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  1. Book: Hedgehog signaling

    Li, Xiaochun

    methods and protocols

    (Methods in molecular biology ; 2374 ; Springer protocols)

    2022  

    Author's details edited by Xiaochun Li
    Series title Methods in molecular biology ; 2374
    Springer protocols
    Collection
    Keywords Cellular signal transduction/Methodology ; Hedgehog proteins ; Cellular signal transduction ; Transcription factors
    Subject code 571.74
    Language English
    Size xi, 244 Seiten, Illustrationen, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT021110637
    ISBN 978-1-0716-1700-7 ; 9781071617014 ; 1-0716-1700-1 ; 107161701X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 7042 -2374- not available for loan Lesesaal EG

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  2. Article ; Online: Intracellular Angiotensin II Stimulation of Sodium Transporter Expression in Proximal Tubule Cells via AT

    Li, Xiaochun / Zhuo, Jialong

    Cells

    2023  Volume 12, Issue 11

    Abstract: The current prevailing paradigm in the renin-angiotensin system dictates that most, if not all, biological, physiological, and pathological responses to its most potent peptide, angiotensin II (Ang II), are mediated by extracellular Ang II activating its ...

    Abstract The current prevailing paradigm in the renin-angiotensin system dictates that most, if not all, biological, physiological, and pathological responses to its most potent peptide, angiotensin II (Ang II), are mediated by extracellular Ang II activating its cell surface receptors. Whether intracellular (or intracrine) Ang II and its receptors are involved remains incompletely understood. The present study tested the hypothesis that extracellular Ang II is taken up by the proximal tubules of the kidney by an AT
    MeSH term(s) Male ; Mice ; Animals ; Angiotensin II/pharmacology ; Angiotensin II/metabolism ; NF-kappa B/metabolism ; Sodium/metabolism ; Sodium-Hydrogen Exchanger 3/metabolism ; Sodium-Glucose Transporter 2/metabolism ; Losartan/pharmacology ; MAP Kinase Signaling System ; Sodium-Hydrogen Exchangers/metabolism ; Signal Transduction
    Chemical Substances Angiotensin II (11128-99-7) ; Ro 106-9920 ; U 0126 ; NF-kappa B ; Sodium (9NEZ333N27) ; Sodium-Hydrogen Exchanger 3 ; Sodium-Glucose Transporter 2 ; Losartan (JMS50MPO89) ; Sodium-Hydrogen Exchangers
    Language English
    Publishing date 2023-05-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12111492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Variable selection for latent class analysis in the presence of missing data with application to record linkage.

    Xu, Huiping / Li, Xiaochun / Zhang, Zuoyi / Grannis, Shaun

    Statistical methods in medical research

    2024  , Page(s) 9622802241242317

    Abstract: The Fellegi-Sunter model is a latent class model widely used in probabilistic linkage to identify records that belong to the same entity. Record linkage practitioners typically employ all available matching fields in the model with the premise that more ... ...

    Abstract The Fellegi-Sunter model is a latent class model widely used in probabilistic linkage to identify records that belong to the same entity. Record linkage practitioners typically employ all available matching fields in the model with the premise that more fields convey greater information about the true match status and hence result in improved match performance. In the context of model-based clustering, it is well known that such a premise is incorrect and the inclusion of noisy variables could compromise the clustering. Variable selection procedures have therefore been developed to remove noisy variables. Although these procedures have the potential to improve record matching, they cannot be applied directly due to the ubiquity of the missing data in record linkage applications. In this paper, we modify the stepwise variable selection procedure proposed by Fop, Smart, and Murphy and extend it to account for missing data common in record linkage. Through simulation studies, our proposed method is shown to select the correct set of matching fields across various settings, leading to better-performing algorithms. The improved match performance is also seen in a real-world application. We therefore recommend the use of our proposed selection procedure to identify informative matching fields for probabilistic record linkage algorithms.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1136948-6
    ISSN 1477-0334 ; 0962-2802
    ISSN (online) 1477-0334
    ISSN 0962-2802
    DOI 10.1177/09622802241242317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3564: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: A Structural Overview of TRPML1 and the TRPML Family.

    Fine, Michael / Li, Xiaochun

    Handbook of experimental pharmacology

    2022  Volume 278, Page(s) 181–198

    Abstract: This chapter explores the existing structural and functional studies on the endo-lysosomal channel TRPML1 and its analogs TRPML2, TRPML3. These channels represent the mucolipin subfamily of the TRP channel superfamily comprising important roles in ... ...

    Abstract This chapter explores the existing structural and functional studies on the endo-lysosomal channel TRPML1 and its analogs TRPML2, TRPML3. These channels represent the mucolipin subfamily of the TRP channel superfamily comprising important roles in sensory physiology, ion homeostasis, and signal transduction. Since 2016, numerous structures have been determined for all three members using either cryo-EM or X-ray crystallography. These studies along with recent functional analysis have considerably strengthened our knowledge on TRPML channels and its related endo-lysosomal function. This chapter, together with relevant reports in other chapters from this handbook, provides an informative and detailed tool to study the endo-lysosomal cation channels.
    MeSH term(s) Humans ; Lysosomes/metabolism ; Signal Transduction ; Transient Receptor Potential Channels
    Chemical Substances Transient Receptor Potential Channels ; MCOLN1 protein, human
    Language English
    Publishing date 2022-07-25
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2022_602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  5. Article ; Online: Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.

    Sun, Yingyuan / Li, Xiaochun

    Nature cardiovascular research

    2022  Volume 1, Issue 3, Page(s) 238–245

    Abstract: ATP-binding cassette transporter A1 (ABCA1) utilizes energy derived from ATP hydrolysis to export cholesterol and phospholipids from macrophages. ABCA1 plays a central role in the biosynthesis of high-density lipoprotein (HDL), which mediates reverse ... ...

    Abstract ATP-binding cassette transporter A1 (ABCA1) utilizes energy derived from ATP hydrolysis to export cholesterol and phospholipids from macrophages. ABCA1 plays a central role in the biosynthesis of high-density lipoprotein (HDL), which mediates reverse cholesterol transport and prevents detrimental lipid deposition. Mutations in ABCA1 cause Tangier disease characterized by a remarkable reduction in the amount of HDL in blood. Here we present cryo-electron microscopy structures of human ABCA1 in ATP-bound and nucleotide-free states. Structural comparison reveals that ATP molecules pull the nucleotide-binding domains together, inducing movements of transmembrane helices 1, 2, 7 and 8 through a series of salt-bridge interactions. Subsequently, extracellular domains (ECDs) undergo a rotation and introduce conformational changes in the ECD-transmembrane interface. In addition, while we observe a sterol-like molecule in ECDs, no such density was observed in the structure of an HDL-deficiency mutant ABCA1
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article
    ISSN 2731-0590
    ISSN (online) 2731-0590
    DOI 10.1038/s44161-022-00022-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Manual evaluation of record linkage algorithm performance in four real-world datasets.

    Gupta, Agrayan / Xu, Huiping / Li, Xiaochun / Vest, Josh / Grannis, Shaun

    Applied clinical informatics

    2024  

    Abstract: Background: Patient data is fragmented across multiple repositories, yielding suboptimal and costly care. Record linkage algorithms are widely accepted solutions for improving completeness of patient records. However, studies often fail to fully ... ...

    Abstract Background: Patient data is fragmented across multiple repositories, yielding suboptimal and costly care. Record linkage algorithms are widely accepted solutions for improving completeness of patient records. However, studies often fail to fully describe their linkage techniques. Further, while many frameworks evaluate record linkage methods, few focus on producing gold standard datasets. This highlights a need to assess these frameworks and their real-world performance.
    Objective: We use real-world datasets and expand upon previous frameworks to evaluate a consistent approach to the manual review of gold standard datasets and measure its impact on algorithm performance.
    Methods: We applied the framework, which includes elements for data description, reviewer training and adjudication, and software and reviewer descriptions, to four datasets. Record-pairs were formed and 15,000 records were randomly sampled from these pairs. After training, two reviewers determined match status for each record-pair. If reviewers disagreed, a third reviewer was used for final adjudication.
    Results: Between the four datasets, the percent discordant rate ranged from 1.8-13.6%. While reviewers' discordance rate typically ranged between 1% and 5%, one exhibited a 59% discordance rate, showing the importance of the third reviewer. The original analysis was compared to three sensitivity analyses. The original analysis most often exhibited the highest predictive values compared to the sensitivity analyses.
    Conclusion: Reviewers vary in their assessment of a gold standard, which can lead to variances in estimates for matching performance. Our analysis demonstrates how a multi-reviewer process can be applied to create gold standards, identify reviewer discrepancies, and evaluate algorithm performance.
    Language English
    Publishing date 2024-03-20
    Publishing country Germany
    Document type Journal Article
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/a-2291-1391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Wire-Arc Additive Manufacturing of Nano-Treated Aluminum Alloy 2024.

    Chi, Yitian / Murali, Narayanan / Zheng, Tianqi / Liu, Jingke / Li, Xiaochun

    3D printing and additive manufacturing

    2024  Volume 11, Issue 2, Page(s) e529–e536

    Abstract: With high strength and good fatigue resistance, Al-Cu alloys such as AA2024 are widely used in the aerospace and automotive industries. However, the system's susceptibility to hot cracking and other solidification defects hinders its development in metal ...

    Abstract With high strength and good fatigue resistance, Al-Cu alloys such as AA2024 are widely used in the aerospace and automotive industries. However, the system's susceptibility to hot cracking and other solidification defects hinders its development in metal additive manufacturing (AM). A nano-treated AA2024 deposition, with the addition of TiC nanoparticles, is successfully additively manufactured without cracks. Microstructural analysis suggests nanoparticles not only mitigate the hot cracking sensitivity but also significantly refine and homogenize grains, resulting in an average size of 23.2 ± 0.4 μm. Microhardness profiles show consistent mechanical performance along the build direction, regardless of cyclic thermal exposure. Finally, excellent tensile strength and elongation up to 428 MPa and 7.4% were achieved after heat treatment. The combined results show a great promise of nano-treating in high-strength aluminum AM.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2329-7670
    ISSN (online) 2329-7670
    DOI 10.1089/3dp.2022.0150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM.

    Fine, Michael / Li, Xiaochun

    Neuron

    2021  Volume 109, Issue 2, Page(s) 194–196

    Abstract: TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation ... ...

    Abstract TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain.
    MeSH term(s) Chronic Pain ; Cryoelectron Microscopy ; Humans ; Ligands ; TRPA1 Cation Channel/genetics
    Chemical Substances Ligands ; TRPA1 Cation Channel ; TRPA1 protein, human
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

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  9. Article ; Online: Bubbles-Induced Porous Structure-Based Flexible Piezoresistive Sensors for Speech Recognition.

    Gao, Xiaoguang / Yuan, Lin / Xue, Chengzhen / Zhang, Xiaoliang / Meng, Xuejuan / Li, Xiaochun

    ACS applied materials & interfaces

    2024  Volume 16, Issue 7, Page(s) 9532–9543

    Abstract: Flexible piezoresistive sensors with a porous structure that are used in the field of speech recognition are seldom characterized by both high sensitivity and ease of preparation. In this study, a piezoresistive sensor with a porous structure that is ... ...

    Abstract Flexible piezoresistive sensors with a porous structure that are used in the field of speech recognition are seldom characterized by both high sensitivity and ease of preparation. In this study, a piezoresistive sensor with a porous structure that is both highly sensitive and can be prepared by using a simple method is proposed for speech recognition. The preparation process utilizes the interaction of bubbles generated by ethanol evaporation and active agents with polydimethylsiloxane to produce a porous flexible substrate. This preparation process requires neither templates nor harsh experimental conditions such as a low temperature and a low pressure. Furthermore, the prepared piezoresistive sensor has excellent properties, such as a high sensitivity (27.6 kPa
    MeSH term(s) Humans ; Speech ; Porosity ; Speech Perception ; Cold Temperature ; Ethanol
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c18233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation.

    De Giovanni, Marco / Chen, Hongwen / Li, Xiaochun / Cyster, Jason G

    Immunological reviews

    2023  Volume 317, Issue 1, Page(s) 187–202

    Abstract: Neutrophil recruitment from circulation to sites of inflammation is guided by multiple chemoattractant cues emanating from tissue cells, immune cells, and platelets. Here, we focus on the function of one G-protein coupled receptor, GPR35, in neutrophil ... ...

    Abstract Neutrophil recruitment from circulation to sites of inflammation is guided by multiple chemoattractant cues emanating from tissue cells, immune cells, and platelets. Here, we focus on the function of one G-protein coupled receptor, GPR35, in neutrophil recruitment. GPR35 has been challenging to study due the description of multiple ligands and G-protein couplings. Recently, we found that GPR35-expressing hematopoietic cells respond to the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA). We discuss distinct response profiles of GPR35 to 5-HIAA compared to other ligands. To place the functions of 5-HIAA in context, we summarize the actions of serotonin in vascular biology and leukocyte recruitment. Important sources of serotonin and 5-HIAA are platelets and mast cells. We discuss the dynamics of cell migration into inflamed tissues and how multiple platelet and mast cell-derived mediators, including 5-HIAA, cooperate to promote neutrophil recruitment. Additional actions of GPR35 in tissue physiology are reviewed. Finally, we discuss how clinically approved drugs that modulate serotonin uptake and metabolism may influence 5-HIAA-GPR35 function, and we speculate about broader influences of the GPR35 ligand-receptor system in immunity and disease.
    MeSH term(s) Humans ; Mast Cells ; Neutrophils ; Blood Platelets ; Ligands ; Serotonin/metabolism ; Hydroxyindoleacetic Acid/metabolism ; Inflammation ; Cell Movement ; Neutrophil Infiltration ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Ligands ; Serotonin (333DO1RDJY) ; Hydroxyindoleacetic Acid (54-16-0) ; GPR35 protein, human ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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