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  1. Article ; Online: Linear semantic transformation for semi-supervised medical image segmentation.

    Chen, Cheng / Chen, Yunqing / Li, Xiaoheng / Ning, Huansheng / Xiao, Ruoxiu

    Computers in biology and medicine

    2024  Volume 173, Page(s) 108331

    Abstract: Medical image segmentation is a focus research and foundation in developing intelligent medical systems. Recently, deep learning for medical image segmentation has become a standard process and succeeded significantly, promoting the development of ... ...

    Abstract Medical image segmentation is a focus research and foundation in developing intelligent medical systems. Recently, deep learning for medical image segmentation has become a standard process and succeeded significantly, promoting the development of reconstruction, and surgical planning of disease diagnosis. However, semantic learning is often inefficient owing to the lack of supervision of feature maps, resulting in that high-quality segmentation models always rely on numerous and accurate data annotations. Learning robust semantic representation in latent spaces remains a challenge. In this paper, we propose a novel semi-supervised learning framework to learn vital attributes in medical images, which constructs generalized representation from diverse semantics to realize medical image segmentation. We first build a self-supervised learning part that achieves context recovery by reconstructing space and intensity of medical images, which conduct semantic representation for feature maps. Subsequently, we combine semantic-rich feature maps and utilize simple linear semantic transformation to convert them into image segmentation. The proposed framework was tested using five medical segmentation datasets. Quantitative assessments indicate the highest scores of our method on IXI (73.78%), ScaF (47.50%), COVID-19-Seg (50.72%), PC-Seg (65.06%), and Brain-MR (72.63%) datasets. Finally, we compared our method with the latest semi-supervised learning methods and obtained 77.15% and 75.22% DSC values, respectively, ranking first on two representative datasets. The experimental results not only proved that the proposed linear semantic transformation was effectively applied to medical image segmentation, but also presented its simplicity and ease-of-use to pursue robust segmentation in semi-supervised learning. Our code is now open at: https://github.com/QingYunA/Linear-Semantic-Transformation-for-Semi-Supervised-Medical-Image-Segmentation.
    MeSH term(s) Humans ; Semantics ; Brain ; COVID-19 ; Supervised Machine Learning ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Compact acousto-optical Q-switched Yb:ScBO

    Li, Xiaoheng / Lu, Dazhi / Yu, Haohai / Zhang, Huaijin

    Optics letters

    2023  Volume 47, Issue 22, Page(s) 5877–5880

    Abstract: In this Letter, a continuous-wave Yb: ... ...

    Abstract In this Letter, a continuous-wave Yb:ScBO
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.476118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role and regulatory mechanism of m

    Jiang, Lingling / Li, Xiaoheng / Wang, Shasha / Yuan, Zengqiang / Cheng, Jinbo

    Frontiers in genetics

    2022  Volume 13, Page(s) 962774

    Abstract: N6-methyladenosine ( ... ...

    Abstract N6-methyladenosine (m
    Language English
    Publishing date 2022-09-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.962774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Leydig Cell and Spermatogenesis.

    Ge, Ren-Shan / Li, Xiaoheng / Wang, Yiyan

    Advances in experimental medicine and biology

    2021  Volume 1288, Page(s) 111–129

    Abstract: Leydig cells of the testis have the capacity to synthesize androgen (mainly testosterone) from cholesterol. Adult Leydig cells are the cell type for the synthesis of testosterone, which is critical for spermatogenesis. At least four steroidogenic enzymes ...

    Abstract Leydig cells of the testis have the capacity to synthesize androgen (mainly testosterone) from cholesterol. Adult Leydig cells are the cell type for the synthesis of testosterone, which is critical for spermatogenesis. At least four steroidogenic enzymes take part in testosterone synthesis: cytochrome P450 cholesterol side chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase, cytochrome P450 17α-hydroxylase/17,20-lyase and 17β-hydroxysteroid dehydrogenase isoform 3. Testosterone metabolic enzyme steroid 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase are expressed in some precursor Leydig cells. Androgen is transported by androgen-binding protein to Sertoli cells, where it binds to androgen receptor to regulate spermatogenesis.
    MeSH term(s) Androgens ; Humans ; Leydig Cells ; Male ; Spermatogenesis ; Steroid 17-alpha-Hydroxylase ; Testis ; Testosterone
    Chemical Substances Androgens ; Testosterone (3XMK78S47O) ; Steroid 17-alpha-Hydroxylase (EC 1.14.14.19)
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-77779-1_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro.

    Li, Changchang / Shi, Lei / Su, Ming / Li, Xiaoheng / Zhu, Qiqi / Ge, Ren-Shan / Li, Huitao

    Canadian journal of physiology and pharmacology

    2024  Volume 102, Issue 4, Page(s) 270–280

    Abstract: Butorphanol is a synthetic opioid analgesic medication that is primarily used for the management of pain. Butorphanol may have an inhibitory effect on androgen biosynthesis and metabolism in rat immature Leydig cells. The objective of this study was to ... ...

    Abstract Butorphanol is a synthetic opioid analgesic medication that is primarily used for the management of pain. Butorphanol may have an inhibitory effect on androgen biosynthesis and metabolism in rat immature Leydig cells. The objective of this study was to investigate the influence of butorphanol on androgen secretion by rat Leydig cells isolated from the 35-day-old male rats. Rat Leydig cells were cultured with 0.5-50 μM butorphanol for 3 h in vitro
    MeSH term(s) Rats ; Male ; Animals ; Leydig Cells/metabolism ; Androgens/pharmacology ; Androgens/metabolism ; Butorphanol/pharmacology ; Butorphanol/metabolism ; Rats, Sprague-Dawley ; Luteinizing Hormone ; Testosterone/metabolism ; Cells, Cultured
    Chemical Substances Androgens ; Butorphanol (QV897JC36D) ; Luteinizing Hormone (9002-67-9) ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2024-01-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2023-0191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Knowledge, Attitude, and Practice towards Influenza Vaccination among Older Adults in Southern China during the COVID-19 Pandemic.

    You, Yating / Li, Xiaoheng / Chen, Binglin / Zou, Xuan / Liu, Gang / Han, Xinxin

    Vaccines

    2023  Volume 11, Issue 7

    Abstract: Influenza is prevalent globally, leading to severe morbidity and mortality. During the pandemic, knowledge, attitude, and practice (KAP) towards influenza virus and vaccination were less investigated among southern Chinese older adults. A cross-sectional ...

    Abstract Influenza is prevalent globally, leading to severe morbidity and mortality. During the pandemic, knowledge, attitude, and practice (KAP) towards influenza virus and vaccination were less investigated among southern Chinese older adults. A cross-sectional study was conducted through the structured questionnaire among community healthcare centers in selected districts in Shenzhen, southern China from September to October 2021. KAP towards influenza virus and vaccination were analyzed. A multivariable logistic regression model was used to identify associated factors. Among 975 participants, 55.6% were reported to have received influenza vaccination ever, and 46.6% had taken influenza vaccination in 2020 during the pandemic. Only one-fifth of participants knew severe comorbidities happen among severe influenza cases. A total of 88.3% thought older adults should have influenza vaccination. COVID-19 vaccination history was associated with receiving influenza vaccination (OR 1.92, 95% CI 1.32-2.80). People with a high-level income had better KAP towards influenza virus and vaccination. COVID-19 vaccination history was associated with the positive actions of influenza vaccination during the pandemic. Efforts should be made to promote the free influenza vaccination program widely and launch health education events on influenza and its vaccination regularly to improve KAP among older adults.
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11071197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Preference for human papillomavirus vaccine type and vaccination strategy among parents of school-age girls in Guangdong province, China.

    Xie, Pei / Zhao, Jie / Li, Xiaoheng / Zou, Xuan / Liu, Gang / Han, Xinxin

    Preventive medicine reports

    2023  Volume 36, Page(s) 102463

    Abstract: In China, the human papillomavirus (HPV) vaccination coverage among age-eligible girls is rather low, and parent's attitude often plays a determinant role in their girls' HPV vaccination. To accelerate HPV vaccination coverage, several cities and ... ...

    Abstract In China, the human papillomavirus (HPV) vaccination coverage among age-eligible girls is rather low, and parent's attitude often plays a determinant role in their girls' HPV vaccination. To accelerate HPV vaccination coverage, several cities and Guangdong province in China offered different HPV vaccine types with different reimbursement methods. In April 2022, we conducted a province-wide survey to investigate parents of children aged 9-15 in Guangdong province, and analyzed factors associated with their preference for HPV vaccine type and vaccination strategy. Of the 4,967 surveyed respondents, 2,610 (58.1%) have not yet vaccinated their children. Among these parents, 67.9% preferred to vaccinate their children with the nine-valent vaccine, while only 8.1% preferred the quadrivalent vaccine and 7.4% preferred the bivalent vaccine. More parents preferred fixed subsidies with free choices of HPV vaccine type over the domestic bivalent vaccine provided by the government (58.1% vs. 39.3%). The multinomial logistic regression showed that parents' relationship with children, educational level, household income, and vaccination status were significantly associated with parents' preference for HPV vaccine type. Parent's relationship with children, workplace, household income, vaccination status, and age of children, were significantly associated with parents' preference for HPV vaccination strategy. Our findings suggest that policymakers may consider adjusting the current vaccination strategy by offering more vaccination choices. More health education on HPV vaccine and vaccination should also be provided to parents of age-eligible girls. Future research should examine which HPV vaccination strategy is more effective in promoting HPV vaccine uptakes in China.
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2023.102463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Dlg1

    Li, Xiaoheng / Peng, Zhixin / Jiang, Lingling / Zhang, Ping / Yang, Pin / Yuan, Zengqiang / Cheng, Jinbo

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1124845

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1124845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of CaO addition on the CuW composite containing micro- and nano-sized tungsten particles synthesized via aluminothermic coupling with silicothermic reduction

    Cheng Chu / Wang Xinyu / Song Kexing / Song Ziwei / Dou Zhihe / Zhang Mengen / Liu Haitao / Li Xiaoheng / Niu Liye

    Nanotechnology Reviews, Vol 12, Iss 1, Pp 105648-

    2023  Volume 803

    Abstract: CuW composite fabricated by powder metallurgy using ultrafine metal powders as raw materials has the disadvantages such as uneven microstructure and low compactness. A novel method of synthesizing an as-cast CuW composite ingot via an aluminothermic ... ...

    Abstract CuW composite fabricated by powder metallurgy using ultrafine metal powders as raw materials has the disadvantages such as uneven microstructure and low compactness. A novel method of synthesizing an as-cast CuW composite ingot via an aluminothermic coupling with silicothermic reduction is presented; a low-melting-point CaO–Al2O3–SiO2 slag is formed by adding CaO as a slag former, effectively reducing Al2O3 inclusion in the CuW composite. In this study, the effects of CaO addition on the novel synthesis of the CuW composite via the aluminothermic coupling with silicothermic reduction are investigated. The result shows that CaO affects the removal of large particles (≥6 µm) but not the removal of small particles (≤4 µm). With the increase in the ratio of CaO ranging from 0 to 1.0, the inclusions in the CuW composites gradually transform from Al2O3 to calcium aluminates, which are conducive to the separation of the metal and slag. The contents of Si and O in the CuW composites gradually decrease from 9.40 and 14.00% to 6.10 and 3.50%, respectively, while those of Al and Ca gradually increase from 2.54 and 0.02% to 3.83 and 0.26%, respectively.
    Keywords Technology ; T ; Chemical technology ; TP1-1185 ; Physical and theoretical chemistry ; QD450-801
    Subject code 620
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Toxicological Effects of Cadmium on Mammalian Testis.

    Zhu, Qiqi / Li, Xiaoheng / Ge, Ren-Shan

    Frontiers in genetics

    2020  Volume 11, Page(s) 527

    Abstract: Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male testis. In this review, we summarize the effects of cadmium on the development and function of the ... ...

    Abstract Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male testis. In this review, we summarize the effects of cadmium on the development and function of the testis. Cadmium causes severe structural damage to the seminiferous tubules, Sertoli cells, and blood-testis barrier, thus leading to the loss of sperm. Cadmium hinders Leydig cell development, inhibits Leydig cell function, and induces Leydig cell tumors. Cadmium also disrupts the vascular system of the testis. Cadmium is a reactive oxygen species inducer and possibly induces DNA damage, thus epigenetically regulating somatic cell and germ cell function, leading to male subfertility/infertility.
    Language English
    Publishing date 2020-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.00527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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