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Article ; Online: Non-coding RNAs and leaf senescence: Small molecules with important roles.

Li, Shichun / Zhao, Yaning / Tan, Shuya / Li, Zhonghai

2024 Volume 207, Page(s) 108399

Abstract: Non-coding RNAs (ncRNAs) are a special class of functional RNA molecules that are not translated into proteins. ncRNAs have emerged as pivotal regulators of diverse developmental processes in plants. Recent investigations have revealed the association of ...

Abstract	Non-coding RNAs (ncRNAs) are a special class of functional RNA molecules that are not translated into proteins. ncRNAs have emerged as pivotal regulators of diverse developmental processes in plants. Recent investigations have revealed the association of ncRNAs with the regulation of leaf senescence, a complex and tightly regulated developmental process. However, a comprehensive review of the involvement of ncRNAs in the regulation of leaf senescence is still lacking. This manuscript aims to summarize the molecular mechanisms underlying ncRNAs-mediated leaf senescence and the potential applications of ncRNAs to manipulate the onset and progression of leaf senescence. Various classes of ncRNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are discussed in terms of their regulatory mechanisms in leaf senescence. Furthermore, we explore the interactions between ncRNA and the key regulators of senescence, including transcription factors as well as core components in phytohormone signaling pathways. We also discuss the possible challenges and approaches related to ncRNA-mediated leaf senescence. This review contributes to a further understanding of the intricate regulatory network involving ncRNAs in leaf senescence.
MeSH term(s)	Plant Senescence ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Small Interfering
Chemical Substances	RNA, Untranslated ; MicroRNAs ; RNA, Long Noncoding ; RNA, Small Interfering
Language	English
Publishing date	2024-01-23
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2024.108399
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Article ; Online: Apoptotic extracellular vesicles restore homeostasis of the articular microenvironment for the treatment of rheumatoid arthritis.

Li, Xian / Li, Shichun / Fu, Xiaoling / Wang, Yingjun

Bioactive materials

2024 Volume 35, Page(s) 564–576

Abstract: Rheumatoid arthritis (RA) is a severe autoimmune disease with symptoms including synovial inflammation, cartilage erosion, and bone loss in RA lesions, which eventually lead to joint deformity and function loss. Most current treatments fail to achieve ... ...

Abstract	Rheumatoid arthritis (RA) is a severe autoimmune disease with symptoms including synovial inflammation, cartilage erosion, and bone loss in RA lesions, which eventually lead to joint deformity and function loss. Most current treatments fail to achieve satisfying therapeutic outcomes with some adverse effects. Extracellular vesicles derived from apoptotic cells (apoEVs) have emerged as important mediators in intercellular communication regulating diverse physiological and pathological processes. In this study, we investigated the therapeutic efficacy of macrophage-derived and osteoclast-derived apoEVs (Mφ-apoEVs and OC-apoEVs) on RA. The
Language	English
Publishing date	2024-03-04
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2023.11.019
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Article ; Online: Orthogonal retrieval algorithm of atmospheric temperature profiles from pure rotational Raman lidar signals.

Li, Shichun / Dang, Yuanyuan / Zhang, Penghui / Hua, Dengxin / Gao, Yingchun / Di, Huige / Xin, Wenhui

Applied optics

2024 Volume 63, Issue 5, Page(s) 1210–1216

Abstract: Aimed at the stability of calibration coefficients in a general non-orthogonal retrieval algorithm (NRA) of pure rotational Raman lidars (PRRLs), an orthogonal retrieval algorithm (ORA) of atmospheric temperature profiles based on the orthogonal basis ... ...

Abstract	Aimed at the stability of calibration coefficients in a general non-orthogonal retrieval algorithm (NRA) of pure rotational Raman lidars (PRRLs), an orthogonal retrieval algorithm (ORA) of atmospheric temperature profiles based on the orthogonal basis function is proposed. This algorithm eliminates the correlation between the calibration coefficients in the NRA to reduce the influence of the number of calibration points and the selection scheme on the calibration coefficients. In this paper, the stabilities of calibration coefficients in the NRA and ORA are compared and analyzed, and the data analysis for atmospheric temperature profiles with a time resolution of minute-level are given, based on the developed Cloud Precipitation Potential Evaluation (CPPV) lidar data and the parallel radiosonde temperature data. The analysis results show that coefficients of variation (CVs) of ORA calibration coefficients are one order of magnitude smaller than those of NRA coefficients. The mean deviation of the ORA retrieval results is roughly reduced by 16.1% compared with the NRA, and the root-mean-square deviation is roughly reduced by 15.0% compared with the NRA. Therefore, the temperature retrieval performance of the ORA is better than that of the NRA.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.509724
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Article ; Online: Characterization of Nano-Scale Parallel Lamellar Defects in RDX and HMX Single Crystals by Two-Dimension Small Angle X-ray Scattering.

Zhang, Haobin / Xu, Jinjiang / Li, Shichun / Sun, Jie / Wang, Xiaolin

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 12

Abstract: Nano-scale crystal defects extremely affect the security and reliability of explosive charges of weapons. In this work, the nano-scale crystal defects of 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine ( ... ...

Abstract	Nano-scale crystal defects extremely affect the security and reliability of explosive charges of weapons. In this work, the nano-scale crystal defects of 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) single crystals were characterized by two-dimension SAXS. Deducing from the changes of SAXS pattern with sample stage rotating, we firstly found the parallel lamellar nano-scale defects in both RDX and HMX single crystals. Further analysis shows that the average diameter and thickness of nano-scale lamellar defects for RDX single crystal are 66.4 nm and 19.3 nm, respectively. The results of X-ray diffraction (XRD) indicate that the lamellar nano-scale defects distribute along the (001) in RDX and the (011) in HMX, which are verified to be the crystal planes with the lowest binding energy by the theoretical calculation.
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27123871
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Article ; Online: Cleaved lymphocytes in an infant with bilateral bronchopneumonia associated with Escherichia coli infection.

Zhang, Yun / Gong, Xiuchun / Li, Xue / Li, Shichun / Long, Fang / Li, Ting

Pediatric blood & cancer

2023 Volume 70, Issue 10, Page(s) e30512

MeSH term(s)	Infant ; Humans ; Bronchopneumonia/complications ; Escherichia coli Infections/complications ; Pneumonia ; Lymphocytes
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30512
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Article ; Online: Power-modulated integrated path differential absorption lidar for probing benzene concentration.

Liu, Jiahui / Li, Shichun / Wang, Yi / Guan, SiYu / Hua, Dengxin / Xin, Wenhui / Song, Yuehui

Applied optics

2024 Volume 63, Issue 10, Page(s) 2710–2718

Abstract: Aimed at the regional open-path detection of benzene ( ...

Abstract	Aimed at the regional open-path detection of benzene (
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.518447
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Article ; Online: Different intracellular signalling sensitivity and cell behaviour of porcine insulin with aging.

Li, Shichun / Shi, Bo / Huang, Kexin / Wang, Ying

Peptides

2020 Volume 127, Page(s) 170278

Abstract: Insulin has many important biological functions. Insulin interacts with the insulin receptor (IR) to play its physiological role and execute its functions. Here, we isolated porcine hepatocytes from young and aged pigs, which endogenously express the IR, ...

Abstract	Insulin has many important biological functions. Insulin interacts with the insulin receptor (IR) to play its physiological role and execute its functions. Here, we isolated porcine hepatocytes from young and aged pigs, which endogenously express the IR, as a model to study the intracellular signalling properties and cellular behaviour of insulin with aging. Firstly, we analysed the intracellular signal transduction that is triggered by insulin in porcine hepatocytes that were isolated from young and aged pigs and found that insulin can strongly activate insulin receptor subunit (IRS), protein kinase B (AKT), and GSK in a time- and dose-dependent manner in hepatocytes from young pigs. On the contrary, the signalling response to insulin in hepatocytes from aged pigs was significantly reduced compared to that of the young pig. Secondly, the different subcellular locations of insulin/insulin receptor (IR) may result in different biological activities, although nuclear-localized insulin/IR still could exhibit important functions and roles. We found that insulin can translocate into cell nuclei in the hepatocytes of the young pigs; however, insulin/insulin receptor fails to transports into the cell nucleus in hepatocytes from aged pigs, although insulin/insulin receptor could internalize into cell cytoplasm. In summary, in the current study, we explored and compared for the first time insulin's behaviour and signalling properties in the cells of young pig hepatocytes and aged pig hepatocytes. Furthermore, we found that the insulin signalling response in hepatocytes was significantly reduced with age; more importantly, we found that the cell behaviour of insulin was changed significantly in the hepatocytes from aged pigs compared to young pigs, and it is noteworthy that insulin/IR cannot translocate into the cell nuclei in the hepatocytes from the aged pig. This may be a potential new reason contributing to insulin resistance with aging, suggesting that we need to study the reason for insulin resistance from a new point of view.
Language	English
Publishing date	2020-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2020.170278
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Article: Suppressing NK Cells by Astragaloside IV Protects Against Acute Ischemic Stroke in Mice

Li, Shichun / Dou, Baokai / Shu, Shi / Wei, Luyao / Zhu, Shiguo / Ke, Zunji / Wang, Zhifei

Frontiers in pharmacology

2022 Volume 12, Page(s) 802047

Abstract: Natural killer (NK) cells, a key member of innate lymphocytes, are a promising immunotherapeutic target for ischemic stroke. Astragaloside IV (ASIV) is isolated ... ...

Abstract	Natural killer (NK) cells, a key member of innate lymphocytes, are a promising immunotherapeutic target for ischemic stroke. Astragaloside IV (ASIV) is isolated from
Language	English
Publishing date	2022-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.802047
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Article ; Online: Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice.

Chen, Ting / Li, Ziqing / Li, Shichun / Zou, Yingxiang / Gao, Xinyi / Shu, Shi / Wang, Zhifei

International immunopharmacology

2022 Volume 113, Issue Pt A, Page(s) 109290

Abstract: There are two distinct phenotypes of activated microglia, pro-inflammatory M1 and anti-inflammatory M2. Accumulating evidence indicates that shifting the microglial polarization from M1 to M2 is a potential strategy for the treatment of neuroinflammation- ...

Abstract	There are two distinct phenotypes of activated microglia, pro-inflammatory M1 and anti-inflammatory M2. Accumulating evidence indicates that shifting the microglial polarization from M1 to M2 is a potential strategy for the treatment of neuroinflammation-associated brain diseases, including ischemic stroke. Cycloastragenol (CAG) is a hydrolysis product of astragaloside IV, the major active component of Astragalus radix. We have previously demonstrated that CAG has anti-inflammatory effect in a mouse model of ischemic stroke. This study investigated the effect of CAG on the phenotype polarization of microglia in lipopolysaccharide (LPS)-stimulated BV-2 mouse microglial cells and ischemic stroke mice. In LPS-treated BV-2 cells, we found that CAG significantly reduced the expression of M1 markers, including pro-inflammatory cytokines and enzymes. In contrast, CAG promoted the expression of M2 markers, including anti-inflammatory cytokines and growth factor. In addition, CAG inhibited the activation of nuclear factor-κB (NF-κB) and enhanced the activation of nuclear factor E2-related factor 2 (Nrf2) and the expression of its downstream heme oxygenase-1 (HO-1). Furthermore, CAG also inhibited levels of M1 markers, promoted those of M2 markers, and enhanced Nrf2 activation and HO-1 expression in ischemic mouse brain. Importantly, the effect of CAG on M2 markers, but not M1 markers, was reversed by Nrf2 siRNA in LPS-stimulated BV-2 cells. Together, our results suggested that CAG promoted microglial M2 and suppressed M1 polarization through activating Nrf2 and inhibiting NF-κB, respectively, in LPS-stimulated BV-2 cells and ischemic mouse brain. CAG is a promising candidate for the treatment of neuroinflammation-related diseases, including ischemic stroke.
MeSH term(s)	Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Cytokines/metabolism ; Ischemic Stroke ; Lipopolysaccharides ; Microglia ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Sapogenins/pharmacology
Chemical Substances	Anti-Inflammatory Agents ; cycloastragenol (X37D9F2L0V) ; Cytokines ; Lipopolysaccharides ; NF-E2-Related Factor 2 ; NF-kappa B ; Sapogenins
Language	English
Publishing date	2022-10-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.109290
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Article ; Online: Astragaloside IV ameliorates peripheral immunosuppression induced by cerebral ischemia through inhibiting HPA axis.

Zou, Yingxiang / Li, Shichun / Chen, Ting / Li, Ziqing / Gao, Xinyi / Wang, Zhifei

International immunopharmacology

2022 Volume 105, Page(s) 108569

Abstract: Post-ischemic peripheral immunosuppression increases vulnerability to infection which is a common complication and worsens outcome in ischemic stroke patients. Hypothalamic-pituitary-adrenal (HPA) axis plays a key role in post-ischemic immunosuppression. ...

Abstract	Post-ischemic peripheral immunosuppression increases vulnerability to infection which is a common complication and worsens outcome in ischemic stroke patients. Hypothalamic-pituitary-adrenal (HPA) axis plays a key role in post-ischemic immunosuppression. Astragaloside IV (ASIV), isolated from Astragalus membranaceus, possesses immunomodulatory and neuroprotective effects against cerebral ischemic injury. This study investigated the effect of ASIV on cerebral ischemia-induced peripheral immunosuppression and the underlying mechanism in a mouse model of middle cerebral artery occlusion (MCAO). Our results showed that ASIV significantly prevented the atrophy of spleen and the reduction of splenic cell count. Meanwhile, ASIV preserved cell numbers of splenic NK, T, and B cells in the spleen. ASIV also suppressed apoptosis of splenic cells and preserved their proliferation ability. In addition, ASIV robustly reduced the mRNA expression of TNF-α, IL-1β, IL-6 and CRH in the hypothalamus, as well as the enlargement of adrenal gland and the increase of corticosterone in blood, indicating the inhibition of HPA axis by ASIV. Furthermore, ASIV did not enhance the effect of HPA inhibition on reducing splenic atrophy and preserving splenic NK, T, and B cell numbers in MCAO mice. Of note, ASIV did not attenuate splenic cell apoptosis induced by prednisolone, suggesting that ASIV may ameliorate splenic apoptosis through reducing peripheral glucocorticoid level. Our findings demonstrate that ASIV ameliorates post-ischemic peripheral immunosuppression through inhibiting the activation of HPA axis and targeting HPA activation to ameliorate peripheral immunosuppression may be a promising strategy to improve clinical outcomes of ischemic stroke.
MeSH term(s)	Animals ; Humans ; Hypothalamo-Hypophyseal System ; Immunosuppression Therapy ; Infarction, Middle Cerebral Artery/drug therapy ; Mice ; Pituitary-Adrenal System ; Saponins/pharmacology ; Saponins/therapeutic use ; Triterpenes/pharmacology ; Triterpenes/therapeutic use
Chemical Substances	Saponins ; Triterpenes ; astragaloside A (3A592W8XKE)
Language	English
Publishing date	2022-01-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.108569
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