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  1. Article ; Online: Facilely synthesized

    Li, Yongfang

    National science review

    2023  Volume 10, Issue 2, Page(s) nwad011

    Language English
    Publishing date 2023-01-14
    Publishing country China
    Document type Journal Article
    ZDB-ID 2745465-4
    ISSN 2053-714X ; 2053-714X
    ISSN (online) 2053-714X
    ISSN 2053-714X
    DOI 10.1093/nsr/nwad011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Solid-Phase Electrosynthesis.

    Li, Mao / Li, Yongfang

    Accounts of chemical research

    2023  Volume 56, Issue 24, Page(s) 3694–3703

    Abstract: ConspectusThe significance of the new synthetic approach is that it can overcome the limitations of conventional methods and produce previously inaccessible polymer structures and materials. The solid-phase synthesis developed by Merrifield in 1964 is ... ...

    Abstract ConspectusThe significance of the new synthetic approach is that it can overcome the limitations of conventional methods and produce previously inaccessible polymer structures and materials. The solid-phase synthesis developed by Merrifield in 1964 is widely employed for the synthesis of biological molecules, such as peptides, nucleic acids, and oligosaccharides. Although the variety of iterative reactions available is theoretically implemented for most organic synthesis protocols, they are usually required to have high efficiency against sluggish reaction kinetics at the solid-liquid interface and process with protection and deprotection steps. Generally, unsatisfied reaction dynamics at the solid-liquid interface cannot statistically permit accurate and uniform polymer synthesis of sophisticated structures and functions within an acceptable time scale. To address this challenge, we propose the concept of solid-phase electrosynthesis, which simultaneously enables rapidly surface-initiated uniform electrosynthesis and unidirectional assembly of metallopolymers via kinetically accelerated and statistically allowed iterative growth. In particular, on a self-assembled monolayer (SAM) of the metal complex with electroactive unit A, the iterative monomer with two electroactive units A and B can be alternatively activated by oxidative and reductive potentials for A-A and B-B covalent couplings with the SAM, respectively. This enables topochemical one-by-one additions of the iterative monomers to end-on-oriented self-assembled molecules through alternative redox reactions. Each iterative step is purified by washing. Repeating the same iterative reaction enables further reaction of the unreactive sites on the SAMs and repairs the morphology defects, thereby ensuring the statistically allowed uniform synthesis and fabrication of polymer monolayers. The resulting monolayers exhibit subnanometer-uniform morphology over centimeter-sized areas with crystalline states and show thicknesses similar to theoretical molecular lengths. This demonstrates the unidirectional formation of polymer assemblies, providing a pathway for obtaining highly ordered formation of noncrystalline polymers. The length-controlled electrosynthesis of metallopolymers can be generalized for many types of organic ligands and metal species, enabling quantitative design of the composition and sequence-controlled metallopolymers with the precise relationships of structures and properties. Solid-phase electrosynthesis offers a unique approach to synthesize polymer structures and monolayers with enhanced functionality and superior physical properties, including physical density, modulus, and conductance. Through the utilization of precise and efficient iterative growth, this predictable electrosynthesis, coupled with optical and electrical monitoring, not only expands the scope of current synthetic chemistry but also paves a potential way for the automated generation of optoelectric molecular monolayers with large-area dimensional consistency and enhanced physical performance.
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.3c00620
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  3. Article ; Online: Recent Progress in Dopant-Free and Green Solvent-Processable Organic Hole Transport Materials for Efficient and Stable Perovskite Solar Cells.

    Cheng, Qinrong / Chen, Weijie / Li, Yaowen / Li, Yongfang

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2307152

    Abstract: Dopant-free hole transport layers (HTLs) are crucial in enhancing perovskite solar cells (pero-SCs). Nevertheless, conventional processing of these HTL materials involves using toxic solvents, which gives rise to substantial environmental concerns and ... ...

    Abstract Dopant-free hole transport layers (HTLs) are crucial in enhancing perovskite solar cells (pero-SCs). Nevertheless, conventional processing of these HTL materials involves using toxic solvents, which gives rise to substantial environmental concerns and renders them unsuitable for large-scale industrial production. Consequently, there is a pressing need to develop dopant-free HTL materials processed using green solvents to facilitate the production of high-performance pero-SCs. Recently, several strategies have been developed to simultaneously improve the solubility of these materials and regulate molecular stacking for high hole mobility. In this review, a comprehensive overview of the methodologies utilized in developing dopant-free HTL materials processed from green solvents is provided. First, the study provides a brief overview of fundamental information about green solvents and Hansen solubility parameters, which can serve as a guideline for the molecular design of optimal HTL materials. Second, the intrinsic relationships between molecular structure, solubility in green solvents, molecular stacking, and device performance are discussed. Finally, conclusions and perspectives are presented along with the rational design of highly efficient, stable, and green solvent-processable dopant-free HTL materials.
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202307152
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  4. Article ; Online: Understanding the Fast-Triggering Unfolding Dynamics of FK-11 upon Photoexcitation of Azobenzene.

    Xu, Tiantian / Li, Yongfang / Gao, Xin / Zhang, Lu

    The journal of physical chemistry letters

    2024  Volume 15, Issue 13, Page(s) 3531–3540

    Abstract: Photoswitchable molecules can control the activity and functions of biomolecules by triggering conformational changes. However, it is still challenging to fully understand such fast-triggering conformational evolution from nonequilibrium to equilibrium ... ...

    Abstract Photoswitchable molecules can control the activity and functions of biomolecules by triggering conformational changes. However, it is still challenging to fully understand such fast-triggering conformational evolution from nonequilibrium to equilibrium distribution at the molecular level. Herein, we successfully simulated the unfolding of the FK-11 peptide upon the photoinduced trans-to-cis isomerization of azobenzene based on the Markov state model. We found that the ensemble of FK-11 contains five conformational states, constituting two unfolding pathways. More intriguingly, we observed the microsecond-scale conformational propagation of the FK-11 peptide from the fully folded state to the equilibrium populations of the five states. The computed CD spectra match well with the experimental data, validating our simulation method. Overall, our study not only offers a protocol to study the photoisomerization-induced conformational changes of enzymes but also could orientate the rational design of a photoswitchable molecule to manipulate biological functions.
    MeSH term(s) Peptides/chemistry ; Azo Compounds/chemistry ; Computer Simulation
    Chemical Substances azobenzene (F0U1H6UG5C) ; Peptides ; Azo Compounds
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.4c00091
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  5. Article ; Online: Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions.

    Wang, Jixian / Li, Yongfang / Yang, Guo-Yuan / Jin, Kunlin

    Aging and disease

    2024  

    Abstract: This review delves into the multifaceted aspects of age-related balance changes, highlighting their prevalence, underlying causes, and the impact they have on the elderly population. Central to this discussion is the exploration of various physiological ... ...

    Abstract This review delves into the multifaceted aspects of age-related balance changes, highlighting their prevalence, underlying causes, and the impact they have on the elderly population. Central to this discussion is the exploration of various physiological changes that occur with aging, such as alterations in the vestibular, visual, proprioceptive systems, and musculoskeletal degeneration. We examine the role of neurological disorders, cognitive decline, and medication side effects in exacerbating balance issues. The review underscores the significance of early detection and effective intervention strategies in mitigating the risks associated with balance problems, such as falls and reduced mobility. It discusses the effectiveness of diverse intervention strategies, including exercise programs, rehabilitation techniques, and technological advancements like virtual reality, wearable devices, and telemedicine. Additionally, the review stresses the importance of a holistic approach in managing balance disorders, encompassing medication review, addressing comorbidities, and environmental modifications. The paper also presents future research directions, emphasizing the need for a deeper understanding of the complex mechanisms underlying balance changes with aging and the potential of emerging technologies and interdisciplinary approaches in enhancing assessment and intervention methods. This comprehensive review aims to provide valuable insights for healthcare providers, researchers, and policymakers in developing targeted strategies to improve the quality of life and ensure the well-being of the aging population.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250 ; 2152-5250
    ISSN (online) 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2024.0124-1
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  6. Article ; Online: The connotation between perioperative glycemic control approach and sternal wound infection in individuals with diabetes mellitus experiencing cardiac surgery: A meta-analysis.

    Tan, Gang / Li, Yongfang / Zhou, Guangpeng

    International wound journal

    2023  Volume 20, Issue 8, Page(s) 3324–3330

    Abstract: A meta-analysis investigation to measure the connotation between perioperative glycemic control (GC) approach and sternal wound infection (SWI) in individuals with diabetes mellitus (DM) experiencing cardiac surgery (CS). A comprehensive literature ... ...

    Abstract A meta-analysis investigation to measure the connotation between perioperative glycemic control (GC) approach and sternal wound infection (SWI) in individuals with diabetes mellitus (DM) experiencing cardiac surgery (CS). A comprehensive literature inspection till February 2023 was applied and 2654 interrelated investigations were reviewed. The 12 chosen investigations enclosed 1564 individuals with DM and CS in the chosen investigations' starting point, 790 of them were using strict GC, and 774 were using moderate GC. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to compute the value of the Connotation between the perioperative GC approach and SWI in individuals with DM experiencing CS by the dichotomous and continuous approaches and a fixed or random model. Strict GC had significantly lower SWI (OR, 0.33; 95% CI, -0.22-0.50, P < .001) compared with those with moderate GC in individuals with DM and CS. Strict GC had significantly lower SWI compared with those with moderate GC in individuals with DM and CS. However, caused of the small sample sizes of several chosen investigations for this meta-analysis, care must be exercised when dealing with its values.
    MeSH term(s) Humans ; Cardiac Surgical Procedures/adverse effects ; Diabetes Mellitus ; Glycemic Control ; Risk Factors ; Surgical Wound Infection/etiology
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14213
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: [Pathways and mechanisms of RNA interference mediated by viral siRNA].

    Shen, Dongliang / Li, Yongfang

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2021  Volume 37, Issue 4, Page(s) 1237–1248

    Abstract: RNA interference (RNAi) is one of the important mechanisms to regulate gene expression in eukaryotes. One of the original functions of RNAi is to facilitate the antiviral strategy of host. Early studies reveal that invertebrates can use RNAi to resist ... ...

    Abstract RNA interference (RNAi) is one of the important mechanisms to regulate gene expression in eukaryotes. One of the original functions of RNAi is to facilitate the antiviral strategy of host. Early studies reveal that invertebrates can use RNAi to resist viruses. However, if this mechanism exists in mammals is still controversial. The latest studies confirm that mammals do have the RNAi-based immunity, and researchers believe that RNAi-based antiviral immunity is a brand-new immunological mechanism that was neglected in the past. It is worthy to note that virus can also use RNAi to enhance its infectivity and immune escape in host cells. This review introduces the research history of RNAi-based antiviral immunity in animals and summarizes the main findings in this field. Last but not least, we indicate a series of unresolved questions about RNAi-based antiviral immunity, and explore the relationship between RNAi-based antiviral immunity and other innate immunological pathways. The virus-mediated RNAi pathway in animal is not only an interesting basic biology question, but also has important guiding roles in the development of antiviral drugs.
    MeSH term(s) Animals ; Antiviral Agents ; Immunity, Innate/genetics ; Mammals ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Viral
    Chemical Substances Antiviral Agents ; RNA, Small Interfering ; RNA, Viral
    Language Chinese
    Publishing date 2021-05-10
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.200665
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: High-Performance All-Small-Molecule Organic Solar Cells Fabricated via Halogen-Free Preparation Process.

    Du, Bo / Ma, Mengyuan / Zhang, Panpan / Wu, Shangrong / Bin, Haijun / Li, Yongfang

    ACS applied materials & interfaces

    2024  Volume 16, Issue 2, Page(s) 2564–2572

    Abstract: Small-molecule organic photovoltaic materials attract more attention attributing to their precisely defined structure, ease of synthesis, and reduced batch-to-batch variations. The majority of all-small-molecule organic solar cells (ASM-OSCs) have ... ...

    Abstract Small-molecule organic photovoltaic materials attract more attention attributing to their precisely defined structure, ease of synthesis, and reduced batch-to-batch variations. The majority of all-small-molecule organic solar cells (ASM-OSCs) have traditionally relied on halogenated solvents for dissolving photovoltaic materials as well as used for the additives or solvent vapor annealing. However, these halogen-based processes pose risks to the environment and human health, potentially impeding future commercial production. Herein, we conducted an investigation into the impact of various nonhalogen solvents on the performance of the devices. By selecting the high boiling point solvent toluene, we achieved a desirable phase separation and stable morphology characterized by fibrous crystals within the blend film. Consequently, the power conversion efficiencies of 14.4 and 11.7% were obtained from H31:Y6-based small-area (0.04 cm
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c14992
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  9. Article ; Online: RNA N

    Sharma, Bishwas / Govindan, Ganesan / Li, Yongfang / Sunkar, Ramanjulu / Gregory, Brian D

    Non-coding RNA

    2024  Volume 10, Issue 1

    Abstract: Recently, post-transcriptional regulation of mRNA mediated by ... ...

    Abstract Recently, post-transcriptional regulation of mRNA mediated by N
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna10010008
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  10. Article: Study on Fatigue Life of Aluminum Alloy 6061-T6 Based on Random Defect Characteristics.

    Lu, Lei / Chen, Hao / Ren, Mingming / Xu, Sha / Li, Yongfang / Zhou, Tianjun / Yang, Yali

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 5

    Abstract: A certain number of hole-like defects will occur in aluminum alloys under cyclic loading. The internal holes will reduce the strength of the material and cause stress concentration, which will aggravate the development of fatigue damage. A classification ...

    Abstract A certain number of hole-like defects will occur in aluminum alloys under cyclic loading. The internal holes will reduce the strength of the material and cause stress concentration, which will aggravate the development of fatigue damage. A classification method of defect features based on X-ray CT damage data is proposed. The random hole distribution model is established through the linear congruence method and the region division method. The hole parameter is introduced as the intermediate variable of the 3D reconstruction model of internal defects. In the mesoscopic stage, the function relationship between the distribution of random holes and the fatigue life is established based on the coupling relationship between the number and proportion of pores and the fatigue life. In the macroscopic stage, the relationship between the random holes and the macroscopic crack growth life is established by taking the crack length as the damage variable. The crack propagation rate decreased with the increase in the number of holes. The prediction model of the whole life stage is established using the life function from microcrack initiation to macroscopic crack propagation. Finally, the validity of the whole stage fatigue life prediction model is demonstrated through the comparison and verification of experiments, which provides a certain engineering value for the life estimation of 6061-T6 aluminum alloy materials.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17051133
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