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  1. Article: Extraction and purification of isochlorogenic acid C from Chrysanthemum morifolium using ionic liquid‐based ultrasound‐assisted extraction and aqueous two‐phase system

    Li, Shuang

    Food Science & Nutrition, 6(8):2113-2122

    2018  

    Abstract: Ionic liquid‐based ultrasonic‐assisted extraction (IL ‐UAE ) was developed to extract and separate the isochlorogenic acid C (ICGA ) from a cultivar of Chrysanthemum morifolium (Chrysanthemummorifolium Ra Tnat .). The influencing parameters, including IL ...

    Abstract Ionic liquid‐based ultrasonic‐assisted extraction (IL ‐UAE ) was developed to extract and separate the isochlorogenic acid C (ICGA ) from a cultivar of Chrysanthemum morifolium (Chrysanthemummorifolium Ra Tnat .). The influencing parameters, including IL concentration, liquid‐to‐solid ratio, and ultrasonic time, were optimized using response surface methodology. Of the IL s studied, 1‐butyl‐3‐methylimidazolium bromide [(Bmim)Br] exhibited the best extraction ability. The optimized conditions included liquid‐to‐solid ratio of 23.44:1, ultrasonic time of 48.99 min, and IL concentration of 0.65 mol/L. Under the optimal conditions, the extraction yield of ICGA could reach to 4.20 mg/g. An aqueous two‐phase system was applied for purification and separation of ICGA . The maximum extraction efficiency of 98.18% was obtained under the conditions of (NH 4)2SO 4 of 4.5 g, pH of 3.0, and a temperature of 20°C at aqueous solution. Furthermore, the thermodynamic parameters showed that the purification of ICGA from salt‐rich phase to IL ‐rich phase was a spontaneous and exothermic process. The results indicated that the proposed system is simple, rapid, and effective to serve as a viable and sustainable platform for the extraction and purification of ICGA from Chrysanthemum morifolium flowers.
    Keywords Chrysanthemum morifolium ; aqueous two-phase system ; isochlorogenic acid C ; purification ; ultrasonic-assisted extraction
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article: The role of Guanxi in fostering adaptability and work engagement among educators in international educational institutions.

    Li, Shuang / Yu, Shougang

    Frontiers in psychology

    2024  Volume 14, Page(s) 1336189

    Abstract: The present study delves into the intricate relationships between individual adaptability, various dimensions of Guanxi-Ganqing, Renqing, and Xinren-and work engagement among educators working in international educational institutions across major cities ...

    Abstract The present study delves into the intricate relationships between individual adaptability, various dimensions of Guanxi-Ganqing, Renqing, and Xinren-and work engagement among educators working in international educational institutions across major cities in China. Guanxi refers to complex system of social networks and influential relationships that facilitate business and other dealings. Ganqing, Renqing, and Xinren represents distinct but interconnected dimensions. Ganqing refers to the emotional bonding or personal affection that is developed within a Guanxi relationship. Renqing can be understood as the norm of reciprocity or the social obligation to respond to another's needs and to maintain the balance of give and take in relationships. Finally, Xinren: This dimension represents trust and credibility in Guanxi relationships. Employing online data collection via the Qualtrics platform, the study investigates the impact of individual adaptability on work engagement, particularly examining the mediating roles of different Guanxi dimensions. Utilizing Hayes' Process Model 80 for mediation analysis, our findings demonstrate a statistically significant direct effect of individual adaptability on work engagement, thus supporting Hypothesis 1 (H1). The analysis reveals that this relationship is partially mediated by other variables within our model. Significantly, the study highlights the nuanced roles of the Guanxi dimensions of Ganqing, Renqing, and Xinren in this context. Both Ganqing and Renqing were found to amplify the effect of individual adaptability on work engagement, confirming Hypotheses 2a and 2b. However, while Xinren increased the effect size, it did not significantly mediate the relationship between individual adaptability and work engagement, leading to the rejection of Hypothesis 2c. Furthermore, our research provides new insights into the interplay between these Guanxi dimensions. Specifically, Ganqing and Renqing significantly influenced Xinren, which in turn impacted work engagement, thereby supporting Hypotheses 3a and 3b. This mediated chain model suggests a more complex interaction between these factors than previously understood. Our analysis also reveals the differential impacts of these Guanxi dimensions. Notably, Ganqing exhibited a greater influence on work engagement compared to Renqing and Xinren. This finding underscores the critical role of affective bonds in social ties and their importance in enhancing work engagement. These results, robust across statistical metrics including R, R-squared, MSE, F, and
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1336189
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  3. Article ; Online: "Please don't lyse me": Programmed cell death ligand-1 expression on neonatal islet cells promotes xenotransplant acceptance.

    Li, Shuang / Zou, Dawei

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2024  

    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2024.02.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5542: Show issues Location:
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  4. Article ; Online: Frequent loss of

    Li, Shuang / Han, Ting

    iScience

    2024  Volume 27, Issue 5, Page(s) 109646

    Abstract: Most advanced colorectal cancer (CRC) patients cannot benefit from targeted therapy due to lack of actionable targets. By mining data from the DepMap, we ... ...

    Abstract Most advanced colorectal cancer (CRC) patients cannot benefit from targeted therapy due to lack of actionable targets. By mining data from the DepMap, we identified
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109646
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  5. Article: A study on the positive and negative effects of different supervisor monitoring in remote workplaces.

    Li, Shuang / Wang, Yumei

    Frontiers in psychology

    2024  Volume 15, Page(s) 1383207

    Abstract: The current academic research on whether and how the different supervisor monitoring effect in remote workplace is relatively scarce. Based on the Job demand-resource (JD-R) Model, this study proposes that as a kind of work resource, interactional ... ...

    Abstract The current academic research on whether and how the different supervisor monitoring effect in remote workplace is relatively scarce. Based on the Job demand-resource (JD-R) Model, this study proposes that as a kind of work resource, interactional monitoring will enhance employees' self-efficacy, further enhance remote employees' work engagement and reduce their deviant behaviors. While as a kind of work requirement, electronic monitoring will decrease employees' self-efficacy, further reduce remote employee's work engagement and increase their deviant behaviors. This study gets the empirical date of 299 employees who experienced remote work. Amos 23.0, SPSS 23.0 software and process plug-in were used to do the hierarchical regression, bootstrap and simple slope analysis, so that to test the hypothesis. This study broadens the research situation and mechanism of different supervisor monitoring, so as to enrich the comprehensive understanding of the effect of them, and also to provide some inspiration and reference for relevant management practices.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1383207
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  6. Article ; Online: Research progress on the role of colon rectal neoplasia differentially expressed RNA in diseases

    LI Shuang, LI Yang

    Jichu yixue yu linchuang, Vol 42, Iss 10, Pp 1616-

    2022  Volume 1620

    Abstract: Colon rectal neoplasia differentially expressed (CRNDE) RNA is a long non-coding RNA molecule that regulates gene expression at multiple levels including transcriptional, post-transcriptional and translational levels, plays a role in a variety of ... ...

    Abstract Colon rectal neoplasia differentially expressed (CRNDE) RNA is a long non-coding RNA molecule that regulates gene expression at multiple levels including transcriptional, post-transcriptional and translational levels, plays a role in a variety of physiological and pathological processes. CRNDE is involved in the development and prognosis of colorectal tumors, glioma, hepatocellular carcinoma and other tumor diseases, inflammatory response such as pneumonia and sepsis, diabetic cardiomyopathy and osteoporosis. So it is expected to be a new biomarker or therapeutic target.
    Keywords colon rectal neoplasia differentially expressed|tumor|inflammation ; Medicine ; R
    Language Chinese
    Publishing date 2022-10-01T00:00:00Z
    Publisher Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Oxidative Stress Sensing System for 8-OHdG Detection Based on Plasma Coupled Electrochemistry by Transparent ITO/AuNTAs/PtNPs Electrode.

    Bai, Yongchang / Li, Shuang

    Biosensors

    2023  Volume 13, Issue 6

    Abstract: 8-Hydroxydeoxyguanosine (8-OHdG) is the most widely used oxidative stress biomarker of the free radical-induced oxidative damage product of DNA, which may allow a premature assessment of various diseases. This paper designs a label-free, portable ... ...

    Abstract 8-Hydroxydeoxyguanosine (8-OHdG) is the most widely used oxidative stress biomarker of the free radical-induced oxidative damage product of DNA, which may allow a premature assessment of various diseases. This paper designs a label-free, portable biosensor device to directly detect 8-OHdG by plasma-coupled electrochemistry on a transparent and conductive indium tin oxide (ITO) electrode. We reported a flexible printed ITO electrode made from particle-free silver and carbon inks. After inkjet printing, the working electrode was sequentially assembled by gold nanotriangles (AuNTAs) and platinum nanoparticles (PtNPs). This nanomaterial-modified portable biosensor showed excellent electrochemical performance for 8-OHdG detection from 10 μg/mL to 100 μg/mL by our self-developed constant voltage source integrated circuit system. This work demonstrated a portable biosensor for simultaneously integrating nanostructure, electroconductivity, and biocompatibility to construct advanced biosensors for oxidative damage biomarkers. The proposed nanomaterial-modified ITO-based electrochemical portable device was a potential biosensor to approach 8-OHdG point-of-care testing (POCT) in various biological fluid samples, such as saliva and urine samples.
    MeSH term(s) 8-Hydroxy-2'-Deoxyguanosine ; Metal Nanoparticles/chemistry ; Electrochemistry ; Platinum ; Tin Compounds/chemistry ; Oxidative Stress ; Electrodes ; Biosensing Techniques
    Chemical Substances 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; indium tin oxide (71243-84-0) ; Platinum (49DFR088MY) ; Tin Compounds
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13060643
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  8. Article: Application of quantitative orbital analysis to assess the activity of Graves' ophthalmopathy.

    Li, Shuang / Liu, Yue-Jun

    American journal of nuclear medicine and molecular imaging

    2023  Volume 13, Issue 6, Page(s) 259–268

    Abstract: This study aimed to evaluate the diagnostic value of uptake ratios in the extraocular muscles (EOMs), lacrimal glands, and optic nerves to detect the inflammation activity of Graves' ophthalmopathy (GO) using quantitative analysis of 99m technetium ( ...

    Abstract This study aimed to evaluate the diagnostic value of uptake ratios in the extraocular muscles (EOMs), lacrimal glands, and optic nerves to detect the inflammation activity of Graves' ophthalmopathy (GO) using quantitative analysis of 99m technetium (
    Language English
    Publishing date 2023-12-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623515-8
    ISSN 2160-8407
    ISSN 2160-8407
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  9. Article ; Online: How a "Smart regulatory" platform can improve the property fee adjustment dilemma.

    Dong, Dekun / Li, Shuang

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0294920

    Abstract: In the current process of social and economic development, the cost of living and property management is continuously increasing. In order to maintain the normal operation of property management and provide high-quality services, it is necessary to ... ...

    Abstract In the current process of social and economic development, the cost of living and property management is continuously increasing. In order to maintain the normal operation of property management and provide high-quality services, it is necessary to adjust the property fees reasonably. If the property fees cannot be adjusted for a long time, it will have a detrimental impact on the development of the community. However, the traditional regulatory model has failed to accurately define the quality of property services, leading to information asymmetry and a lack of trust between the two parties, resulting in a deadlock in property fee adjustments. With the rise of intelligent management, a new direction for property fee adjustments has been provided. This article first analyzes the pricing dilemma under traditional regulation through game theory. Then, based on the theory of "Smart regulatory", it proposes the idea of constructing a "Smart regulatory" platform and explores the feasibility of this model using game theory and Matlab simulations. The study found that the "Smart regulatory" platform can resolve information asymmetry and encourage both parties to cooperate in the game. After the establishment of the platform, property fee adjustments are influenced by government supervision, government penalties, and the magnitude of property fee increase.
    MeSH term(s) Fees and Charges ; Costs and Cost Analysis
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0294920
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  10. Article ; Online: Evolutionary conservation of sequence motifs at sites of protein modification.

    Li, Shuang / Dohlman, Henrik G

    The Journal of biological chemistry

    2023  Volume 299, Issue 5, Page(s) 104617

    Abstract: Gene duplications are common in biology and are likely to be an important source of functional diversification and specialization. The yeast Saccharomyces cerevisiae underwent a whole-genome duplication event early in evolution, and a substantial number ... ...

    Abstract Gene duplications are common in biology and are likely to be an important source of functional diversification and specialization. The yeast Saccharomyces cerevisiae underwent a whole-genome duplication event early in evolution, and a substantial number of duplicated genes have been retained. We identified more than 3500 instances where only one of two paralogous proteins undergoes posttranslational modification despite having retained the same amino acid residue in both. We also developed a web-based search algorithm (CoSMoS.c.) that scores conservation of amino acid sequences based on 1011 wild and domesticated yeast isolates and used it to compare differentially modified pairs of paralogous proteins. We found that the most common modifications-phosphorylation, ubiquitylation, and acylation but not N-glycosylation-occur in regions of high sequence conservation. Such conservation is evident even for ubiquitylation and succinylation, where there is no established 'consensus site' for modification. Differences in phosphorylation were not associated with predicted secondary structure or solvent accessibility but did mirror known differences in kinase-substrate interactions. Thus, differences in posttranslational modification likely result from differences in adjoining amino acids and their interactions with modifying enzymes. By integrating data from large-scale proteomics and genomics analysis, in a system with such substantial genetic diversity, we obtained a more comprehensive understanding of the functional basis for genetic redundancies that have persisted for 100 million years.
    MeSH term(s) Evolution, Molecular ; Gene Duplication ; Genomics ; Protein Processing, Post-Translational ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.104617
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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