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Article: [Real-World Efficacy and Safety of China-Made Flumatinib Mesylate in the Treatment of Chronic Myeloid Leukemia in Chronic Phase].

Li, Ying-Ying / Wang, Chun-Ling

2024 Volume 32, Issue 1, Page(s) 14–19

Abstract: Objective: To evaluate the efficacy and safty of China-made flumatinib mesylate in the treatment of chronic myeloid leukemia in chronic phase (CML-CP).: Methods: 42 CML-CP patients treated with Chinese produced flumatinib (oral, 600 mg, 1/d) were ... ...

Abstract	Objective: To evaluate the efficacy and safty of China-made flumatinib mesylate in the treatment of chronic myeloid leukemia in chronic phase (CML-CP). Methods: 42 CML-CP patients treated with Chinese produced flumatinib (oral, 600 mg, 1/d) were included in the study, including 14 newly diagnosed patients and 28 patients underwent conversion therapy. The hematological, cytogenetic and molecular response and safety were observed and evaluated after 3, 6 and 12 months of treatment. Results: 35 patients were treated for more than 3 months, among which 31 patients were treated for more than 6 months and 17 patients were treated for more than 12 months. After 3 months of treatment, 33 patients underwent hematological, cytogenetic and molecular examination. Of these, 32 patients achieved complete hematological response (CHR), 13 patients achieved complete cytogenetic response (CCyR), 20 patients showed BCR-ABL Conclusion: In the real world, China-made flumatinib mesylate has a positive short-term efficacy and reliable safety in the treatment of CML-CP patients, whether as first-line treatment or second- and third-line conversion therapy.
MeSH term(s)	Humans ; Imatinib Mesylate/therapeutic use ; Treatment Outcome ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Anemia ; Thrombocytopenia ; China ; Mesylates/therapeutic use ; Antineoplastic Agents/therapeutic use ; Fusion Proteins, bcr-abl/genetics
Chemical Substances	Imatinib Mesylate (8A1O1M485B) ; Protein Kinase Inhibitors ; Mesylates ; Antineoplastic Agents ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
Language	Chinese
Publishing date	2024-02-23
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2024.01.004
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Article ; Online: Exploring the Cooperation of the Redox Non-innocent Ligand and Di-Cobalt Center for the Water Oxidation Reaction Catalyzed by a Binuclear Complex.

Li, Ying-Ying / Liao, Rong-Zhen

ChemSusChem

2024 , Page(s) e202400123

Abstract: Water oxidation is a crucial reaction in the artificial photosynthesis system. In the present work, density functional calculations were employed to decipher the mechanism of water oxidation catalyzed by a binuclear cobalt complex, which was disclosed to ...

Abstract	Water oxidation is a crucial reaction in the artificial photosynthesis system. In the present work, density functional calculations were employed to decipher the mechanism of water oxidation catalyzed by a binuclear cobalt complex, which was disclosed to be a homogeneous water oxidation catalyst in pH=7 phosphate buffer. The calculations showed that the catalytic cycle starts from the CoIII,III-OH2 species. Then, a proton-coupled electron transfer followed by a one-electron transfer process leads to the generation of the formal CoIV,IV-OH intermediate. The subsequent PCET produces the active species, namely the formal CoIV,V=O intermediate (4). The oxidation processes mainly occur on the ligand moiety, including the coordinated water moiety, implying a redox non-innocent behavior. Two cobalt centers keep their oxidation states and provide one catalytic center for water activation during the oxidation process. 4 triggers the O-O bond formation via the water nucleophilic attack pathway, in which the phosphate buffer ion functions as the proton acceptor. The O-O bond formation is the rate-limiting step with a calculated total barrier of 17.7 kcal/mol. The last electron oxidation process coupled with an intramolecular electron transfer results in the generation of O2.
Language	English
Publishing date	2024-04-25
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202400123
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Article ; Online: Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration.

Li, Ying-Ying / Ji, Shuai-Fei / Fu, Xiao-Bing / Jiang, Yu-Feng / Sun, Xiao-Yan

Military Medical Research

2024 Volume 11, Issue 1, Page(s) 13

Abstract: Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores ... ...

Abstract	Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration, promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic transitions. The field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical properties. However, a comprehensive understanding of the underlying mechanisms remains somewhat elusive, limiting the broader application of these innovations. In this review, we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised skin. The first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for regeneration. The second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity, facilitating efficient cellular reprogramming and, consequently, promoting the regeneration of skin appendages. In summary, the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing, coupled with the restoration of multiple skin appendage functions.
MeSH term(s)	Humans ; Wound Healing/physiology ; Biocompatible Materials/therapeutic use ; Biocompatible Materials/chemistry ; Skin/injuries ; Cicatrix/pathology
Chemical Substances	Biocompatible Materials
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2054-9369
ISSN (online)	2054-9369
ISSN	2054-9369
DOI	10.1186/s40779-024-00519-6
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Article: A Rare Hemoglobin Variant Detected in a Pregnant Chinese Woman.

Li, Ying-Ying / Xie, Hong-Jian / Yang, Ling / Mai, Jia

Clinical laboratory

2023 Volume 69, Issue 7

Abstract: Background: Hemoglobin Variant (HBB:c.155 C>A) is a rare mutation caused by β-globin gene mutation called Hemoglobin North Manchester. So far, its existence has no adverse effect on human body, and it is a rare benign hemoglobin variant.: Methods: We ...

Abstract	Background: Hemoglobin Variant (HBB:c.155 C>A) is a rare mutation caused by β-globin gene mutation called Hemoglobin North Manchester. So far, its existence has no adverse effect on human body, and it is a rare benign hemoglobin variant. Methods: We reported a 32-year-old pregnant woman with discordant HbA1c and glucose measurements. In 75 g oral glucose tolerance test (OGTT), the pregnant woman got hyperglycemia at 1h-OGTT and 2h-OGTT. However, the pregnant woman had a low HbA1c of 3.9%. Subsequently, gene sequencing identified a rare mutation in the gene (HBB:c.155 C>A). Results: We report for the first time that a case of North Manchester mutation in a Chinese female patient. In this case, it was found that the North Manchester variant could affect the examination of HbA1c when measured by ion-exchange high-performance liquid chromatography (HPLC), causing in falsely low HbA1c. Conclusions: Hemoglobin variants may lead to false HbA1c measurement. Clinicians should consider hemoglobin variants when HbA1c results are inconsistent with other laboratory tests.
MeSH term(s)	Adult ; Female ; Humans ; Pregnancy ; Chromatography, High Pressure Liquid/methods ; East Asian People ; Glycated Hemoglobin/genetics ; Hemoglobins, Abnormal/genetics ; Hemoglobins, Abnormal/analysis ; Mutation
Chemical Substances	Glycated Hemoglobin ; Hemoglobins, Abnormal
Language	English
Publishing date	2023-07-06
Publishing country	Germany
Document type	Case Reports
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.221222
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Article: [Retrograde Transurethral Contrast-enhanced Ultrasound in the Diagnosis of Bladder Rupture:Report of Two Cases].

Zhang, Chao / Li, Ying-Ying / Zhang, Ming-Bo

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2022 Volume 44, Issue 5, Page(s) 929–932

Abstract: Bladder rupture refers to a series of diseases caused by bladder wall laceration and urine flowing into the abdominal cavity.Two cases of bladder rupture diagnosed by retrograde transurethral contrast-enhanced ultrasound were reviewed in this report.We ... ...

Abstract	Bladder rupture refers to a series of diseases caused by bladder wall laceration and urine flowing into the abdominal cavity.Two cases of bladder rupture diagnosed by retrograde transurethral contrast-enhanced ultrasound were reviewed in this report.We discussed the value of retrograde transurethral contrast-enhanced ultrasound in the diagnosis,classification,and prognosis evaluation of bladder rupture,aiming to provide evidence for clinical diagnosis and treatment.
MeSH term(s)	Humans ; Urinary Bladder/diagnostic imaging ; Ultrasonography ; Prognosis
Language	Chinese
Publishing date	2022-10-19
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000-503X.14665
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Article: Case report: Strategies for improving outcomes in patients with primary ovarian small-cell neuroendocrine carcinoma.

Li, YingYing / Wu, Yueling / Zhang, Ying / Li, Xiaofang

Frontiers in oncology

2022 Volume 12, Page(s) 954289

Abstract: Small-cell neuroendocrine carcinoma (SCNEC) of the ovary is a gynecological malignancy characterized by rapid progression and poor prognosis. SCNEC is divided into primary and metastatic tumor. Primary ovarian neuroendocrine cancer is extremely rare and ... ...

Abstract	Small-cell neuroendocrine carcinoma (SCNEC) of the ovary is a gynecological malignancy characterized by rapid progression and poor prognosis. SCNEC is divided into primary and metastatic tumor. Primary ovarian neuroendocrine cancer is extremely rare and has a low 5-year survival rate. This paper reports the clinical manifestations of a 58-year-old patient with primary ovarian Small-cell neuroendocrine carcinoma and the prognosis after surgical adjuvant chemotherapy. The prevailing literature on this carcinoma is also reviewed and summarized. Our analysis reveals that histopathological examination is the standard diagnostic tool for ovarian SCNEC. We also highlight the importance of comprehensive imaging evaluation, early pathological diagnosis and comprehensive aggressive treatment to the prognosis of patients.
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.954289
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Article: Persistent organic pollution in Antarctic marine biota: Level, transport and risk assessment.

Li, Ying-Ying / Ma, Yu-Xin / Zhu, Guo-Ping

Ying yong sheng tai xue bao = The journal of applied ecology

2021 Volume 32, Issue 2, Page(s) 750–762

Abstract: Although the Antarctic is considered as a pristine region away from human pollution, traditional and emerging persistent organic pollutants (POPs), such as organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers ...

Title translation	南极海洋生物持久性有机污染物:水平、传递与风险评价.
Abstract	Although the Antarctic is considered as a pristine region away from human pollution, traditional and emerging persistent organic pollutants (POPs), such as organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and per-/polyfluoroalkyl substances (PFASs), have been constantly detected in the Antarctic, which received global concerns. POPs are persistent and toxic, prone to accumulate in organisms and further pose environmental risks. In order to understand their biogeochemical processes as well as impacts on organisms in the Antarctic, we summarized the research status of POPs in different trophic levels in the Antarctic marine, combining their living habits. We also proposed the future research directions of POPs in the vulnerable Antarctic ecosystem. Researches showed that the Antar-ctic was the region under the lowest pollution level all over the world. However, the types of POPs in Antarctic marine organisms were increasing in the past decades, meaning the area was affected increasingly by the activities inside and/or outside of this area. Scattered research data and different techniques hamper red the elucidation about the mechanism of POPs transport along the food chain. It is urgent to establish long-term monitoring and assessment program on POPs dynamics of Antarctic marine ecosystem.
MeSH term(s)	Antarctic Regions ; Biota ; Ecosystem ; Environmental Monitoring ; Humans ; Hydrocarbons, Chlorinated/analysis ; Pesticides/analysis ; Polychlorinated Biphenyls ; Risk Assessment ; Water Pollutants, Chemical/analysis
Chemical Substances	Hydrocarbons, Chlorinated ; Pesticides ; Water Pollutants, Chemical ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2021-03-02
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202102.031
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Article ; Online: Mechanism and selectivity of photocatalyzed CO

Zhang, Ya-Qiong / Li, Ying-Ying / Maseras, Feliu / Liao, Rong-Zhen

Dalton transactions (Cambridge, England : 2003)

2022 Volume 51, Issue 9, Page(s) 3747–3759

Abstract: The phosphine-substituted Ru(II) polypyridyl complex, [ ... ...

Abstract	The phosphine-substituted Ru(II) polypyridyl complex, [Ru
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d1dt03825g
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Article ; Online: Distinctive Impact of Heat Treatment on the Mechanical Behavior of Nacreous and Crossed-Lamellar Structures in Biological Shells: Critical Role of Organic Matrix.

Li, Ying-Ying / Liang, Si-Min / Ji, Hong-Mei / Li, Xiao-Wu

ACS biomaterials science & engineering

2022 Volume 8, Issue 3, Page(s) 1143–1155

Abstract: As biological ceramic composites, mollusk shells exhibit an excellent strength-toughness combination that should be dependent on aragonite/organic matrix interfaces. The mechanical properties and fracture mechanisms of the nacreous structure in ... ...

Abstract	As biological ceramic composites, mollusk shells exhibit an excellent strength-toughness combination that should be dependent on aragonite/organic matrix interfaces. The mechanical properties and fracture mechanisms of the nacreous structure in the
MeSH term(s)	Animal Shells/chemistry ; Animals ; Calcium Carbonate/analysis ; Hot Temperature ; Nacre/analysis ; Water/analysis
Chemical Substances	Nacre ; Water (059QF0KO0R) ; Calcium Carbonate (H0G9379FGK)
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.1c01538
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Article ; Online: Prevalence and prognosis of frailty in older patients with stage B heart failure with preserved ejection fraction.

Meng, Chen / Chai, Ke / Li, Ying-Ying / Luo, Yao / Wang, Hua / Yang, Jie-Fu

ESC heart failure

2023 Volume 10, Issue 2, Page(s) 1133–1143

Abstract: Aims: Frailty in older patients with stage B heart failure with preserved ejection fraction (HFpEF) has not been fully explored. We evaluated the prevalence and prognostic significance of frailty in older patients diagnosed with stage B HFpEF.: ... ...

Abstract	Aims: Frailty in older patients with stage B heart failure with preserved ejection fraction (HFpEF) has not been fully explored. We evaluated the prevalence and prognostic significance of frailty in older patients diagnosed with stage B HFpEF. Methods: Our prospective cohort study included inpatients aged ≥65 years who were followed up for 3 years. Stage B HFpEF was defined as cardiac structural or functional abnormalities with a left ventricular ejection fraction (LVEF) ≥ 50% without signs or symptoms. Frailty was assessed using the Fried phenotype. The primary outcome was 3-year all-cause mortality or readmission. Results: Overall, 520 older inpatients diagnosed with stage B HFpEF [mean ± standard deviation age: 75.5 ± 6.25 years, male: 222 (42.7%)] were included in the study. Of these, 145 (27.9%) were frail. Frail patients were older (78.5 ± 6.23 vs. 74.3 ± 6.22 years, P < 0.001), with a lower body mass index (24.6 ± 3.60 vs. 25.7 ± 3.27 kg/m Conclusions: Frailty is common in elderly patients with stage B HFpEF. Physical frailty, particularly low physical activity, can independently predict the long-term prognosis in these patients.
MeSH term(s)	Humans ; Male ; Stroke Volume ; Heart Failure/diagnosis ; Ventricular Function, Left ; Frailty/epidemiology ; Prospective Studies ; Prevalence ; Activities of Daily Living ; Prognosis
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14274
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