Article ; Online: Peptides for disrupting and degrading amyloids.
Current opinion in chemical biology
2021 Volume 64, Page(s) 124–130
Abstract: Amyloid proteins can aggregate into insoluble fibrils and form amyloid deposits in the human brain, which is the hallmark of many neurodegenerative diseases. Promising strategies toward pathological amyloid proteins and deposition include investigating ... ...
Abstract | Amyloid proteins can aggregate into insoluble fibrils and form amyloid deposits in the human brain, which is the hallmark of many neurodegenerative diseases. Promising strategies toward pathological amyloid proteins and deposition include investigating inhibitors that can disrupt amyloid aggregation or induce misfolding protein degradation. In this review, recent progress of peptide-based inhibitors, including amyloid sequence-derived inhibitors, designed peptides, and peptide mimics, is highlighted. Based on the increased understanding of peptide design and precise amyloid structures, these peptides exhibit advanced inhibitory activities against fibrous aggregation as well as enhanced druggability. |
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MeSH term(s) | Amyloid/chemistry ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Humans ; Neurodegenerative Diseases/metabolism ; Peptides/chemistry ; Peptides/pharmacology |
Chemical Substances | Amyloid ; Amyloid beta-Peptides ; Peptides |
Language | English |
Publishing date | 2021-07-16 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 1439176-4 |
ISSN | 1879-0402 ; 1367-5931 |
ISSN (online) | 1879-0402 |
ISSN | 1367-5931 |
DOI | 10.1016/j.cbpa.2021.05.011 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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