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Article ; Online: Prenatal ultrasound diagnosis of primary myxomatous degeneration of cardiac valves in a fetus: Case report.

Gao, Wen-Juan / Li, Xue-Ning

The journal of obstetrics and gynaecology research

2022 Volume 48, Issue 10, Page(s) 2620–2623

Abstract: Primary myxomatous degeneration of cardiac valves is a rare cardiac malformation. We discovered a case of fetal primary myxomatous degeneration of cardiac valves during routine prenatal ultrasound examination. This is the first time such a case has been ... ...

Abstract	Primary myxomatous degeneration of cardiac valves is a rare cardiac malformation. We discovered a case of fetal primary myxomatous degeneration of cardiac valves during routine prenatal ultrasound examination. This is the first time such a case has been detected on prenatal ultrasound.
MeSH term(s)	Female ; Fetus ; Humans ; Mitral Valve ; Pregnancy ; Prenatal Diagnosis ; Ultrasonography ; Ultrasonography, Prenatal
Language	English
Publishing date	2022-07-10
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15331
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Article ; Online: Enantioselective Synthesis of Axially Chiral Diaryl Ethers via NHC Catalyzed Desymmetrization and Following Resolution.

Zhou, Bang-An / Li, Xue-Ning / Zhang, Chun-Lin / Wang, Zhi-Xiang / Ye, Song

Angewandte Chemie (International ed. in English)

2023 Volume 63, Issue 4, Page(s) e202314228

Abstract: Axially chiral diaryl ethers are present in numerous natural products and bioactive molecules. However, only few catalytic enantioselective approaches have been established to access diaryl ether atropisomers. Herein, we report the N-heterocyclic carbene- ...

Abstract	Axially chiral diaryl ethers are present in numerous natural products and bioactive molecules. However, only few catalytic enantioselective approaches have been established to access diaryl ether atropisomers. Herein, we report the N-heterocyclic carbene-catalyzed enantioselective synthesis of axially chiral diaryl ethers via desymmetrization of prochiral 2-aryloxyisophthalaldehydes with aliphatic alcohols, phenol derivatives, and heteroaromatic amines. This reaction features mild reaction conditions, good functional group tolerance, broad substrate scope and excellent enantioselectivity. The utility of this methodology is illustrated by late-stage functionalization, gram-scale synthesis, and diverse enantioretentive transformations. Control experiments and DFT calculations support the association of NHC-catalyzed desymmetrization with following kinetic resolution to enhance the enantioselectivity.
Language	English
Publishing date	2023-12-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202314228
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Article ; Online: Low vitamin D during pregnancy is associated with infantile eczema by up-regulation of PI3K/AKT/mTOR signaling pathway and affecting FOXP3 expression: A bidirectional cohort study.

Ding, Ya-Jie / Li, Xue-Ning / Xiao, Zhe / Li, Chen-Yang / Jia, Li-Hong

The Journal of nutritional biochemistry

2023 Volume 124, Page(s) 109516

Abstract: Vitamin D has received increasing attention because of its association with atopic disease development. Limited studies that have been done on the impact of maternal vitamin D levels during pregnancy on infantile eczema are still debatable. We wanted to ... ...

Abstract	Vitamin D has received increasing attention because of its association with atopic disease development. Limited studies that have been done on the impact of maternal vitamin D levels during pregnancy on infantile eczema are still debatable. We wanted to discover the effect of maternal vitamin D on infantile eczema and explore whether regulatory T cells (Treg) play a role in this process. 219 pairs of mothers and children were enrolled. Maternal fasting venous blood was collected in pregnancy's second and third trimesters to determine vitamin D levels. Cord blood and placenta samples were collected during childbirth for detecting levels of genes, proteins and cytokines. Pediatricians followed up the prevalence of eczema in infants within 1 year. The reported rate of vitamin D deficiency and insufficiency was 35.6% and 28.3%. Lower maternal 25(OH)D
MeSH term(s)	Infant ; Child ; Humans ; Female ; Pregnancy ; Dermatitis, Atopic ; Cohort Studies ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt ; Up-Regulation ; Placenta ; Vitamin D ; Vitamin D Deficiency ; Vitamins ; Eczema/epidemiology ; TOR Serine-Threonine Kinases/genetics ; Signal Transduction ; Forkhead Transcription Factors/genetics
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Vitamin D (1406-16-2) ; Vitamins ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Forkhead Transcription Factors ; FOXP3 protein, human
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2023.109516
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Zs.A 2838: Show issues

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Article: Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment.

Wang, Zheng / Li, Xue-Ning / Yang, Shao-Nan / Wang, Yuan / Gao, Ke-Jin / Han, Bin / Ma, Ai-Jun

World journal of psychiatry

2023 Volume 13, Issue 9, Page(s) 630–644

Abstract: Background: Exosomal miRNAs play crucial roles in many central nervous system diseases. Cerebral small vessel disease (CVSD) is a small vessel disease that is affected by various factors. This study aimed to investigate the role of exosomal miR-320e in ... ...

Abstract	Background: Exosomal miRNAs play crucial roles in many central nervous system diseases. Cerebral small vessel disease (CVSD) is a small vessel disease that is affected by various factors. This study aimed to investigate the role of exosomal miR-320e in the Wnt/β-catenin pathway stimulated by oxidative stress and assess its clinical correlation with psychiatric symptoms in patients with CVSD. Aim: To explore whether exosomal miR-320e could suppress the Wnt/β-catenin pathway and play a protective role in CVSD progression, as well as examine its potential correlation with cognitive impairment and depression in patients with CVSD. Methods: Differentially expressed exosomal miRNAs were filtered by sequencing plasma exosomes from patients with CVSD and healthy controls. Bioinformatics and dual luciferase analyses were used to confirm the binding of miR-320e to Wnt2, and the mRNA and protein levels of downstream components in the Wnt/β-catenin pathway were evaluated when overexpressed or with knockdown of miR-320e under H Results: High-throughput sequencing revealed that exosomal miR-320e was downregulated in patients with CVSD. Bioinformatics analysis and dual-luciferase reporter gene experiments showed that exosomal miR-320e inhibited the Wnt/β-catenin pathway in response to oxidative stress by targeting the 3' noncoding region of Wnt2. Uptake of exosomes carrying miR-320e into endothelial cells could also target Wnt2 and inhibit the Wnt2/β-catenin pathway. Elevated miR-320e expression may protect patients with CVSD from relatively severe cognitive impairment and depression, as it was found to have a positive correlation with the MoCA/EFA and HAMD/BDI scores. Conclusion: Our results suggest that exosomal miR-320e suppresses the Wnt/β-catenin pathway and may play a protective role in CVSD progression.
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ISSN	2220-3206
ISSN	2220-3206
DOI	10.5498/wjp.v13.i9.630
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Article ; Online: Pharmacokinetics and Safety of Eptinezumab in Healthy Chinese Participants: A Randomized Clinical Trial.

Li, Xue-Ning / Xu, Hong-Rong / Cui, Ellen / Petersen, Kamilla Buchberg / Ryding, Janka / Ettrup, Anders / Østergaard, Jette Buch / Larsen, Frank

Clinical drug investigation

2023 Volume 43, Issue 11, Page(s) 873–881

Abstract: Background and objective: Most evidence suggests that the pharmacokinetics of monoclonal antibodies (mAbs) are not meaningfully altered by patient characteristics, including racial/ethnic differences. Nevertheless, the pharmacokinetic profile of ... ...

Abstract	Background and objective: Most evidence suggests that the pharmacokinetics of monoclonal antibodies (mAbs) are not meaningfully altered by patient characteristics, including racial/ethnic differences. Nevertheless, the pharmacokinetic profile of eptinezumab has not been evaluated in a Chinese population. This study was designed to confirm the hypothesis that the pharmacokinetic profile of the anti-calcitonin gene-related peptide mAb, eptinezumab, is similar in healthy Chinese individuals to that of healthy non-Asian individuals and non-Asian patients with migraine. Methods: Over a study period of 12 weeks, healthy adult Chinese participants (N = 20) were randomized (1:1) to receive a single intravenous dose of eptinezumab 100 mg (n = 10) or 300 mg (n = 10) in a prospective, single-site, open-label parallel-group trial. Blood samples for the evaluation of plasma eptinezumab concentrations were obtained over 84 days, and standard pharmacokinetic parameters were derived. Results: Mean maximum plasma concentrations (C Conclusion: The pharmacokinetic profile of eptinezumab in healthy Chinese individuals was generally similar to that reported for non-Asian populations with migraine, and eptinezumab was generally well tolerated. Evaluation of immunogenicity showed no evidence of an impact of anti-drug antibodies or neutralizing antibodies on safety profiles. This supports the globally approved doses of 100 mg and 300 mg as being appropriate for Chinese patients with episodic migraine or chronic migraine.
MeSH term(s)	Adult ; Humans ; East Asian People ; Prospective Studies ; Migraine Disorders/drug therapy ; Antibodies, Neutralizing/therapeutic use ; Double-Blind Method
Chemical Substances	eptinezumab (8202AY8I7H) ; Antibodies, Neutralizing
Language	English
Publishing date	2023-11-02
Publishing country	New Zealand
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-023-01315-1
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Zs.A 2807: Show issues

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Article ; Online: The Association Between Environmental Lead Exposure and Recurrent Respiratory Infections in Children Aged 3-7 Years in Shenyang, China.

Li, Xue-Ning / Liu, Ying / Huang, Na / Cheng, Xiao-Jun / Jia, Li-Hong

Indian pediatrics

2020 Volume 57, Issue 11, Page(s) 1023–1025

Abstract: Objective: To investigate the lead exposure levels, and the effect of blood lead level (BLL) on recurrent respiratory infections in children aged 3-7 years in Shenyang.: Methods: A case-control study including 78 children with recurrent respiratory ... ...

Abstract	Objective: To investigate the lead exposure levels, and the effect of blood lead level (BLL) on recurrent respiratory infections in children aged 3-7 years in Shenyang. Methods: A case-control study including 78 children with recurrent respiratory infections and 141 controls was performed. Venous blood was obtained for BLL, and a questionnaire was completed. Results: The BLL was significantly higher in children with recurrent respiratory infections than that in the control group [Median (IQR): 2.56 (1.29-6.19) vs 1.99 (0.90-5.92) µg/dL, P=0.029]. Children with BLL ≥1.95 µg/dL were more likely to be suffering from recurrent respiratory infections (OR=2.328, 95%CI=1.228-4.413) than those with BLL <1.95 µg/dL. Conclusions: High lead level can increase the risk of respiratory infections in preschool children.
MeSH term(s)	Case-Control Studies ; Child, Preschool ; China/epidemiology ; Environmental Exposure/adverse effects ; Humans ; Lead ; Lead Poisoning/epidemiology ; Respiratory Tract Infections/epidemiology
Chemical Substances	Lead (2P299V784P)
Language	English
Publishing date	2020-11-24
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article ; Online: Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects.

Yang, Meng-Jie / Xu, Hong-Rong / Li, Hui / Chen, Wei-Li / Yuan, Fei / Li, Xue-Ning

Drug design, development and therapy

2020 Volume 14, Page(s) 1219–1226

Abstract: Purpose: Aprepitant is used to prevent nausea and vomiting associated with moderately and highly emetogenic chemotherapy. In this open-label, 2-period study, the safety, tolerability, and pharmacokinetics (PK) of aprepitant (EMEND: Patients and ... ...

Abstract	Purpose: Aprepitant is used to prevent nausea and vomiting associated with moderately and highly emetogenic chemotherapy. In this open-label, 2-period study, the safety, tolerability, and pharmacokinetics (PK) of aprepitant (EMEND Patients and methods: Twelve Chinese and 12 Caucasian subjects were to receive a 125 mg single-dose of aprepitant during period 1; subsequently, after 15 days washout, only Chinese subjects were to receive the 3-day regimen in period 2. In each period, serial blood samples were collected and analyzed by a validated liquid chromatographic and mass spectrometric method to characterize aprepitant PK across both groups. Results: In both Chinese and Caucasian subjects, there were no serious adverse events. AUC Conclusion: Aprepitant is generally safe and well tolerated in healthy Chinese and Caucasian subjects. Aprepitant PK is comparable between Chinese and Caucasian subjects following single-dose administration. The PK following a clinical 3-day regimen on healthy Chinese subjects has been characterized.
MeSH term(s)	Administration, Oral ; Adolescent ; Adult ; Aprepitant/administration & dosage ; Aprepitant/blood ; Aprepitant/pharmacokinetics ; Asians ; Drug Tolerance ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Whites ; Young Adult
Chemical Substances	Aprepitant (1NF15YR6UY)
Language	English
Publishing date	2020-03-24
Publishing country	New Zealand
Document type	Comparative Study ; Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S243924
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Article: Development and Validation of a Plasma FAM19A5 and MRI-Based Radiomics Model for Prediction of Parkinson's Disease and Parkinson's Disease With Depression.

Li, Xue-Ning / Hao, Da-Peng / Qu, Mei-Jie / Zhang, Meng / Ma, An-Bang / Pan, Xu-Dong / Ma, Ai-Jun

Frontiers in neuroscience

2021 Volume 15, Page(s) 795539

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.795539
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Article ; Online: Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China.

Li, Xue-Ning / Wu, Dan / Liu, Ying / Zhang, Shuang-Shuang / Tian, Fu-Lin / Sun, Qi / Wei, Wei / Cao, Xia / Jia, Li-Hong

Ecotoxicology and environmental safety

2021 Volume 228, Page(s) 112987

Abstract: Increasing evidence shows that human exposure to bisphenols can increase the risk of allergic disease, such as child asthma. However, the mechanism by which exposure to bisphenols causes allergic disease is unclear. In addition, the effects of exposure ... ...

Abstract	Increasing evidence shows that human exposure to bisphenols can increase the risk of allergic disease, such as child asthma. However, the mechanism by which exposure to bisphenols causes allergic disease is unclear. In addition, the effects of exposure to bisphenols during pregnancy on infantile eczema have been poorly studied. The aim of our study was to investigate the effect of bisphenols (BPA, BPF and BPS) exposure during pregnancy on immune cells in cord blood, and on the occurrence of infantile eczema. 111 mother-child pairs with urine samples from pregnant women and cord blood were recruited from a birth cohort established in February 2019 in Shenyang, China. The levels of urinary bisphenols and Th1-, Th2-, Treg- and Th17-related genes, and cytokines in cord blood, as well as the incidence of infantile eczema at 6 and 12 months follow up were determined. Our results show that BPA, BPF and BPS were detected in 100%, 63.1% and 46.8% of the urine samples, respectively. The median concentration of urine specific gravity adjusted BPA (SG-BPA) was 7.46 ng/mL. High SG-BPA levels during pregnancy was independently associated with increased risk of infantile eczema (adjusted OR = 2.731, 95%CI: 1.064-7.012, P = 0.037). Higher levels of FOXP3 gene in cord blood had a significantly lower risk of developing eczema in infants (adjusted OR=0.430, 95%CI: 0.190-0.972, P = 0.042). However, BPS and BPF levels were not associated with infantile eczema. FOXP3 gene levels in cord blood mediated the relationship between SG-BPA levels during pregnancy and infantile eczema (indirect effect: β = 0.350 [CI:0.011,1.077]). Our findings indicate that high levels of BPA exposure during pregnancy increase the risk of infantile eczema, which may be associated with down-regulation of FOXP3 gene expression in cord blood.
Language	English
Publishing date	2021-11-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2021.112987
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Zs.A 1418: Show issues

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Article ; Online: Association of prenatal factors and cord blood lead levels in China: A nested cohort cross-sectional study.

Li, Xue-Ning / Jia, Li-Hong / Cao, Xia / Zhang, Shuang-Shuang / Pu, Rui / Cheng, Xiao-Jun / Liu, Ying

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2021 Volume 67, Page(s) 126783

Abstract: Background: Lead exposure all over the world has gradually declined. As fetuses are more prone to lead exposure, even to low levels of lead exposure, it is important to monitor blood lead levels (BLLs) in pregnancy.: Methods: We obtained data on BLLs ...

Abstract	Background: Lead exposure all over the world has gradually declined. As fetuses are more prone to lead exposure, even to low levels of lead exposure, it is important to monitor blood lead levels (BLLs) in pregnancy. Methods: We obtained data on BLLs in the third trimester of pregnancy from medical records and measured cord BLLs obtained from 121 mother-child pairs in Shenyang, China from September 2019 to February 2020. We also estimated relationships between socio-demographic, lifestyle and dietary factors during pregnancy as well as cord BLLs to identify the source of lead exposure during pregnancy. BLLs was estimated by atomic absorption spectrometry through graphite furnace ionization techniques. The data which obtained by questionnaires during pregnancy included maternal sociodemographic, lifestyle, dietary factors. We have established three multivariate logistic regression models in which the dichotomous BLLs was used as the dependent variable (cord BLLs ≥20 μg/L vs <20 μg/L). Results: The median and geometric mean of cord BLLs were 22.90 μg/L, 21.88 μg/L and BLLs in the third trimester of pregnancy were 25.29 μg/L, 24.66 μg/L, respectively. BLLs showed significant correlations between cord and the third trimester of pregnancy (r = 0.277, P = 0.012). Pregnant women who had not been exposed to passive smoking had lower OR (95 %) [0.43(0.19-0.94)] for cord BLLs ≥20 μg/L than pregnant women who had. Intake of docosahexaenoic acid (DHA) during third trimester of pregnancy presented an OR (95 %) [0.23(0.08-0.61)] for cord BLLs ≥20 μg/L. Consuming more whole grains (>3 times/week) and beverage (≥1 times/week) showed an OR (95%CI) for cord BLLs ≥20 μg/L of 0.09(0.02-0.53) and 0.19(0.06-0.69), respectively. Conclusion: This study showed the cord BLLs of Chinese are still higher than most developed countries. Passive smoking is a risk factor for cord BLLs ≥20 μg/L and supplement of DHA, whole grains and beverage consumption during pregnancy may act as a beneficial factor against having cord BLLs ≥20 μg/L.
MeSH term(s)	China ; Cross-Sectional Studies ; Female ; Fetal Blood ; Humans ; Lead/blood ; Pregnancy ; Tobacco Smoke Pollution ; Vitamins
Chemical Substances	Tobacco Smoke Pollution ; Vitamins ; Lead (2P299V784P)
Language	English
Publishing date	2021-05-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2021.126783
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