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Article: Efficacy of neuromuscular electrical stimulation on Wilson's disease patients with dysphagia.

Li, Xue-Wei / Li, Liang-Yong

2019 Volume 31, Issue 12, Page(s) 971–974

Abstract: Purpose] Dysphagia is a neurological symptom that is observed in more than half of patients with Wilson's disease. It is often associated with aspiration pneumonia, dehydration, and malnutrition, resulting in drastic reduction of the quality of life. ... ...

Abstract	[Purpose] Dysphagia is a neurological symptom that is observed in more than half of patients with Wilson's disease. It is often associated with aspiration pneumonia, dehydration, and malnutrition, resulting in drastic reduction of the quality of life. Neuromuscular electrical stimulation could be an adjunct therapy for dysphagia treatment. However, there is limited data about the application of NMES for dysphagia in Wilson's disease. Thus, we explored the potential application of NMES for dysphagia treatment in Wilson's disease. [Participants and Methods] Sixty Wilson's disease patients who suffered from dysphagia were randomized into two groups. Swallowing function training was taught to the control group (n=30) while Neuromuscular electrical stimulation therapy was given to treatment group (n=30). Eight weeks post treatment, using the water swallow test and the Standardized Swallowing Assessment, the swallowing function was determined. [Results] None of the patients experienced discomfort before, during or after the intervention. After 8 weeks of therapy, when compared to the control, an increased improvement in swallowing function was noted for the treatment group. [Conclusion] Neuromuscular electrical stimulation treatment can improve swallowing function in Wilson's disease patients afflicted with dysphagia. Therefore, it has the potential to be a form of therapy in clinical practice.
Language	English
Publishing date	2019-12-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.31.971
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Article ; Online: Circular RNA in gastric cancer.

Li, Xue-Wei / Yang, Wen-Hui / Xu, Jun

Chinese medical journal

2020 Volume 133, Issue 15, Page(s) 1868–1877

Abstract: Gastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor. With the continuous ... ...

Abstract	Gastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor. With the continuous improvement of molecular biology techniques, research on circular RNA (circRNA) has gradually expanded over time. Much data supports the role of circRNA in tumorigenesis. Moreover, due to its structural specificity and biological stability, circRNA is anticipated to be a potential biomarker for tumor diagnosis. Studies have confirmed that circRNA can participate in the proliferation, invasion, metastasis, and apoptosis of GC. These findings will lead to novel directions for the diagnosis and treatment of GC. This article reviews the structure and function of circRNA, summarizes the current studies on circRNA, and discusses the potential diagnostic value of circRNA in GC.
MeSH term(s)	Apoptosis ; Humans ; MicroRNAs ; Prognosis ; RNA, Circular ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics
Chemical Substances	MicroRNAs ; RNA, Circular
Language	English
Publishing date	2020-07-27
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000000908
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Article ; Online: Multiphonon processes of the inelastic electron transfer in olfaction.

Zhang, Shu-Quan / Cui, Yu / Li, Xue-Wei / Sun, Yong / Wang, Zi-Wu

Physical chemistry chemical physics : PCCP

2022 Volume 24, Issue 8, Page(s) 5048–5051

Abstract: Inelastic electron transfer, regarded as one of the potential mechanisms to explain odorant recognition in atomic-scale processes, is still a matter of intense debate. Here, we study multiphonon processes of electron transfer using the Markvart model and ...

Abstract	Inelastic electron transfer, regarded as one of the potential mechanisms to explain odorant recognition in atomic-scale processes, is still a matter of intense debate. Here, we study multiphonon processes of electron transfer using the Markvart model and calculate their lifetimes with the values of key parameters widely adopted in olfactory systems. We find that these multiphonon processes are as quick as the single phonon process, which suggests that contributions from different phonon modes of an odorant molecule should be included for electron transfer in olfaction. Meanwhile, the temperature dependence of electron transfer could be analyzed effectively based on the reorganization energy which is expanded into the linewidth of multiphonon processes. Our theoretical results not only enrich the knowledge of the mechanism of olfaction recognition, but also provide insights into quantum processes in biological systems.
MeSH term(s)	Electron Transport ; Electrons ; Odorants ; Smell ; Temperature
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp04414a
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Article: Efficacy and safety of third-line or later-line targeted treatment for patients with metastatic colorectal cancer: a meta-analysis.

Xue, Wen-Hui / Li, Xue-Wei / Ding, Ya-Qian / Wu, Na / Pei, Bei-Bei / Ma, Xiao-Yan / Xie, Jun / Yang, Wen-Hui

Frontiers in oncology

2023 Volume 13, Page(s) 1165040

Abstract: Targeted therapy has been standardized in front-line therapies for metastatic colorectal cancer (mCRC), while explicit recommendations for third- or later-line are still lacking. This study evaluated the efficacy and safety of combining targeted therapy ... ...

Abstract	Targeted therapy has been standardized in front-line therapies for metastatic colorectal cancer (mCRC), while explicit recommendations for third- or later-line are still lacking. This study evaluated the efficacy and safety of combining targeted therapy with chemotherapy in the third- or later-line treatment for mCRC
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1165040
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Article ; Online: Bioinformatic analysis of adenocarcinoma at esophagogastric junction and mutation sites screening of Involucrin gene

LYU Xue / LI Xue-wei / YANG Ting / ZHENG Jin-xiu / ZHU Zi-he / YANG Tao / XU Jun

Jichu yixue yu linchuang, Vol 42, Iss 2, Pp 235-

2022 Volume 242

Abstract: Objective To detect the gene mutations in patients with Adenocarcinoma at esophagogastric junction(AEG) and to analyze the effect of Involucrin (IVL) mutation on the biological function of tumor cells. Methods Whole exome sequencing was performed on ... ...

Abstract	Objective To detect the gene mutations in patients with Adenocarcinoma at esophagogastric junction(AEG) and to analyze the effect of Involucrin (IVL) mutation on the biological function of tumor cells. Methods Whole exome sequencing was performed on cancerous and paired adjacent normal tissues from 22 AEG patients in Shanxi province. IVL was selected for further investigation of mutation sites. Esophagus cancer data from TCGA were divided into three groups based on IVL mutations. Differentially-expressed genes were screened and proceeded via Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Cell proliferation and migration assays were performed to evaluate the effect of over-expression of IVL on KYSE 150 cells. Mutant IVL oligopeptides were synthesized and used to evaluate the binding activity with TGase1. Results Five IVL mutation sites were identified in 22 AEG. GO annotation indicated that these mutations were related to the epithelial differentiation and activity of cell differentiation regulation. KEGG analysis demonstrates that IVL mutations are associated with cAMP signaling pathway. IVL over-expression inhibits the proliferation and migration of esophageal cancer cells(P＜0.05). In addition, Q439H mutant IVL oligopeptides shows lower binding affinity to TGase1 than wild-type oligopeptides. Conclusions The seventh amino acid mutation in IVL repeat motif does weaken IVL binding to TGase1. This mutation may affect tumor-related biological processes and signaling pathways.
Keywords	adenocarcinoma at esophagogastric junction\|involucrin\|gene mutation ; Medicine ; R
Language	Chinese
Publishing date	2022-02-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The AP2/ERF transcription factor MdDREB2A regulates nitrogen utilisation and sucrose transport under drought stress.

Zhang, Ting-Ting / Lin, Yu-Jing / Liu, Hao-Feng / Liu, Ya-Qi / Zeng, Zhi-Feng / Lu, Xiao-Yan / Li, Xue-Wei / Zhang, Zhen-Lu / Zhang, Shuai / You, Chun-Xiang / Guan, Qing-Mei / Lang, Zhao-Bo / Wang, Xiao-Fei

Plant, cell & environment

2024 Volume 47, Issue 5, Page(s) 1668–1684

Abstract: Drought stress is one of the main environmental factors limiting plant growth and development. Plants adapt to changing soil moisture by modifying root architecture, inducing stomatal closure, and inhibiting shoot growth. The AP2/ERF transcription factor ...

Abstract	Drought stress is one of the main environmental factors limiting plant growth and development. Plants adapt to changing soil moisture by modifying root architecture, inducing stomatal closure, and inhibiting shoot growth. The AP2/ERF transcription factor DREB2A plays a key role in maintaining plant growth in response to drought stress, but the molecular mechanism underlying this process remains to be elucidated. Here, it was found that overexpression of MdDREB2A positively regulated nitrogen utilisation by interacting with DRE cis-elements of the MdNIR1 promoter. Meanwhile, MdDREB2A could also directly bind to the promoter of MdSWEET12, which may enhance root development and nitrogen assimilation, ultimately promoting plant growth. Overall, this regulatory mechanism provides an idea for plants in coordinating with drought tolerance and nitrogen assimilation to maintain optimal plant growth and development under drought stress.
MeSH term(s)	Plant Proteins/genetics ; Plant Proteins/metabolism ; Droughts ; Plants, Genetically Modified/metabolism ; Promoter Regions, Genetic ; Sucrose/metabolism ; Gene Expression Regulation, Plant ; Stress, Physiological/genetics
Chemical Substances	Plant Proteins ; Sucrose (57-50-1)
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.14834
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Article: Complete Genome Sequence of the Biocontrol Agent

Zhang, Chun-Mei / Xu, Ming-Jie / Li, Xue-Wei / Gong, Yuan / Xing, Ke / Qin, Sheng

Molecular plant-microbe interactions : MPMI

2021 Volume 34, Issue 7, Page(s) 839–841

Abstract: Pseudomonas ... ...

Abstract	Pseudomonas chlororaphis
MeSH term(s)	Fungi ; Plant Development ; Pseudomonas/genetics ; Rhizosphere
Language	English
Publishing date	2021-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	743331-1
ISSN	1943-7706 ; 0894-0282
ISSN (online)	1943-7706
ISSN	0894-0282
DOI	10.1094/MPMI-01-21-0005-A
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Article: Complete Genome Sequence of the Biocontrol Agent Pseudomonas chlororaphis subsp. aureofaciens SPS-41

Zhang, Chun-Mei / Xu, Ming-Jie / Li, Xue-Wei / Gong, Yuan / Xing, Ke / Qin, Sheng

Molecular plant-microbe interactions. 2021 July, v. 34, no. 7

2021

Abstract: Pseudomonas chlororaphis subsp. aureofaciens SPS-41 is a plant growth–promoting rhizobacterium with biocontrol potential that was isolated from the rhizosphere of sweet potato in Xuzhou, Jiangsu Province, China. Our previous study demonstrated that ... ...

Abstract	Pseudomonas chlororaphis subsp. aureofaciens SPS-41 is a plant growth–promoting rhizobacterium with biocontrol potential that was isolated from the rhizosphere of sweet potato in Xuzhou, Jiangsu Province, China. Our previous study demonstrated that volatile organic compounds (VOCs) produced by SPS-41 inhibited black spot disease fungi Ceratocystis fimbriata in postharvest sweet potatoes and a variety of other plant pathogens, and the VOCs also displayed strong nematocidal activity. In order to further explore the application potential of this strain, we here report the complete genome sequence of strain SPS-41. The genome consists of one chromosome (6,757,898 bp) with a G+C content 63.10%, which contains 5,951 coding genes, 67 transfer RNA genes, 16 ribosome RNA genes, and 85 other non-coding RNA genes. No plasmid was detected. The information of the genome will provide resources for studying the biocontrol mechanism of this strain. Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
Keywords	Ceratocystis fimbriata ; Pseudomonas chlororaphis ; biological control ; biological control agents ; chromosomes ; nematicidal properties ; non-coding RNA ; nucleotide sequences ; plant growth-promoting rhizobacteria ; plasmids ; rhizosphere ; ribosomes ; sweet potatoes ; transfer RNA ; volatile organic compounds ; China
Language	English
Dates of publication	2021-07
Size	p. 839-841.
Publishing place	The American Phytopathological Society
Document type	Article
ZDB-ID	743331-1
ISSN	1943-7706 ; 0894-0282
ISSN (online)	1943-7706
ISSN	0894-0282
DOI	10.1094/MPMI-01-21-0005-A
Database	NAL-Catalogue (AGRICOLA)

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Article: Antioxidant activity of Yesso scallop (Patinopecten yessoensis) female gonad hydrolysates-ribose Maillard reaction products extracted with organic reagents, before and after in vitro digestion

Han, Jia-Run / Han, Yi-Tong / Li, Xue-Wei / Gu, Qing / Li, Ping / Zhu, Bei-Wei

Food bioscience. 2021 Oct., v. 43

2021

Abstract: Yesso scallop (Patinopecten yessoensis) gonad is the main by-product during processing. Our previous studies found that its Alcalase hydrolysates can act as a worthy precursor for Maillard reaction in the presence of ribose. Basing on the understanding ... ...

Abstract	Yesso scallop (Patinopecten yessoensis) gonad is the main by-product during processing. Our previous studies found that its Alcalase hydrolysates can act as a worthy precursor for Maillard reaction in the presence of ribose. Basing on the understanding of the characteristics of scallop female gonad hydrolysates (SFGHs)-ribose Maillard reaction products (MRPs), it was further extracted by different organic reagents and then was subjected to an in vitro digestion. The effects of digestion on the antioxidant and antimicrobial capacities of organic extracts from SFGHs-ribose MRPs were determined. Results showed that the scavenging activities of ethanol and methanol extracts on both ABTS·⁺ and DPPH·⁺ increased significantly before digestion, where methanol extracts were better than that of ethanol. However, the ·OH scavenging and linoleic acid peroxidation inhibition activities of MRPs were reduced in both extracts. Interestingly, there was a significant increase in the ABTS·⁺, ·OH scavenging activities and peroxidation inhibition capacity for all samples following digestion except for DPPH·⁺ scavenging activity. MRPs-methanol extracts showed the highest antimicrobial effect against Escherichia coli (E. coli) than other samples. Moreover, the HepG2 cell viability of MRPs-methanol extracts after digestion was increased to 89.58 %, which was 1.49, 1.26 and 1.14 times higher than H₂O₂-treated, SFGHs and MRPs group, respectively. Therefore, it is suggested that methanol extraction can improve the antioxidant capacity of SFGHs-ribose MRPs during digestion, and the corresponding extracts can be utilized as food antioxidants.
Keywords	Escherichia coli ; Mizuhopecten yessoensis ; antimicrobial properties ; antioxidant activity ; byproducts ; cell viability ; digestion ; ethanol ; females ; human cell lines ; linoleic acid ; methanol ; peroxidation ; ribose ; scallops ; subtilisin
Language	English
Dates of publication	2021-10
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2212-4292
DOI	10.1016/j.fbio.2021.101262
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: COX-2 inhibition by celecoxib in epithelial ovarian cancer attenuates E-cadherin suppression through reduced Snail nuclear translocation.

Wang, Yan-Ping / Wang, Qu-Yuan / Li, Chang-Hui / Li, Xue-Wei

Chemico-biological interactions

2018 Volume 292, Page(s) 24–29

Abstract: Elevated cyclooxygenase-2 (COX-2) closely associates with tumor progression and distant metastasis in various human cancers. However, the role of COX-2 in epithelial ovarian cancer (EOC), and its mechanistic details, remain poorly understood. In the ... ...

Abstract	Elevated cyclooxygenase-2 (COX-2) closely associates with tumor progression and distant metastasis in various human cancers. However, the role of COX-2 in epithelial ovarian cancer (EOC), and its mechanistic details, remain poorly understood. In the present study, we tested hypothesis that COX-2 induces loss of expression of E-cadherin, with resulting promotion of cancer cells' invasiveness in ovarian cancer. First, we observed an inverse relationship between COX-2 and E-cadherin expression as COX-2 was enhanced but E-cadherin was decreased in surgically-resected specimens of EOC. Depletion of COX-2, by celecoxib treatment, resulted in attenuated nuclear translocation of Snail, and, in turn, significantly increased E-cadherin in EOC cell line SKOV3, which was established to be due to the reduced binding of Snail onto E-cadherin promoter. Such COX-2 inhibition resulted in reduced invasion of EOC cells, similar to what was achieved through Snail silencing in SKOV as well as ES-2 EOC cells. These results suggest that COX-2-Snail signaling plays a critical role in regulation of E-cadherin and might provide insights into mechanisms for paracrine inflammation-mediated aggressiveness in EOC.
MeSH term(s)	Blotting, Western ; Cadherins/antagonists & inhibitors ; Cadherins/genetics ; Cadherins/metabolism ; Carcinoma, Ovarian Epithelial ; Celecoxib/pharmacology ; Cell Line, Tumor ; Cyclooxygenase 2/metabolism ; Down-Regulation ; Female ; Humans ; Inflammation/drug therapy ; Neoplasms, Glandular and Epithelial/drug therapy ; Neoplasms, Glandular and Epithelial/physiopathology ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/physiopathology ; Polymerase Chain Reaction ; Promoter Regions, Genetic ; Signal Transduction/drug effects ; Snail Family Transcription Factors/metabolism
Chemical Substances	Cadherins ; Snail Family Transcription Factors ; Cyclooxygenase 2 (EC 1.14.99.1) ; PTGS2 protein, human (EC 1.14.99.1) ; Celecoxib (JCX84Q7J1L)
Language	English
Publishing date	2018-06-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2018.06.020
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