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Article ; Online: Hypoxia-Inducible Factor-1: A Bridge Between Plasma Nitric Oxide and Adverse Outcomes in Critically Ill Patients.

Ruan, Hang / Li, Shu-Sheng / Ran, Xiao

2024 Volume 52, Issue 4, Page(s) e211–e212

MeSH term(s)	Humans ; Hypoxia-Inducible Factor 1 ; Nitric Oxide ; Critical Illness ; Hypoxia
Chemical Substances	Hypoxia-Inducible Factor 1 ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000006164
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Article ; Online: Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS).

Huang, Qianrui / Le, Yue / Li, Shusheng / Bian, Yi

Respiratory research

2024 Volume 25, Issue 1, Page(s) 30

Abstract: Acute respiratory distress syndrome (ARDS) is a common condition associated with critically ill patients, characterized by bilateral chest radiographical opacities with refractory hypoxemia due to noncardiogenic pulmonary edema. Despite significant ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is a common condition associated with critically ill patients, characterized by bilateral chest radiographical opacities with refractory hypoxemia due to noncardiogenic pulmonary edema. Despite significant advances, the mortality of ARDS remains unacceptably high, and there are still no effective targeted pharmacotherapeutic agents. With the outbreak of coronavirus disease 19 worldwide, the mortality of ARDS has increased correspondingly. Comprehending the pathophysiology and the underlying molecular mechanisms of ARDS may thus be essential to developing effective therapeutic strategies and reducing mortality. To facilitate further understanding of its pathogenesis and exploring novel therapeutics, this review provides comprehensive information of ARDS from pathophysiology to molecular mechanisms and presents targeted therapeutics. We first describe the pathogenesis and pathophysiology of ARDS that involve dysregulated inflammation, alveolar-capillary barrier dysfunction, impaired alveolar fluid clearance and oxidative stress. Next, we summarize the molecular mechanisms and signaling pathways related to the above four aspects of ARDS pathophysiology, along with the latest research progress. Finally, we discuss the emerging therapeutic strategies that show exciting promise in ARDS, including several pharmacologic therapies, microRNA-based therapies and mesenchymal stromal cell therapies, highlighting the pathophysiological basis and the influences on signal transduction pathways for their use.
MeSH term(s)	Humans ; Respiratory Distress Syndrome ; Lung ; MicroRNAs/genetics ; Signal Transduction ; Pulmonary Edema
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-024-02678-5
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Article ; Online: Dyslipidemia versus obesity as predictors of ischemic stroke prognosis: a multi-center study in China.

Ruan, Hang / Ran, Xiao / Li, Shu-Sheng / Zhang, Qin

Lipids in health and disease

2024 Volume 23, Issue 1, Page(s) 72

Abstract: Background: This multicenter observational study aimed to determine whether dyslipidemia or obesity contributes more significantly to unfavorable clinical outcomes in patients experiencing a first-ever ischemic stroke (IS).: Methods: The study ... ...

Abstract	Background: This multicenter observational study aimed to determine whether dyslipidemia or obesity contributes more significantly to unfavorable clinical outcomes in patients experiencing a first-ever ischemic stroke (IS). Methods: The study employed a machine learning predictive model to investigate associations among body mass index (BMI), body fat percentage (BFP), high-density lipoprotein (HDL), triglycerides (TG), and total cholesterol (TC) with adverse outcomes in IS patients. Extensive real-world clinical data was utilized, and risk factors significantly linked to adverse outcomes were identified through multivariate analysis, propensity score matching (PSM), and regression discontinuity design (RDD) techniques. Furthermore, these findings were validated via a nationwide multicenter prospective cohort study. Results: In the derived cohort, a total of 45,162 patients diagnosed with IS were assessed, with 522 experiencing adverse outcomes. A multifactorial analysis incorporating PSM and RDD methods identified TG (adjusted odds ratio (OR) = 1.110; 95% confidence interval (CI): 1.041-1.183; P < 0.01) and TC (adjusted OR = 1.139; 95%CI: 1.039-1.248; P < 0.01) as risk factors. However, BMI, BFP, and HDL showed no significant effect. In the validation cohort, 1410 controls and 941 patients were enrolled, confirming that lipid levels are more strongly correlated with the prognosis of IS patients compared to obesity (TC, OR = 1.369; 95%CI: 1.069-1.754; P < 0.05; TG, OR = 1.332; 95%CI: 1.097-1.618; P < 0.01). Conclusion: This study suggests that dyslipidemia has a more substantial impact on the prognosis of IS patients compared to obesity. This highlights the importance of prioritizing dyslipidemia management in the treatment and prevention of adverse outcomes in IS patients.
MeSH term(s)	Humans ; Ischemic Stroke ; Prospective Studies ; Cholesterol, HDL ; Obesity/complications ; Risk Factors ; Triglycerides ; Lipoproteins, HDL ; Dyslipidemias ; China/epidemiology
Chemical Substances	Cholesterol, HDL ; Triglycerides ; Lipoproteins, HDL
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Multicenter Study ; Observational Study ; Journal Article
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-024-02061-9
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Article ; Online: HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy.

Ling, Jianmin / Yu, Shanshan / Xiong, Feng / Li, Shusheng

International immunopharmacology

2023 Volume 122, Page(s) 110448

Abstract: Sepsis-associated encephalopathy (SAE) is associated with a higher risk of cognitive deficits; however, its potential mechanisms are still unknow. Recently, researches show that HSPB8, a family of small heat shock proteins, affects cognitive function and ...

Abstract	Sepsis-associated encephalopathy (SAE) is associated with a higher risk of cognitive deficits; however, its potential mechanisms are still unknow. Recently, researches show that HSPB8, a family of small heat shock proteins, affects cognitive function and ameliorates sepsis-induced dysfunction. However, the role of HSPB8 in SAE-associated cognitive impairment has not been elucidated. In this study, we found that HSPB8 expression was up-regulated in the brain of mice with lipopolysaccharide-induced sepsis. HSPB8 overexpression alleviated cognitive decline in SAE mice. In addition, exogenous HSPB8 exerts neuroprotective effects and salvages synaptic function via regulating NRF1/TFAM-induced mitochondrial biogenesis and DRP1-mediate mitochondrial fission in a lipopolysaccharide-induced mouse model. Furthermore, HSPB8 overexpression inhibits IBA1 and NLRP3 activation in the SAE model. Overexpression of HSPB8 may be an efficient treatment for relieving SAE-related cognitive decline.
MeSH term(s)	Mice ; Animals ; Sepsis-Associated Encephalopathy/complications ; Lipopolysaccharides ; Up-Regulation ; Cognitive Dysfunction ; Sepsis/complications ; Molecular Chaperones
Chemical Substances	Lipopolysaccharides ; Molecular Chaperones
Language	English
Publishing date	2023-07-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110448
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Zs.A 5408: Show issues

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Article ; Online: Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics-a narrative review.

Ruan, Hang / Zhang, Qin / Zhang, You-Ping / Li, Shu-Sheng / Ran, Xiao

Critical care (London, England)

2024 Volume 28, Issue 1, Page(s) 100

Abstract: Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α (HIF-1α), a notable transcription factor, ... ...

Abstract	Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α (HIF-1α), a notable transcription factor, assumes a pivotal role in the onset and progression of sepsis. This review aims to furnish a comprehensive overview of HIF-1α's mechanism of action in sepsis, scrutinizing its involvement in inflammatory regulation, hypoxia adaptation, immune response, and organ dysfunction. The review encompasses an analysis of the structural features, regulatory activation, and downstream signaling pathways of HIF-1α, alongside its mechanism of action in the pathophysiological processes of sepsis. Furthermore, it will delve into the roles of HIF-1α in modulating the inflammatory response, including its association with inflammatory mediators, immune cell activation, and vasodilation. Additionally, attention will be directed toward the regulatory function of HIF-1α in hypoxic environments and its linkage with intracellular signaling, oxidative stress, and mitochondrial damage. Finally, the potential therapeutic value of HIF-1α as a targeted therapy and its significance in the clinical management of sepsis will be discussed, aiming to serve as a significant reference for an in-depth understanding of sepsis pathogenesis and potential therapeutic targets, as well as to establish a theoretical foundation for clinical applications.
MeSH term(s)	Humans ; Multiple Organ Failure ; Signal Transduction ; Sepsis ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-024-04885-4
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Zs.A 5517: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy.

Ling, Jianmin / Yu, Shanshan / Xiong, Feng / Xu, Tingting / Li, Shusheng

Drug design, development and therapy

2023 Volume 17, Page(s) 2775–2786

Abstract: Background: Epidemiological studies have indicated that lung injury is a frequent complication of sepsis. Mitophagy is vital to multiple pathological processes and diseases; however, its influence on sepsis-induced acute lung injury remains elusive. ... ...

Abstract	Background: Epidemiological studies have indicated that lung injury is a frequent complication of sepsis. Mitophagy is vital to multiple pathological processes and diseases; however, its influence on sepsis-induced acute lung injury remains elusive. Melatonin has multiple antioxidant action and anti-inflammatory effects, including regulating mitophagy and inflammatory cytokine expression. Whereas, little is known about the affection of melatonin and mitophagy on CLP-induced ALI. Methods: The in vivo effect of melatonin on OPTN-mediated mitophagy was studied by CLP-induced ALI in a mouse model using C57BL/6 followed by treatment with vehicle and melatonin (30 mg/kg/d, intraperitoneal injection). ALI was assayed by lung wet /dry ratio, hematoxylin and eosin staining, and immunohistochemical staining. Signaling pathway changes were subsequently determined by Western blotting and immunofluorescence staining. The effects of melatonin on STAT3 activation and TNF-α production were detected by Western blotting, PCR, and immunohistochemical staining. Results: Our results indicated that OPTN, mitophagy adaptors were significantly repressed in CLP-induced ALI, accompanied by overactivation of mitophagy and inflammation. At the same time, we found that melatonin treatment alleviated ALI caused by CLP, and the effect was highly correlated with OPTN-related mitophagy. Furthermore, we demonstrated that OPTN-related mitophagy, which was normalized by melatonin, blocked STAT3 involved epithelial barrier and inflammation in vivo. Conclusion: Overall, our results confirm that mitophagy is adjusted by melatonin in the CLP-induced ALI. Moreover, manipulation of mitophagy through melatonin could be a possible treatment to reduce sepsis-associated lung injury.
MeSH term(s)	Mice ; Animals ; Mice, Inbred C57BL ; Melatonin/pharmacology ; Mitophagy ; Acute Lung Injury/drug therapy ; Acute Lung Injury/etiology ; Sepsis/complications ; Sepsis/drug therapy ; Inflammation
Chemical Substances	Melatonin (JL5DK93RCL)
Language	English
Publishing date	2023-09-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S423264
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Article ; Online: Elevated MMP-8 levels, inversely associated with BMI, predict mortality in mechanically ventilated patients: an observational multicenter study.

Ruan, Hang / Li, Shu-Sheng / Zhang, Qin / Ran, Xiao

Critical care (London, England)

2023 Volume 27, Issue 1, Page(s) 290

Abstract: Background: The present study aimed to investigate the correlation between weight status and mortality in mechanically ventilated patients and explore the potential mediators.: Methods: Three medical centers encompassing 3301 critically ill patients ... ...

Abstract	Background: The present study aimed to investigate the correlation between weight status and mortality in mechanically ventilated patients and explore the potential mediators. Methods: Three medical centers encompassing 3301 critically ill patients receiving mechanical ventilation were assembled for retrospective analysis to compare mortality across various weight categories of patients using machine learning algorithms. Bioinformatics analysis identified genes exhibiting differential expression among distinct weight categories. A prospective study was then conducted on a distinct cohort of 50 healthy individuals and 193 other mechanically ventilated patients. The expression levels of the genes identified through bioinformatics analysis were quantified through enzyme-linked immunosorbent assay (ELISA). Results: The retrospective analysis revealed that overweight individuals had a lower mortality rate than underweight individuals, and body mass index (BMI) was an independent protective factor. Bioinformatics analysis identified matrix metalloproteinase 8 (MMP-8) as a differentially expressed gene between overweight and underweight populations. The results of further prospective studies showed that overweight patients had significantly lower MMP-8 levels than underweight patients ((3.717 (2.628, 4.191) vs. 2.763 (1.923, 3.753), ng/ml, P = 0.002). High MMP-8 levels were associated with increased mortality risk (OR = 4.249, P = 0.005), indicating that elevated level of MMP-8 predicts the mortality risk of underweight patients receiving mechanical ventilation. Conclusions: This study provides evidence for a protective effect of obesity in mechanically ventilated patients and highlights the potential role of MMP-8 level as a biomarker for predicting mortality risk in this population.
MeSH term(s)	Humans ; Body Mass Index ; Matrix Metalloproteinase 8 ; Overweight ; Prospective Studies ; Respiration, Artificial ; Retrospective Studies ; Thinness ; Observational Studies as Topic
Chemical Substances	Matrix Metalloproteinase 8 (EC 3.4.24.34)
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04579-3
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: MFEAFN: Multi-scale feature enhanced adaptive fusion network for image semantic segmentation.

Li, Shusheng / Wan, Liang / Tang, Lu / Zhang, Zhining

PloS one

2022 Volume 17, Issue 9, Page(s) e0274249

Abstract: Low-level features contain spatial detail information, and high-level features contain rich semantic information. Semantic segmentation research focuses on fully acquiring and effectively fusing spatial detail with semantic information. This paper ... ...

Abstract	Low-level features contain spatial detail information, and high-level features contain rich semantic information. Semantic segmentation research focuses on fully acquiring and effectively fusing spatial detail with semantic information. This paper proposes a multiscale feature-enhanced adaptive fusion network named MFEAFN to improve semantic segmentation performance. First, we designed a Double Spatial Pyramid Module named DSPM to extract more high-level semantic information. Second, we designed a Focusing Selective Fusion Module named FSFM to fuse different scales and levels of feature maps. Specifically, the feature maps are enhanced to adaptively fuse these features by generating attention weights through a spatial attention mechanism and a two-dimensional discrete cosine transform, respectively. To validate the effectiveness of FSFM, we designed different fusion modules for comparison and ablation experiments. MFEAFN achieved 82.64% and 78.46% mIoU on the PASCAL VOC2012 and Cityscapes datasets. In addition, our method has better segmentation results than state-of-the-art methods.
MeSH term(s)	Gene Fusion ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Semantics
Language	English
Publishing date	2022-09-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0274249
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Article ; Online: Actinomyces odontolyticus

Ruan, Hang / Tao, Yi-Ming / Li, Shu-Sheng

Archives of Iranian medicine

2022 Volume 25, Issue 6, Page(s) 402–404

MeSH term(s)	Actinomyces ; Empyema, Pleural/diagnostic imaging ; Empyema, Pleural/drug therapy ; Humans ; Lung Abscess/diagnostic imaging ; Lung Abscess/drug therapy
Language	English
Publishing date	2022-06-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2204979-4
ISSN	1735-3947 ; 1029-2977
ISSN (online)	1735-3947
ISSN	1029-2977
DOI	10.34172/aim.2022.65
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Zs.A 6228: Show issues

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Article: The Efficacy and Safety of Sodium Bicarbonate Ringer's Solution in Critically Ill Patients: A Retrospective Cohort Study.

Bian, Yi / Xu, Tingting / Le, Yue / Li, Shusheng

Frontiers in pharmacology

2022 Volume 13, Page(s) 829394

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.829394
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