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Article ; Online: Association between childhood obesity and gut microbiota: 16S rRNA gene sequencing-based cohort study.

Li, Xu-Ming / Lv, Qing / Chen, Ya-Jun / Yan, Lu-Biao / Xiong, Xin

2024 Volume 30, Issue 16, Page(s) 2249–2257

Abstract: Background: This study aimed to identify characteristic gut genera in obese and normal-weight children (8-12 years old) using 16S rDNA sequencing. The research aimed to provide insights for mechanistic studies and prevention strategies for childhood ... ...

Abstract	Background: This study aimed to identify characteristic gut genera in obese and normal-weight children (8-12 years old) using 16S rDNA sequencing. The research aimed to provide insights for mechanistic studies and prevention strategies for childhood obesity. Thirty normal-weight and thirty age- and sex-matched obese children were included. Questionnaires and body measurements were collected, and fecal samples underwent 16S rDNA sequencing. Significant differences in body mass index (BMI) and body-fat percentage were observed between the groups. Analysis of gut microbiota diversity revealed lower α-diversity in obese children. Di-fferences in gut microbiota composition were found between the two groups. Aim: To identify the characteristic gut genera in obese and normal-weight children (8-12-year-old) using 16S rDNA sequencing, and provide a basis for subsequent mechanistic studies and prevention strategies for childhood obesity. Methods: Thirty each normal-weight, 1:1 matched for age and sex, and obese children, with an obese status from 2020 to 2022, were included in the control and obese groups, respectively. Basic information was collected through questionnaires and body measurements were obtained from both obese and normal-weight children. Fecal samples were collected from both groups and subjected to 16S rDNA sequencing using an Illumina MiSeq sequencing platform for gut microbiota diversity analysis. Results: Significant differences in BMI and body-fat percentage were observed between the two groups. The Ace and Chao1 indices were significantly lower in the obese group than those in the control group, whereas differences were not significant in the Shannon and Simpson indices. Kruskal-Wallis tests indicated significant differences in unweighted and weighted UniFrac distances between the gut microbiota of normal-weight and obese children ( Conclusion: Obese children exhibited lower α-diversity in their gut microbiota than did the normal-weight children. Significant differences were observed in the composition of gut microbiota between obese and normal-weight children.
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Pediatric Obesity/microbiology ; Pediatric Obesity/diagnosis ; Child ; RNA, Ribosomal, 16S/genetics ; Male ; Female ; Feces/microbiology ; Body Mass Index ; Case-Control Studies ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/classification ; DNA, Bacterial/isolation & purification ; DNA, Bacterial/analysis ; DNA, Bacterial/genetics
Chemical Substances	RNA, Ribosomal, 16S ; DNA, Bacterial
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v30.i16.2249
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Article ; Online: FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation.

Yuan, Zhikun / Yang, Lingfeng / Li, Yanhui / Li, Xuming / Peng, Changgui / Pan, Jianying / Cai, Daozhang

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 282

Abstract: Objective: Ferritin heavy chain 1 (FTH1) is an important subunit of ferro-storing proteins and is indispensable for iron metabolism. Though it has been extensively studied in numerous organs and diseases, the relationship between FTH1 and osteoarthritis ...

Abstract	Objective: Ferritin heavy chain 1 (FTH1) is an important subunit of ferro-storing proteins and is indispensable for iron metabolism. Though it has been extensively studied in numerous organs and diseases, the relationship between FTH1 and osteoarthritis (OA) is unclear. Design: Primary murine chondrocytes and cartilage explants were treated with FTH1 siRNA for 72 h. Mice were injected with adenovirus expressing FTH1 after destabilized medial meniscus (DMM) surgery. These approaches were used to determine the effect of FTH1 expression on the pathophysiology of OA. Results: FTH1 expression was down regulated in OA patients and mice after DMM surgery. Knock down of FTH1 induced articular cartilage damage and extracellular matrix degradation in cartilage explants. Further, over expression of FTH1 reduced the susceptibility of chondrocytes to ferroptosis and reversed decrements in SOX9 and aggrecan after DMM surgery. Moreover, FTH1 relieved OA by inhibition of the chondrocyte MAPK pathway. Conclusion: This study found FTH1 to play an essential role in extracellular matrix degradation, ferroptosis, and chondrocytes senescence during OA progression. Further, injection of adenovirus expressing FTH1 may be a potential strategy for OA prevention and therapy.
MeSH term(s)	Animals ; Humans ; Mice ; Adenoviridae/genetics ; Aggrecans ; Chondrocytes ; Extracellular Matrix ; Ferritins ; Osteoarthritis/genetics ; Oxidoreductases
Chemical Substances	Aggrecans ; Ferritins (9007-73-2) ; FTH1 protein, human (EC 1.-) ; Oxidoreductases (EC 1.-) ; Fth1 protein, mouse (EC 1.-)
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07411-3
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Article ; Online: Building structure-borne noise measurements and estimation due to train operations in tunnel.

Li, Xuming / Chen, Yekai / Zou, Chao / Wang, Hao / Zheng, Bokai / Chen, Jialiang

The Science of the total environment

2024 Volume 926, Page(s) 172080

Abstract: The perception of structure-borne noise is particularly salient when train passes through the tunnel under the buildings, which has a negative impact on human health. In the process of constructing buildings along metro lines, it is crucial to estimate ... ...

Abstract	The perception of structure-borne noise is particularly salient when train passes through the tunnel under the buildings, which has a negative impact on human health. In the process of constructing buildings along metro lines, it is crucial to estimate indoor structure-borne noise levels in order to enhance design and prevent any negative impact on human comfort. This study conducted measurements of structure-borne noise, reverberation time, and train-induced vibrations in Guangzhou, China to investigate the generation, propagation, and dissipation mechanisms of structure-borne noise. An approach based on Short-Time Fourier Transform and Schroeder integral was proposed for obtaining frequency-dependent reverberation time. Additionally, a deep learning-based approach incorporating indoor vibrations, frequency-dependent reverberation time, and room parameters as inputs was proposed based on Genetic Algorithm-Artificial Neural Network. The estimated structure-borne noise levels demonstrated good agreement with measured values, indicating the feasibility of the approach. The finding of this research facilitates a clear comprehension of the generation, distribution, and dissipation mechanisms of indoor structure-borne noise for engineers while also enabling convenient acquisition of indoor structure-borne noise. The estimated noise levels can be effectively utilized during building design processes along metro lines to mitigate adverse impacts on human comfort.
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172080
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Article ; Online: Noise annoyance and vibration perception assessment on passengers during train operation in Guangzhou Metro

Li, Xuming / Hu, Zihao / Zou, Chao

Environ Sci Pollut Res. 2022 Jan., v. 29, no. 3 p.4246-4259

2022

Abstract: With the development of urban rail transit, taking the metro train has become one of the main modes of transportation, and passengers have an increasing demand for the comfort of taking the metro trains. This paper mainly discusses the impact of noise ... ...

Abstract	With the development of urban rail transit, taking the metro train has become one of the main modes of transportation, and passengers have an increasing demand for the comfort of taking the metro trains. This paper mainly discusses the impact of noise and vibration caused by metro train on passengers. All 13 metro lines in Guangzhou, China, were selected to conduct the questionnaire survey on the subjective perception of 601 respondents. At the same time, noise and vibration measurements were carried out in the train. The results show that the distribution of noise and vibrations along the metro lines is not uniform, and 50.6% of the interviewees are disturbed by noise. Wheel-rail squeal was found to be the most annoying and disturbing noise source. Three dose-response relationships for noise, vertical vibration, and horizontal vibration are proposed, respectively. The proposed dose-response relationship can be applied to the evaluation of noise annoyance or vibration perception in an environment similar to metro lines. Once the noise or vibration level of a metro line is obtained, the noise disturbance or vibration perception can be estimated. As for the dose-response relationship of vibration perception, people’s sensitivity to vibration is much lower than that to noise. Horizontal vibrations are more acceptable to passengers, while vertical vibrations are more disturbing to passengers. The results are helpful to predict the noise annoyance and vibration perception of train passengers between metro stations, and to achieve the purpose of designing effective noise and vibration reduction measures.
Keywords	dose response ; people ; questionnaires ; rail transportation ; surveys ; vibration ; China
Language	English
Dates of publication	2022-01
Size	p. 4246-4259.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-15896-x
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Article ; Online: Nosocomial surveillance of multidrug-resistant

Duan, Zhimei / Li, Xuming / Li, Song / Zhou, Hui / Hu, Long / Xia, Han / Xie, Lixin / Xie, Fei

Microbiology spectrum

2024 Volume 12, Issue 2, Page(s) e0220723

Abstract: Acinetobacter ... ...

Abstract	Acinetobacter baumannii
MeSH term(s)	Humans ; Acinetobacter baumannii/genetics ; Cross Infection/epidemiology ; Phylogeny ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Drug Resistance, Multiple, Bacterial/genetics ; Anti-Bacterial Agents/pharmacology ; Hospitals ; Genomics ; Microbial Sensitivity Tests
Chemical Substances	Interleukin-1 Receptor-Like 1 Protein ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02207-23
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Article ; Online: Noise annoyance and vibration perception assessment on passengers during train operation in Guangzhou Metro.

Li, Xuming / Hu, Zihao / Zou, Chao

Environmental science and pollution research international

2021 Volume 29, Issue 3, Page(s) 4246–4259

Abstract	With the development of urban rail transit, taking the metro train has become one of the main modes of transportation, and passengers have an increasing demand for the comfort of taking the metro trains. This paper mainly discusses the impact of noise and vibration caused by metro train on passengers. All 13 metro lines in Guangzhou, China, were selected to conduct the questionnaire survey on the subjective perception of 601 respondents. At the same time, noise and vibration measurements were carried out in the train. The results show that the distribution of noise and vibrations along the metro lines is not uniform, and 50.6% of the interviewees are disturbed by noise. Wheel-rail squeal was found to be the most annoying and disturbing noise source. Three dose-response relationships for noise, vertical vibration, and horizontal vibration are proposed, respectively. The proposed dose-response relationship can be applied to the evaluation of noise annoyance or vibration perception in an environment similar to metro lines. Once the noise or vibration level of a metro line is obtained, the noise disturbance or vibration perception can be estimated. As for the dose-response relationship of vibration perception, people's sensitivity to vibration is much lower than that to noise. Horizontal vibrations are more acceptable to passengers, while vertical vibrations are more disturbing to passengers. The results are helpful to predict the noise annoyance and vibration perception of train passengers between metro stations, and to achieve the purpose of designing effective noise and vibration reduction measures.
MeSH term(s)	China ; Humans ; Noise ; Perception ; Railroads ; Surveys and Questionnaires ; Vibration
Language	English
Publishing date	2021-08-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-15896-x
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Article ; Online: Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report.

Liu, Xiaoyi / Wang, Jing / Liu, Jun / Li, Xuming / Guan, Yuanlin / Qian, Suyun / Jia, Xinlei

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1269963

Abstract: Background: Cryptosporidium: Case presentation: Here, we reported the use of metagenomic next-generation sequencing (mNGS) to assist in the diagnosis and treatment of a 10-year-old boy with severe : Conclusion: Our study emphasized the importance ... ...

Abstract	Background: Cryptosporidium Case presentation: Here, we reported the use of metagenomic next-generation sequencing (mNGS) to assist in the diagnosis and treatment of a 10-year-old boy with severe Conclusion: Our study emphasized the importance of recognizing the potential severity of
MeSH term(s)	Male ; Child ; Humans ; Cryptosporidiosis/epidemiology ; Cryptosporidium/genetics ; Diarrhea/diagnosis ; Diarrhea/epidemiology ; High-Throughput Nucleotide Sequencing ; Intensive Care Units, Pediatric
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1269963
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Article: A quantitative analysis of thyroid fine needle aspiration (FNA) using needles with different gauges.

Li, Li / Ma, Xiaoli / Li, Xuming / Rong, Yue / Zhang, Jiesi / Ye, Yuquan

Hellenic journal of nuclear medicine

2022

Abstract: Objective: The aim of this study is to compare the results of three gauge (G) needles (22G, 23G and 25G) in terms of cell amount in thyroid fine needle aspiration (FNA).: Subjects and methods: In the retrospective study, a total of 443 patients ... ...

Abstract	Objective: The aim of this study is to compare the results of three gauge (G) needles (22G, 23G and 25G) in terms of cell amount in thyroid fine needle aspiration (FNA). Subjects and methods: In the retrospective study, a total of 443 patients undergoing FNA for the first time between 2017 and 2018 were included in the study, and assigned to 3 groups with 22-gauge, 23-gauge and 25-gauge needles, respectively. Results: The cell amount of a suspicion for the four diagnosis groups, including malignancy and malignant, benign nodules, follicular of undetermined significance (FLUS), and follicular neoplasia was mainly in the range of 0-10000, 0-300, 0-150, and 500-2500, respectively. The cut-off values of 22G needle 20000, 300, 1000, and 2500, while the cut-off values of 23G and 25G were 10000, 400, 1000, and 2500; 5000, 400, 1500, and 2000, respectively for the four diagnosis groups. Conclusion: Large-gauge needles resulted in more cellular specimens than small-gauge needles only in the cases of malignant tumors. Small-gauge needles resulted in a higher comfort level of the patients, and had no difference in cell number in nodules with abundant blood supply, compared with large-gauge needles.
Language	English
Publishing date	2022-12-14
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2186026-9
ISSN	1790-5427 ; 1108-1430
ISSN	1790-5427 ; 1108-1430
DOI	10.1967/s002449912515
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Article ; Online: Development of lipidated polycarbonates with broad-spectrum antimicrobial activity.

Gao, Ruixuan / Li, Xuming / Xue, Menglin / Shen, Ning / Wang, Minghui / Zhang, Jingyao / Cao, Chuanhai / Cai, Jianfeng

Biomaterials science

2023 Volume 11, Issue 5, Page(s) 1840–1852

Abstract: Antimicrobial resistance is a global challenge owing to the lack of discovering effective antibiotic agents. Antimicrobial polymers containing the cationic groups and hydrophobic groups which mimic natural host-defense peptides (HDPs) show great promise ... ...

Abstract	Antimicrobial resistance is a global challenge owing to the lack of discovering effective antibiotic agents. Antimicrobial polymers containing the cationic groups and hydrophobic groups which mimic natural host-defense peptides (HDPs) show great promise in combating bacteria. Herein, we report the synthesis of lipidated polycarbonates bearing primary amino groups and hydrophobic moieties (including both the terminal long alkyl chain and hydrophobic groups in the sequences) by ring-opening polymerization. The hydrophobic/hydrophilic group ratios were adjusted deliberately and the lengths of the alkyl chains at the end of the polymers were modified to achieve the optimized combination for the lead polymers, which exhibited potent and broad-spectrum bactericidal activity against a panel of Gram-positive and Gram-negative bacteria. The polymers only showed very limited hemolytic activity, demonstrating their excellent selectivity. Comprehensive analyses using biochemical and biophysical assays revealed the strong interaction between the polymers and bacteria membranes. Moreover, the polymers also showed strong biofilm inhibition activity and did not readily induce antibiotic resistance. Our results suggest that lipidated polycarbonates could be a new class of antimicrobial agents.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Anti-Infective Agents/pharmacology ; Bacteria ; Polymers/pharmacology ; Polymers/chemistry ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; polycarbonate (25766-59-0) ; Anti-Infective Agents ; Polymers
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d2bm01995g
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Article ; Online: The value of next-generation metagenomic sequencing in pathogen detection of pleural effusions and ascites from children with sepsis.

Liu, Gang / Wang, Lijuan / Li, Xuming / Zhang, Ye / Long, Hu / Wang, Yi / Gao, Hengmiao / Xia, Han / Qian, Suyun

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1130483

Abstract: Objective: To investigate the diagnostic value of metagenomic next-generation sequencing (mNGS) using pleural effusion and ascites from children with sepsis.: Methods: In this study, children with sepsis or severe sepsis and appeared pleural or ... ...

Abstract	Objective: To investigate the diagnostic value of metagenomic next-generation sequencing (mNGS) using pleural effusion and ascites from children with sepsis. Methods: In this study, children with sepsis or severe sepsis and appeared pleural or peritoneal effusions were enrolled, of whom the pleural effusions or ascites and blood samples were conducted pathogen detection using both conventional and mNGS methods. The samples were divided into pathogen-consistent and pathogen-inconsistent groups based on the consistency of mNGS results from different sample types, and into exudate and transudate groups based on their pleural effusion and ascites properties. The pathogen positive rates, pathogen spectrum, consistency between different sample types, and clinical diagnosis consistency were compared between mNGS and conventional pathogen tests. Results: A total of 42 pleural effusions or ascites and 50 other type samples were collected from 32 children. The pathogen positive rate of the mNGS test was significantly higher than that of traditional methods (78.57% Conclusion: Compared to conventional methods, mNGS has great advantages in pathogen detection of pleural effusion and ascites samples. Moreover, consistent results of mNGS tests with different sample types provide more reference values in clinical diagnosis.
MeSH term(s)	Child ; Humans ; Ascites/diagnosis ; Pleural Effusion ; Exudates and Transudates ; Sepsis/diagnosis ; High-Throughput Nucleotide Sequencing ; Metagenomics ; Sensitivity and Specificity
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1130483
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