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  1. Book ; Online ; E-Book: The boletes of China

    Li, Yan-Chun / Yang, Zhu L.

    Tylopilus S. l

    2022  

    Author's details Yan-Chun Li and Zhu L. Yang
    Keywords Biodiversity ; Boletàcies ; Biodiversitat ; Xina
    Subject code 333.740684
    Language English
    Size 1 online resource (418 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-2986-2 ; 9789811629853 ; 978-981-16-2986-0 ; 9811629854
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The structural stability of Mn

    Zhang, Junran / Lu, Yunhao / Li, Yanchun

    Journal of physics. Condensed matter : an Institute of Physics journal

    2024  Volume 36, Issue 19

    Abstract: Pressure engineering has attracted growing interest in the understanding of structural changes and structure-property relations of layered materials. In this study, we investigated the effect of pressure on the crystal structure of ... ...

    Abstract Pressure engineering has attracted growing interest in the understanding of structural changes and structure-property relations of layered materials. In this study, we investigated the effect of pressure on the crystal structure of Mn
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ad2587
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  3. Article ; Online: Inhibitory Effects of the Polyphenols from the Root of

    Liang, Yan / Ban, Yue / Liu, Lei / Li, Yanchun

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 5

    Abstract: Marine mangrove vegetation has been traditionally employed in folk medicine to address various ailments. Notably, ...

    Abstract Marine mangrove vegetation has been traditionally employed in folk medicine to address various ailments. Notably,
    MeSH term(s) Humans ; Polyphenols ; Rhizophoraceae ; Fatty Acid Synthases/metabolism ; Colonic Neoplasms ; Fatty Acids
    Chemical Substances Polyphenols ; Fatty Acid Synthases (EC 2.3.1.85) ; Fatty Acids
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29051180
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Hypoxia treatment and resistance training alters microRNA profiling in rats skeletal muscle.

    Mei, Tao / Hu, Yang / Zhang, Ying / Li, Yanchun

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8388

    Abstract: MicroRNAs (miRNAs) may play a crucial regulatory role in the process of muscle atrophy induced by high-altitude hypoxia and its amelioration through resistance training. However, research in this aspect is still lacking. Therefore, this study aimed to ... ...

    Abstract MicroRNAs (miRNAs) may play a crucial regulatory role in the process of muscle atrophy induced by high-altitude hypoxia and its amelioration through resistance training. However, research in this aspect is still lacking. Therefore, this study aimed to employ miRNA microarray analysis to investigate the expression profile of miRNAs in skeletal muscle from an animal model of hypoxia-induced muscle atrophy and resistance training aimed at mitigating muscle atrophy. The study utilized a simulated hypoxic environment (oxygen concentration at 11.2%) to induce muscle atrophy and established a rat model of resistance training using ladder climbing, with a total intervention period of 4 weeks. The miRNA expression profile revealed 9 differentially expressed miRNAs influenced by hypoxia (e.g., miR-341, miR-32-5p, miR-465-5p) and 14 differentially expressed miRNAs influenced by resistance training under hypoxic conditions (e.g., miR-338-5p, miR-203a-3p, miR-92b-3p) (∣log2(FC)∣ ≥ 1.5, p < 0.05). The differentially expressed miRNAs were found to target genes involved in muscle protein synthesis and degradation (such as Utrn, mdm2, eIF4E), biological processes (such as negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent), and signaling pathways (such as Wnt signaling pathway, MAPK signaling pathway, ubiquitin-mediated proteolysis, mTOR signaling pathway). This study provides a foundation for understanding and further exploring the molecular mechanisms underlying hypoxia-induced rats muscle atrophy and the mitigation of atrophy through resistance training.
    MeSH term(s) Humans ; Rats ; Animals ; Resistance Training ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Hypoxia/genetics ; Hypoxia/metabolism ; Muscle, Skeletal/metabolism ; Muscular Atrophy/genetics ; Muscular Atrophy/metabolism ; Gene Expression Profiling
    Chemical Substances MicroRNAs ; MIRN338 microRNA, human ; MIRN338 microRNA, rat
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58996-7
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  5. Article ; Online: Clinicopathological characteristics and outcomes of PLA2R related idiopathic membranous nephropathy in patients with seronegative PLA2R antibodies.

    Li, Xue / Shen, Yang / Li, Yanchun / Ma, Lijie / Sun, Qianmei

    Renal failure

    2024  Volume 46, Issue 1, Page(s) 2297015

    Abstract: Background: Idiopathic membranous nephropathy (IMN) with deposits of phospholipase A2 receptor (PLA2R) antigen in glomerular tissue (GAg+) but no circulating serum PLA2R antibody (SAb-) has been reported. However, little is known about the ... ...

    Abstract Background: Idiopathic membranous nephropathy (IMN) with deposits of phospholipase A2 receptor (PLA2R) antigen in glomerular tissue (GAg+) but no circulating serum PLA2R antibody (SAb-) has been reported. However, little is known about the clinicopathological characteristics and prognosis of this subtype.
    Methods: A total of 74 IMN patients with GAg + identified by kidney biopsy were enrolled in this study. We categorized patients into two groups based on the presence or absence of serum PLA2R antibody. Data on clinical features, pathological features, and outcomes were collected. Kaplan-Meier analysis of complete remission (CR) and partial remission (PR) comparing SAb-/GAg + and SAb+/GAg + patients. Cox proportional hazards models was used to examine factors associated with CR and PR.
    Results: Among 74 IMN patients, 14 were SAb-/GAg+. Compared with SAb+/GAg + patients, SAb-/GAg + patients presented with higher levels of albumin, lower levels of cholesterol and low density lipoprotein cholesterol (all
    Conclusion: IMN with PLA2R staining on kidney biopsy but without serum PLA2R antibody has milder clinical manifestations and a better prognosis.
    MeSH term(s) Humans ; Glomerulonephritis, Membranous/pathology ; Receptors, Phospholipase A2 ; Autoantibodies ; Albumins ; Cholesterol ; Retrospective Studies
    Chemical Substances Receptors, Phospholipase A2 ; Autoantibodies ; Albumins ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2023.2297015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1331: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Exploring the interplay of liquid crystal orientation and spherical elastic shell deformation in spatial confinement.

    Liu, You-Lu / Zhu, You-Liang / Li, Yan-Chun / Lu, Zhong-Yuan

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 7, Page(s) 6180–6188

    Abstract: The application of liquid crystal technology typically relies on the precise control of molecular orientation at a surface or interface. This control can be achieved through a combination of morphological and chemical methods. Consequently, variations in ...

    Abstract The application of liquid crystal technology typically relies on the precise control of molecular orientation at a surface or interface. This control can be achieved through a combination of morphological and chemical methods. Consequently, variations in constrained boundary flexibility can result in a diverse range of phase behaviors. In this study, we delve into the self-assembly of liquid crystals within elastic spatial confinement by using the Gay-Berne model with the aid of molecular dynamics simulations. Our findings reveal that a spherical elastic shell promotes a more regular and orderly alignment of liquid crystals compared to a hard shell. Moreover, during the cooling process, the hard-shell confined system undergoes an isotropic-smectic phase transition. In contrast, the phase behavior within the spherical elastic shell closely mirrors the isotropic-nematic-smectic phase transition observed in bulk systems. This indicates that the orientational arrangement of liquid crystals and the deformations induced by a flexible interface engage in a competitive interplay during the self-assembly process. Importantly, we found that phase behavior could be manipulated by altering the flexibility of the confined boundaries. This insight offers a fresh perspective for the design of innovative materials, particularly in the realm of liquid crystal/polymer composites.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04479c
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  7. Article ; Online: Alveolar rhabdomyosarcoma with multiple bone marrow infiltration.

    Wang, Kun / Chen, Zhihong / Li, Yanchun / Mao, Zhiqun

    The Lancet. Oncology

    2023  Volume 24, Issue 5, Page(s) e228

    MeSH term(s) Humans ; Bone Marrow ; Rhabdomyosarcoma, Alveolar/therapy ; Diagnosis, Differential ; Rhabdomyosarcoma
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00015-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  8. Article ; Online: Comparison of the force fields on monomeric and fibrillar PHF6 of tau protein.

    Li, Yanchun / Peng, Xubiao

    Biophysical chemistry

    2021  Volume 277, Page(s) 106631

    Abstract: ... The ... ...

    Abstract The hexapeptide
    MeSH term(s) Alzheimer Disease ; Molecular Dynamics Simulation ; Peptide Fragments ; Protein Aggregates ; tau Proteins
    Chemical Substances Peptide Fragments ; Protein Aggregates ; tau Proteins
    Language English
    Publishing date 2021-06-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/j.bpc.2021.106631
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    Zs.A 1147: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma with significant granuloma: case report and literature review.

    Nie, Chenchen / Xie, Xun / Li, Hangyan / Li, Yangcan / Chen, Zhihong / Li, Yanchun / Li, Zhenfeng

    Diagnostic pathology

    2024  Volume 19, Issue 1, Page(s) 34

    Abstract: Background: Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+IFDCS) is a rare disease characterized by mild clinical symptoms and non-specific imaging findings. The diagnosis of the disease depends on pathological ... ...

    Abstract Background: Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+IFDCS) is a rare disease characterized by mild clinical symptoms and non-specific imaging findings. The diagnosis of the disease depends on pathological diagnosis. However, EBV+IFDCS has a very broad spectrum of histological morphology and immune phenotypes, and its histopathological features have not been fully described by pathologists.
    Case presentation: A 59-year-old female, with no significant discomfort, was found to have a splenic mass during a routine physical examination. Microscopic examination at low magnification revealed numerous epithelioid granulomas, amidst which a substantial inflammatory response was observed. Interspersed among the dense inflammatory cells were spindle or oval-shaped cells, distributed sporadically with indistinct boundaries. Under high magnification, these spindle cells had subtle features: smooth and clear nuclear membranes, inconspicuous small nucleoli, and infrequent mitotic figures. Immunophenotypically, the spindle cells expressed CD21 and CD23, and Epstein-Barr encoding region (EBER) in situ hybridization yielded positive results. The inflammatory milieu predominantly consisted of T cells, with a minority of plasma cells expressing IgG4. The confluence of morphological and immunohistochemical findings led to the final pathological diagnosis of EBV+IFDCS in this case.
    Conclusions: The presentation of EBV+IFDCS with pronounced granulomatous changes is rare. This morphological variant poses a high risk of misdiagnosis, frequently leading to confusion with other granulomatous diseases. Accurate diagnosis necessitates a comprehensive analysis, integrating immunohistochemistry and in situ hybridization. The case presented here is instrumental in raising awareness and understanding of EBV+IFDCS, with the goal of reducing misdiagnoses and unrecognized cases.
    MeSH term(s) Female ; Humans ; Middle Aged ; Dendritic Cell Sarcoma, Follicular/diagnosis ; Dendritic Cell Sarcoma, Follicular/pathology ; Herpesvirus 4, Human/genetics ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/pathology ; Granuloma, Plasma Cell/diagnosis ; Granuloma/diagnosis ; Soft Tissue Neoplasms
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2210518-9
    ISSN 1746-1596 ; 1746-1596
    ISSN (online) 1746-1596
    ISSN 1746-1596
    DOI 10.1186/s13000-024-01457-6
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  10. Article ; Online: Rhamnose modified antibodies show improved immune killing towards EGFR-positive solid tumor cells.

    Hong, Haofei / Zhao, Jie / Zhou, Kun / Li, Yanchun / Li, Dan / Wu, Zhimeng

    Carbohydrate research

    2024  Volume 536, Page(s) 109038

    Abstract: Therapeutic monoclonal antibodies (mAbs) against the epidermal growth factor receptor (EGFR) have shown clinical efficacy in colorectal cancer and other solid cancers. Enhancing the effector functions of these anti-EGFR mAbs is believed to be a valuable ... ...

    Abstract Therapeutic monoclonal antibodies (mAbs) against the epidermal growth factor receptor (EGFR) have shown clinical efficacy in colorectal cancer and other solid cancers. Enhancing the effector functions of these anti-EGFR mAbs is believed to be a valuable approach to achieve improved efficacy in clinical setting. Here, we report the development of an effector function-enhanced antibody by rhamnose (Rha) functionalization. Cetuximab, a human/mouse chimeric anti-EGFR mAb, was selected and site-specifically conjugated with Rha haptens. The obtained cetuximab-Rha conjugate was shown to be able to selectively redirect amounts of endogenous anti-Rha antibodies onto EGFR-positive solid tumor cells and thereby provide more Fc domains to achieve enhancement of effector functions including complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated phagocytosis (ADCP). Particularly, CDC, one powerful cell killing mechanism which is inactive in cetuximab, was dramatically improved. This study demonstrates the potential of rhamnose-modified antibody for EGFR-positive solid tumor immunotherapy.
    MeSH term(s) Animals ; Humans ; Mice ; Cetuximab/pharmacology ; Rhamnose/pharmacology ; Antibodies, Monoclonal/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; ErbB Receptors ; Cell Line, Tumor
    Chemical Substances Cetuximab (PQX0D8J21J) ; Rhamnose (QN34XC755A) ; Antibodies, Monoclonal ; Antineoplastic Agents ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2024.109038
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    In stock of ZB MED Bonn / Germany

    Z 2002/704: Show issues
    Z 4.3: Show issues

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