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  1. Book ; Online ; E-Book: Microfluidic devices for biomedical applications

    Li, Xiujun James / Zhou, Yu

    (Woodhead publishing series in biomaterials)

    2021  

    Author's details edited by XiuJun (James) Li, Yu Zhou
    Series title Woodhead publishing series in biomaterials
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xix, 700 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Elsevier Woodhead Publishing
    Publishing place Duxford
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021075332
    ISBN 978-0-12-822755-8 ; 9780128199718 ; 0-12-822755-9 ; 0128199717
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Microfluidic 3D cell culture: potential application for tissue-based bioassays.

    Li, Xiujun James / Valadez, Alejandra V / Zuo, Peng / Nie, Zhihong

    Bioanalysis

    2012  Volume 4, Issue 12, Page(s) 1509–1525

    Abstract: Current fundamental investigations of human biology and the development of therapeutic drugs commonly rely on 2D monolayer cell culture systems. However, 2D cell culture systems do not accurately recapitulate the structure, function or physiology of ... ...

    Abstract Current fundamental investigations of human biology and the development of therapeutic drugs commonly rely on 2D monolayer cell culture systems. However, 2D cell culture systems do not accurately recapitulate the structure, function or physiology of living tissues, nor the highly complex and dynamic 3D environments in vivo. Microfluidic technology can provide microscale complex structures and well-controlled parameters to mimic the in vivo environment of cells. The combination of microfluidic technology with 3D cell culture offers great potential for in vivo-like tissue-based applications, such as the emerging organ-on-a-chip system. This article will review recent advances in the microfluidic technology for 3D cell culture and their biological applications.
    MeSH term(s) Animals ; Biological Assay/methods ; Biological Assay/trends ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Cell Line, Tumor/physiology ; Cell Proliferation ; Cell Survival ; Hepatocytes/physiology ; Humans ; Mice ; Microfluidics/methods ; Microfluidics/trends ; Myocytes, Cardiac/physiology ; NIH 3T3 Cells/physiology ; Neurons/cytology ; Neurons/physiology ; Rats ; Stem Cells/physiology ; Tissue Engineering/methods ; Tissue Engineering/trends
    Language English
    Publishing date 2012-07-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio.12.133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Announcing our finalists!

    Burton, Casey / Guallar-Hoyas, Cristina / Li, Xiujun James / Nemes, Peter / Shuhendler, Adam

    Bioanalysis

    2014  Volume 6, Issue 14, Page(s) 1883–1888

    MeSH term(s) Awards and Prizes ; Career Mobility ; Chemistry Techniques, Analytical/methods ; Humans ; Research ; Research Personnel
    Language English
    Publishing date 2014
    Publishing country England
    Document type Interview
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio.14.183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Contraction study of a single cardiac muscle cell in a microfluidic chip.

    Li, Xiujun James / Li, Paul C H

    Methods in molecular biology (Clifton, N.J.)

    2006  Volume 321, Page(s) 199–225

    Abstract: This chapter introduces a microfluidic method to study the contraction of a single cardiac muscle cell (cardiomyocyte). This method integrates single-cell selection, cell retention, dye loading, chemical stimulation, and fluorescence measurement for ... ...

    Abstract This chapter introduces a microfluidic method to study the contraction of a single cardiac muscle cell (cardiomyocyte). This method integrates single-cell selection, cell retention, dye loading, chemical stimulation, and fluorescence measurement for intracellular calcium on one microfluidic chip. Before single-cell experiments, the bonded chip was modified in order to make the channel deep enough to accommodate a large, single cardiomyocyte. After the modification, a single heart muscle cell could be selected and retained at a cell retention structure. Fluo-4 AM was loaded in the cell for the measurement of intracellular calcium ion concentration in the cell. Subsequently, caffeine was introduced into the chamber to induce the contraction of the cardiomyocyte. During contraction, fluorescence measurement was used to monitor the intracellular calcium level,and an optical imaging system was used to monitor the shape to confirm the contraction. The resting [Ca2+]i of cardiomyocyte was determined and was consistent with the value of approx 100 nM in the literature.
    MeSH term(s) Aniline Compounds ; Animals ; Caffeine ; Cells, Cultured ; Microfluidics/instrumentation ; Myocardial Contraction/physiology ; Myocytes, Cardiac/physiology ; Rabbits ; Xanthenes
    Chemical Substances Aniline Compounds ; Fluo 4 ; Xanthenes ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2006-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1064-3745
    ISSN 1064-3745
    DOI 10.1385/1-59259-997-4:199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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