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  1. Article ; Online: A Blockchain-Based Verifiable User Data Access Control Policy for Secured Cloud Data Storage.

    Li, Xinlong

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 2254411

    Abstract: Adding the adequate level of security of information systems dealing with sensitive data, privacy, or defense systems involves some form of access control. The audits performed are dealing with the determination of the allowed activities of the legal ... ...

    Abstract Adding the adequate level of security of information systems dealing with sensitive data, privacy, or defense systems involves some form of access control. The audits performed are dealing with the determination of the allowed activities of the legal users, when attempting to access resources of the system. Usually, full access is provided after the user has been successfully authenticated through an authentication mechanism (e.g., password), while the corresponding authorization control is based on the confidentiality level of the respective resources and the authorization level assigned to each user. A very important diversification occurring in modern digital technologies is related to the identification based on blockchain technology, which is presented as a public, distributed data series, unable to modify its history and grouped in time-numbered blocks. In this work, a blockchain-based verifiable user data access control policy for secured cloud data storage is suggested for a version associated with big data in health care. It is an innovative system of applying classified access policies to secure resources in the cloud, which operates based on blockchain technology. System evaluation is carried out by studying a case in its resilience to Eclipse attack under different malicious user capabilities for routing table poisoning.
    MeSH term(s) Blockchain ; Cloud Computing ; Computer Security ; Information Storage and Retrieval ; Policy
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/2254411
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  2. Article ; Online: Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis.

    Lu, Kai / Li, Xinlong / Wu, Jie

    Immunity, inflammation and disease

    2024  Volume 12, Issue 1, Page(s) e1135

    Abstract: Introduction: Although sirtuin 3 (SIRT3) is known to be involved in dexmedetomidine (DEX)-mediated alleviation of renal ischemia and reperfusion injury, the influence of the association between DEX and SIRT3 on nephritis development remains unclear. In ... ...

    Abstract Introduction: Although sirtuin 3 (SIRT3) is known to be involved in dexmedetomidine (DEX)-mediated alleviation of renal ischemia and reperfusion injury, the influence of the association between DEX and SIRT3 on nephritis development remains unclear. In this study, the role of SIRT3 in DEX-mediated amelioration of inflammation and oxidative stress in nephritis as well as the possible underlying mechanism were explored in vivo and in vitro.
    Methods: An animal model of glomerulonephritis was generated by injecting mice with interferon-alpha (IFNα)-expressing adenoviruses, and periodic acid-Schiff staining was then used to reveal pathogenicity-related changes in the renal tissue. Additionally, human embryonic kidney cells (HEK293) and renal mesangial cells (RMCs) were treated with IFNα to establish cell models of inflammation in vitro.
    Results: DEX administration alleviated glomerulonephritis in the animal model and upregulated SIRT3 expression in the renal tissue. SIRT3 knockdown inhibited the renoprotective effects of DEX against nephritis. IFNα induced inflammation, oxidative stress, and apoptosis in the RMCs and HEK293 cells and reduced their growth, as evidenced by the evaluation of cytokine levels (enzyme-linked immunosorbent assay), reactive oxygen species generation, catalase and superoxide dismutase activities, nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 signal transduction, apoptotic cell proportion, and cell viability. In addition to promoting SIRT3 expression, DEX inhibited IFNα-induced inflammation, oxidative stress, and apoptosis in these cells and promoted their viability. SIRT3 knockdown partially reversed the beneficial effects of DEX on RMCs and HEK293 cells.
    Conclusions: Our results suggest that DEX exhibits renoprotective activity during nephritis progression, protecting renal cells against inflammatory injury by promoting SIRT3 expression.
    MeSH term(s) Animals ; Humans ; Mice ; Dexmedetomidine/pharmacology ; Glomerulonephritis ; HEK293 Cells ; Inflammation ; Interferon-alpha ; Nephritis ; Oxidative Stress ; Sirtuin 3/genetics
    Chemical Substances Dexmedetomidine (67VB76HONO) ; Interferon-alpha ; Sirtuin 3 (EC 3.5.1.-) ; Sirt3 protein, mouse
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740382-8
    ISSN 2050-4527 ; 2050-4527
    ISSN (online) 2050-4527
    ISSN 2050-4527
    DOI 10.1002/iid3.1135
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  3. Article ; Online: DDoS Attack Detection by Hybrid Deep Learning Methodologies

    Li Xinlong / Chen Zhibin

    Security and Communication Networks, Vol

    2022  Volume 2022

    Abstract: A Distributed Denial of Service (DDoS) attack occurs when large amounts of traffic from hundreds, thousands, or even millions of other computers are routed to a network or server to crash the system and disrupt its function. These attacks are commonly ... ...

    Abstract A Distributed Denial of Service (DDoS) attack occurs when large amounts of traffic from hundreds, thousands, or even millions of other computers are routed to a network or server to crash the system and disrupt its function. These attacks are commonly used to shut down websites or applications temporarily. Such problems often need to be addressed with models that can manage the time information contained in network traffic flows. In this work, we apply a Hybrid Deep Learning method to detect malicious web traffic in the form of DDoS attacks, controlling the web flow of information reaching a server, using any dependencies between the different elements of a data stream. An original and cutting-edge Hierarchical Temporal Memory (HTM) hybrid model has been proposed. The operation of this model is predicated primarily on the portion of the cerebral cortex known as the neocortex. The neocortex is in charge of various fundamental brain functions, including the perception of senses, the comprehension of language, and the control of movement. For the hybrid implementation to be capable of encoding time sequences that incorporate incoming data, a Long Short-Term Memory (LSTM) shell is added.
    Keywords Technology (General) ; T1-995 ; Science (General) ; Q1-390
    Subject code 005
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Efficacy of TTFields in high-grade gliomas: a protocol for systematic review and meta-analysis.

    Li, Xinlong / Wang, Juncheng / Yuan, Guoqiang / Pan, Yawen

    BMJ open

    2023  Volume 13, Issue 9, Page(s) e073753

    Abstract: Introduction: Despite their recent FDA(Food and Drug Administration) approval, tumour treatment fields (TTFields) have not seen acceptance as part of standard of care (SOC) for the treatment of high-grade gliomas (HGGs). Few studies have reported the ... ...

    Abstract Introduction: Despite their recent FDA(Food and Drug Administration) approval, tumour treatment fields (TTFields) have not seen acceptance as part of standard of care (SOC) for the treatment of high-grade gliomas (HGGs). Few studies have reported the clinical effect of simultaneous or sequential use of TTFields with the current SOC. However, whether TTFields are beneficial over the standard treatment remains to be established with a meta-analysis. Therefore, we here performed a systematic review and meta-analysis to understand the benefit of TTFields for patients with HGGs.
    Methods and analysis: We registered this systematic review with the PROSPERO network (registration number: CRD42023398972) and aimed to follow the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines in the study. All articles related to TTFields in glioma will be systematically searched for in the following databases since their inception until November 2023: the China National Knowledge Infrastructure, Embase, Cochrane Library, Wanfang Database, China Science Journal Database, China Biomedical Documentation Database, VIP database, Web of Science and PubMed. Article screening and data extraction will be done independently by the authors and cross-checked by two of the authors on completion. The Cochrane risk of bias assessment tool will be used for quality assessment of the included studies. Review Manager V.5.3 (Cochrane Collaboration) will be used to perform the meta-analysis.
    Ethics and dissemination: Ethical approval is not required because the data used will be obtained from published studies, and there will be no concerns about privacy. The results of this study will be published in a peer-reviewed journal.
    Prospero registration number: CRD42023398972.
    MeSH term(s) United States ; Humans ; Systematic Reviews as Topic ; Meta-Analysis as Topic ; Glioma/therapy ; China ; Databases, Factual
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073753
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  5. Article ; Online: Relationship between ozone and air temperature in future conditions: A case study in sichuan basin, China.

    Wang, Ju / Li, Juan / Li, Xinlong / Wang, Dali / Fang, Chunsheng

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 343, Page(s) 123276

    Abstract: The Sichuan Basin (SCB) is located in southwestern China and has a unique topography where ozone ( ... ...

    Abstract The Sichuan Basin (SCB) is located in southwestern China and has a unique topography where ozone (O
    MeSH term(s) Ozone/analysis ; Temperature ; Air Pollutants/analysis ; Environmental Monitoring/methods ; Air Pollution/analysis ; China
    Chemical Substances Ozone (66H7ZZK23N) ; Air Pollutants
    Language English
    Publishing date 2023-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.123276
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Characteristics of Air Pollutants Emission and Its Impacts on Public Health of Chengdu, Western China.

    Wang, Ju / Li, Juan / Li, Xinlong / Fang, Chunsheng

    International journal of environmental research and public health

    2022  Volume 19, Issue 24

    Abstract: Pollution caused by ... ...

    Abstract Pollution caused by PM
    MeSH term(s) Humans ; Air Pollutants/analysis ; Particulate Matter/analysis ; Public Health ; Environmental Monitoring/methods ; Air Pollution/analysis ; China/epidemiology
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192416852
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  7. Article ; Online: Sensitivity Analysis of the WOFOST Crop Model Parameters Using the EFAST Method and Verification of Its Adaptability in the Yellow River Irrigation Area, Northwest China

    Li, Xinlong / Tan, Junli / Li, Hong / Wang, Lili / Niu, Guoli / Wang, Xina

    Agronomy. 2023 Aug. 30, v. 13, no. 9

    2023  

    Abstract: Sensitivity analysis, calibration, and verification of crop model parameters improve crop model efficiency and accuracy, facilitating its application. This study selected five sites within the Ningxia Yellow River Irrigation Area. Using meteorological ... ...

    Abstract Sensitivity analysis, calibration, and verification of crop model parameters improve crop model efficiency and accuracy, facilitating its application. This study selected five sites within the Ningxia Yellow River Irrigation Area. Using meteorological data, soil data, and field management information, the EFAST (Extended Fourier Amplitude Sensitivity Test) method was used to conduct first-order and global sensitivity analyses of spring wheat parameters in the WOFOST (World Food Studies Simulation) Model. A Structural Equation Model (SEM) analyzed the contribution of crop parameters to different simulation indices, with parameter sensitivity rankings being discussed under varying water supply and climate conditions. Finally, the adapted WOFOST model was employed to assess its applicability in the Ningxia Yellow River Irrigation Area. TMNFTB3.0 (correction factor of total assimilation rate at 3 °C), SPAN (life span of leaves growing at 35 °C), SLATB0 (specific leaf area in the initial period), and CFET (correction factor transpiration rate) showed higher sensitivity index for most simulation indices. Under the same meteorological conditions, different water supply conditions have a limited impact on crop parameter sensitivity, mainly affecting leaf senescence, leaf area, and assimilate conversion to storage organs. The corrected crop parameters significantly enhanced the wheat yield simulation accuracy by the WOFOST model (ME = 0.9964; RMSE = 0.2516; MBE = 0.1392; R2 = 0.0331). The localized WOFOST model can predict regional crop yield, with this study providing a theoretical foundation for its regional application, adjustment, and optimization.
    Keywords agronomy ; calibration ; climate ; crop models ; irrigation ; leaf area ; leaves ; longevity ; meteorological data ; soil ; specific leaf area ; spring wheat ; structural equation modeling ; transpiration ; water supply ; China ; Yellow River
    Language English
    Dates of publication 2023-0830
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy13092294
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  8. Article ; Online: Hydrothermal pretreatment based on biogas slurry recycling to improve methane yield of typical plant wastes from South China

    Liu, Xiangmeng / Zou, Jintuo / Xu, Sunqiang / Li, Xinlong / Xie, Jun / Yu, Qiang

    Industrial Crops & Products. 2023 Sept., v. 200 p.116686-

    2023  

    Abstract: Lignin content of feedstock contributed more for the biomass recalcitrance despite of the comprehensive effect from multiple physical and chemical characteristics based on the anaerobic digestion analysis of 16 plant wastes from South China. With the ... ...

    Abstract Lignin content of feedstock contributed more for the biomass recalcitrance despite of the comprehensive effect from multiple physical and chemical characteristics based on the anaerobic digestion analysis of 16 plant wastes from South China. With the objective of improving anaerobic digestion performance of mixed fruit shell, hydrothermal pretreatment based on biogas slurry recycling (HPBSR) was proposed. Compared with traditional hydrothermal pretreatment, the lignin content of mixed fruit shell was reduced by 4.51–21.13% after HPBSR. The soluble chemical oxygen demand of liquid fraction under 200 ℃ increased by 87.45% relative to the control group with biogas slurry. And the cumulative methane yield of anaerobic digestion was 129.97 mL/gVS, which was 45.01% and 18.78% higher than the control group without treatment and the hydrothermal pretreatment group, respectively. Moreover, the HPBSR experimental group did not produce anaerobic digestion inhibitors (furfural and 5-hydroxymethylfurfural), and the higher humic acid concentration would be another possible reason for the improvement of methane yield. The related results will provide insights into the resource utilization of biogas slurry.
    Keywords anaerobic digestion ; biogas ; biomass ; chemical oxygen demand ; feedstocks ; fruits ; furfural ; humic acids ; hydroxymethylfurfural ; lignin content ; liquids ; methane production ; slurries ; China ; Hydrothermal pretreatment ; Plant waste ; Biogas slurry
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2023.116686
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    In stock of ZB MED Bonn / Germany

    Z 5577: Show issues

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  9. Article: [Effects of PBMC mitochondrial autophagy on exercise energy consumption and mitochondrial respiratory chain complex enzyme activity in high altitude migrants].

    Kong, Hai-Jun / Wang, Feng-Hua / Li, Xin-Long / Gan, Sheng-Qian / Chen, Xiao'an

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2023  Volume 38, Issue 6, Page(s) 655–659

    MeSH term(s) Humans ; Altitude ; Electron Transport ; Leukocytes, Mononuclear ; Transients and Migrants
    Language Chinese
    Publishing date 2023-06-12
    Publishing country China
    Document type Journal Article
    ISSN 1000-6834
    ISSN 1000-6834
    DOI 10.12047/j.cjap.6345.2022.119
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  10. Article: Genomic analysis of

    Yuan, Chao / An, Tianfeng / Li, Xinlong / Zou, Jiao / Lin, Zhan / Gu, Jiale / Hu, Ruixia / Fang, Zhongze

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1272636

    Abstract: Ralstonia ... ...

    Abstract Ralstonia pickettii
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1272636
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