LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 316

Search options

  1. Article ; Online: The application of the ICD-10 for antepartum stillbirth patients in a referral centre of Eastern China: a retrospective study from 2015 to 2022.

    Feng, Chuan-Shou / Li, Shu-Fen / Ju, Hui-Hui

    BMC pregnancy and childbirth

    2024  Volume 24, Issue 1, Page(s) 164

    Abstract: Background: The causes of some stillbirths are unclear, and additional work must be done to investigate the risk factors for stillbirths.: Objective: To apply the International Classification of Disease-10 (ICD-10) for antepartum stillbirth at a ... ...

    Abstract Background: The causes of some stillbirths are unclear, and additional work must be done to investigate the risk factors for stillbirths.
    Objective: To apply the International Classification of Disease-10 (ICD-10) for antepartum stillbirth at a referral center in eastern China.
    Methods: Antepartum stillbirths were grouped according to the cause of death according to the International Classification of Disease-10 (ICD-10) criteria. The main maternal condition at the time of antepartum stillbirth was assigned to each patient.
    Results: Antepartum stillbirths were mostly classified as fetal deaths of unspecified cause, antepartum hypoxia. Although more than half of the mothers were without an identified condition at the time of the antepartum stillbirth, where there was a maternal condition associated with perinatal death, maternal medical and surgical conditions and maternal complications during pregnancy were most common. Of all the stillbirths, 51.2% occurred between 28 and 37 weeks of gestation, the main causes of stillbirth at different gestational ages also differed. Autopsy and chromosomal microarray analysis (CMA) were recommended in all stillbirths, but only 3.6% received autopsy and 10.5% underwent chromosomal microarray analysis.
    Conclusions: The ICD-10 is helpful in classifying the causes of stillbirths, but more than half of the stillbirths in our study were unexplained; therefore, additional work must be done. And the ICD-10 score may need to be improved, such as by classifying stillbirths according to gestational age. Autopsy and CMA could help determine the cause of stillbirth, but the acceptance of these methods is currently low.
    MeSH term(s) Pregnancy ; Female ; Humans ; Stillbirth/epidemiology ; Retrospective Studies ; International Classification of Diseases ; Fetal Death/etiology ; Referral and Consultation ; Cause of Death
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-024-06313-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Book ; Thesis: Extraction of xanthines and cocoa butter from cocoa beans with supercritical CO 2

    Li, Shufen

    1993  

    Author's details by Shufen Li
    Keywords Kakaobohne ; Xanthin ; Extraktion ; Kohlendioxid ; Überkritischer Zustand ; Kakaobutter
    Subject Superkritischer Zustand ; Überkritisches Fluid ; Überkritisches Gas ; Überkritische Flüssigkeit ; Kohlendioxyd ; Kohlenstoffdioxid ; CO2 ; R 744 ; R-744 ; R744 ; Lösungsmittelextraktion ; Extrahieren ; Kakaosamen ; Kakaofett ; CAS 69-89-6 ; Dihydroxypurin ; Purindion ; Purindiol
    Size XI, 183 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zurich, Swiss Federal Inst. of Technology, Diss., 1993
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x. Best.-Nr. Diss ETH 10084 ; Zsfassung in dt. Sprache
    HBZ-ID HT007342605
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

    More links

    Kategorien

  3. Article ; Online: Di-Isatropolone C, a Spontaneous Isatropolone C Dimer Derivative with Autophagy Activity.

    Fu, Jie / Liu, Xiaoyan / Zhang, Miaoqing / Liu, Jiachang / Li, Shufen / Jiang, Bingya / Wu, Linzhuan

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: Isatropolone C ... ...

    Abstract Isatropolone C from
    MeSH term(s) Autophagy ; Carbon ; Cyclopentanes ; Ethers ; Polymers ; Heterocyclic Compounds, Fused-Ring
    Chemical Substances Isatropolone C ; Carbon (7440-44-0) ; Cyclopentanes ; Ethers ; Polymers ; Heterocyclic Compounds, Fused-Ring
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071477
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Ros-responsive nano-platform for lipid-specific fluorescence imaging of atherosclerosis.

    Liu, Qi / Li, Shufen / Ma, Di / Chen, Jingruo / Li, Chengming / Zhuang, Weihua / Chen, Mao

    Journal of colloid and interface science

    2024  Volume 667, Page(s) 520–528

    Abstract: Fluorescent probes that specifically targeting Lipid droplets (LDs) have shown potential in biological imaging. Albeit, their in vivo applications are limited due to the hydrophobicity, low signal-to-noise ratio (SNR) and LDs-specificity. Thus, we ... ...

    Abstract Fluorescent probes that specifically targeting Lipid droplets (LDs) have shown potential in biological imaging. Albeit, their in vivo applications are limited due to the hydrophobicity, low signal-to-noise ratio (SNR) and LDs-specificity. Thus, we designed a novel probe namely MeOND, and a reactive oxygen species (ROS)-responsive nano-platform to improve in vivo LDs-specific imaging. MeOND exhibits a remarkable twisted intramolecular charge transfer (TICT) effect with a strongly enhanced near-infrared emission in low-polarity lipid environment. Also, MeOND demonstrates satisfactory biocompatibility and superior intracellular LDs imaging capabilities. MeOND encapsulated nano-platform (MeOND@PMM) presented favorable water solubility and biocompatibility. MeOND@PMM remains stable in physiological conditions but quickly degrades in the environment of elevated ROS level. The released MeOND could then light up the intracellular LDs in atherosclerotic plaques. The design of the probe and nano-platform is expected to provide a better tool for the scientific research of LDs and LDs-related diseases.
    MeSH term(s) Reactive Oxygen Species/metabolism ; Optical Imaging ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/metabolism ; Fluorescent Dyes/chemistry ; Animals ; Mice ; Lipid Droplets/chemistry ; Lipid Droplets/metabolism ; Nanoparticles/chemistry ; Humans ; Particle Size ; RAW 264.7 Cells ; Surface Properties
    Chemical Substances Reactive Oxygen Species ; Fluorescent Dyes
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.04.117
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Exploring and Selecting Features to Predict the Next Outcomes of MLB Games.

    Li, Shu-Fen / Huang, Mei-Ling / Li, Yun-Zhi

    Entropy (Basel, Switzerland)

    2022  Volume 24, Issue 2

    Abstract: 1) Background and Objective: Major League Baseball (MLB) is one of the most popular international sport events worldwide. Many people are very interest in the related activities, and they are also curious about the outcome of the next game. There are ... ...

    Abstract (1) Background and Objective: Major League Baseball (MLB) is one of the most popular international sport events worldwide. Many people are very interest in the related activities, and they are also curious about the outcome of the next game. There are many factors that affect the outcome of a baseball game, and it is very difficult to predict the outcome of the game precisely. At present, relevant research predicts the accuracy of the next game falls between 55% and 62%. (2) Methods: This research collected MLB game data from 2015 to 2019 and organized a total of 30 datasets for each team to predict the outcome of the next game. The prediction method used includes one-dimensional convolutional neural network (1DCNN) and three machine-learning methods, namely an artificial neural network (ANN), support vector machine (SVM), and logistic regression (LR). (3) Results: The prediction results show that, among the four prediction models, SVM obtains the highest prediction accuracies of 64.25% and 65.75% without feature selection and with feature selection, respectively; and the best AUCs are 0.6495 and 0.6501, respectively. (4) Conclusions: This study used feature selection and optimized parameter combination to increase the prediction performance to around 65%, which surpasses the prediction accuracies when compared to the state-of-the-art works in the literature.
    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e24020288
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Circ_0004712 promotes endometriotic epithelial cell proliferation, migration and invasion by regulating miR-488-3p/ROCK1 axis in vitro.

    Xu, Ke / Chen, Yang / Li, Shufen / Chen, Li / Huang, Xiaoyang

    Reproductive biology

    2022  Volume 22, Issue 3, Page(s) 100667

    Abstract: Recent evidence indicates that circular RNAs (circRNAs) play crucial regulatory roles in the pathogenesis and development of endometriosis. Circ_0004712 was found to be differentially expressed in endometriosis. However, the detailed function and ... ...

    Abstract Recent evidence indicates that circular RNAs (circRNAs) play crucial regulatory roles in the pathogenesis and development of endometriosis. Circ_0004712 was found to be differentially expressed in endometriosis. However, the detailed function and mechanism of circ_0004712 in endometriosis are still unclear. Quantitative real-time polymerase chain reaction and Western blot were used for the detection of circ_0004712, miR-488-3p and ROCK1 (Rho Associated Coiled-Coil Containing Protein Kinase 1) levels. In vitro experiments in endometrial endothelial cells were performed by cell counting kit-8, EdU, transwell, wound healing assays, and flow cytometry, respectively. The molecular mechanism of circ_0004712 function was investigated using bioinformatics target predication, dual-luciferase reporter, and RNA immunoprecipitation (RIP) assays. The expression of circ_0004712 was higher in endometriotic endometrial tissues and epithelial cells. Knockdown of circ_0004712 suppressed cell proliferation, migration, invasion, EMT process and induced apoptosis in ectopic endometrial epithelial cells in vitro. Mechanistically, circ_0004712 acted as a ceRNA to sponge miR-488-3p, thus elevating the expression of ROCK1, which was confirmed to be a target of miR-488-3p. Rescue experiments suggested that miR-488-3p inhibition reversed the inhibitory effects of circ_0004712 silencing on cell growth and metastasis. Moreover, miR-488-3p restoration restrained the proliferation and metastasis in ectopic endometrial epithelial cells, which were attenuated by ROCK1 overexpression. Circ_0004712 knockdown suppressed the proliferation and metastasis of ectopic endometrial epithelial cells via miR-488-3p/ROCK1 axis in vitro, suggesting a new insight into the pathogenesis of endometriosis.
    MeSH term(s) Cell Movement ; Cell Proliferation ; Endometriosis ; Endothelial Cells ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs ; rho-Associated Kinases
    Chemical Substances MIRN488 microRNA, human ; MicroRNAs ; ROCK1 protein, human (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-06-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2189316-0
    ISSN 2300-732X ; 1642-431X
    ISSN (online) 2300-732X
    ISSN 1642-431X
    DOI 10.1016/j.repbio.2022.100667
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: A lipid activated color switchable probe for the imaging of diseased aortic valves.

    Zhuang, Weihua / Li, Junli / Qu, Tianyi / Shao, Ruochen / Chen, Jingruo / Li, Shufen / Chen, Mao / Wang, Yunbing

    Talanta

    2024  Volume 275, Page(s) 126069

    Abstract: Lipid deposition has been considered one of the key factors in the occurrence of valvular heart disease (VHD) and a great potential target for the diagnosis of VHD. However, the development of lipid imaging technologies and efficient lipid specific ... ...

    Abstract Lipid deposition has been considered one of the key factors in the occurrence of valvular heart disease (VHD) and a great potential target for the diagnosis of VHD. However, the development of lipid imaging technologies and efficient lipid specific probes is in urgent demand. In this work, we have prepared a lipid droplets (LDs) targeted fluorescence probe CPTM based on a push-pull electronic structure for the imaging of diseased aortic valves. CPTM showed obvious twisted intramolecular charge transfer (TICT) effect and its emission changed from 600 nm in water to 508 nm in oil. CPTM not only exhibited good biocompatibility and high photostability, but also impressive LDs specific imaging performance in human primary valvular interstitial cells and human diseased aortic valves. Moreover, the dynamic changes of intracellular LDs could be monitor in real-time after staining with CPTM. These results were expected to offer new ideals for the designing of novel LDs specific probes for further bioimaging applications.
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.126069
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Genome-wide analysis of transposable elements and satellite DNA in

    Zhang, Guo-Jun / Jia, Ke-Li / Wang, Jin / Gao, Wu-Jun / Li, Shu-Fen

    Frontiers in plant science

    2023  Volume 14, Page(s) 1230250

    Abstract: Transposable elements (TEs) and satellite DNAs, two major categories of repetitive sequences, are expected to accumulate in non-recombining genome regions, including sex-linked regions, and contribute to sex chromosome evolution. The dioecious plant, ...

    Abstract Transposable elements (TEs) and satellite DNAs, two major categories of repetitive sequences, are expected to accumulate in non-recombining genome regions, including sex-linked regions, and contribute to sex chromosome evolution. The dioecious plant,
    Language English
    Publishing date 2023-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1230250
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune Responses.

    Zhu, Xiangtao / Guan, Zihan / Fang, Yujie / Zhang, Yulan / Guan, Zhenqiong / Li, Shufen / Peng, Ke

    Journal of virology

    2023  Volume 97, Issue 4, Page(s) e0181422

    Abstract: Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus that causes severe and potentially fatal hemorrhagic fever in humans. Autophagy is a self-degradative process that can restrict viral replication at multiple infection steps. In this study, we ...

    Abstract Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus that causes severe and potentially fatal hemorrhagic fever in humans. Autophagy is a self-degradative process that can restrict viral replication at multiple infection steps. In this study, we evaluated the effects of RVFV-triggered autophagy on viral replication and immune responses. Our results showed that RVFV infection triggered autophagosome formation and induced complete autophagy. Impairing autophagy flux by depleting autophagy-related gene 5 (
    MeSH term(s) Immunity, Innate/immunology ; Rift Valley fever virus/immunology ; Nucleoproteins/immunology ; Nucleoproteins/metabolism ; Autophagy/immunology ; Virus Replication ; Cell Line ; Rift Valley Fever/immunology ; Humans ; Animals ; Macrophages/virology
    Chemical Substances Nucleoproteins ; SQSTM1 protein, human
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01814-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: A glutathione-responsive PEGylated nanogel with doxorubicin-conjugation for cancer therapy.

    Li, Shufen / Wang, Qiang / Duan, Xiao / Pei, Zhen / He, Zhipeng / Guo, Wei / Han, Lingna

    Journal of materials chemistry. B

    2023  Volume 11, Issue 48, Page(s) 11612–11619

    Abstract: The complexity, degradability, and stability of drug delivery systems are crucial factors for clinical application. Herein, a glutathione (GSH)-responsive polyethylene glycol (PEG)ylated nanogel conjugated with doxorubicin (Dox) was prepared based on a ... ...

    Abstract The complexity, degradability, and stability of drug delivery systems are crucial factors for clinical application. Herein, a glutathione (GSH)-responsive polyethylene glycol (PEG)ylated nanogel conjugated with doxorubicin (Dox) was prepared based on a linker with disulfide bonds, PEG, and Dox using a one-pot method. FT-IR and UV-vis analyses confirmed that all raw materials were incorporated in the Dox-conjugated nanogel structure. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) results showed that the particle size of the Dox-conjugated nanogel was at the nanoscale and could be responsively disrupted in high GSH concentration. The
    MeSH term(s) Animals ; Mice ; Nanogels/therapeutic use ; Spectroscopy, Fourier Transform Infrared ; Doxorubicin/chemistry ; Glutathione/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology ; Polyethylene Glycols/chemistry
    Chemical Substances polyethylene glycol polyethyleneimine nanogel ; Nanogels ; Doxorubicin (80168379AG) ; Glutathione (GAN16C9B8O) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb01731a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top