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Article ; Online: Uterine myxoid leiomyosarcoma: identification of a novel PLAG1 fusion partner.

Li, Wen-Qi / Wu, Hai-Xia / Li, Han-Bo / Shen, Yan

2024

Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Letter
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2024.01.009
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Zs.A 723: Show issues

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Article ; Online: A retrospective cohort study evaluating the improvement of medical records management based on whole-process control.

Gu, Jun-Hua / Li, Wen-Qi / Chen, Chuan-Jun

Technology and health care : official journal of the European Society for Engineering and Medicine

2023 Volume 31, Issue 5, Page(s) 1901–1910

Abstract: Background: Whole-process management is a novel approach widely applied in industry and commerce; however, it is not widely used in the management of medical records in hospitals.: Objective: The purpose of this study is to investigate the ... ...

Abstract	Background: Whole-process management is a novel approach widely applied in industry and commerce; however, it is not widely used in the management of medical records in hospitals. Objective: The purpose of this study is to investigate the application of whole-process control in the administration of a hospital's medical records department to achieve refined management of medical records. Methods: Whole-process control is a management measure that begins with process conception and implementation and includes control over all processes. The control group included medical records that were created prior to the implementation of whole-process control, i.e., those created between June 1 and December 31, 2020. The observation group included medical records that were created after the implementation of whole-process control. The behavior of the medical records staff (in terms of medical record collection, sorting, entry, inquiry, and supply) and the final quality of the medical records (the number of grade-A medical records and their front-page quality) were compared between the two groups, and subjective judgments related to staff satisfaction were reviewed. Results: The implementation of whole-process control improved the behavior of the medical records staff. The final quality of the medical records was also improved, as was the job satisfaction of the medical records staff. Conclusion: Implementing whole-process control improved the management of medical records and quality of medical records.
MeSH term(s)	Humans ; Retrospective Studies ; Medical Records ; Hospitals ; Forms and Records Control
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-220863
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Zs.A 3846: Show issues

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Article: [Efficacy and Prognosis of Chemotherapy Regimen Containing BTK Inhibitor in Treatment of Recurrent/Refractory Mantle Cell Lymphoma].

Chen, Huan / Liu, Xi-Yang / Chang, Yu / Chen, Zi-Qi / Li, Wen-Qi / Zhang, Lei

Zhongguo shi yan xue ye xue za zhi

2024 Volume 32, Issue 1, Page(s) 125–131

Abstract: Objective: To investigate the efficacy and prognosis of chemotherapy regimen containing Bruton's tyrosine kinase (BTK) inhibitor in the treatment of relapsed/refractory mantle cell lymphoma (R/R MCL).: Methods: The clinical data of 134 patients with ... ...

Abstract	Objective: To investigate the efficacy and prognosis of chemotherapy regimen containing Bruton's tyrosine kinase (BTK) inhibitor in the treatment of relapsed/refractory mantle cell lymphoma (R/R MCL). Methods: The clinical data of 134 patients with R/R MCL were collected and analyzed retrospectively. The clinical characteristics of patients and effect of chemotherapy regimen on efficacy, overall survival (OS) and progression-free survival (PFS) were observed. Results: The median age of the patients was 58(56-61) years old, and male to female ratio was about 2.9∶1. Patients with Ann Arbor stage III-IV accounted for 77.6%, extranodal involvement > 2 for 43.3%, bone marrow involvement for 60.4%, gastrointestinal involvement for 24.6%, and hepatosplenomegaly for 38.1%. The median follow-up time was 30 (2-103) months, overall response rate (ORR) was 41.8%, 3-year PFS was not reached, and 3-year and 5-year OS rate was 62.7% and 53.8%, respectively. The ORR of BTK inhibitor group was 56.9%, which was higher than 32.5% of non-BTK inhibitor group ( Conclusions: The chemotherapy regimen containing BTK inhibitors can effectively improve the efficacy and prolong the PFS of R/R MCL patients. Ki-67, B symptoms, MIPI score, and Ann Arbor stage are independent prognostic factors for R/R MCL patients.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Middle Aged ; Lymphoma, Mantle-Cell/drug therapy ; Lymphoma, Mantle-Cell/pathology ; Ki-67 Antigen ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Prognosis
Chemical Substances	Ki-67 Antigen
Language	Chinese
Publishing date	2024-02-23
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2024.01.020
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Zs.A 6603: Show issues

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Article ; Online: Differentiation Between Internal Carotid Artery Hypoplasia and Acquired Narrowing by Neurovascular Ultrasound: Case Series and Literature Review.

Chen, Yan-Ru / Li, Wen-Qi / Liu, Ji-Hong

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2022 Volume 42, Issue 4, Page(s) 765–776

Abstract: Uniformly narrowed internal carotid artery (ICA) without proximal steno-occlusion or parietal anomalies is often subject to misdiagnosis due to lack of awareness. We combined our experiences of 4 cases with 29 previously published cases to form a ... ...

Abstract	Uniformly narrowed internal carotid artery (ICA) without proximal steno-occlusion or parietal anomalies is often subject to misdiagnosis due to lack of awareness. We combined our experiences of 4 cases with 29 previously published cases to form a retrospective series including 18 cases of ICA hypoplasia and 15 cases of ICA acquired narrowing. The ultrasonic manifestations of ICA acquired narrowing and ICA hypoplasia are extremely similar, but narrowed ICA without intracranial occlusion or bottle-neck-sign highly indicates ICA hypoplasia, whereas moyamoya vessels favor ICA acquired narrowing, thus promoting the understanding of and discriminability between the two on neurovascular ultrasound.
MeSH term(s)	Humans ; Carotid Artery, Internal/diagnostic imaging ; Retrospective Studies ; Ultrasonography ; Moyamoya Disease ; Carotid Stenosis
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.16083
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 495: Show issues

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Article ; Online: Corrigendum to "LncRNA HIF1A-AS2 modulated by HPV16 E6 regulates apoptosis of cervical cancer cells via P53/caspase9/caspase3 axis" [Cellular Signalling 97 (2022) 110390].

Guan, Hong-Mei / Li, Wen-Qi / Liu, Jie / Zhou, Jue-Yu

Cellular signalling

2022 Volume 102, Page(s) 110519

Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Published Erratum
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2022.110519
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Zs.A 2579: Show issues

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Article ; Online: LncRNA HIF1A-AS2 modulated by HPV16 E6 regulates apoptosis of cervical cancer cells via P53/caspase9/caspase3 axis.

Guan, Hong-Mei / Li, Wen-Qi / Liu, Jie / Zhou, Jue-Yu

Cellular signalling

2022 Volume 97, Page(s) 110390

Abstract: Background: Plentiful evidence proves that lncRNAs play a crucial role in tumor development. However, the function and mechanism that were mediated by lncRNA HIF1A-AS2 in cervical cancer remain unclear.: Methods: The lncRNA HIF1A-AS2 was identified ... ...

Abstract	Background: Plentiful evidence proves that lncRNAs play a crucial role in tumor development. However, the function and mechanism that were mediated by lncRNA HIF1A-AS2 in cervical cancer remain unclear. Methods: The lncRNA HIF1A-AS2 was identified via high-throughput microarray analysis of three HPV 16-positive cervical squamous cell carcinoma (CSCC) samples and three HPV-negative normal controls. The expression of HIF1A-AS2 was detected by qRT-PCR in clinical tissues and cancer cells. In vitro and in vivo assays were performed through downregulation or upregulation of HIF1A-AS2. The possible mechanisms of HIF1A-AS2 in cervical cancer cells were explored by western blot, flow cytometric analysis and rescue assays. Results: HIF1A-AS2 was significantly increased in cervical cancer tissue, and in the HPV- positive cervical cancer cells. Further investigation showed that the inhibition of HIF1A-AS2 suppressed cell proliferation, migration, invasion, and induced apoptosis, while up-regulation of HIF1A-AS2 revealed opposite results. In terms of mechanism, we found that HIF1A-AS2 was mediated by HPV16 E6 and regulated cell apoptosis via P53/caspase 9/caspase 3 axis. Conclusion: Our findings demonstrate that HIF1A-AS2 functions as a carcinogenic lncRNA that promotes tumor development, and serves as a candidate prognostic factor, which may contribute to the treatment of cervical cancer.
MeSH term(s)	Apoptosis/genetics ; Caspase 3/metabolism ; Caspase 9 ; Cell Line, Tumor ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Oncogene Proteins, Viral ; Papillomavirus Infections/genetics ; RNA, Long Noncoding/genetics ; Repressor Proteins ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Uterine Cervical Neoplasms/genetics
Chemical Substances	E6 protein, Human papillomavirus type 16 ; Oncogene Proteins, Viral ; RNA, Long Noncoding ; Repressor Proteins ; Tumor Suppressor Protein p53 ; CASP3 protein, human (EC 3.4.22.-) ; CASP9 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-)
Language	English
Publishing date	2022-06-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2022.110390
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Zs.A 2579: Show issues

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Article: [Changes in Soil Nitrogen Components and Their Relationship with Environmental Factors with Different Tea Plantation Ages].

Shao, Qi / Wu, Tao / Xie, Xue-Feng / Xu, Zi-Qing / Li, Wen-Qi / Jiang, Guo-Jun / Zhang, Jian-Zhen / Xu, Fei

Huan jing ke xue= Huanjing kexue

2024 Volume 45, Issue 3, Page(s) 1665–1673

Abstract: Changes in soil nitrogen components in tea gardens affect the soil nitrogen supply capacity and nitrogen cycle. In this study, soil samples were collected from forest land, cultivated land, and tea gardens with different plantation ages (30, 50, and 70 ... ...

Abstract	Changes in soil nitrogen components in tea gardens affect the soil nitrogen supply capacity and nitrogen cycle. In this study, soil samples were collected from forest land, cultivated land, and tea gardens with different plantation ages (30, 50, and 70 years) to explore the changes in soil nitrogen components and their relationship with physicochemical properties and enzyme activities. The results showed that:① with the increase in tea plantation age, the silt, total phosphorus, and urease and catalase activities gradually increased, whereas the sand, clay, pH, electrical conductivity, soil organic carbon, and the activities of invertase gradually decreased. The alkaline phosphatase activity increased first and then decreased with the increase in tea plantation age, and no significant differences were observed in soil water content and acid phosphatase activity. ② With the increase in tea plantation age, the contents of acid ammonia nitrogen, amino acid nitrogen, and nitrate nitrogen (NO
MeSH term(s)	Soil/chemistry ; Alkaline Phosphatase ; Sand ; Nitrogen/analysis ; Carbon ; Urease ; Ammonia ; Phosphorus/analysis ; Tea ; Soil Microbiology ; China
Chemical Substances	Soil ; Alkaline Phosphatase (EC 3.1.3.1) ; Sand ; Nitrogen (N762921K75) ; Carbon (7440-44-0) ; Urease (EC 3.5.1.5) ; Ammonia (7664-41-7) ; Phosphorus (27YLU75U4W) ; Tea
Language	Chinese
Publishing date	2024-03-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202304162
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Article ; Online: Discovery of N-benzyl-6-methylpicolinamide as a potential scaffold for bleaching herbicides.

Zhang, Hui-Xia / Huang, Di / Ren, Meng-Nan / Li, Wen-Qi / Wei, Shao-Peng / Ji, Zhi-Qin

Pest management science

2024

Abstract: Background: In pesticide research, bleaching herbicides have always been a hot topic. Our previous research showed that N-(4-fluorobenzyl)-2-methoxybenzamide is an innovative lead compound for bleaching herbicides.: Results: A total of 40 derivatives ...

Abstract	Background: In pesticide research, bleaching herbicides have always been a hot topic. Our previous research showed that N-(4-fluorobenzyl)-2-methoxybenzamide is an innovative lead compound for bleaching herbicides. Results: A total of 40 derivatives of picolinamides were prepared and evaluated for their herbicidal activity by Petri dish tests and postemergence trials. The structure-activity relationship (SAR) revealed that introducing electron-withdrawing groups at the 3- or 4-positions of the benzyl significantly enhances herbicidal activity. Furthermore, ZI-04 induced similar symptoms such as bleaching effect in treated weeds and accumulation of biosynthetic precursors for carotenoids as observed with diflufenican. ZI-04 also exhibited significant cross-resistance to diflufenican and had a lower resistance risk than diflufenican. Conclusion: N-benzyl-6-methylpicolinamides were discovered as a novel scaffold for bleaching herbicides. The accumulation of phytoene, phytofluene and ζ-Carotene in radish cotyledons, and cross-resistance observed with diflufenican, showed that title compounds can interfere with carotenoid biosynthesis. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.8030
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Z 2731: Show issues

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Article: [Effect of

Li, Wen-Qi / Xiang, Qi / Xie, Xue-Feng / Wu, Tao / Jiang, Guo-Jun / Zhang, Jian-Zhen / Pu, Li-Jie / Xu, Fei

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 5, Page(s) 2735–2745

Abstract: The invasion ... ...

Abstract	The invasion of
MeSH term(s)	Wetlands ; Ecosystem ; Soil/chemistry ; Bays ; Clay ; Carbon/analysis ; Introduced Species ; Poaceae ; Nitrogen/analysis ; Phosphorus/analysis ; China
Chemical Substances	Soil ; Clay (T1FAD4SS2M) ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W)
Language	Chinese
Publishing date	2023-05-08
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202206204
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Article ; Online: Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1α in colorectal cancer.

Chen, Yi-Hong / Xu, Nan-Zhu / Hong, Chang / Li, Wen-Qi / Zhang, Yi-Qiong / Yu, Xin-Yi / Huang, Yue-Le / Zhou, Jue-Yu

Cell death & disease

2022 Volume 13, Issue 11, Page(s) 939

Abstract: Myosin 1b (Myo1b) is an important single-headed membrane-associated motor of class I myosins that participate in many critical physiological and pathological processes. Mounting evidence suggests that the dysregulation of Myo1b expression has been ... ...

Abstract	Myosin 1b (Myo1b) is an important single-headed membrane-associated motor of class I myosins that participate in many critical physiological and pathological processes. Mounting evidence suggests that the dysregulation of Myo1b expression has been extensively investigated in the development and progression of several tumors. However, the functional mechanism of Myo1b in CRC angiogenesis and autophagy progression remains unclear. Herein, we found that the expression of Myo1b was upregulated in CRC tissues and its high expression was correlated with worse survival. The overexpression of Myo1b promoted the proliferation, migration and invasion of CRC cells. Conversely, silencing of Myo1b suppressed tumor progression both in vitro and in vivo. Further studies indicated that Myo1b inhibited the autophagosome-lysosome fusion and potentiated the VEGF secretion of CRC cells to promote angiogenesis. Mechanistically, Myo1b blocked the autophagic degradation of HIF-1α and then led to the accumulation of HIF-1α, thus enhancing VEGF secretion and then promoting tumor angiogenesis in CRC. Together, our study provided novel insights into the role of Myo1b in CRC progression and revealed that it might be a feasible predictive biomarker and promising therapeutic target for CRC patients.
MeSH term(s)	Humans ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Cell Line, Tumor ; Neovascularization, Pathologic/metabolism ; Myosins ; Autophagy/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Colorectal Neoplasms/pathology ; Myosin Type I/genetics
Chemical Substances	Vascular Endothelial Growth Factor A ; Myosins (EC 3.6.4.1) ; Hypoxia-Inducible Factor 1, alpha Subunit ; MYO1B protein, human ; Myosin Type I (EC 3.6.1.-)
Language	English
Publishing date	2022-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-022-05397-1
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