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Article ; Online: Construction of Harmful Gas Monitoring System in Coal Mine Working Environment

Li Yijie

E3S Web of Conferences, Vol 252, p

2021 Volume 03057

Abstract: In order to improve the accuracy, sensitivity, reliability, stability and maintainability of the coal mine safety monitoring system, and enhance the coal mine safety guarantee ability, combined with the national coal mine environmental monitoring network ...

Abstract	In order to improve the accuracy, sensitivity, reliability, stability and maintainability of the coal mine safety monitoring system, and enhance the coal mine safety guarantee ability, combined with the national coal mine environmental monitoring network construction scheme and the coal mine safety production and environmental monitoring management regulations, the coal mine safety production status and environmental data are analyzed. In order to improve the production efficiency and provide reliable guarantee for the safety production of coal mine, the monitoring system of harmful gas in the working site of coal mine roadway is established.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction of ring monitoring network for river and lake environmental monitoring system

Li Yijie

E3S Web of Conferences, Vol 257, p

2021 Volume 03048

Abstract: With the continuous improvement of the level of science and technology in China, people’s desire for green water and blue sky is becoming more and more intense. Water pollution, air pollution, soil pollution and other issues always affect the lives of ... ...

Abstract	With the continuous improvement of the level of science and technology in China, people’s desire for green water and blue sky is becoming more and more intense. Water pollution, air pollution, soil pollution and other issues always affect the lives of residents. Environmental detection is the basic work of environmental protection. In this paper, based on the problems of environmental monitoring of rivers and lakes, we set up a ring network for environmental monitoring of rivers and lakes. The system is mainly composed of sensor nodes and monitoring center to monitor the main indicators of river and lake environment. In order to ensure people’s high requirements and high standards for the environment. To realize the complete monitoring of rivers and lakes.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Structure of Monitoring Node and Monitoring Center of Environmental Monitoring System

Li Yijie

E3S Web of Conferences, Vol 245, p

2021 Volume 02015

Abstract: The monitoring items shall be determined in a scientific and reasonable way according to the environmental monitoring standards and specifications, The purpose of environmental monitoring is to reflect the monitoring data of environmental monitoring ... ...

Abstract	The monitoring items shall be determined in a scientific and reasonable way according to the environmental monitoring standards and specifications, The purpose of environmental monitoring is to reflect the monitoring data of environmental monitoring system in real time, accurately and comprehensively. It provides scientific basis for environmental planning and macro decision-making. It makes the environmental monitoring system feasible and economical. Guided by the technical route of environmental monitoring, combined with the practical principle and priority monitoring principle, the comprehensive planning and reasonable arrangement are made. Environmental protection, scientific research and other purposes. Aiming at the monitoring node and monitoring center of environmental monitoring system, this paper analyzes the important position of environmental management and monitoring plan. This paper discusses the composition and structure of the monitoring system, in order to maximize the role of environmental management, reduce and mitigate the impact of monitoring projects on the ecological environment, and realize the sustainable development and operation of environmental system monitoring.
Keywords	Environmental sciences ; GE1-350
Subject code	333 ; 710
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: BPTF promotes glioma development through USP34-mediated de-ubiquitination of FOXC1.

Pan, Yanling / Yuan, Feng / Lin, Zhiren / Li, Yijie

Histology and histopathology

2024 , Page(s) 18748

Abstract: Glioma is the most prevalent malignant tumor of the brain, and the study of the molecular mechanisms associated with its development has important clinical significance. Our previous study found that BPTF promotes the malignant phenotype of glioma and is ...

Abstract	Glioma is the most prevalent malignant tumor of the brain, and the study of the molecular mechanisms associated with its development has important clinical significance. Our previous study found that BPTF promotes the malignant phenotype of glioma and is significantly associated with poor prognosis; the downstream regulatory mechanisms are explored in this study. Western blot and immunohistochemical staining were used to detect protein expression in cells or tissues. BPTF knockdown as well as FOXC1-overexpressing lentiviruses were used in combination for the construction of the U251 cell model, leading to functional rescue experiments. CCK8 assay, flow cytometry, scratch assay, and Transwell assay were used to detect cell proliferation, apoptosis, and migration, respectively. Finally, immunoprecipitation assays, combined with western blot (WB), were used to detect the interaction between proteins as well as the level of ubiquitination modification. The obtained results suggested that BPTF knockdown may inhibit the malignant behavior of glioma cells by downregulating FOXC1 expression. Moreover, FOXC1 expression was significantly higher in glioma tissues than in normal brain tissues and was significantly associated with higher tumor stage and worse patient prognosis. Finally, the mechanism of FOXC1 regulation by BPTF was found to result from the affected protein stability of FOXC1 through USP34-mediated de-ubiquitylation. In conclusion, the BPTF/FOXC1 axis was identified as a key promotor in glioma development and may be a potential target in the inhibition of glioma development.
Language	English
Publishing date	2024-04-15
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-748
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Article ; Online: An 800MΩ-Input-Impedance 95.3dB-DR Δ-ΔΣ AFE for Dry-Electrode Wearable EEG Recording.

Li, Yuying / Li, Yijie / Li, Hao / Hong, Zhiliang / Xu, Jiawei

IEEE transactions on biomedical circuits and systems

2024 Volume PP

Abstract: Non-invasive, closed-loop brain modulation offers an accessible and cost-effective means of evaluating and modulating one's mental and physical well-being, such as Parkinson's disease, epilepsy, and sleep disorders. However, wearable EEG systems pose ... ...

Abstract	Non-invasive, closed-loop brain modulation offers an accessible and cost-effective means of evaluating and modulating one's mental and physical well-being, such as Parkinson's disease, epilepsy, and sleep disorders. However, wearable EEG systems pose significant challenges for the analog front-end (AFE) circuits in view of μV-level EEG signals of interest, multiple sources of interference, and ill-defined skin contact. This paper presents a direct-digitization AFE tailored for dry-electrode scalp EEG recording, characterized by wide input dynamic range (DR) and high input impedance. The AFE utilizes a second-order 5-bit delta-delta sigma (Δ-ΔΣ) ADC to shape DC electrode offset (DEO) and low-frequency disturbances while retaining high accuracy. A non-inverting pseudo-differential instrumentation amplifier (IA) embedded in the ADC ensures high input impedance (Zin) and common-mode rejection ratio (CMRR). Fabricated in a standard 0.18-μm CMOS process, the AFE delivers 700-mVpp input signal range, 95.3-dB DR, 87-dB SNDR, and 800-MΩ input impedance at 50 Hz while consuming 88.4μW from a 1.2 V supply. The benefits of high DR and high input impedance have been validated by dry-electrode EEG measurement.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ISSN	1940-9990
ISSN (online)	1940-9990
DOI	10.1109/TBCAS.2024.3374891
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Clinical and genetic analysis of a child with Cerebral creatine deficiency syndrome due to variant of SLC6A8 gene].

Zhang, Yunjiang / Ding, Yifeng / Li, Yijie / Zhou, Shuizhen

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2023 Volume 40, Issue 11, Page(s) 1397–1403

Abstract: Objective: To explore the clinical features and genetic variant in a child with Cerebral creatine deficiency syndrome (CCDS).: Methods: A child who had presented at the Affiliated Children's Hospital of Fudan University on March 5, 2021 was selected ... ...

Abstract	Objective: To explore the clinical features and genetic variant in a child with Cerebral creatine deficiency syndrome (CCDS). Methods: A child who had presented at the Affiliated Children's Hospital of Fudan University on March 5, 2021 was selected as the study subject. Whole exome sequencing (WES) was carried out for the child, and candidate variant was verified by Sanger sequencing. The level of creatine in the brain was determined by magnetic resonance spectroscopy. Results: The patient, a 1-year-and-10-month male, had presented with developmental delay and epilepsy. Both his mother and grandmother had a history of convulsions. MRS showed reduced cerebral creatine in bilateral basal ganglia and thalamus. The child was found to harbor a hemizygous splicing variant of the SLC6A8 gene, namely c.1767+1_1767+2insA, which may lead to protein truncation. The variant was not found in the public databases. Both his mother and grandmother were heterozygous carriers for the same variant. Conclusion: The hemizygous c.1767+1_1767+2insA variant of the SLC6A8 gene probably underlay the CCDS in this child. Discovery of the novel variant has also expanded the mutational spectrum of the SLC6A8 gene.
MeSH term(s)	Humans ; Male ; Amino Acid Metabolism, Inborn Errors ; Brain ; Creatine/genetics ; Heterozygote ; Mothers ; Nerve Tissue Proteins ; Plasma Membrane Neurotransmitter Transport Proteins/genetics ; Infant
Chemical Substances	Creatine (MU72812GK0) ; Nerve Tissue Proteins ; Plasma Membrane Neurotransmitter Transport Proteins ; SLC6A8 protein, human
Language	Chinese
Publishing date	2023-10-31
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760/cma.j.cn511374-20211025-00847
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Article ; Online: A 107.6 dB-DR Three-Step Incremental ADC for Motion-Tolerate Biopotential Signals Recording.

Fang, Lairong / Zhang, Shuwen / Li, Yijie / Wu, Shunmin / Zeng, Xiaoyang / Hong, Zhiliang / Xu, Jiawei

IEEE transactions on biomedical circuits and systems

2024 Volume 18, Issue 1, Page(s) 111–122

Abstract: This article describes a power-efficient, high dynamic range (DR) incremental ADC (IADC) for wearable biopotential signals recording, where DC and low-frequency disturbances such as electrode offset, 50/60 Hz interference and motion artifact must be ... ...

Abstract	This article describes a power-efficient, high dynamic range (DR) incremental ADC (IADC) for wearable biopotential signals recording, where DC and low-frequency disturbances such as electrode offset, 50/60 Hz interference and motion artifact must be tolerated. To achieve a wide DR, the IADC performs a three-step conversion by combining zoom-SAR and extended counting (EC) on top of a second-order incremental delta-sigma modulator (ΔΣM). The hybrid architecture notably reduces the oversampling ratio (OSR) with respect to conventional incremental ΔΣMs, while using the EC further improves the Signal-to-Noise-and-Distortion Ratio (SNDR) by 7.4 to 25.6 dB. Fabricated in a 0.18-μm CMOS technology, the IADC achieves 107.6-dB DR, 104.9-dB peak SNR, and 99.3-dB peak SNDR at 2 kS/s while dissipating 130 μW from 1.8-V (analog) / 1.2-V (digital) supply. This translates to a highly competitive FoM
MeSH term(s)	Equipment Design ; Signal Processing, Computer-Assisted ; Electrocardiography ; Amplifiers, Electronic ; Motion
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ISSN	1940-9990
ISSN (online)	1940-9990
DOI	10.1109/TBCAS.2023.3312976
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Article ; Online: The use of supramolecular systems in biomedical applications for antimicrobial properties, biocompatibility, and drug delivery.

Li, Yijie / Vrana, Nihal Engin / Letellier, Baptiste / Lavalle, Philippe / Guilbaud-Chéreau, Chloé

Biomedical materials (Bristol, England)

2024

Abstract: Supramolecular chemistry is versatile for developing stimuli-responsive, dynamic and multifunctional structures. In the context of biomedical engineering applications, supramolecular assemblies are particularly useful as coatings for they can closely ... ...

Abstract	Supramolecular chemistry is versatile for developing stimuli-responsive, dynamic and multifunctional structures. In the context of biomedical engineering applications, supramolecular assemblies are particularly useful as coatings for they can closely mimic the natural structure and organisation of the extracellular matrix (ECM), they can also fabricate other complex systems like drug delivery systems and bioinks. In the current context of growing medical device-associated complications and the developments in the controlled drug delivery and regenerative medicine fields,supramolecular assemblies are becoming an indispensable part of the biomedical engineering arsenal. This review covers the different supramolecular assemblies in different biomedical applications with a specific focus on antimicrobial coatings, coatings that enhance biocompatibility, surface modifications on implantable medical devices, systems that promote therapeutic efficiency in cancer therapy, and the development in bioinks. The introduced supramolecularsystems include multilayer coating by polyelectrolytes, polymers incorporated with nanoparticles, coating simulation of ECM, and drug delivery systems. A perspective on the application of supramolecular systems is also included.
Language	English
Publishing date	2024-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ad49f4
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Article ; Online: Antigen cross-presentation in dendric cells: From bench to bedside.

Zhang, Tingting / Aipire, Adila / Li, Yijie / Guo, Changying / Li, Jinyao

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 168, Page(s) 115758

Abstract: Cross-presentation (XPT) is an adaptation of the cellular process in which dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules for recognition of the cytotoxic T lymphocytes (CTL) and natural ... ...

Abstract	Cross-presentation (XPT) is an adaptation of the cellular process in which dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules for recognition of the cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, resulting in immunity or tolerance. Recent advances in DCs have broadened our understanding of the underlying mechanisms of XPT and strengthened their application in tumor immunotherapy. In this review, we summarized the known mechanisms of XPT, including the receptor-mediated internalization of exogenous antigens, endosome escape, engagement of the other XPT-related proteins, and adjuvants, which significantly enhance the XPT capacity of DCs. Consequently, various strategies to enhance XPT can be adopted and optimized to improve outcomes of DC-based therapy.
MeSH term(s)	Cross-Priming ; Dendritic Cells ; Antigen Presentation ; Antigens/metabolism ; Histocompatibility Antigens Class I
Chemical Substances	Antigens ; Histocompatibility Antigens Class I
Language	English
Publishing date	2023-10-20
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115758
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Article ; Online: New insights for infection mechanism and potential targets of COVID-19: Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches.

Jia, Kexin / Li, Yijie / Liu, Tiegang / Gu, Xiaohong / Li, Xiaojiaoyang

Chinese herbal medicines

2023 Volume 15, Issue 2, Page(s) 157–168

Abstract: The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide. Currently, there is no accepted specific drug for ...

Abstract	The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide. Currently, there is no accepted specific drug for COVID-19 treatment. Therefore, it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with COVID-19. According to several reliable reports from China, traditional Chinese medicine (TCM), especially for three Chinese patent medicines and three Chinese medicine formulas, has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western medicines. In this review, we systematically summarized and analyzed the pathogenesis of COVID-19, the detailed clinical practice, active ingredients investigation, network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 combat. Additionally, we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism, which provides guidance for the development of new drugs against COVID-19. Collectively, by addressing critical challenges, for example, unclear targets and complicated active ingredients of these medicines and formulas, we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.
Language	English
Publishing date	2023-03-08
Publishing country	Singapore
Document type	Journal Article ; Review
ISSN	2589-3610
ISSN (online)	2589-3610
DOI	10.1016/j.chmed.2022.06.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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