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  1. Article ; Online: Comment on "Salvage of Declined Extended Criteria DCD Livers Using In-Situ Normothermic Regional Perfusion".

    Li, Jian / Li, Yongnan

    Annals of surgery open : perspectives of surgical history, education, and clinical approaches

    2023  Volume 4, Issue 1, Page(s) e240

    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3593
    ISSN (online) 2691-3593
    DOI 10.1097/AS9.0000000000000240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extracorporeal Membrane Oxygenation and New Mental Health Diagnoses in Adult Survivors of Critical Illness.

    Li, Jian / Li, Yongnan

    JAMA

    2023  Volume 329, Issue 10, Page(s) 844

    MeSH term(s) Adult ; Humans ; Critical Illness/psychology ; Critical Illness/therapy ; Extracorporeal Membrane Oxygenation/adverse effects ; Extracorporeal Membrane Oxygenation/psychology ; Follow-Up Studies ; Mental Disorders/diagnosis ; Mental Disorders/etiology ; Mental Disorders/psychology ; Mental Disorders/therapy ; Retrospective Studies ; Survivors/psychology
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.24707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Reply: Different criteria for initiating extracorporeal cardiopulmonary resuscitation influence clinical results.

    Li, Mingming / Zhai, Kerong / Wei, Shilin / Li, Yongnan

    JTCVS open

    2023  Volume 13, Page(s) 215–216

    Language English
    Publishing date 2023-02-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2023.02.001
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  4. Article: Immune diversity in lophotrochozoans, with a focus on recognition and effector systems.

    Li, Yongnan / Xue, Yu / Peng, Zhangjie / Zhang, Linlin

    Computational and structural biotechnology journal

    2023  Volume 21, Page(s) 2262–2275

    Abstract: Lophotrochozoa is one of the most species-rich but immunologically poorly explored phyla. Although lack of acquired response in a narrow sense, lophotrochozoans possess various genetic mechanisms that enhance the diversity and specificity of innate ... ...

    Abstract Lophotrochozoa is one of the most species-rich but immunologically poorly explored phyla. Although lack of acquired response in a narrow sense, lophotrochozoans possess various genetic mechanisms that enhance the diversity and specificity of innate immune system. Here, we review the recent advances of comparative immunology studies in lophotrochozoans with focus on immune recognition and effector systems. Haemocytes and coelomocytes are general important yet understudied player. Comparative genomics studies suggest expansion and functional divergence of lophotrochozoan immune reorganization systems is not as "homogeneous and simple" as we thought including the large-scale expansion and molecular divergence of pattern recognition receptors (PRRs) (TLRs, RLRs, lectins, etc.) and signaling adapters (MyD88s etc.), significant domain recombination of immune receptors (RLR, NLRs, lectins, etc.), extensive somatic recombination of fibrinogenrelated proteins (FREPs) in snails. Furthermore, there are repeatedly identified molecular mechanisms that generate immune effector diversity, including high polymorphism of antimicrobial peptides and proteins (AMPs), reactive oxygen and nitrogen species (RONS) and cytokines. Finally, we argue that the next generation omics tools and the recently emerged genome editing technicism will revolutionize our understanding of innate immune system in a comparative immunology perspective.
    Language English
    Publishing date 2023-03-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2023.03.031
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  5. Article ; Online: Which strategy is better for lung transplantation: Cardiopulmonary bypass or extracorporeal membrane oxygenation?

    Yang, Jianbao / Xie, Xinling / Li, Jian / Li, Yongnan / Li, Bin / Wang, Cheng / Jiang, Peng

    Perfusion

    2024  , Page(s) 2676591241242018

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 645038-6
    ISSN 1477-111X ; 0267-6591
    ISSN (online) 1477-111X
    ISSN 0267-6591
    DOI 10.1177/02676591241242018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Metal-Binding Proteins Cross-Linking with Endoplasmic Reticulum Stress in Cardiovascular Diseases.

    Li, Kejuan / Li, Yongnan / Ding, Hong / Chen, Jianshu / Zhang, Xiaowei

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 4

    Abstract: The endoplasmic reticulum (ER), an essential organelle in eukaryotic cells, is widely distributed in myocardial cells. The ER is where secreted protein synthesis, folding, post-translational modification, and transport are all carried out. It is also ... ...

    Abstract The endoplasmic reticulum (ER), an essential organelle in eukaryotic cells, is widely distributed in myocardial cells. The ER is where secreted protein synthesis, folding, post-translational modification, and transport are all carried out. It is also where calcium homeostasis, lipid synthesis, and other processes that are crucial for normal biological cell functioning are regulated. We are concerned that ER stress (ERS) is widespread in various damaged cells. To protect cells' function, ERS reduces the accumulation of misfolded proteins by activating the unfolded protein response (UPR) pathway in response to numerous stimulating factors, such as ischemia or hypoxia, metabolic disorders, and inflammation. If these stimulatory factors are not eliminated for a long time, resulting in the persistence of the UPR, it will aggravate cell damage through a series of mechanisms. In the cardiovascular system, it will cause related cardiovascular diseases and seriously endanger human health. Furthermore, there has been a growing number of studies on the antioxidative stress role of metal-binding proteins. We observed that a variety of metal-binding proteins can inhibit ERS and, hence, mitigate myocardial damage.
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10040171
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  7. Article: Post-ischemic inflammatory response in the brain: Targeting immune cell in ischemic stroke therapy.

    Shen, Xueyang / Li, Mingming / Shao, Kangmei / Li, Yongnan / Ge, Zhaoming

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1076016

    Abstract: An ischemic stroke occurs when the blood supply is obstructed to the vascular basin, causing the death of nerve cells and forming the ischemic core. Subsequently, the brain enters the stage of reconstruction and repair. The whole process includes ... ...

    Abstract An ischemic stroke occurs when the blood supply is obstructed to the vascular basin, causing the death of nerve cells and forming the ischemic core. Subsequently, the brain enters the stage of reconstruction and repair. The whole process includes cellular brain damage, inflammatory reaction, blood-brain barrier destruction, and nerve repair. During this process, the proportion and function of neurons, immune cells, glial cells, endothelial cells, and other cells change. Identifying potential differences in gene expression between cell types or heterogeneity between cells of the same type helps to understand the cellular changes that occur in the brain and the context of disease. The recent emergence of single-cell sequencing technology has promoted the exploration of single-cell diversity and the elucidation of the molecular mechanism of ischemic stroke, thus providing new ideas and directions for the diagnosis and clinical treatment of ischemic stroke.
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1076016
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  8. Article: Early growth response-1: Key mediators of cell death and novel targets for cardiovascular disease therapy.

    Xie, Yixin / Li, Yongnan / Chen, Jianshu / Ding, Hong / Zhang, Xiaowei

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1162662

    Abstract: Significance: Cardiovascular diseases are seen to be a primary cause of death, and their prevalence has significantly increased across the globe in the past few years. Several studies have shown that cell death is closely linked to the pathogenesis of ... ...

    Abstract Significance: Cardiovascular diseases are seen to be a primary cause of death, and their prevalence has significantly increased across the globe in the past few years. Several studies have shown that cell death is closely linked to the pathogenesis of cardiovascular diseases. Furthermore, many molecular and cellular mechanisms are involved in the pathogenesis of the cardiac cell death mechanism. One of the factors that played a vital role in the pathogenesis of cardiac cell death mechanisms included the early growth response-1 (
    Recent advances: Studies have shown that abnormal
    Future directions: The primary regulatory role played by the
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1162662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Research progress of extracorporeal cardiopulmonary resuscitation combined with therapeutic hypothermia on brain protection].

    Yao, Min / Zhai, Kerong / Li, Mingming / Li, Yongnan / Ge, Zhaoming

    Zhonghua wei zhong bing ji jiu yi xue

    2023  Volume 35, Issue 5, Page(s) 554–557

    Abstract: Compared with conventional cardiopulmonary resuscitation (CCPR), extracorporeal cardiopulmonary resuscitation (ECPR) can improve the survival rate of patients with cardiac arrest, and reduce the risk of reperfusion injury. However, it is still difficult ... ...

    Abstract Compared with conventional cardiopulmonary resuscitation (CCPR), extracorporeal cardiopulmonary resuscitation (ECPR) can improve the survival rate of patients with cardiac arrest, and reduce the risk of reperfusion injury. However, it is still difficult to avoid the risk of secondary brain damage. Low temperature management has good neuroprotective potential for ECPR patients, which minimizes brain damage. However, unlike CCPR, ECPR has no clear prognostic indicator. The relationship between ECPR combined with hypothermia management-related treatment measure and neurological prognosis is not clear. This article reviews the effect of ECPR combined with different therapeutic hypothermia on brain protection and provides a reference for the prevention and treatment of neurological injury in patients with ECPR.
    MeSH term(s) Humans ; Brain ; Cardiopulmonary Resuscitation ; Brain Injuries ; Hypothermia, Induced ; Heart Arrest
    Language Chinese
    Publishing date 2023-06-12
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 2095-4352
    ISSN 2095-4352
    DOI 10.3760/cma.j.cn121430-20210823-01237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Neutrophil extracellular traps in acute coronary syndrome.

    Wu, Yawen / Wei, Shilin / Wu, Xiangyang / Li, Yongnan / Han, Xue

    Journal of inflammation (London, England)

    2023  Volume 20, Issue 1, Page(s) 17

    Abstract: Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and death worldwide. Neutrophil extracellular traps ( ... ...

    Abstract Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and death worldwide. Neutrophil extracellular traps (NETs) are reticular structures released by neutrophils activation and have various biological functions. NETs are closely related to the occurrence and development of ACS and also the subsequent damage after myocardial infarction. The mechanisms are complex and interdependent on various pathways, which require further exploration. This article reviewed the role and mechanism of NETs in ACS, thereby providing a valuable reference for the diagnosis and clinical treatment of ACS.
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2164385-4
    ISSN 1476-9255
    ISSN 1476-9255
    DOI 10.1186/s12950-023-00344-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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