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  1. Article: [Chemical Characteristics of Shallow Groundwater in the Yellow River Diversion Area of Henan Province and Identification of Main Control Pollution Sources].

    Wang, Shuai / Ren, Yu / Guo, Hong / Cao, Wen-Geng / Li, Xiang-Zhi / Xiao, Shun-Yu

    Huan jing ke xue= Huanjing kexue

    2024  Volume 45, Issue 2, Page(s) 792–801

    Abstract: The northern plain of Henan in the lower reaches of the Yellow River is an area where the Yellow River is frequently diverted. The shallow groundwater quality in this area is poor, and many types of components have been found to be exceeding the limit ... ...

    Abstract The northern plain of Henan in the lower reaches of the Yellow River is an area where the Yellow River is frequently diverted. The shallow groundwater quality in this area is poor, and many types of components have been found to be exceeding the limit value; however, the contribution of various environmental factors to water quality needs to be further quantified. In order to clarify the genesis of water quality of shallow groundwater in the study area, 330 groups of shallow groundwater samples were collected via a regional water quality survey. The evolution of shallow groundwater quality in the Yellow River diversion area of northern Henan was revealed using the principal component-absolute principal component score-multiple linear regression (PCA-APCS-MLR) model. The results showed that the components with a shallow groundwater excess rate greater than 10% in descending order were manganese, iron, total hardness, total dissolved solids, sodium, fluoride, arsenic, chloride ions, sulfate, and ammonium. In particular, the excess rate of manganese reached 76%. The four factors of dissolution enrichment, native origin of soil, redox conditions, and agricultural activities were identified as the main reasons for poor groundwater quality, which accounted for 71.24% of the cumulative interpretation rate of variance. In addition, the recharge from the surface water also influenced the groundwater quality. The effects of dissolution between the water and aquifer matrix and redox condition in the aquifer of the Yellow River dried-riverway like Xinxiang were significantly enhanced, resulting in the increasing concentration of iron, arsenic, total hardness, TDS, and other components in groundwater. Fluoride enrichment was caused by dissolution enrichment, the origin of the soil, and lateral replenishment of the Yellow River. Groundwater with high manganese concentration was widely affected by the soil matrix. Nitrate pollution of the groundwater was caused by the extensive use of chemical fertilizers in agricultural activities in individual areas.
    Language Chinese
    Publishing date 2024-03-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202303263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy and Safety Analysis of Phloroglucinol in Combination with Oxytocin for the Induction of Labor in Women with Term Premature Rupture of Membranes (PROM).

    Yu, Jiazheng / Chen, Lili / Wang, Xia / Li, Xiangzhi

    Computational and mathematical methods in medicine

    2022  Volume 2022, Page(s) 2617075

    Abstract: Objective: The purpose of this study was to investigate the efficacy and safety of phloroglucinol in combination with oxytocin in the induction of labor in women who had experienced term premature rupture of membranes (PROM).: Methods: Data from 100 ... ...

    Abstract Objective: The purpose of this study was to investigate the efficacy and safety of phloroglucinol in combination with oxytocin in the induction of labor in women who had experienced term premature rupture of membranes (PROM).
    Methods: Data from 100 women who experienced PROM between December 2020 and December 2021 were retrospectively evaluated in this study. The puerperae were categorized into observation and control groups based on their uterine contraction regimens. The observation group consisted of 53 participants that had been treated with phloroglucinol in combination with oxytocin, and the control group consisted of 47 participants that had been treated with oxytocin alone. It was observed and compared in terms of the Bishop score before and after the administration of the puerpera to see which group had the best index. A study was performed after the drug was administered to examine its effects on the duration of labor (including the first, second, and third stages of labor), the mode of delivery (including natural vaginal delivery and cesarean section), the incidence of adverse pregnancy outcomes (fetal distress and neonatal asphyxia), successful labor induction, and complication rates.
    Results: Patients in the observation group had a significantly higher Bishop score after administration than those in the control group (
    Conclusion: In conclusion, the use of phloroglucinol in combination with intravenous oxytocin in the process of promoting cervical ripening and induction of labor for women with PROM who are at term was investigated. This study could help women speed up cervical dilation, improve the cervical Bishop scores, shorten the total labour process, improve the effective rate of vaginal delivery, and be very safe, making it a good candidate for clinical promotion and application.
    MeSH term(s) Cervical Ripening ; Cesarean Section ; Female ; Humans ; Infant, Newborn ; Labor, Induced ; Oxytocics/adverse effects ; Oxytocin/adverse effects ; Patient Reported Outcome Measures ; Phloroglucinol/adverse effects ; Pregnancy ; Retrospective Studies
    Chemical Substances Oxytocics ; Oxytocin (50-56-6) ; Phloroglucinol (DHD7FFG6YS)
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252430-7
    ISSN 1748-6718 ; 1748-670X ; 1027-3662
    ISSN (online) 1748-6718
    ISSN 1748-670X ; 1027-3662
    DOI 10.1155/2022/2617075
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  3. Article ; Online: The impacts of Cu(II) complexation on gatifloxacin adsorption onto goethite and hematite.

    Li, Xiangzhi / Bi, Erping

    Journal of environmental quality

    2020  Volume 49, Issue 1, Page(s) 50–60

    Abstract: Gatifloxacin (GAT) is a new generation fluoroquinolone antibiotic and its adsorption onto iron minerals influenced by coexisting trace elements [e.g., Cu(II)] has not been well investigated. To evaluate the adsorption behavior of GAT and Cu(II) onto ... ...

    Abstract Gatifloxacin (GAT) is a new generation fluoroquinolone antibiotic and its adsorption onto iron minerals influenced by coexisting trace elements [e.g., Cu(II)] has not been well investigated. To evaluate the adsorption behavior of GAT and Cu(II) onto goethite and hematite, the complexation constants of GAT with Cu(II) were determined using potentiometric titration, and the effects of Cu(II) concentration and solution pH on GAT adsorption were investigated using batch experiments. It was observed that GAT adsorption was negatively correlated with molar concentration ratio of Cu(II) to GAT. In our experimental pH range (i.e., 3.0-10.8), the calculated main species involved in GAT adsorption were Cu(GAT
    MeSH term(s) Adsorption ; Ferric Compounds ; Gatifloxacin ; Iron Compounds ; Minerals
    Chemical Substances Ferric Compounds ; Iron Compounds ; Minerals ; goethite (1310-14-1) ; ferric oxide (1K09F3G675) ; Gatifloxacin (L4618BD7KJ)
    Language English
    Publishing date 2020-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120525-0
    ISSN 1537-2537 ; 0047-2425
    ISSN (online) 1537-2537
    ISSN 0047-2425
    DOI 10.1002/jeq2.20016
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  4. Article: The impacts of Cu(II) complexation on gatifloxacin adsorption onto goethite and hematite

    Li, Xiangzhi / Bi, Erping

    Journal of environmental quality. 2020 Jan., v. 49, no. 1

    2020  

    Abstract: Gatifloxacin (GAT) is a new generation fluoroquinolone antibiotic and its adsorption onto iron minerals influenced by coexisting trace elements [e.g., Cu(II)] has not been well investigated. To evaluate the adsorption behavior of GAT and Cu(II) onto ... ...

    Abstract Gatifloxacin (GAT) is a new generation fluoroquinolone antibiotic and its adsorption onto iron minerals influenced by coexisting trace elements [e.g., Cu(II)] has not been well investigated. To evaluate the adsorption behavior of GAT and Cu(II) onto goethite and hematite, the complexation constants of GAT with Cu(II) were determined using potentiometric titration, and the effects of Cu(II) concentration and solution pH on GAT adsorption were investigated using batch experiments. It was observed that GAT adsorption was negatively correlated with molar concentration ratio of Cu(II) to GAT. In our experimental pH range (i.e., 3.0–10.8), the calculated main species involved in GAT adsorption were Cu(GAT±)²⁺ and Cu(GAT±)₂²⁺ under acidic to neutral conditions, and formation of Cu(GAT⁻)₂(s) facilitated the removal of GAT from solution under alkaline condition. The adsorption data were well fitted by the Freundlich model and showed high nonlinearity. In adsorption onto goethite, the primary interactions shifted from electrostatic repulsion to formation of goethite–Cu(II)–GAT ternary surface complexes with increase of GAT concentration. For hematite, electrostatic repulsion was the main inhibiting mechanism and became stronger with increase of Cu(II) concentration. Our findings suggest that it is necessary to consider the complexation between GAT and coexisting metal cations in evaluating its transport in soils rich in different iron minerals.
    Keywords adsorption ; antibiotics ; electrostatic interactions ; environmental quality ; fluoroquinolones ; goethite ; hematite ; pH ; sorption isotherms ; titration
    Language English
    Dates of publication 2020-01
    Size p. 50-60.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 120525-0
    ISSN 1537-2537 ; 0047-2425
    ISSN (online) 1537-2537
    ISSN 0047-2425
    DOI 10.1002/jeq2.20016
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Drivers of spatiotemporal variations in traditional heating under carbon neutrality commitment: Evidence from China at city-level

    Zhang, Tianzuo / Sun, Xin / Li, Xiangzhi / Liu, Huanran / Hong, Jinglan

    Journal of Cleaner Production. 2023 June, v. 406 p.137142-

    2023  

    Abstract: Coal-fired winter heating (CFH), one of the humankind's most carbon-intensive activities, imposes a considerable burden on the environment, society, and economy. To support the sustainable development of cities, this study constructed a CFH inventory ... ...

    Abstract Coal-fired winter heating (CFH), one of the humankind's most carbon-intensive activities, imposes a considerable burden on the environment, society, and economy. To support the sustainable development of cities, this study constructed a CFH inventory characterized by long time series and high spatial resolution, including 187 prefecture-level cities in China. Based on the inventory, the life-cycle environmental and social economic impacts of CFH since 2011 were analyzed. Temporospatial variations, driving factors, and optimal heat combinations were further explored. In accordance with the results, the carbon footprint of CFH in China was 1.14 billion tons CO₂-eq in 2020. The social cost in 2020 decreased to $ 139.7 billion in 2020 compared with $ 149.9 billion in 2017. Scattered heating activities only comprised only around 27% of heating fuel coal consumption but accounted for 60% of the total social costs. Region-specific heating policies are necessary because driving factors significantly vary among cities. Promoting central heating systems in most parts of China has mitigated the conflict between social costs and heating demand. However, the scattered heating systems still need to improve the development of sustainable winter heating in northwestern China. The scientific and reasonable top-level design of heating methods is highly required because clean heating methods may take more than 7 years to realize their environmental–economic co–benefits compared with CFH.
    Keywords carbon ; carbon footprint ; coal ; heat ; inventories ; sustainable development ; time series analysis ; China ; Coal-fired winter heating ; City-level ; Driving factor analysis ; Life cycle assessment ; Life cycle costing ; Social cost
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2023.137142
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK Signaling.

    Chen, Xiaoqing / Zhu, Jing / Li, Xiangzhi / Chen, Jintao / Zhou, Zhisheng / Fan, Xulong / Liang, Ruijian / Liu, Haiyan / Zhu, Dajiang

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 1, Page(s) 6

    Abstract: Background: Ferroptosis, a distinct iron-dependent form of regulated cell death, is induced by severe lipid peroxidation due to reactive oxygen species (ROS) generation. Breast cancer patient survival is correlated with the tumor-suppressing properties ... ...

    Abstract Background: Ferroptosis, a distinct iron-dependent form of regulated cell death, is induced by severe lipid peroxidation due to reactive oxygen species (ROS) generation. Breast cancer patient survival is correlated with the tumor-suppressing properties of Rho guanosine triphosphatase hydrolase enzyme (GTPase)-activating protein 6 (ARHGAP6). This study investigates the impact and mechanisms of ARHGAP6 on ferroptosis in breast cancer.
    Methods: Using quantitative RT-PCR, Western blotting, and immunofluorescence staining, ARHGAP6 expression was detected in a gene expression dataset, cancer tissue samples, and cells. ARHGAP6 was overexpressed or silenced in breast cancer cell lines. Cell proliferation was measured using 5-ethynyl-2-deoxyuridine (EdU) assay, and cell death rate was determined using LDH cytotoxicity assay. As indicators of ferroptosis, Fe2+ ion content, lipid ROS, glutathione peroxidase 4 (GPX4), ChaC glutathione specific gamma-glutamylcyclotransferase 1 (CHAC1), prostaglandin-endoperoxide synthase 2 (PTGS2), solute carrier family 7 member 11 (SLC7A11), and acyl-CoA synthetase long chain family member 4 (ACSL4) levels were evaluated.
    Results: ARHGAP6 was obviously downregulated in cancer tissues and cells. ARHGAP6 overexpression decreased cell proliferation, elevated cell death and lipid ROS, decreased GPX4 and SLC7A11, increased PTGS2, ACSL4, and CHAC1, and inhibited RhoA/ROCK1 and p38 MAPK signaling in cancer cells. ARHGAP6 knockdown exerted opposite effects to those of ARHGAP6 overexpression. p38 signaling suppression reversed the effect of ARHGAP6 knockdown on ferroptosis, while RhoA/ROCK1 signaling inhibition compromised the effect of ARHGAP6 on p38 MAPK signaling. In mice models, ARHGAP6 together with the ferroptosis inducer RSL3 cooperatively enhanced ferroptosis and inhibited tumor growth of cancer cells. ARHGAP6 mRNA level was positively correlated with that of ferroptosis indicators in tumor tissues.
    Conclusions: This study revealed that ARHGAP6 inhibited tumor growth of breast cancer by inducing ferroptosis via RhoA/ROCK1/p38 MAPK signaling. Integrating ARHGAP6 with ferroptosis-inducing agents may be a promising therapeutic strategy for breast cancer treatment.
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Breast Neoplasms/genetics ; Cyclooxygenase 2 ; Ferroptosis/genetics ; GTPase-Activating Proteins/genetics ; Lipids ; p38 Mitogen-Activated Protein Kinases/genetics ; Reactive Oxygen Species ; rho-Associated Kinases/genetics
    Chemical Substances ARHGAP6 protein, human ; Cyclooxygenase 2 (EC 1.14.99.1) ; GTPase-Activating Proteins ; Lipids ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Reactive Oxygen Species ; rho-Associated Kinases (EC 2.7.11.1) ; ROCK1 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2024-01-29
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2901006
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  7. Article ; Online: Modifiable risk factors for thyroid cancer: lifestyle and residence environment.

    Shen, Yi / Wang, Xian / Wang, Lu / Xiong, Dandan / Wu, Cailian / Cen, Liting / Xie, Lianguang / Li, Xiangzhi

    Endokrynologia Polska

    2024  

    Abstract: In recent years, there has been a rapid increase in the prevalence of benign and malignant tumours of the thyroid gland worldwide, positioning it as one of the most prevalent neoplasms within the endocrine system. While the pathogenesis of thyroid ... ...

    Abstract In recent years, there has been a rapid increase in the prevalence of benign and malignant tumours of the thyroid gland worldwide, positioning it as one of the most prevalent neoplasms within the endocrine system. While the pathogenesis of thyroid tumours is still unclear, an increasing number of studies have found that certain lifestyle and residence environments are associated with their occurrence and development. This article endeavours to elucidate the correlation between lifestyle, residential environment, and the increased prevalence of thyroid cancer in recent years. It specifies the frequency of the lifestyle and outlines the scope of the residential environment. It also endeavours to summarise the main mechanistic pathways of various modifiable risk factors that cause thyroid cancer. Factors that prevent thyroid cancer include smoking and alcohol consumption, quality and regular sleep, consumption of cruciferous vegetables and dairy products, and consistent long-term exercise. Conversely, individuals with specific genetic mutations have an elevated risk of thyroid cancer from prolonged and frequent use of mobile phones. In addition, individuals who work in high-pressure jobs, work night shifts, and live near volcanoes or in environments associated with pesticides have an elevated risk of developing thyroid cancer. The impact of living near a nuclear power plant on thyroid cancer remains inconclusive. Raising awareness of modifiable risk factors for thyroid cancer will help to accurately prevent and control thyroid cancer. It will provide a scientific basis for future research on lifestyles and living environments suitable for people at high risk of thyroid cancer.
    Language English
    Publishing date 2024-03-18
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 419270-9
    ISSN 2299-8306 ; 0423-104X
    ISSN (online) 2299-8306
    ISSN 0423-104X
    DOI 10.5603/ep.97258
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  8. Article ; Online: Different binding characteristics of ciprofloxacin to iron mineral surfaces: Thermodynamic evidence and site energy distribution analysis.

    Li, Xiangzhi / Lei, Feifei / Li, Binghua / Bi, Erping

    Journal of environmental quality

    2021  Volume 50, Issue 3, Page(s) 706–716

    Abstract: Iron minerals in soil play an important role in controlling the migration of fluoroquinolones. In this study, batch experiments were carried out to investigate interactions in ciprofloxacin (CIP) adsorption to goethite, hematite, and magnetite at pH 6.0. ...

    Abstract Iron minerals in soil play an important role in controlling the migration of fluoroquinolones. In this study, batch experiments were carried out to investigate interactions in ciprofloxacin (CIP) adsorption to goethite, hematite, and magnetite at pH 6.0. Thermodynamics and the site energy distribution theory (SEDT) were adopted to clarify the complexation types. Using the adsorption results, pH-dependent interactions were qualitatively elucidated. The thermodynamic data revealed the difference in adsorption mechanisms. With increasing sorbate loading, CIP adsorption to hematite and magnetite was endothermic, and both enthalpy change and entropy change decreased; however, CIP sorption to goethite showed opposite characteristics. The higher adsorption capacity and affinity of CIP to hematite and magnetite than those to goethite were caused by their higher site energy of the highest occurring frequency (E
    MeSH term(s) Adsorption ; Ciprofloxacin ; Hydrogen-Ion Concentration ; Iron ; Minerals ; Thermodynamics
    Chemical Substances Minerals ; Ciprofloxacin (5E8K9I0O4U) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120525-0
    ISSN 1537-2537 ; 0047-2425
    ISSN (online) 1537-2537
    ISSN 0047-2425
    DOI 10.1002/jeq2.20214
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  9. Article: Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways.

    Li, Zhenqi / Jin, Liquan / Xia, Lu / Li, Xiangzhi / Guan, Yunfei / He, Hongyang

    Frontiers in oncology

    2023  Volume 13, Page(s) 1042567

    Abstract: Aim: To explore whether C-reactive protein (CRP) mediates the risk of body mass index (BMI) in pancreatic cancer (PC) and calculate the mediate proportion of CRP in this possible mechanism.: Methods: Based on two-sample Mendelian randomization (TSMR), ...

    Abstract Aim: To explore whether C-reactive protein (CRP) mediates the risk of body mass index (BMI) in pancreatic cancer (PC) and calculate the mediate proportion of CRP in this possible mechanism.
    Methods: Based on two-sample Mendelian randomization (TSMR), a two-step Mendelian randomization (TM) model was conducted to determine whether CRP was a mediator of the causal relationship between BMI and PC. The multivariable Mendelian randomization (MVMR) study was designed for mediating analysis and to calculate the mediating proportion mediated by CRP.
    Results: BMI has a positive causal relationship with PC (n = 393 SNPs, OR = 1.484, 95% CI: 1.021-2.157, p< 0.05). BMI has a positive causal relationship with CRP (n = 179 SNPs, OR = 1.393, 95% CI: 1.320-1.469, p< 0.05). CRP has a positive causal relationship with PC (n = 54 SNPs, OR = 1.348, 95% CI: 1.004-1.809, p
    Conclusions: In clinical practice, while actively advocating for weight loss among obese patients, we should focus on chronic inflammation levels in obese patients as well. In addition, anti-inflammatory dietary patterns and appropriate physical activity are important in preventing PC.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1042567
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  10. Article ; Online: Remediation of aniline-contaminated aquifer by combining in-well Rhizobium borbori and circulated groundwater electrolysis.

    Cao, Wengeng / Wen, Zhang / Li, Shuang / Ren, Yu / Nan, Tian / Li, Xiangzhi

    Journal of hazardous materials

    2023  Volume 465, Page(s) 133046

    Abstract: Aniline has become a common groundwater contaminant due to its wide use as a raw material in agriculture and pharmaceutical products. The current technologies for in situ remediation of aniline in groundwater are limited by the strains deficient in ... ...

    Abstract Aniline has become a common groundwater contaminant due to its wide use as a raw material in agriculture and pharmaceutical products. The current technologies for in situ remediation of aniline in groundwater are limited by the strains deficient in bacterial species, limited oxygen supply, excessive waste gas load and cost. Accordingly, we conducted a laboratory sand tank experiment to remediate groundwater contaminated with aniline by combining circulated groundwater electrolysis and in-well Rhizobium borbori, which was isolated from activated sludge. The results of the experiment indicated that the optimum concentration of aniline for Rhizobium borbori is about 5 mg/L, beyond which the maximum cell density and the highest specific growth rate decreases as the aniline concentration increases. The optimized duration for immobilizing the Rhizobium borbori into the bioreactor is 4-5 days. Though the Rhizobium borbori was strongly inhibited by the high-concentration of aniline, the immobilized bioreactor in the 350 mg/L aniline solution successfully formed biofilm. The aniline volatilization had limited influence on the observation of bioremediation performance, and the combination of circulated groundwater and in-well Rhizobium borbori supplied a steady dose of oxygen to the bioreactor efficiently degrading the entire region between the injection and extraction well. In addition, a numerical model for the sand tank remediation experiment was used to estimate the yield coefficient of oxygen to be 0.484 g/g, which indicates the presence of ammonia nitrogen as by-products; accordingly, a smaller wellbore size as well a higher circulation flow rate and intensity of current are recommended to improve the water quality. Despite the positive outcomes and potential of the newly developed technology to degrade subsurface aniline, parallel experiments should be conducted to estimate the environmental risk of the by-products and explore the controlling mechanisms of each component in this comprehensive system.
    MeSH term(s) Water Pollutants, Chemical/analysis ; Sand ; Groundwater/microbiology ; Aniline Compounds/metabolism ; Oxygen ; Environmental Restoration and Remediation ; Rhizobium
    Chemical Substances Water Pollutants, Chemical ; Sand ; aniline (SIR7XX2F1K) ; Aniline Compounds ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-11-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.133046
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