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Article: Ferroptosis: a dual-edged sword in tumour growth.

Zhao, Xiangye / Li, Xiaoning / Xu, Yinghui

2024 Volume 14, Page(s) 1330910

Abstract: Ferroptosis, a recently identified form of non-apoptotic cell death, is distinguished by its dependence on iron-triggered lipid peroxidation and accumulation of iron. It has been linked to various disorders, including the development of tumours. ... ...

Abstract	Ferroptosis, a recently identified form of non-apoptotic cell death, is distinguished by its dependence on iron-triggered lipid peroxidation and accumulation of iron. It has been linked to various disorders, including the development of tumours. Interestingly, ferroptosis appears to exhibit a dual role in the context of tumour growth. This article provides a thorough exploration of the inherent ambivalence within ferroptosis, encompassing both its facilitation and inhibition of tumorous proliferation. It examines potential therapeutic targets associated with ferroptosis, the susceptibility of cancerous cells to ferroptosis, strategies to enhance the efficacy of existing cancer treatments, the interaction between ferroptosis and the immune response to tumours, and the fundamental mechanisms governing ferroptosis-induced tumour progression. A comprehensive understanding of how ferroptosis contributes to tumour biology and the strategic management of its dual nature are crucial for maximizing its therapeutic potential.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1330910
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Article: Effect of electroacupuncture of "Jiaji" (EX-B2) on NOD-like receptor protein 3 mediated pyroptosis in spinal cord tissue of rats with acute spinal cord injury.

Mei, Ji-Lin / Yang, Zhi-Xin / Li, Xiao-Ning

Zhen ci yan jiu = Acupuncture research

2024 Volume 49, Issue 2, Page(s) 110–118

Abstract: Objectives: To observe the effect of electroacupuncture (EA) stimulation of "Jiaji"(EX-B2) on motor function, histomorphology, and expression of NOD-like receptor protein 3 (NLRP3) and N-terminal domain of gasdermin D (GSDMD-N) in the spinal cord tissue ...

Title translation	夹脊电针对急性脊髓损伤大鼠脊髓组织NOD样受体热蛋白结构域相关蛋白3介导的细胞焦亡的影响.
Abstract	Objectives: To observe the effect of electroacupuncture (EA) stimulation of "Jiaji"(EX-B2) on motor function, histomorphology, and expression of NOD-like receptor protein 3 (NLRP3) and N-terminal domain of gasdermin D (GSDMD-N) in the spinal cord tissue of rats with spinal cord injury (SCI), so as to explore its mechanism underlying improvement of SCI. Methods: Forty eight female SD rats were randomly divided into sham surgery (sham), SCI model (model), EA, and NLRP3 agonist (monosodium urate, MSU) combined with Jiaji EA (MSU+EA) groups, with 12 rats in each group which were further divided into 3 d and 7 d subgroups, with 6 rats at each time point. Two EA groups received EA stimulation of EX-B2 with a frequency of 100 Hz, electrical current of 1-2 mA for 30 min, once a day for 3 or 7 days. After 5 min, 6 h, and 24 h of modeling, rats of the MSU+EA group received intraperitoneal injection of MSU (200 μg/kg, 200 μg/mL) . The motor function was evaluated using Basso-Beattie-Bresnahan (BBB) scale, the morphological structure of rat spinal cord tissue was observed by H.E. staining. The expression of pyroptosis related factors NLRP3, cleaved Caspase-1 and GSDMD-N of the spinal cord was observed by using immunohistochemistry and Western blot separately, the expression and localization of Iba-1 and GSDMD-N in the spinal cord tissue were observed using immunofluorescence double staining method. Results: Compared with the sham group, the BBB scores after modeling and on day 3 and 7 were decreased ( Conclusions: EA of EX-B2 can improve the motor function of SCI rats, which may be related to its functions in inhibiting pyroptosis of microglia mediated by NLRP3/Caspase-1 signaling pathway.
MeSH term(s)	Animals ; Female ; Rats ; Caspase 1 ; Caspases ; Electroacupuncture ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Pyroptosis ; Rats, Sprague-Dawley ; Spinal Cord ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/therapy
Chemical Substances	Caspase 1 (EC 3.4.22.36) ; Caspases (EC 3.4.22.-) ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat
Language	Chinese
Publishing date	2024-02-27
Publishing country	China
Document type	Journal Article
ZDB-ID	1283179-7
ISSN	1000-0607
ISSN	1000-0607
DOI	10.13702/j.1000-0607.20230701
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Article ; Online: Isolation, Identification, and Biological Characterization of Phage vB_KpnM_KpVB3 Targeting Carbapenem-Resistant Klebsiella pneumoniae ST11.

Liu, Shihui / Xu, Hao / Cao, Ruonan / Yang, Zhenghai / Li, Xiaoning

Journal of global antimicrobial resistance

2024

Abstract: Objectives: This study aimed to isolate a phage capable of lysing carbapenem-resistant Klebsiella pneumoniae (CRKP) and to analyze its biological characteristics and whole genome sequence.: Methods: The phage was isolated and purified from the sewage. ...

Abstract	Objectives: This study aimed to isolate a phage capable of lysing carbapenem-resistant Klebsiella pneumoniae (CRKP) and to analyze its biological characteristics and whole genome sequence. Methods: The phage was isolated and purified from the sewage. Transmission electron microscopy (TEM) was employed to observe the bacteriophage's morphology. Phenotypic characterization of the bacteriophages were determined. The genomic information was analyzed. Evolutionary relationships were established through comparative genomics, proteomics, and phylogenetic analysis. Results: The isolation of a virulent phage, named Klebsiella phage vB_KpnM_KpVB3, was notable for forming 6-7 mm transparent circular zones, each surrounded by a distinct halo. The phage had a head diameter of approximately 30 nm and a tail length of about 20 nm, being identified as a member of the Myoviridae family and the Caudovirales order. The optimal multiplicity of infection (MOI) was 0.00001, with an incubation period of 20 minutes and a lysis period of 60 minutes, and the number of released phages after lysis was 133±35 PFU/cell. The phage was relatively stable at temperatures ranging from 10 to 40°C and at pH values ranging from 3 to 11. Its lytic efficiency against CRKP was 30.30%. It has been shown to be able to destroy the biofilm of host bacteria. The bacteriophage genome consists of double-stranded DNA (dsDNA) with a total length of 48,394 base pairs, a GC content of 48.99%, and 78 open reading frames (ORFs). Conclusion: The study resulted in the isolation vB_KpnM_KpVB3, a phage demonstrating potential therapeutic efficacy against infections caused by CRKP.
Language	English
Publishing date	2024-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7173
ISSN (online)	2213-7173
ISSN	2213-7173
DOI	10.1016/j.jgar.2024.03.007
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Article ; Online: Social media heterogeneity and preventive behaviours during the COVID-19 outbreak: a survey on online shopping.

Xue, Hu / Li, Xiaoning / Yang, Yuye / Liu, Ying / Geng, Xianhui

BMC public health

2024 Volume 24, Issue 1, Page(s) 1193

Abstract: Background: Residents' adoption of preventive behaviours proved beneficial in preventing the large-scale transmission of the virus during the early stages of the COVID-19 outbreak. It is critical to investigate how social media triggers residents' ... ...

Abstract	Background: Residents' adoption of preventive behaviours proved beneficial in preventing the large-scale transmission of the virus during the early stages of the COVID-19 outbreak. It is critical to investigate how social media triggers residents' preventive behaviour decisions during the COVID-19 outbreak. Methods: This paper selected online shopping as a specific preventive behaviour for empirical investigation. An online cross-sectional survey was conducted through the Sojump website from 1 to 15 March 2020, and a total of 1,289 valid questionnaires were collected from China. This paper uses multiple regression analysis to investigate the heterogeneous impacts of different information sources on residents' online shopping willingness and online shopping behaviour and the heterogeneous impacts of different information content in social media on the transformation of residents' online shopping willingness and online shopping behaviour. Results: The findings indicate that both official-media and self-media positively promote residents' online shopping willingness and behaviour, with official-media having a stronger promotional effect than self-media. Furthermore, official-media and self-media can collaboratively promote residents' online shopping willingness and online shopping behaviour. The ease-of-use and usefulness of information significantly promoted the transformation of residents' online shopping willingness. Conclusions: This study analyses the heterogeneous impacts of social media on residents' preventive behaviours from the perspectives of information source differentiation and information content differentiation, which enriches related studies and provides feasible paths for promoting residents' preventive behaviours.
MeSH term(s)	Humans ; Social Media/statistics & numerical data ; COVID-19/prevention & control ; COVID-19/epidemiology ; COVID-19/psychology ; Cross-Sectional Studies ; China/epidemiology ; Male ; Female ; Adult ; Surveys and Questionnaires ; Middle Aged ; Young Adult ; Health Behavior ; Consumer Behavior/statistics & numerical data
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18253-y
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Article ; Online: Applied Forces Changed Myopia Lens Optical Performance but Not Retinal Image Quality Tested Using a Newly Designed Digital Colmascope.

Li, Xiaoning / Pan, Lun / Lan, Weizhong / Yang, Zhikuan

Clinical optometry

2023 Volume 15, Page(s) 65–74

Abstract: Background: The aim of this study was to investigate the effects of applied forces generated by a rim screw on the optical performance of mounted myopia lenses. The residual refractive error and retinal image quality of the corrected eyes were also ... ...

Abstract	Background: The aim of this study was to investigate the effects of applied forces generated by a rim screw on the optical performance of mounted myopia lenses. The residual refractive error and retinal image quality of the corrected eyes were also investigated. Methods: For 120 lenses, internal lens stress was measured using a newly designed digital strain viewer (colmascope). Sixty myopic adults (120 eyes) were recruited. The effects of internal lens stress on residual refraction and retinal image quality were evaluated using OPD Scan III. The results were compared between loose and tight mounting and between the right and left eyes. Results: Significant differences were observed among nine lens zones in both the right and left lenses, regardless of the mounting state (P < 0.001). The differences were mainly derived from the five vertically arranged zones (P < 0.05). Significant differences in internal lens stress were observed between the right and left lenses (P < 0.05). No significant differences in central residual refractive error and retinal image quality of the corrected eyes were found between the loose- and tight-mounted lenses. Conclusion: The applied forces generated by the rim screw changed the peripheral optical performance of the mounted myopia lenses but exerted only negligible impacts on the central residual refractive error and visual image quality.
Language	English
Publishing date	2023-04-13
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2587459-7
ISSN	1179-2752 ; 1179-2752
ISSN (online)	1179-2752
ISSN	1179-2752
DOI	10.2147/OPTO.S400840
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Article: Effect of acupuncture on BDNF signaling pathways in several nervous system diseases.

Miao, Chenxin / Li, Xiaoning / Zhang, Yishu

Frontiers in neurology

2023 Volume 14, Page(s) 1248348

Abstract: In recent years, the understanding of the mechanisms of acupuncture in the treatment of neurological disorders has deepened, and considerable progress has been made in basic and clinical research on acupuncture, but the relationship between acupuncture ... ...

Abstract	In recent years, the understanding of the mechanisms of acupuncture in the treatment of neurological disorders has deepened, and considerable progress has been made in basic and clinical research on acupuncture, but the relationship between acupuncture treatment mechanisms and brain-derived neurotrophic factor (BDNF) has not yet been elucidated. A wealth of evidence has shown that acupuncture exhibits a dual regulatory function of activating or inhibiting different BDNF pathways. This review focuses on recent research advances on the effect of acupuncture on BDNF and downstream signaling pathways in several neurological disorders. Firstly, the signaling pathways of BDNF and its function in regulating plasticity are outlined. Furthermore, this review discusses explicitly the regulation of BDNF by acupuncture in several nervous system diseases, including neuropathic pain, Parkinson's disease, cerebral ischemia, depression, spinal cord injury, and other diseases. The underlying mechanisms of BDNF regulation by acupuncture are also discussed. This review aims to improve the theoretical system of the mechanism of acupuncture action through further elucidation of the mechanism of acupuncture modulation of BDNF in the treatment of neurological diseases and to provide evidence to support the wide application of acupuncture in clinical practice.
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1248348
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Article ; Online: Thermally activated delayed fluorescence materials for organic light-emitting diodes.

Li, Xiaoning / Fu, Shiyao / Xie, Yujun / Li, Zhen

Reports on progress in physics. Physical Society (Great Britain)

2023 Volume 86, Issue 9

Abstract: Recently, the remarkable advances in thermally activated delayed fluorescence (TADF) materials have attracted much attention due to their 100% exciton utilization efficiency in organic light-emitting diodes (OLEDs). Although the commercialization of TADF ...

Abstract	Recently, the remarkable advances in thermally activated delayed fluorescence (TADF) materials have attracted much attention due to their 100% exciton utilization efficiency in organic light-emitting diodes (OLEDs). Although the commercialization of TADF materials is at an early stage, they exhibit enormous potential for next-generation OLEDs due to the comparable electroluminescence performance to metal of their phosphorescent complex counterparts, but without the presence of precious metal elements. This review summarizes the different types of TADF small molecules with various photophysical properties and the state-of-the-art molecular design strategies. Furthermore, the device engineering is discussed, and emerging optoelectronic applications, such as organic light-emitting electrochemical cells, organic lasing, and organic scintillators, are introduced. It is anticipated that this review can clarify the design of efficient TADF emitters and point out the direction of future development.
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	205657-4
ISSN	1361-6633 ; 0034-4885
ISSN (online)	1361-6633
ISSN	0034-4885
DOI	10.1088/1361-6633/ace06a
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Article ; Online: Combining

Wang, Chengchao / Li, Xiaoning / Liu, Linhua

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 6, Page(s) 4950–4958

Abstract: Organic polymers have attracted widespread interest in various fields ranging from optic and optoelectronic devices to optical system design owing to their light weight, high machinability, excellent thermal performance and reasonable costs. The complex ... ...

Abstract	Organic polymers have attracted widespread interest in various fields ranging from optic and optoelectronic devices to optical system design owing to their light weight, high machinability, excellent thermal performance and reasonable costs. The complex refractive index is an inherent property of organic polymers and directly affects the accuracy of optical system simulation. This study introduces a theoretical protocol to accurately predict the complex refractive indices of organic polymers in the 0-5000 cm
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp04768c
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Article ; Online: Dental arch spatial changes after premature loss of first primary molars: a systematic review and meta-analysis of split-mouth studies.

Zhao, Jingzi / Jin, Hua / Li, Xiaoning / Qin, Xiurong

BMC oral health

2023 Volume 23, Issue 1, Page(s) 430

Abstract: Background: This study aimed to evaluate spatial changes in dental arches resulting from premature loss of first primary molars and assess the necessity of a space maintainer.: Methods: We searched the electronic databases PubMed, Cochrane Library, ... ...

Abstract	Background: This study aimed to evaluate spatial changes in dental arches resulting from premature loss of first primary molars and assess the necessity of a space maintainer. Methods: We searched the electronic databases PubMed, Cochrane Library, ClinicalTrials, and EMBASE. Split-mouth studies involving unilateral premature loss of a primary first molar were included. Quality assessment of selected studies made use of the ROBINS-I tool. Mean space differences were calculated for the D + E and D spaces, arch width, arch length, arch perimeter. Results: Of the 329 studies considered, 11 split-mouth studies were selected, including 246 cases in the maxilla and 217 in the mandible from 477 individuals aged 5-10 years. Over the medium-term follow-up period (6-24 months), space loss was 0.65 mm in the maxillary D + E (MD 0.65, 95% CI 0.15-1.16, P = 0.01), 1.24 mm in the mandibular D + E (MD 1.24, 95% CI 0.60-1.89, P < 0.01), and 1.47 mm in the mandibular D (MD 1.47, 95% CI 0.66-2.28, P < 0.01). There was no significant change in arch width, length, or arch perimeter between the initial and follow-up examinations (P > 0.05). Conclusions: After premature loss of first primary molars, space can be lost, but the amount of loss would not affect arch width, length, or arch perimeter over the 6-24 months follow-up period.
MeSH term(s)	Humans ; Dental Arch ; Mouth ; Face ; Mandible ; Molar
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03111-x
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Article: [Research progress of acupuncture-moxibustion in treatment of spinal cord injury through mediating inflammatory reaction].

Mei, Ji-Lin / Yang, Zhi-Xin / Li, Xiao-Ning

Zhen ci yan jiu = Acupuncture research

2023 Volume 48, Issue 7, Page(s) 699–705

Abstract: Inflammatory reaction after spinal cord injury (SCI) is the main obstacle to the recovery of neural function. In the occurrence and development of SCI, the complex regulatory mechanisms are involved in inflammatory reaction, including the activation of ... ...

Abstract	Inflammatory reaction after spinal cord injury (SCI) is the main obstacle to the recovery of neural function. In the occurrence and development of SCI, the complex regulatory mechanisms are involved in inflammatory reaction, including the activation of inflammatory cells (e.g.macrophages and microglia), and the release of cytokines (e.g. tumor necrosis factor, interleukin and chemokines). Acupuncture-moxibustion is significantly effective in clinical treatment of SCI, and its mechanism is related to adjusting the function of inflammatory cells after SCI, modulating the expression of cytokines and the activation of NLRP3 inflammatory bodies, as well as the expression of high mobility group protein B1 and calcitonin gene related peptide. This article summarizes the research progress of mechanism of inflammatory reaction after SCI and the effects of acupuncture-moxibustion intervention in recent years so that the new ideas can be provided to clarify the pathogenesis of SCI and the effect of acupuncture-moxibustion intervention.
MeSH term(s)	Humans ; Moxibustion ; Spinal Cord Injuries/therapy ; Acupuncture Therapy ; Cytokines/metabolism ; Macrophages/metabolism ; Macrophages/pathology ; Inflammation/therapy ; Spinal Cord
Chemical Substances	Cytokines
Language	Chinese
Publishing date	2023-07-31
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1283179-7
ISSN	1000-0607
ISSN	1000-0607
DOI	10.13702/j.1000-0607.20221181
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