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Article ; Online: Clipping Noise Compensation for Overlapped Time Domain Multiplexing toward Low Peak-to-Average Power Ratio.

Huang, Chongda / Zhang, Qianzhen / Li, Xiaoyuan / Xiao, Yue

2024 Volume 24, Issue 5

Abstract: Overlapped Time Domain Multiplexing (OvTDM) is a high-rate transmission technology that employs the idea of superposition coded modulation (SCM) scheme for signal generation, aiming to achieve maximum channel capacity sharing. Meanwhile, it is also ... ...

Abstract	Overlapped Time Domain Multiplexing (OvTDM) is a high-rate transmission technology that employs the idea of superposition coded modulation (SCM) scheme for signal generation, aiming to achieve maximum channel capacity sharing. Meanwhile, it is also widely considered as a promising technique toward physical layer security. As a main drawback of such system, a high peak-to-average power ratio (PAPR) issue in this system, arising from multi-layer superposition, can be addressed through intentional clipping. However, the detection at the receiver side is vulnerable to nonlinear distortion caused by clipping, which can degrade the performance. To mitigate this distortion, this paper proposed an iterative scheme for estimating and partially canceling clipping distortion at the receiver. We managed to mitigate the impact of clipping noise as much as possible and minimize the cost of optimizing PAPR, thereby improving the transmission performance of OvTDM in the context of amplitude clipping.
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24051607
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An instrument-free visual quantitative detection method based on clock reaction: the detection of thrombin as an example.

Wu, Tianxiang / Li, Xiao-Yuan

Analytical methods : advancing methods and applications

2022 Volume 15, Issue 1, Page(s) 48–55

Abstract: Instrument-free visual quantitative detection in chemical and biochemical analysis is of great significance in practical applications especially in point-of-care testing and in places where resources are limited. In this paper, we report the development ... ...

Abstract	Instrument-free visual quantitative detection in chemical and biochemical analysis is of great significance in practical applications especially in point-of-care testing and in places where resources are limited. In this paper, we report the development of a time-based instrument-free visual quantitative detection method by employing a clock reaction, a type of chemical reaction displaying characteristic clocking behavior. The feasibility of the method was illustrated by the quantitative detection of thrombin in buffer solution using the lapse of time as the readout signal. The linear range of detection was from 1.3 to 43 nM (
MeSH term(s)	Thrombin/analysis ; Serum/chemistry ; Point-of-Care Testing ; Colorimetry/methods
Chemical Substances	Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2022-12-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d2ay01786e
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Article ; Online: Beneficial bacteria as biocontrol agents for American foulbrood disease in honey bees (Apis mellifera).

Ye, Manhong / Li, Xiaoyuan / Yang, Fengping / Zhou, Bin

Journal of insect science (Online)

2023 Volume 23, Issue 2

Abstract: American foulbrood (AFB) is a cosmopolitan bacterial disease that affects honey bee (Apis mellifera) larvae and causes great economic losses in apiculture. Currently, no satisfactory methods are available for AFB treatment mainly due to the difficulties ... ...

Abstract	American foulbrood (AFB) is a cosmopolitan bacterial disease that affects honey bee (Apis mellifera) larvae and causes great economic losses in apiculture. Currently, no satisfactory methods are available for AFB treatment mainly due to the difficulties to eradicate the tenacious spores produced by the etiological agent of AFB, Paenibacillus larvae (Bacillales, Paenibacillaceae). This present review focused on the beneficial bacteria that displayed antagonistic activities against P. larvae and demonstrated potential in AFB control. Emphases were placed on commensal bacteria (genus Bacillus and lactic acid bacteria in particular) in the alimentary tract of honey bees. The probiotic roles lactic acid bacteria play in combating the pathogenic P. larvae and the limitations referring to the application of these beneficial bacteria were addressed.
MeSH term(s)	Bees ; Animals ; United States ; Larva/microbiology ; Paenibacillus larvae ; Beekeeping ; Gastrointestinal Tract
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2049098-7
ISSN	1536-2442 ; 1536-2442
ISSN (online)	1536-2442
ISSN	1536-2442
DOI	10.1093/jisesa/iead013
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Article ; Online: Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy.

Li, Xiaoyuan / Jing, Xin / Yu, Ziqian / Huang, Yubin

Advanced healthcare materials

2023 Volume 12, Issue 23, Page(s) e2300375

Abstract: Diabetic foot ulcer (DFU), a common complication of diabetes, has become a great burden to both patients and the society. The delayed wound closure of ulcer sites resulting from vascular damage and neutrophil dysfunction facilitates bacterial infection. ... ...

Abstract	Diabetic foot ulcer (DFU), a common complication of diabetes, has become a great burden to both patients and the society. The delayed wound closure of ulcer sites resulting from vascular damage and neutrophil dysfunction facilitates bacterial infection. Once drug resistance occurs or bacterial biofilm is formed, conventional therapy tends to fail and amputation is unavoidable. Therefore, effective antibacterial treatment beyond antibiotics is of utmost importance to accelerate the wound healing process and prevent amputation. Considering the complexity of multidrug resistance, biofilm formation, and special microenvironments (such as hyperglycemia, hypoxia, and abnormal pH value) at the infected site of DFU, several antibacterial agents and different mechanisms have been explored to achieve the desired outcome. The present review focuses on the recent progress of antibacterial treatments, including metal-based medications, natural and synthesized antimicrobial peptides, antibacterial polymers, and sensitizer-based therapy. This review provides a valuable reference for the innovation of antibacterial material design for DFU therapy.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Diabetic Foot/drug therapy ; Diabetic Foot/complications ; Diabetes Mellitus/drug therapy ; Wound Healing ; Bacterial Infections/drug therapy ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-05-14
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202300375
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Article ; Online: Successful glucocorticoid withdrawal in Chinese lupus nephritis patients: A single centre experience.

Li, Xiaoyuan / Tan, Ying / Yu, Feng / Zhao, Minghui

International immunopharmacology

2023 Volume 125, Issue Pt A, Page(s) 111156

Abstract: Objective: To evaluate the proportion of patients successfully withdrawn from glucocorticoids (GC) in a longitudinal cohort of patients with lupus nephritis over a period of 20 years, clinical and pathological predictors of patients with GC withdrawal ... ...

Abstract	Objective: To evaluate the proportion of patients successfully withdrawn from glucocorticoids (GC) in a longitudinal cohort of patients with lupus nephritis over a period of 20 years, clinical and pathological predictors of patients with GC withdrawal and renal outcomes after GC withdrawal were further explored. Methods: Patients with successful GC withdrawal were identified for the cohort, and the following data were collected: demographic characteristics, clinical manifestations, pathological findings at disease onset, flares, and renal outcomes subsequent to GC withdrawal. Results: There were 365 patients with lupus nephritis included with a median follow-up of 109.5 (83.5,165.3) months in our cohort. A total of 21 patients (5.8 %) achieved successful GC discontinuation, with a median duration of 7.5 (3,10) years necessary for GC withdrawal. The average duration of GC reduction from 7.5 mg/d to complete withdrawal lasted for approximately 25 months (18,30). Patients in the GC-withdrawal group had a lower prevalence of nephrotic syndrome (NS) at onset (28.5 % vs. 47.3 %, P = 0.035), a higher prevalence of positive anti-double-stranded DNA (anti-dsDNA) antibody (85.7 % vs. 61.6 %, P = 0.028) and more severe endocapillary hypercellularity in the renal histopathology evaluations (3(2.5,3) vs. 3(2,3), P = 0.022). NS at disease onset was an independent risk factor to predict unachievable GC withdrawal (OR 0.296, 95 % CI (0.104,0.842), P = 0.022) by multivariate analysis. With a median follow-up of 34 (20,42) months, none of these patients had flares after GC withdrawal. Conclusions: The discontinuation of GC therapy in LN patients with complete remission and a stable treatment regimen for at least 5 years was feasible without an increased risk of flares, ESKD or death. Low-dose GC withdrawal necessitates a prolonged duration of time and meticulous monitoring.
MeSH term(s)	Humans ; Lupus Nephritis/drug therapy ; Glucocorticoids/therapeutic use ; East Asian People ; Kidney ; Remission Induction ; Lupus Erythematosus, Systemic/drug therapy ; Retrospective Studies
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2023-11-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.111156
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Article ; Online: Neuron-specific deletion of VEGF or its receptor Flk-1 occludes the antidepressant-like effects of desipramine and fluoxetine in mice.

Deyama, Satoshi / Li, Xiao-Yuan / Duman, Ronald S

Neuropsychopharmacology reports

2023 Volume 44, Issue 1, Page(s) 246–249

Abstract: Vascular endothelial growth factor (VEGF) signaling is known to be involved in the antidepressant-like effects of conventional antidepressants, such as desipramine (DMI), a tricyclic antidepressant, and fluoxetine (FLX), a selective serotonin reuptake ... ...

Abstract	Vascular endothelial growth factor (VEGF) signaling is known to be involved in the antidepressant-like effects of conventional antidepressants, such as desipramine (DMI), a tricyclic antidepressant, and fluoxetine (FLX), a selective serotonin reuptake inhibitor; however, the precise role of neuronal VEGF signaling in mediating these effects remains unclear. Using mice with excitatory neuron-specific deletion of VEGF and its receptor, fetal liver kinase 1 (Flk-1) in the forebrain, we examined the effects of forebrain excitatory neuron-specific deletion of VEGF or Flk-1 on the antidepressant-like effects of repeated DMI and chronic FLX administration in the forced swim test (FST). Repeated intraperitoneal (i.p.) injections of DMI (10, 10, and 20 mg/kg at 24, 4, and 1 h before the FST, respectively) significantly decreased immobility in control mice; however, this effect was completely blocked in mice with neuron-specific VEGF or Flk-1 deletion. Although chronic treatment with FLX (18 mg/kg/day, i.p.) did not impact immobility in control mice 1 day after the 22nd injection, immobility was significantly reduced 1 day after the preswim and the 23rd FLX injection. However, in mice with neuron-specific Flk-1 deletion, chronic FLX treatment significantly increased immobility in the preswim and failed to produce antidepressant-like effects. Collectively, these findings indicate that neuronal VEGF-Flk-1 signaling contributes to the antidepressant-like actions of conventional antidepressants.
MeSH term(s)	Mice ; Animals ; Fluoxetine/pharmacology ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/pharmacology ; Desipramine/metabolism ; Desipramine/pharmacology ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Vascular Endothelial Growth Factor Receptor-2/pharmacology ; Antidepressive Agents/pharmacology ; Neurons/metabolism
Chemical Substances	Fluoxetine (01K63SUP8D) ; Vascular Endothelial Growth Factor A ; Desipramine (TG537D343B) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; Antidepressive Agents
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ISSN	2574-173X
ISSN (online)	2574-173X
DOI	10.1002/npr2.12393
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Article ; Online: A framework for quantifying the value of information to mitigate risk in the optimal design of distributed energy systems under uncertainty

Niu, Jide / Li, Xiaoyuan / Tian, Zhe / Yang, Hongxing

Applied Energy. 2023, p.121717-

2023 , Page(s) 121717–

Abstract: Distributed energy systems (DESs) are regarded as promising systems for integrating renewable energy sources. However, uncertainties arising from renewable energy and loads introduce significant complexity to DES design and may even result in reliability ...

Abstract	Distributed energy systems (DESs) are regarded as promising systems for integrating renewable energy sources. However, uncertainties arising from renewable energy and loads introduce significant complexity to DES design and may even result in reliability and economic risks when the design of DESs relies on limited information. Gathering more information can reduce uncertainty, thereby improving the robustness of the DES scheme. However, obtaining information comes at a cost, and too much information can result in redundant work and unnecessary computing burden. Conversely, discarding or ignoring information may pose risks to reliability and the economy. Therefore, this study presents a framework for quantifying the value of uncertainty information, which can help to understand how information affects risk and identify key information that facilitates DES risk aversion. Two information value indices, namely the expected values of information for reliability (EVPIr) and economy (EVPIe), are developed to measure the risk reduction of reliability and economy when more information is added to the design of DESs. Furthermore, a two-layer information value quantification model based on mixed integer linear programming is built to optimize the design of DESs based on uncertain information and quantify the value of information based on a relatively complete information set. The proposed information value quantification method is tested on a real DES under three types of uncertain design boundary scenarios. The results show that the values of EVPIr and EVPIe decrease with increasing information of uncertain design boundary scenarios, indicating that more information reduces risks. An unexpected discovery is that the probability information of the scenario set is not critical for DESs. The deviations of EVPIe are within ±2%. The proposed approach offers a quantitative means to evaluate and filter key information for planning scenarios, which can facilitate the generation of streamlined planning scenarios without compromising reliability and economy.
Keywords	energy ; models ; renewable energy sources ; risk ; risk reduction ; uncertainty ; Value of information ; Risk assessment ; Distributed energy system
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2000772-3
ISSN	0306-2619
ISSN	0306-2619
DOI	10.1016/j.apenergy.2023.121717
Database	NAL-Catalogue (AGRICOLA)

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Article: Mask Use Depends on the Individual, Situation, and Location-Even Without COVID-19 Transmission: An Observational Study in Shanghai.

English, Alexander S / Li, Xiaoyuan

Frontiers in psychology

2021 Volume 12, Page(s) 754102

Abstract: COVID-19 has drastically altered people's mask-wearing behaviors around the world. What is unknown is how long these mask behaviors will last post-COVID-19? To investigate how individual, situational, and locational factors influence mask use in the ... ...

Abstract	COVID-19 has drastically altered people's mask-wearing behaviors around the world. What is unknown is how long these mask behaviors will last post-COVID-19? To investigate how individual, situational, and locational factors influence mask use in the absence of community spread of COVID-19, we conducted an observational study in public areas in the megacity of Shanghai, China. Researchers coded people's mask use in various suburban and urban districts and outdoor and indoor locations with and without mask requirements. Firstly, even without any local transmissions in more than 40days, 62% of the sample (
Language	English
Publishing date	2021-10-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.754102
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Article ; Online: Field-tested innovation: Sustainable utilization of secondary alumina dross for flash setting admixtures production.

Chen, Chao / Yan, Dahai / Li, Xiaoyuan / Liu, Meijia / Cui, Changhao / Li, Li

Journal of environmental management

2024 Volume 358, Page(s) 120857

Abstract: Secondary alumina dross (SAD) has emerged as an alternative to bauxite in the production of flash setting admixtures (FSA), a critical admixture in shotcrete. However, the presence of hazardous components has hampered its large-scale adoption. This study ...

Abstract	Secondary alumina dross (SAD) has emerged as an alternative to bauxite in the production of flash setting admixtures (FSA), a critical admixture in shotcrete. However, the presence of hazardous components has hampered its large-scale adoption. This study conducted field tests at an FSA factory, utilizing SAD as the primary raw material, to evaluate the feasibility and environmental risks. The results confirmed that SAD can effectively replace bauxite in FSA production without compromising quality, as it closely resembled the chemical properties of bauxite. Emissions of fluorides, heavy metals, dioxins in flue gases during production met the relevant Chinese standards. The analysis of hazardous component distribution revealed that more than 50% of volatile components, such as Cl, Cd, Pb, and Zn, were directed into fly ash, exhibiting a significant internal accumulation pattern. In contrast, more than 95% of low-volatility components, including Cu, Cr, Mn, and F, were transferred to the FSA, and the introduction of CaCO
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120857
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Article: Editorial: Recent progress in polymer-based biomaterials as adhesives.

Li, Xiaoyuan / Ding, Jianxun / Xie, Denghui / He, Shasha / Guo, Jinshan

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1305531

Language	English
Publishing date	2023-12-12
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1305531
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