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Article ; Online: In memory of Robie W. Macdonald (1948-2022): A scientist and a friend.

Li, Yi-Fan

Environmental science and ecotechnology

2023 Volume 18, Page(s) 100331

Language	English
Publishing date	2023-10-10
Publishing country	Netherlands
Document type	Editorial
ISSN	2666-4984
ISSN (online)	2666-4984
DOI	10.1016/j.ese.2023.100331
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Article: The prognostic value of including S-1 regimens in stage II and III gastric cancer patients: A propensity score matching and subgroup analyses.

Li, Yifan / Liang, Sujiao

Journal of Cancer

2023 Volume 14, Issue 10, Page(s) 1848–1858

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-06-26
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.84535
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Article: Pancreatic cancer in young adults - an evolving entity?

Li, Yifan / Zhang, Xiaojuan

American journal of cancer research

2023 Volume 13, Issue 7, Page(s) 2763–2772

Abstract: The incidence of early-onset pancreatic cancer (EOPC) among young population (<50 years) is rising in the last decade, with gender, medical overtreatment, and genetic factors as the risk factors in EOPC. Nevertheless, the role of genetic factors in the ... ...

Abstract	The incidence of early-onset pancreatic cancer (EOPC) among young population (<50 years) is rising in the last decade, with gender, medical overtreatment, and genetic factors as the risk factors in EOPC. Nevertheless, the role of genetic factors in the development of EOPC needs further exploration since the studies were carried out with small sample size and ambiguous evidence. Notable, the high incidence of pathogenic germline variant (PGV) appears to be involved in EOPC. Compared with average-age-onset pancreatic cancer (AOPC), EOPC patients display a distinctive genomic feature on several well-known tumor suppressor and oncogenic genes including, including SMAD4, RAS wild wild-type, CDKN2A BRCA1, BRCA2 and FOXC2, which is different from the findings of studies with AOPC and LOPC, suggesting the dynamic evolving entity of EOPC. In addition, the potential gender-related incidence found in several countries also suggests the involvement of genetic or socioenvironmental factors in the development of AOPC. Therefore, further prospective epidemiological and molecular studies are warranted to elucidate the shifting epidemiology of this disease and, most importantly, to better exploit the opportunities for the early diagnosis of the disease.
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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Article ; Online: Effect of topical application of autologous platelet gel on sternal wound infection after cardiac surgery: A meta-analysis.

Li, Yifan / Wu, Zhong

International wound journal

2023 Volume 21, Issue 3, Page(s) e14761

Abstract: Following heart operation, a severe life-threatening complication has been identified by investigators who have recently discovered that local application of platelet-rich plasma (PRP) can lower the rate of wound infection in heart surgery. Nevertheless, ...

Abstract	Following heart operation, a severe life-threatening complication has been identified by investigators who have recently discovered that local application of platelet-rich plasma (PRP) can lower the rate of wound infection in heart surgery. Nevertheless, due to the low quality of these trials, we have tried to perform high-quality meta-analyses to prove the efficacy of PRP in heart surgery for post-operative wound infections. In this study, five randomised controlled trials (RCTs) were chosen from three databases, and there were 1005 studies to analyse the data. Among 181 cases, PRP was applied to the surgical site, and 205 in the control group. Both the CI and the OR or the average difference (MD) were computed with either a fixed or random-effect model. A meta-analysis of the data was carried out with RevMan 5.3. The results showed that there were no statistically significant differences in the incidence of post-operative surgical site infection (SSI) in control group compared to those treated with PRP gel (OR, 0.97; 95% CI, 0.38, 2.47; p = 0.95); In the heart operation, the local application of PRP gel decreased the rate of drainage after operation (MD, -217.82; 95% CI, -335.38, -100.26; p = 0.0003); The operation time of the PRP gel was not significantly different from that of the control group (MD, 12.65; 95% CI, -2.95, 28.24; p = 0.11). Contrary to earlier research, the application of autoplatelet gel in heart surgery did not seem to decrease operative site infections after the operation, but it did decrease the amount of postoperative drainage. Nevertheless, because of the limited number of RCTs in this meta-analysis, caution should be exercised in their treatment. More high-quality randomised, large-sample trials are required to further confirm the findings.
MeSH term(s)	Humans ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/epidemiology ; Platelet-Rich Plasma ; Cardiac Surgical Procedures/adverse effects ; Drainage ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14761
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Article ; Online: Anti-Biofilm Activity of Assamsaponin A, Theasaponin E1, and Theasaponin E2 against

Chen, Yuhong / Gao, Ying / Li, Yifan / Yin, Junfeng

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Biofilm formation plays a crucial role in the pathogenesis ... ...

Abstract	Biofilm formation plays a crucial role in the pathogenesis of
MeSH term(s)	Candida albicans ; Saponins/pharmacology ; Biofilms ; Tea ; Oleanolic Acid/analogs & derivatives
Chemical Substances	theasaponin E2 ; theasaponin E1 ; Saponins ; Tea ; Oleanolic Acid (6SMK8R7TGJ)
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073599
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Article: Inquiry of the Practice of Leadership in Chengguan: A Study Based on the Ethnographic Research of Z City.

Li, Hua / Li, Yifan

Frontiers in psychology

2022 Volume 13, Page(s) 857043

Abstract: Chengguan, the Urban Administrative Law Enforcement Bureau, has been criticized for its dismal public image and poor job performance. Based on an ethnographic case study in Z City, we analyzed the type of leadership that results in passive work ... ...

Abstract	Chengguan, the Urban Administrative Law Enforcement Bureau, has been criticized for its dismal public image and poor job performance. Based on an ethnographic case study in Z City, we analyzed the type of leadership that results in passive work performance in Chengguan, and we examined whether any leadership style can be used to improve Chengguan's image and performance. We developed a new leadership ontology of CNP (Cognition-Normalization-Performance) on this foundation, and ethnographic research was conducted in three phases: leader's cognition, followers' normalization, and organization performance. Several implications were drawn. Leader selection should be cautious and can be improved by studying the leader's traits and behavior. This is done by investigating candidates' leadership career paths, trait characteristics, motive profiles, and other qualities. It is useful to change leaders by strengthening followers' unity and cohesion by setting up a labor union, youth federation, women's federation, and other groups. A leader should be selected among individuals who have completed leadership training as opposed to appointing one from outside the organization. On the one hand, the superior should help to improve the leadership environment (context), supervise problems in the organization's operation and performance, and track changes over time. On the other hand, the leader can also provide the followers with a flexible and adaptive place of work.
Language	English
Publishing date	2022-06-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.857043
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Article: Prognostic nomograms for gastric carcinoma after surgery to assist decision-making for postoperative treatment with chemotherapy cycles <9 or chemotherapy cycles ≥9.

Li, Yifan / Zhang, Xiaojuan

Frontiers in surgery

2022 Volume 9, Page(s) 916483

Abstract: Objective: We sought to develop novel nomograms to accurately predict overall survival (OS) of chemotherapy cycles <9 and chemotherapy cycles ≥9 and construct risk stratification to differentiate low-risk and high-risk of two cohorts.: Methods: ... ...

Abstract	Objective: We sought to develop novel nomograms to accurately predict overall survival (OS) of chemotherapy cycles <9 and chemotherapy cycles ≥9 and construct risk stratification to differentiate low-risk and high-risk of two cohorts. Methods: Patients who underwent curative-intent resection for gastric cancer between January 2002 and May 2020 at a single China institution were identified. Variables associated with OS were recorded and analyzed according to multivariable Cox models. Nomograms predicting 3- and 5-year OS were built according to variables resulting from multivariable Cox models. Discrimination ability was calculated using the Harrell's Concordance Index. The constructed nomogram was subjected to 1,000 resamples bootstrap for internal validation. Calibration curves for the new nomograms were used to test the consistency between the predicted and actual 3- and 5-year OS. Decision curve analysis (DCA) was performed to assess the clinical net benefit. The Concordance index (C-index) and time-dependent receiver operating characteristic (t-ROC) curves were used to evaluate and compare the discriminative abilities of the new nomograms. Finally, prognostic risk stratification of gastric cancer was conducted with X-tile software and nomograms converted into a risk-stratified prognosis model. Results: For the nomogram predict OS of chemotherapy cycles <9, C-index was 0.711 (95% CI, 0.663-0.760) in internal validation and 0.722 (95% CI, 0.662-0.783) in external validation, which was better than AJCC 8th edition TNM staging (internal validation: 0.627, 95% CI, 0.585-0.670) and (external validation: 0.595,95% CI, 0.543-0.648). The C-index of the nomogram for chemotherapy cycles ≥9 in internal validation was 0.755 (95% CI, 0.728-0.782) and 0.785 (95% CI, 0.747-0.823) in external validation, which was superior to the AJCC 8th edition TNM staging (internal validation: 0.712 95% CI, 0.688-0.737) and (external validation 0.734, 95% CI, 0.699-0.770).The calibration curves, t-ROC curves and DCA of the two nomogram models show that the recognition performance of the two nomogram models was outstanding. The statistical differences in the prognosis among the two risk stratification groups further showed that our model had an excellent risk stratification performance. Conclusion: This is first reported risk stratification for chemotherapy cycles of gastric carcinoma. Our proposed nomograms can effectively evaluate postoperative prognosis of patients with different chemotherapy cycles of gastric carcinoma. Chemotherapy cycles ≥9 is therefore recommended for high-risk patients with chemotherapy cycles <9, but not for low-risk patients. Meanwhile, combination with multiple therapies are essential to high-risk patients with chemotherapy cycles ≥9 and unnecessary for low-risk patients.
Language	English
Publishing date	2022-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.916483
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Article ; Online: Postoperative recurrence of gastric cancer depends on whether the chemotherapy cycle was more than 9 cycles: Based on a retrospective and observational study of follow-up within 3 years of 843 patients.

Li, Yifan / Zhao, Haoliang

Medicine

2022 Volume 101, Issue 5, Page(s) e28620

Abstract: Abstract: We retrospectively reviewed the medical records of patients with pathologically confirmed gastric cancer/adenocarcinoma who underwent curative surgical resection follow-up within 3 years at Shanxi cancer hospital between 2002 and 2020. The ... ...

Abstract	Abstract: We retrospectively reviewed the medical records of patients with pathologically confirmed gastric cancer/adenocarcinoma who underwent curative surgical resection follow-up within 3 years at Shanxi cancer hospital between 2002 and 2020. The clinicopathologic parameters explored included gender, age at surgery, vascular invasion, neural invasion, Tumor infiltration depth (T stage), N stage, TNM stage, chemotherapy, Lauren classification, maximum diameter of tumor, type of gastrectomy, tumor location and survival data.With a median follow-up of 29 months (range 0-36 months), the ratio of patients with recurrence was 26.80% (n = 226) and the death rate of patients was 45.31% (n = 382) in this period. According to the results of univariate analysis, gender (P = .014), age at surgery (P = .010), vascular invasion (P = .000), neural invasion (P = .000), T stage (P = .000), N stage (P = .000), TNM stage (P = .000), chemotherapy cycle (P = .000), lauren classification (P = .000), maximum diameter of tumor (P = .000), type of gastrectomy (P = .000) were independent risk factors of recurrence of follow-up within 3 years. From the multivariate analysis by logistic regression showed that TNM Stage (P = .002), chemotherapy cycle (P = .000) were risk factors of recurrence of follow-up within 3 years. Univariate analysis of survival by Kaplan-Meier showed that gender (P = .038), vascular invasion (P = .000), neural invasion (P = .000), maximum diameter of tumor (P = .000), Lauren classification (P = .000), T stage (P = .000), N stage (P = .000), TNM Stage (P = .000) and type of gastrectomy (P = .000) were key factors linked to overall survival of follow-up within 3 years. The results of the multivariate analysis by Cox regression were clearly presented that T Stage (P = .000), TNM stage (P = .001), maximum diameter of tumor (P = .001) were key factors of overall survival of follow-up within 3 years.TNM Stage, chemotherapy cycle were closely related to recurrence and of follow-up within 3 years. More than 9 cycles of chemotherapy was able to reduce the probability of recurrence. T Stage, TNM stage, maximum diameter of tumor were independent factors associated with overall survival of gastric cancer of follow-up within 3 years. For maximum diameter of tumor, the probability of death of more than 6 cm was 1.317 times less than 6 cm within 3 years of follow-up.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/surgery ; Follow-Up Studies ; Gastrectomy ; Humans ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000028620
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Article: Disrupted visual input unveils the computational details of artificial neural networks for face perception.

Li, Yi-Fan / Ying, Haojiang

Frontiers in computational neuroscience

2022 Volume 16, Page(s) 1054421

Abstract: Background: Convolutional Neural Network (DCNN), with its great performance, has attracted attention of researchers from many disciplines. The studies of the DCNN and that of biological neural systems have inspired each other reciprocally. The brain- ... ...

Abstract	Background: Convolutional Neural Network (DCNN), with its great performance, has attracted attention of researchers from many disciplines. The studies of the DCNN and that of biological neural systems have inspired each other reciprocally. The brain-inspired neural networks not only achieve great performance but also serve as a computational model of biological neural systems. Methods: Here in this study, we trained and tested several typical DCNNs (AlexNet, VGG11, VGG13, VGG16, DenseNet, MobileNet, and EfficientNet) with a face ethnicity categorization task for experiment 1, and an emotion categorization task for experiment 2. We measured the performance of DCNNs by testing them with original and lossy visual inputs (various kinds of image occlusion) and compared their performance with human participants. Moreover, the class activation map (CAM) method allowed us to visualize the foci of the "attention" of these DCNNs. Results: The results suggested that the VGG13 performed the best: Its performance closely resembled human participants in terms of psychophysics measurements, it utilized similar areas of visual inputs as humans, and it had the most consistent performance with inputs having various kinds of impairments. Discussion: In general, we examined the processing mechanism of DCNNs using a new paradigm and found that VGG13 might be the most human-like DCNN in this task. This study also highlighted a possible paradigm to study and develop DCNNs using human perception as a benchmark.
Language	English
Publishing date	2022-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452964-3
ISSN	1662-5188
ISSN	1662-5188
DOI	10.3389/fncom.2022.1054421
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Article ; Online: Vitamin D and myopia: a review.

Yu, Chu-Yao / Dong, Li / Li, Yi-Fan / Wei, Wen-Bin

International ophthalmology

2024 Volume 44, Issue 1, Page(s) 95

Abstract: Myopia is a worldwide public health problem of vision disorder caused by multiple factors, which has posed a huge socioeconomic burden, raising concerns about sight-threatening ocular complications. Vitamin D, as a kind of fat-soluble vitamin, related to ...

Abstract	Myopia is a worldwide public health problem of vision disorder caused by multiple factors, which has posed a huge socioeconomic burden, raising concerns about sight-threatening ocular complications. Vitamin D, as a kind of fat-soluble vitamin, related to time-spent-outdoors, has been considered by extensive studies to have potential relationship with myopia. We reviewed studies published in a decade which estimated the association of blood vitamin D status with myopia and summarized the universality and individuality of all research articles. Several research articles suggested the known environmental risk factors of myopia, including age, gender, ethnicity, education level, parental and school conditions, time-spent-outdoors, and sunlight exposure, and recent epidemiological studies demonstrate that increased vitamin D levels, by virtue of the extended outdoor time, may be an important modifiable factor and a protective effect that delay the progression of myopia in children and adolescents rather than in adults. The genetic studies have been conducted to get access to the evidence of gene polymorphism for explaining the association of serum vitamin D status and myopia, but the precise genetic interpretation of vitamin D and myopia remains unclear so far; on the other hand, the possible mechanisms are various like copolymerization mechanism, calcium homeostasis and imbalance of ciliary muscle function regulation, but nearly all of the investigators are inclined to remain skeptical. This article reviews the age-related epidemiological proofs, existent genetics correlations, possible underlying biological mechanisms and further values for the protective association between vitamin D and myopia, providing the possibility of prevention or postponement for myopia.
MeSH term(s)	Adolescent ; Adult ; Child ; Humans ; Vitamin D ; Vitamins ; Myopia/epidemiology ; Myopia/etiology ; Ciliary Body ; Educational Status
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2024-02-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-024-03009-9
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