronounced kinetic isotope effects (KIE) could be observed due to tunnelling. Our findings provide insights into improving the substrate scope and the development of new transformations for the FeCl₃/TEMPO system.
    Keywords ambient temperature ; benzyl alcohol ; density functional theory ; hydrogen ; isotopes ; oxidation
    Language English
    Dates of publication 2022-0106
    Size p. 565-568.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc06035j
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  9. Article: Congenital bilateral ectopic parotid glands: case report and systematic review of the literatures.

    Xie, Shang / Li, Zi-Meng / Li, Shi-Jun / Cai, Zhi-Gang

    Gland surgery

    2021  Volume 10, Issue 3, Page(s) 1165–1170

    Abstract: Cheek swelling can be attributed to several pathologies, including masseteric hypertrophy, diffuse inflammatory changes and neoplasia. We report an extremely rare case of bilateral cheek swelling as a result of ectopic parotid glands. This case is a ... ...

    Abstract Cheek swelling can be attributed to several pathologies, including masseteric hypertrophy, diffuse inflammatory changes and neoplasia. We report an extremely rare case of bilateral cheek swelling as a result of ectopic parotid glands. This case is a young female patient with bilateral ectopic parotid glands superficial to the masseter muscle and the zygomatic arch, demonstrated by the enhanced computed tomography (CT). Medical history, clinical features, videography and management of this case are described. After two years of observation, no significant change in symptoms was observed on this patient. Besides, we conducted a case report and systematic review of cases of ectopic parotid gland. A literature search was performed using PubMed, Web of Science, and Ovid electronic database. A total of 144 papers were retrieved and only one paper was included in the systematic review. In conclusion, bilateral ectopic parotid gland is extremely rare and easily confused with other lumps in the area of head and neck. CT, magnetic resonance imaging (MRI), ultrasound imaging and parotid sialography allow for noninvasive diagnosis of ectopic parotid gland. If the parotid ectopic is highly suspected and the patient does not have obvious symptoms, conservative treatment and long-term observation follow-up are recommended.
    Language English
    Publishing date 2021-03-15
    Publishing country China (Republic : 1949- )
    Document type Case Reports
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs-20-751
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  10. Article ; Online: Generation of Leydig-like cells: approaches, characterization, and challenges.

    Li, Zhao-Hui / Lu, Jun-Dong / Li, Shi-Jun / Chen, Hao-Lin / Su, Zhi-Jian

    Asian journal of andrology

    2022  Volume 24, Issue 4, Page(s) 335–344

    Abstract: Testosterone production by Leydig cells (LCs) plays a crucial role in male reproduction. The functional degeneration of LCs can cause testosterone deficiency, ultimately resulting in primary male hypogonadism. Transplantation of exogenous LCs with the ... ...

    Abstract Testosterone production by Leydig cells (LCs) plays a crucial role in male reproduction. The functional degeneration of LCs can cause testosterone deficiency, ultimately resulting in primary male hypogonadism. Transplantation of exogenous LCs with the ability to produce testosterone in response to the regulation of the hypothalamus-pituitary-gonad axis could be a promising alternative option to treat male primary hypogonadism. Recent studies have shown that it is possible to generate Leydig-like cells from stem cells by various approaches. In addition, somatic cells, such as embryonic or adult fibroblasts, have also been successfully reprogrammed into Leydig-like cells. In this review, we summarized the recent advances in the generation of Leydig-like cells, with an emphasis on comparing the effectiveness and safety of different protocols used and the cells generated. By further analyzing the characteristics of Leydig-like cells generated from fibroblasts based on small signaling molecules and regulatory factors, we found that although the cells may produce testosterone, they are significantly different from real LCs. For future in vivo applications, it is important that the steroidogenic cells generated be evaluated not only for their steroidogenic functions but also for their overall cell metabolic state by proteomics or transcriptomic tools.
    MeSH term(s) Adult ; Eunuchism ; Fibroblasts/metabolism ; Humans ; Leydig Cells/metabolism ; Male ; Stem Cells/metabolism ; Testosterone/metabolism
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-01-13
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/aja202193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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