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Article: Body mass index, blood glucose, and mortality in patients with ischemic stroke in the intensive care unit: A retrospective cohort study.

Ma, Zisheng / Li, Shunxian / Lin, Xinjiang

2022 Volume 16, Page(s) 946397

Abstract: Background: Excessive BMI was associated with lower mortality after stroke. However, some believed that excessive BMI can lead to a poor prognosis because of some physiological mechanism, such as glucose metabolism disorder. Therefore, this study aims ... ...

Abstract	Background: Excessive BMI was associated with lower mortality after stroke. However, some believed that excessive BMI can lead to a poor prognosis because of some physiological mechanism, such as glucose metabolism disorder. Therefore, this study aims to discuss the association between mortality, BMI, and blood glucose. Materials and methods: This was a retrospective observational study and all data were extracted from the Medical Information Mart for Intensive Care III database. The exposure was BMI classified into the normal weight group and the excessive weight group. The outcome concluded 30-day, 90-day, and 1-year mortality. The association between two groups and mortality was elucidated by Cox regression models, propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). The underlying effect of blood glucose on the "obesity paradox" was analyzed by causal mediation analysis. Results: According to Cox regression models, a significant beneficial effect of excessive BMI in terms of mortality was observed: 30-day mortality (HR 0.57, 95% CI 0.35-0.90, Conclusion: For ischemic stroke patients in the Intensive Care Unit, those with excessive BMI are associated with both lower short-term mortality and lower long-term mortality, while the protective effect on 30-day mortality weakened accompanied by the increase of blood glucose.
Language	English
Publishing date	2022-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.946397
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Article ; Online: Identification of disordered profiles of gut microbiota and functional component in stroke and poststroke epilepsy.

Wei, Duncan / Chen, Xiaopu / Xu, Jing / Yin, Yongling / Peng, Xiaotang / Li, Shunxian / He, Wenzhen

Brain and behavior

2023 Volume 13, Issue 12, Page(s) e3318

Abstract: Aims: It is estimated that 11.5% of patients with stroke (STR) were at risk of suffering poststroke epilepsy (PSE) within 5 years. Gut microbiota is shown to affect health in humans by producing metabolites. The association between dysregulation of gut ... ...

Abstract	Aims: It is estimated that 11.5% of patients with stroke (STR) were at risk of suffering poststroke epilepsy (PSE) within 5 years. Gut microbiota is shown to affect health in humans by producing metabolites. The association between dysregulation of gut microbiota and STR/PSE remains unclear. The aim of this study was to identify potential gut microbiota and functional component in STR and PSE, which may provide a theoretical foundation for diagnosis and treatment of STR and PSE. Methods: The fresh stool samples were collected from 19 healthy controls, 27 STR patients, and 20 PSE patients for 16S rRNA gene sequencing. Analysis of amplicon sequence variant and community diversity was performed, followed by the identification of dominant species, species differences analysis, diagnostic, and functional analysis of species in STR and PSE. Results: Community diversity was decreased in STR and PSE. Some disordered profiles of gut microbiota in STR and PSE were identified, such as the increase of Enterococcus and the decrease of butyricicoccus in STR, the increase of Escherichia Shigella and Clostridium innocuum-group and the decrease of Faecalibacterium in PSE, and the decrease of Anaerostipes in both STR and PSE. Moreover, potential diagnostic biomarkers for STR (butyricicoccus), PSE (Faecalibacterium), STR, and PSE (NK4A214_group and Veillonella) were identified. Several significantly dysfunctional components were identified, including l-tryptophan biosynthesis in STR, fatty acid biosynthesis in PSE, and Stress_Tolerant and anaerobic in both STR and PSE. Conclusion: The disturbed gut microbiota and related dysfunctional components are closely associated with the progression of STR and PSE.
MeSH term(s)	Humans ; Gastrointestinal Microbiome/physiology ; RNA, Ribosomal, 16S/genetics ; Stroke/complications ; Epilepsy/complications ; Feces/microbiology
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3318
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Article: Transcriptomic analysis of the anti-inflammatory effect of

Jiao, Chunwei / Liang, Huijia / Liu, Li / Li, Shunxian / Chen, Jiaming / Xie, Yizhen

Frontiers in pharmacology

2022 Volume 13, Page(s) 1035101

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-10-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1035101
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Article ; Online: An active ingredient isolated from

Jiao, Chunwei / Yun, Hao / Liang, Huijia / Lian, Xiaodong / Li, Shunxian / Chen, Jiaming / Qadir, Javeria / Yang, Burton B / Xie, Yizhen

Aging

2022 Volume 14, Issue 13, Page(s) 5376–5389

Abstract: ... The ... ...

Abstract	The mushroom
MeSH term(s)	Animals ; Burns/drug therapy ; Cell Proliferation ; Mice ; Oils/pharmacology ; Reishi ; Smad Proteins ; TRPV Cation Channels/pharmacology ; Wound Healing
Chemical Substances	Oils ; Smad Proteins ; TRPV Cation Channels ; TRPV1 protein, mouse
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204119
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Article: MiR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4

Cai, De / Wei, Duncan / Chen, Siqia / Chen, Xianguang / Li, Shunxian / Chen, Wenjie / He, Wenzhen

Life sciences. 2019 Aug. 15, v. 231

2019

Abstract: Our previous study indicated that microRNA 145 (miR-145) and its predicated target, erythropoietin-producing hepatoma (EPH) receptor A4 (EPHA4), was closely associated with ischemic stroke. In this study, we aimed to further explore their function in a ... ...

Abstract	Our previous study indicated that microRNA 145 (miR-145) and its predicated target, erythropoietin-producing hepatoma (EPH) receptor A4 (EPHA4), was closely associated with ischemic stroke. In this study, we aimed to further explore their function in a model of oxygen-glucose deprivation (OGD). The expression of miR-145 in the blood of 44 patients with ischemic stroke and 37 normal controls was detected by qRT-PCR. After transfection with either the wild- or mutant-type pGL3-promoter EPHA4 3′UTR into the miR-145 mimic and miR-145 inhibitor, a dual-luciferase reporter assay was performed to explore the interaction between miR-145 and EPHA4. qRT-PCR and Western blot were performed to further explore the effects of miR-145 on EPHA4 expression after an miR-145 mimic, an miR-145 inhibitor or LV-sh-EPHA4 was transfected into cerebral cortical neurons. The expression of miR-145 was significantly upregulated in the blood of patients with ischemic stroke compared to that of normal controls. Dual-luciferase reporter assay, qRT-PCR and Western blot results indicated that miR-145 indeed targets EPHA4 through its 3′-UTR and regulates the expression level of EPHA4 at both the mRNA and protein levels. Moreover, the OGD model was successfully constructed, and miR-145 exerted a protective effects in cell viability in the OGD model by downregulating EPHA4. The expression of LOC105376244 could be regulated by the miR-145-EPHA4 interaction. MiR-145 exerted a protective effects in cell viability in the OGD model by downregulating EPHA4, which suggested their potential roles in ischemic stroke and requires further research.
Keywords	3' untranslated regions ; Western blotting ; bioluminescence assay ; blood ; cell viability ; enzymes ; hepatoma ; humans ; microRNA ; models ; neurons ; patients ; protective effect ; protein content ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; stroke ; transfection
Language	English
Dates of publication	2019-0815
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2019.05.073
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Article ; Online: Identification of key genes and upstream regulators in ischemic stroke.

Zhang, Qian / Chen, Wenjie / Chen, Siqia / Li, Shunxian / Wei, Duncan / He, Wenzhen

Brain and behavior

2019 Volume 9, Issue 7, Page(s) e01319

Abstract: Introduction: Ischemic stroke (IS) causes severe neurological impairments and physical disabilities and has a high economic burden. Our study aims to identify the key genes and upstream regulators in IS by integrated microarray analysis.: Methods: An ...

Abstract	Introduction: Ischemic stroke (IS) causes severe neurological impairments and physical disabilities and has a high economic burden. Our study aims to identify the key genes and upstream regulators in IS by integrated microarray analysis. Methods: An integrated analysis of microarray studies of IS was performed to identify the differentially expressed genes (DEGs) in IS compared to normal control. Based on these DEGs, we performed the functional annotation and transcriptional regulatory network constructions. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to verify the expression of DEGs. Results: From two Gene Expression Omnibus datasets obtained, we obtained 1526 DEGs (534 up-regulated and 992 down-regulated genes) between IS and normal control. The results of functional annotation showed that Oxidative phosphorylation and Alzheimer's disease were significantly enriched pathways in IS. Top four transcription factors (TFs) with the most downstream genes including PAX4, POU2F1, ELK1, and NKX2-5. The expression of six genes (ID3, ICAM2, DCTPP1, ANTXR2, DUSP1, and RGS2) was detected by qRT-PCR. Except for DUSP1 and RGS2, the other four genes in qRT-PCR played the same pattern with that in our integrated analysis. Conclusions: The dysregulation of these six genes may involve with the process of ischemic stroke (IS). Four TFs (PAX4, POU2F1, ELK1 and NKX2-5) were concluded to play a role in IS. Our finding provided clues for exploring mechanism and developing novel diagnostic and therapeutic strategies for IS.
MeSH term(s)	Adult ; Aged ; Brain Ischemia/complications ; Brain Ischemia/genetics ; Female ; Gene Expression ; Gene Expression Profiling/methods ; Humans ; Male ; Microarray Analysis/methods ; Middle Aged ; Real-Time Polymerase Chain Reaction ; Stroke/etiology ; Stroke/genetics ; Up-Regulation/genetics
Language	English
Publishing date	2019-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.1319
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Article ; Online: MiR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4.

Cai, De / Wei, Duncan / Chen, Siqia / Chen, Xianguang / Li, Shunxian / Chen, Wenjie / He, Wenzhen

Life sciences

2019 Volume 231, Page(s) 116517

Abstract	Our previous study indicated that microRNA 145 (miR-145) and its predicated target, erythropoietin-producing hepatoma (EPH) receptor A4 (EPHA4), was closely associated with ischemic stroke. In this study, we aimed to further explore their function in a model of oxygen-glucose deprivation (OGD). The expression of miR-145 in the blood of 44 patients with ischemic stroke and 37 normal controls was detected by qRT-PCR. After transfection with either the wild- or mutant-type pGL3-promoter EPHA4 3'UTR into the miR-145 mimic and miR-145 inhibitor, a dual-luciferase reporter assay was performed to explore the interaction between miR-145 and EPHA4. qRT-PCR and Western blot were performed to further explore the effects of miR-145 on EPHA4 expression after an miR-145 mimic, an miR-145 inhibitor or LV-sh-EPHA4 was transfected into cerebral cortical neurons. The expression of miR-145 was significantly upregulated in the blood of patients with ischemic stroke compared to that of normal controls. Dual-luciferase reporter assay, qRT-PCR and Western blot results indicated that miR-145 indeed targets EPHA4 through its 3'-UTR and regulates the expression level of EPHA4 at both the mRNA and protein levels. Moreover, the OGD model was successfully constructed, and miR-145 exerted a protective effects in cell viability in the OGD model by downregulating EPHA4. The expression of LOC105376244 could be regulated by the miR-145-EPHA4 interaction. MiR-145 exerted a protective effects in cell viability in the OGD model by downregulating EPHA4, which suggested their potential roles in ischemic stroke and requires further research.
MeSH term(s)	Aged ; Apoptosis/drug effects ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Cell Hypoxia/physiology ; Cell Survival/genetics ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Down-Regulation ; Female ; Glucose/metabolism ; Humans ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; Middle Aged ; Neurons/cytology ; Neurons/metabolism ; Oxygen/metabolism ; Primary Cell Culture ; RNA, Messenger/metabolism ; Receptor, EphA4/metabolism ; Stroke/metabolism
Chemical Substances	MIRN145 microRNA, human ; MicroRNAs ; RNA, Messenger ; Receptor, EphA4 (EC 2.7.10.1) ; Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065)
Language	English
Publishing date	2019-05-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2019.05.073
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Article: Polysaccharide from Pycnoporus sanguineus ameliorates dextran sulfate sodium‐induced colitis via helper T cells repertoire modulation and autophagy suppression

Li, Muxia / Luo, Ting / Huang, Yong / Su, Jiyan / Li, Dan / Chen, Xiaohong / Zhang, Yifan / Huang, Longhua / Li, Shunxian / Jiao, Chunwei / Li, Wenzhi / Xie, Yizhen / Li, Wende

Phytotherapy research. 2020 Oct., v. 34, no. 10

2020

Abstract: Inflammatory bowel disease (IBD) is a chronic autoimmune disease associated with various risk factors. Pycnoporus sanguineus (L.) Murrill is a saprotrophic fungus used worldwide for its industrial and medical purposes. Here, polysaccharide from P. ... ...

Abstract	Inflammatory bowel disease (IBD) is a chronic autoimmune disease associated with various risk factors. Pycnoporus sanguineus (L.) Murrill is a saprotrophic fungus used worldwide for its industrial and medical purposes. Here, polysaccharide from P. sanguineus (PPS) was explored for its antiinflammatory potential in a murine colitis model of IBD induced by dextran sulfate sodium (DSS). PPS ameliorated the colitis as manifested by the lowered disease activity index (DAI), prolonged colon, and reduced serum lipopolysaccharide (LPS). PPS recovered the histological lesion by upregulating the expressions of Zonula occludens‐1 (ZO‐1), E‐cadherin, and proliferating cell nuclear antigen (PCNA). PPS inhibited the helper T cells (Th)‐mediated immune response by decreasing the proportions of Th cells (including Th2 cells, Th17 cells, and regulatory T cells), which was accompanied with reductions on myeloperoxidase (MPO) activity and releases of several interleukins and chemokines within the colon. Moreover, PPS exhibited an evident inhibition on autophagy, in which the ratio of light chain 3 (LC3) II/I was declined, while the expression of p62 and Beclin‐1 was increased. The present study highlighted important clinical implications for the treatment application of PPS against IBD, which relies on the regulation of Th cells repertoire and autophagy suppression to restore epithelium barrier.
Keywords	Pycnoporus sanguineus ; T-lymphocytes ; autoimmune diseases ; autophagy ; blood serum ; cadherins ; chemokines ; colitis ; colon ; dextran sulfate ; epithelium ; fungi ; histology ; immune response ; interleukins ; light ; lipopolysaccharides ; mice ; models ; myeloperoxidase ; phytotherapy ; proliferating cell nuclear antigen ; research ; risk factors ; saprotrophs
Language	English
Dates of publication	2020-10
Size	p. 2649-2664.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	NAL-light ; JOURNAL ARTICLE
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6695
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Article ; Online: Altered Long Non-Coding RNA Transcriptomic Profiles in Ischemic Stroke.

He, Wenzhen / Wei, Duncan / Cai, De / Chen, Siqia / Li, Shunxian / Chen, Wenjie

Human gene therapy

2018 Volume 29, Issue 6, Page(s) 719–732

Abstract: A previous study described the important regulatory roles of microRNAs (miRNAs) in ischemic stroke. However, the functional significance of long non-coding RNA (lncRNAs) in ischemic stroke was largely unknown. This study aimed to identify lncRNA ... ...

Abstract	A previous study described the important regulatory roles of microRNAs (miRNAs) in ischemic stroke. However, the functional significance of long non-coding RNA (lncRNAs) in ischemic stroke was largely unknown. This study aimed to identify lncRNA profiling and elucidate the regulatory mechanisms in the pathophysiology of stroke. RNA sequencing was performed on the blood of three ischemic stroke patients and three normal controls. Differential expression analysis was used to identify differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs). After further correlation and co-expression analysis, the corresponding co-expression networks and miRN-lncRNA-mRNA interaction network were then constructed. The expression of DElncRNAs and DEmRNAs was verified in Gene Expression Omnibus. RNA sequencing and subsequent bioinformatics analysis produced a total of 61 DElncRNAs (14 upregulated and 47 downregulated) and 673 DEmRNAs (432 upregulated and 241 downregulated). LOC105372881 and LOC101929707 were the most highly increased and decreased lncRNAs in ischemic stroke. LncRNA-mRNA co-expression networks were constructed according to 3,008 positively co-expressed and 607 negatively co-expressed lncRNA-mRNA pairs. The DElncRNAs may play roles in the pathways of glycolysis/gluconeogenesis, arrhythmogenic right ventricular cardiomyopathy, adherens junction, lysosome, and hematopoietic cell lineage by regulating their co-expressed mRNAs. Combined with previous data, a miRNA-lncRNA-mRNA interaction network for ischemic stroke was constructed. Based on GSE22255, the expression of six DElncRNAs (CEBPA-AS1, LINC00884, HCG27, MATN1-AS1, HCG26, and LINC01184) and 11 DEmRNAs (TREML4, AHSP, PI3, TESC, ANXA3, OAS1, OAS2, IFI6, ISG15, IFI44L, and LY6E) was similar to the current sequencing data. This study is the first to identify blood lncRNAs in human ischemic stroke using RNA sequencing. The findings may be the foundation for understanding the potential role of lncRNAs in ischemic stroke.
MeSH term(s)	Aged ; Aged, 80 and over ; Brain Ischemia/complications ; Brain Ischemia/genetics ; Cluster Analysis ; Databases, Genetic ; Down-Regulation/genetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reproducibility of Results ; Stroke/complications ; Stroke/genetics ; Transcriptome/genetics ; Up-Regulation/genetics
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger
Language	English
Publishing date	2018-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2017.064
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Article ; Online: Bioinformatic Analysis of Potential microRNAs in Ischemic Stroke.

He, Wenzhen / Chen, Siqia / Chen, Xianguang / Li, Shunxian / Chen, Wenjie

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2016 Volume 25, Issue 7, Page(s) 1753–1759

Abstract: Background: MicroRNAs (miRNAs) are part of the brain's response to ischemia. This study aimed to screen potential miRNAs for the prediction and novel treatments of ischemic stroke.: Methods: Two mRNA and 1 miRNA microarray expression profile data ... ...

Abstract	Background: MicroRNAs (miRNAs) are part of the brain's response to ischemia. This study aimed to screen potential miRNAs for the prediction and novel treatments of ischemic stroke. Methods: Two mRNA and 1 miRNA microarray expression profile data were downloaded from the Gene Expression Omnibus database. Then, differentially expressed mRNAs and miRNAs were identified. Based on the miRNA-target pairs predicted, an miRNA-target interaction network was established. Bioinformatics analysis (Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment) was applied to interpret the function of the miRNA targets. Results: In total, 16 differentially expressed miRNAs and 1345 differentially expressed genes were identified in ischemic stroke, respectively. Importantly, 445 miRNA-target pairs with an inverse correlation of expression were obtained, and the miRNA functional synergistic network was generated. Two miRNAs (miR-145 and miR-122) may represent potential biomarkers in ischemic stroke by being involved in the process of postischemic neuronal damage and thrombosis, respectively. Three novel miRNAs (miR-99b, miR-542-3p, and miR-455-5p) were deregulated, suggesting their roles in the pathological processes of ischemic stroke. Functional annotation indicated that apoptotic signaling cascades play an important role in patients with ischemic stroke. Conclusion: miR-145 and miR-122 represent new biomarkers and underlying targets for the prevention and treatment of ischemic stroke.
MeSH term(s)	Brain Ischemia/diagnosis ; Brain Ischemia/genetics ; Case-Control Studies ; Computational Biology ; Databases, Genetic ; Gene Expression Profiling/methods ; Gene Expression Regulation ; Gene Regulatory Networks ; Genetic Association Studies ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; MicroRNAs/genetics ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Stroke/diagnosis ; Stroke/genetics
Chemical Substances	Genetic Markers ; MicroRNAs
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2016.03.023
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