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  1. Article ; Online: Cardinality Constrained Portfolio Optimization via Alternating Direction Method of Multipliers.

    Shi, Zhang-Lei / Li, Xiao Peng / Leung, Chi-Sing / So, Hing Cheung

    IEEE transactions on neural networks and learning systems

    2024  Volume 35, Issue 2, Page(s) 2901–2909

    Abstract: Inspired by sparse learning, the Markowitz mean-variance model with a sparse regularization term is popularly used in sparse portfolio optimization. However, in penalty-based portfolio optimization algorithms, the cardinality level of the resultant ... ...

    Abstract Inspired by sparse learning, the Markowitz mean-variance model with a sparse regularization term is popularly used in sparse portfolio optimization. However, in penalty-based portfolio optimization algorithms, the cardinality level of the resultant portfolio relies on the choice of the regularization parameter. This brief formulates the mean-variance model as a cardinality ( l
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3192065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: EGFR alterations in glioblastoma play a role in antitumor immunity regulation.

    Li, Xiao-Peng / Guo, Zheng-Qian / Wang, Bao-Feng / Zhao, Min

    Frontiers in oncology

    2023  Volume 13, Page(s) 1236246

    Abstract: The epidermal growth factor receptor (EGFR) is the most frequently altered gene in glioblastoma (GBM), which plays an important role in tumor development and anti-tumor immune response. While current molecular targeted therapies against the EGFR ... ...

    Abstract The epidermal growth factor receptor (EGFR) is the most frequently altered gene in glioblastoma (GBM), which plays an important role in tumor development and anti-tumor immune response. While current molecular targeted therapies against the EGFR signaling pathway and its downstream key molecules have not demonstrated favorable clinical outcomes in GBM. Whereas tumor immunotherapies, especially immune checkpoint inhibitors, have shown durable antitumor responses in many cancers. However, the clinical efficacy is limited in patients carrying EGFR alterations, indicating that EGFR signaling may involve tumor immune response. Recent studies reveal that EGFR alterations not only promote GBM cell proliferation but also influence immune components in the tumor microenvironment (TME), leading to the recruitment of immunosuppressive cells (e.g., M2-like TAMs, MDSCs, and Tregs), and inhibition of T and NK cell activation. Moreover, EGFR alterations upregulate the expression of immunosuppressive molecules or cytokines (such as PD-L1, CD73, TGF-β). This review explores the role of EGFR alterations in establishing an immunosuppressive TME and hopes to provide a theoretical basis for combining targeted EGFR inhibitors with immunotherapy for GBM.
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1236246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fast Robust Matrix Completion via Entry-Wise ℓ

    Li, Xiao Peng / Shi, Zhang-Lei / Liu, Qi / So, Hing Cheung

    IEEE transactions on cybernetics

    2023  Volume 53, Issue 11, Page(s) 7199–7212

    Abstract: Matrix completion (MC) aims at recovering missing entries, given an incomplete matrix. Existing algorithms for MC are mainly designed for noiseless or Gaussian noise scenarios and, thus, they are not robust to impulsive noise. For outlier resistance, ... ...

    Abstract Matrix completion (MC) aims at recovering missing entries, given an incomplete matrix. Existing algorithms for MC are mainly designed for noiseless or Gaussian noise scenarios and, thus, they are not robust to impulsive noise. For outlier resistance, entry-wise l
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2022.3224070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sparse Index Tracking With K-Sparsity or ϵ-Deviation Constraint via ℓ

    Li, Xiao Peng / Shi, Zhang-Lei / Leung, Chi-Sing / So, Hing Cheung

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 12, Page(s) 10930–10943

    Abstract: Sparse index tracking, as one of the passive investment strategies, is to track a benchmark financial index via constructing a portfolio with a few assets in a market index. It can be considered as parameter learning in an adaptive system, in which we ... ...

    Abstract Sparse index tracking, as one of the passive investment strategies, is to track a benchmark financial index via constructing a portfolio with a few assets in a market index. It can be considered as parameter learning in an adaptive system, in which we periodically update the selected assets and their investment percentages based on the sliding window approach. However, many existing algorithms for sparse index tracking cannot explicitly and directly control the number of assets or the tracking error. This article formulates sparse index tracking as two constrained optimization problems and then proposes two algorithms, namely, nonnegative orthogonal matching pursuit with projected gradient descent (NNOMP-PGD) and alternating direction method of multipliers for l
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3171819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Robust Tensor Completion via Capped Frobenius Norm.

    Li, Xiao Peng / Wang, Zhi-Yong / Shi, Zhang-Lei / So, Hing Cheung / Sidiropoulos, Nicholas D

    IEEE transactions on neural networks and learning systems

    2023  Volume PP

    Abstract: Tensor completion (TC) refers to restoring the missing entries in a given tensor by making use of the low-rank structure. Most existing algorithms have excellent performance in Gaussian noise or impulsive noise scenarios. Generally speaking, the ... ...

    Abstract Tensor completion (TC) refers to restoring the missing entries in a given tensor by making use of the low-rank structure. Most existing algorithms have excellent performance in Gaussian noise or impulsive noise scenarios. Generally speaking, the Frobenius-norm-based methods achieve excellent performance in additive Gaussian noise, while their recovery severely degrades in impulsive noise. Although the algorithms using the l
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2023.3236415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions.

    Yang, YuLing / Zhang, JiaNi / Wu, SiWen / Deng, Yu / Wang, ShiHan / Xie, Li / Li, XiaoPeng / Yang, Li

    Biomaterials

    2024  Volume 308, Page(s) 122558

    Abstract: Mesenchymal stem cell (MSC)-based therapy is an effective strategy for regenerative therapy. However, safety and ease of use are still issues to be overcome in clinical applications. Exosomes are naturally derived nanoparticles containing bioactive ... ...

    Abstract Mesenchymal stem cell (MSC)-based therapy is an effective strategy for regenerative therapy. However, safety and ease of use are still issues to be overcome in clinical applications. Exosomes are naturally derived nanoparticles containing bioactive molecules, which serve as ideal cell-free therapeutic modalities. However, issues such as delivery, long-term preservation and activity maintenance of exosomes are other problems that limit their application. In this study, we proposed the use of rapid freeze-dry-thaw macroporous hydrogels for the encapsulation of HucMSC-derived exosomes (HucMSC-Exos) combined with an antimicrobial peptide coating. This exosome-encapsulated hyaluronic acid macroporous hydrogel HD-DP7/Exo can achieve long-term storage and transport by lyophilization and can be rapidly redissolved for treatment. After comprehensively comparing the therapeutic effects of HucMSC-Exos and HucMSC-loaded hydrogels, we found that HucMSC-Exos could also effectively regulate fibroblasts, vascular endothelial cells, and macrophages and inhibit myofibroblast-mediated fibrosis, thus promoting tissue regeneration and inhibiting scar formation in a mouse model of deep second-degree burn infection healing. These properties of lyophilized storage and whole-process-repair make HD-DP7/Exo have potential application value and application prospects.
    MeSH term(s) Animals ; Exosomes/metabolism ; Hydrogels/chemistry ; Wound Healing/drug effects ; Mice ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Antimicrobial Peptides/chemistry ; Antimicrobial Peptides/pharmacology ; Bandages ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Burns/therapy ; Hyaluronic Acid/chemistry ; Male ; Cicatrix ; Mice, Inbred C57BL
    Chemical Substances Hydrogels ; MicroRNAs ; Antimicrobial Peptides ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2024.122558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Grassland soil organic carbon and the effects of irrigated cropping in Alberta, Canada

    Wang, Zhi‐Ping / Li, Xiao‐Peng / Pelletier, Rick / Chang, Scott X. / Bork, Edward W.

    Soil use and management. 2022 Apr., v. 38, no. 2

    2022  

    Abstract: High heterogeneity in the spatial distribution of soil organic carbon (SOC) in grasslands causes uncertainty in estimating its content and storage. In this study, we investigated the spatial distribution of SOC content and storage in the prairies of ... ...

    Abstract High heterogeneity in the spatial distribution of soil organic carbon (SOC) in grasslands causes uncertainty in estimating its content and storage. In this study, we investigated the spatial distribution of SOC content and storage in the prairies of southern Alberta, Canada, and how it is affected by land use such as irrigated cropping and other environmental conditions such as cattle grazing, slope landscape position and dominant plant species. The mean SOC content was determined to be 11.5 g kg–¹ (range: 8.9 to 22.4 g kg–¹) in the 0–10 cm layer and 6.8 g kg–¹ (range: 4.0 to 13.3 g kg–¹) in the 10–30 cm layer; mean SOC storage was 1.59 kg C m–² (range: 1.23 to 2.78 kg C m–²) in the 0–10 cm layer and 2.07 kg C m–² (range: 1.21 to 3.62 kg C m–²) in the 10–30 cm layer. The SOC content was significantly affected by slope position in both the 0–10 and 10–30 cm layers, in the following order: bottom >middle > top position. Moreover, SOC storage was higher in sites dominated by shrubs than graminoid/forb communities. Thus, SOC content and storage had distinctly clustered spatial patterns throughout the study area and were significant differences between the 0–10 and 10–30 cm soil layers. Prior land‐use change from arid grassland to irrigated cropland increased SOC content and storage in bulk soils.
    Keywords administrative management ; arid grasslands ; carbon sequestration ; cattle ; forbs ; graminoids ; grassland soils ; irrigated farming ; irrigation ; land use change ; landscape position ; soil organic carbon ; uncertainty ; Alberta
    Language English
    Dates of publication 2022-04
    Size p. 1189-1202.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 742151-5
    ISSN 1475-2743 ; 0266-0032
    ISSN (online) 1475-2743
    ISSN 0266-0032
    DOI 10.1111/sum.12780
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4234: Show issues

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  8. Article ; Online: Differential Selective Etching of Functional Groups Strategy for Preparation of Organic Hollow Porous Silica

    Li Jie / Zhang Jia / Wen ZhuoQiong / Yu Cui / Li XiaoPeng

    E3S Web of Conferences, Vol 252, p

    2021  Volume 02051

    Abstract: In this study, different structural of organic hollow porous silica were prepared based on differential selective etching of functional groups strategy, using ammonia as catalyst, cetyltrimethylammonium bromide (CTAB) as pore-forming agent and emulsifier, ...

    Abstract In this study, different structural of organic hollow porous silica were prepared based on differential selective etching of functional groups strategy, using ammonia as catalyst, cetyltrimethylammonium bromide (CTAB) as pore-forming agent and emulsifier, cyano silica (CN-SiO2) or vinyl silica (V-SiO2) formed by hydrolysis condensation of 2-cyanoethyl triethoxysilane (CTES) or vinyl triethoxysilane (VTES) were used as cores, NH-SiO2 prepared by 3-aminopropyl triethoxysilane (APTES), SH-SiO2 prepared by mercaptopropyl trimethoxysilane (MPTMS) and UD-SiO2 prepared by urea-propyl triethoxysilane (UPTES) as shells, separately. The morphology and structure of the products were characterized by scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The study results showed that CN-SiO2 as core was considered to be benefit for the preparation of organic hollow porous silica compared to V-SiO2 as core. In addition, core-shell structure obtained from CN-SiO2NH-SiO2 tend to be changed into hollow porous structure in alkaline condition on account of differential selective etching of functional groups strategy.
    Keywords Environmental sciences ; GE1-350
    Subject code 620
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Power system parameters matching of in-wheel motor drive electric vehicle

    Ren Wei Chen / Fang Yi / Li Xiao Peng / Xu Zheng / Wang Xu Long

    E3S Web of Conferences, Vol 257, p

    2021  Volume 01044

    Abstract: Based on the line-controlled chassis platform, the low-speed outer rotor motor is used to drive the wheel directly in the designed in-wheel motor line-controlled electric vehicle. The power system parameters of the designed four-wheel independent drive ... ...

    Abstract Based on the line-controlled chassis platform, the low-speed outer rotor motor is used to drive the wheel directly in the designed in-wheel motor line-controlled electric vehicle. The power system parameters of the designed four-wheel independent drive electric vehicle are matched and simulated by offline simulation. Firstly, based on the theoretical basis of the research on the parameter matching of the power system of pure electric vehicles, the type selection and parameter matching of the hub motor and power battery are carried out according to the established dynamic and economic indicators. Then, the designed component parameters are repeatedly corrected until the design goal is achieved; Finally, the vehicle model is built in AVL cruise, and the design results are simulated by software.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Ti

    Gao, Fu-Lin / Liu, Ji / Li, Xiao-Peng / Ma, Qian / Zhang, Tingting / Yu, Zhong-Zhen / Shang, Jie / Li, Run-Wei / Li, Xiaofeng

    ACS nano

    2023  Volume 17, Issue 16, Page(s) 16036–16047

    Abstract: Although skin-like sensors that can simultaneously detect various physical stimuli are of fair importance in cutting-edge human-machine interaction, robotic, and healthcare applications, they still face challenges in facile, scalable, and cost-effective ... ...

    Abstract Although skin-like sensors that can simultaneously detect various physical stimuli are of fair importance in cutting-edge human-machine interaction, robotic, and healthcare applications, they still face challenges in facile, scalable, and cost-effective production using conventional active materials. The emerging two-dimensional transition metal carbide, Ti
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c04650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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