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  1. Article ; Online: Comparing Equil patch versus traditional catheter insulin pump in type 2 diabetes using continuous glucose monitoring metrics and profiles.

    Li, Yu-Jiao / Shao, Zi-Yue / Zhu, Yun-Qing / Chen, Da-Shuang / Zhu, Jian

    Journal of diabetes

    2024  Volume 16, Issue 4, Page(s) e13536

    Abstract: Aims: It is not clear whether there are differences in glycemic control between the Equil patch and the MMT-712 insulin pump. Our objective was to compare two types of insulin pumps in the treatment of type 2 diabetes mellitus (T2DM), using continuous ... ...

    Abstract Aims: It is not clear whether there are differences in glycemic control between the Equil patch and the MMT-712 insulin pump. Our objective was to compare two types of insulin pumps in the treatment of type 2 diabetes mellitus (T2DM), using continuous glucose monitoring (CGM) metrics and profiles.
    Methods: This was a randomized case-crossover clinical trial. Participants were hospitalized and randomly allocated to two groups and underwent two types of insulin pump treatments (group A: Equil patch-Medtronic MMT-712 insulin pump; group B: Medtronic MMT-712-Equil patch insulin pump) separated by a 1-day washout period. Glycemic control was achieved after 7-8 days of insulin pump therapy. Each patient received CGM for 5 consecutive days (from day 1 to day 5). On day 3 of CGM performance, the Equil patch insulin pump treatment was switched to Medtronic MMT-712 insulin pump treatment at the same basal and bolus insulin doses or vice versa. CGM metrics and profiles including glycemic variability (GV), time in range (TIR, 3.9-10.0 mmol/L), time below range (TBR, <3.9 mmol/L), time above range (TAR, >10.0 mmol/L), and postprandial glucose excursions, as well as incidence of hypoglycemia.
    Results: Forty-six T2DM patients completed the study. There was no significant difference in parameters of daily GV and postprandial glucose excursions between the Equil patch insulin pump treatment and the Medtronic insulin pump treatment. Similarly, there was no between-treatment difference in TIR, TBR, and TAR, as well as the incidence of hypoglycemia.
    Conclusion: The Equil patch insulin pump was similar to the traditional MMT-712 insulin pump in terms of glycemic control. Equil patch insulin pump is a reliable tool for glycemic management of diabetes mellitus.
    MeSH term(s) Humans ; Blood Glucose ; Blood Glucose Self-Monitoring ; Catheters ; Continuous Glucose Monitoring ; Diabetes Mellitus, Type 2/drug therapy ; Glucose ; Hypoglycemia/chemically induced ; Hypoglycemia/prevention & control ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Cross-Over Studies
    Chemical Substances Blood Glucose ; Glucose (IY9XDZ35W2) ; Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2024-04-10
    Publishing country Australia
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2503337-2
    ISSN 1753-0407 ; 1753-0393
    ISSN (online) 1753-0407
    ISSN 1753-0393
    DOI 10.1111/1753-0407.13536
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  2. Article ; Online: Hand grip strength is inversely associated with total daily insulin dose requirement in patients with type 2 diabetes mellitus: a cross-sectional study.

    Chen, Da-Shuang / Zhu, Yun-Qing / Ni, Wen-Ji / Li, Yu-Jiao / Yin, Guo-Ping / Shao, Zi-Yue / Zhu, Jian

    PeerJ

    2023  Volume 11, Page(s) e15761

    Abstract: Background: Short-term (2 weeks to 3 months) insulin intensive therapy using continuous subcutaneous insulin infusion (CSII) can improve islet beta cell function and prolong glycemic remission in patients with newly diagnosed type 2 diabetes mellitus ( ... ...

    Abstract Background: Short-term (2 weeks to 3 months) insulin intensive therapy using continuous subcutaneous insulin infusion (CSII) can improve islet beta cell function and prolong glycemic remission in patients with newly diagnosed type 2 diabetes mellitus (T2DM). However, the total daily insulin dose (TDD, IU/kg/d) required to achieve near-normoglycemic control with CSII still needs to be frequently adjusted based on blood glucose monitoring. Although real-time continuous glucose monitoring (rtCGM), which measures the interstitial fluid glucose concentration continuously without much difficulty, facilitates the adjustment of insulin dosage, its adoption in the T2DM population is strictly limited by insurance coverage and lack of awareness of rtCGM among clinicians. Thus, it is of clinical significance to identify easy-to-use parameters that may allow a more rapid and accurate prediction of TDD requirement. This study aimed to explore the association between hand grip strength (HGS) and TDD requirement in patients with T2DM receiving CSII therapy.
    Methods: A total of 180 eligible patients with T2DM were enrolled in the study and divided into three groups based on their HGS: low (L), medium (M), and high (H). The TDD requirement was calculated on day 7 or 8 of CSII treatment. Anthropometric parameters, including HGS, skeletal muscle mass, skeletal muscle index (SMI) and 6-m gait speed, and laboratory data, were collected on the morning of the second day after admission, within the first 24 h of CSII therapy. These parameters were used to identify significant predictors of TDD requirement using Pearson or Spearman correlation test, and stepwise multiple regression analysis.
    Results: There were no significant differences in age, duration of T2DM, waist-to-hip ratio (WHR), body mass index (BMI), blood pressure, liver function, estimated glomerular filtration rate, triglyceride, total cholesterol, glycosylated hemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), and homeostasis model assessment of beta cell function (HOMA-β) among the groups. The H group had higher body muscle mass-to-fat ratio (BMFR), skeletal muscle mass-to-fat ratio (SMFR), SMI, 6-m gait speed, and lower TDD requirement than the M and L groups. The HGS negatively correlated with TDD requirement (r = -0.33,
    Conclusion: Lower HGS is associated with an increased TDD requirement in T2DM patients. HGS may facilitate the prediction of TDD requirement in T2DM patients receiving CSII therapy.
    MeSH term(s) Humans ; Insulin/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/therapeutic use ; Blood Glucose Self-Monitoring ; Cross-Sectional Studies ; Glycated Hemoglobin ; Hand Strength ; Blood Glucose/metabolism ; Insulin, Regular, Human/therapeutic use
    Chemical Substances Insulin ; Hypoglycemic Agents ; Glycated Hemoglobin ; Blood Glucose ; Insulin, Regular, Human
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15761
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  3. Article ; Online: Improvement of Learning and Memory by Elevating Brain D-Aspartate in a Mouse Model of Fragile X Syndrome.

    Li, Yu-Jiao / Zhang, Kun / Sun, Ting / Guo, Yan-Yan / Yang, Qi / Liu, Shui-Bing / Wu, Yu-Mei / Zhao, Ming-Gao

    Molecular neurobiology

    2023  Volume 60, Issue 11, Page(s) 6410–6423

    Abstract: Fragile X syndrome (FXS) is an inherited human mental retardation that arises from expansion of a CGG repeat in the Fmr1 gene, causing loss of the fragile X mental retardation protein (FMRP). It is reported that N-methyl-D-aspartate receptor (NMDAR)- ... ...

    Abstract Fragile X syndrome (FXS) is an inherited human mental retardation that arises from expansion of a CGG repeat in the Fmr1 gene, causing loss of the fragile X mental retardation protein (FMRP). It is reported that N-methyl-D-aspartate receptor (NMDAR)-mediated facilitation of long-term potentiation (LTP) and fear memory are impaired in Fmr1 knockout (KO) mice. In this study, biological, pharmacological, and electrophysiological techniques were performed to determine the roles of D-aspartate (D-Asp), a modulator of NMDAR, and its metabolizing enzyme D-aspartate oxidase (DDO) in Fmr1 KO mice. Levels of D-Asp were decreased in the medial prefrontal cortex (mPFC ); however, the levels of its metabolizing enzyme DDO were increased. Electrophysiological recordings indicated that oral drinking of D-Asp recovered LTP induction in mPFC from Fmr1 KO mice. Moreover, chronic oral administration of D-Asp reversed behavioral deficits of cognition and locomotor coordination in Fmr1 KO mice. The therapeutic action of D-Asp was partially through regulating functions of NMDARs and mGluR5/mTOR/4E-BP signaling pathways. In conclusion, supplement of D-Asp may benefit for synaptic plasticity and behaviors in Fmr1 KO mice and offer a potential therapeutic strategy for FXS.
    MeSH term(s) Mice ; Animals ; Humans ; D-Aspartic Acid ; Fragile X Syndrome/drug therapy ; Fragile X Syndrome/metabolism ; Learning ; Long-Term Potentiation/physiology ; Fragile X Mental Retardation Protein/metabolism ; Mice, Knockout ; Brain/metabolism ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemical Substances D-Aspartic Acid (4SR0Q8YD1X) ; Fragile X Mental Retardation Protein (139135-51-6) ; Fmr1 protein, mouse
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03438-0
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  4. Article ; Online: Prognostic nomograms for nasopharyngeal carcinoma with nodal features and potential indication for N staging system: Validation and comparison of seven N stage schemes.

    Peng, Wen-Sa / Xing, Xing / Li, Yu-Jiao / Ding, Jian-Hui / Mo, Miao / Xu, Ting-Ting / Zhou, Xin / Hu, Chao-Su

    Oral oncology

    2023  Volume 144, Page(s) 106438

    Abstract: Purpose: To identify the prognostic value of the nodal features, propose a nomogram-based N stage system and evaluate the performance of seven N stage schemes of nasopharyngeal carcinoma (NPC) patients.: Methods: Data from 1638 non-distant metastatic ...

    Abstract Purpose: To identify the prognostic value of the nodal features, propose a nomogram-based N stage system and evaluate the performance of seven N stage schemes of nasopharyngeal carcinoma (NPC) patients.
    Methods: Data from 1638 non-distant metastatic NPC patients were used to develop nomograms predicting 3-year and 5-year overall survival (OS) and distant metastasis-free survival (DMFS). Based on nomogram and multivariate analyses, a new N-stage scheme was proposed. The performance of the nomogram-based N staging system was assessed against five newly proposed N staging systems and the current 8th N staging system using a quantitative model to compare hazard consistency, discrimination, outcome prediction, and sample size balance. The Kaplan-Meier method with log-rank tests was used to compare survival differences.
    Results: Nomograms to predict OS and DMFS were constructed using extranodal extension infiltrating the surrounding structures (ENEmax), maximal axial diameter (MAD), large retropharyngeal lymph nodes (RLN, minimal axial diameter > 1.5 cm), multiple central nodal necrosis (CNN), and total lymph node (LN) number and level. Multivariate analysis showed the independent prognostic value of ENEmax and MAD > 3 cm for all selected survival endpoints (p < 0.05). Large RLN and lower neck involvement were independently associated with OS (p < 0.05). We proposed using a large RLN and MAD > 3 cm as N2 factors, and ENEmax and lower neck involvement as N3 factors. Among the seven N-stage schemes, our nomogram-based N scheme and ENEmax to N3 scheme (ENE3) ranked in the top two in the overall comparison with the elevated outcome predicting value (highest c-index). However, between the N0, N1, N1, and N2 subgroups, the ENE3 scheme showed no difference in OS or DMFS (p > 0.05).
    Conclusion: The predictive model highlighted the independent prognostic value of ENEmax, cervical lymph node, MAD, and large RLN, which can be used as criteria for future N staging.
    MeSH term(s) Humans ; Nasopharyngeal Carcinoma/pathology ; Prognosis ; Nomograms ; Nasopharyngeal Neoplasms/pathology ; Neoplasm Staging ; Retrospective Studies ; Lymphatic Metastasis/pathology ; Magnetic Resonance Imaging ; Lymph Nodes/pathology
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2023.106438
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    Zs.A 4869: Show issues Location:
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    Zs.A 456: Show issues Location:
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  5. Article ; Online: DUSP2 Deletion Inhibits Macrophage Migration by Inhibiting ERK Activation in Zebrafish

    Li, Yu-Jiao / Wang, Xin-Liang / Shi, Ling-Yu / Wang, Zong-Yi / Zhao, Zi-Ang / Ge, Shu-Chao / Hu, Bing

    Fishes. 2023 June 12, v. 8, no. 6

    2023  

    Abstract: Dual-specificity phosphatase 2 (DUSP2) regulates the activation of members of the mitogen-activated protein kinase (MAPK) family, which is involved in a variety of cellular processes including cell proliferation, differentiation, apoptosis, and migration. ...

    Abstract Dual-specificity phosphatase 2 (DUSP2) regulates the activation of members of the mitogen-activated protein kinase (MAPK) family, which is involved in a variety of cellular processes including cell proliferation, differentiation, apoptosis, and migration. DUSP2 also regulates the expression of inflammatory mediators in macrophages; however, it remains unknown whether DUSP2 participates in macrophage migration. Here, using the tail fin injury model in zebrafish larvae, we found that the deletion of DUSP2 inhibited the expression of pro-inflammatory cytokines and macrophage chemokines. Moreover, live imaging results showed that the migration of macrophages to the injury site was inhibited after DUSP2 deletion. This inhibitory effect was mediated through the reduced activation of extracellular regulated protein kinases (ERK) in DUSP2 knockout zebrafish.
    Keywords Danio rerio ; apoptosis ; cell proliferation ; chemokines ; macrophages ; mitogen-activated protein kinase ; models ; tail
    Language English
    Dates of publication 2023-0612
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ISSN 2410-3888
    DOI 10.3390/fishes8060310
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: 8-O-acetyl shanzhiside methylester protects against sleep deprivation-induced cognitive deficits and anxiety-like behaviors by regulating NLRP3 and Nrf2 pathways in mice.

    Li, Yu-Jiao / He, Xiao-Lu / Zhang, Jie-Yu / Liu, Xue-Jiao / Liang, Jia-Long / Zhou, Qing / Zhou, Guo-Hua

    Metabolic brain disease

    2022  Volume 38, Issue 2, Page(s) 641–655

    Abstract: Sleep deprivation (SD) is prevalent throughout the world, which has negative effects on cognitive abilities, and causing mood alterations. 8-O-acetyl shanzhiside methylester (8-OaS), a chief component in Lamiophlomis rotata (L. rotata) Kudo, possesses ... ...

    Abstract Sleep deprivation (SD) is prevalent throughout the world, which has negative effects on cognitive abilities, and causing mood alterations. 8-O-acetyl shanzhiside methylester (8-OaS), a chief component in Lamiophlomis rotata (L. rotata) Kudo, possesses potent neuroprotective properties and analgesic effects. Here, we evaluated the alleviative effects of 8-OaS on memory impairment and anxiety in mice subjected to SD (for 72-h). Our results demonstrated that 8-OaS (0.2, 2, 20 mg/kg) administration dose-dependently ameliorated behavioral abnormalities in SD mice, accompanied with restored synaptic plasticity and reduced shrinkage and loss of hippocampal neurons. 8-OaS reduced the inflammatory response and oxidative stress injury in hippocampus caused by SD, which may be related to inhibition of NLRP3 inflammasome-mediated inflammatory process and activation of the Nrf2/HO-1 pathway. SD also led to increases in the expressions of TLR-4/MyD88, active NF-κB, pro-IL-1β, TNFα and MDA, as well as a decrease in the level of SOD in mice hippocampus, which were reversed by 8-OaS administration. Moreover, our molecular docking analyses showed that 8-OaS also has good affinity for NLRP3 and Nrf2 signaling pathways. These results suggested that 8-OaS could be used as a novel herbal medicine for the treatment of sleep loss and for use as a structural base for developing new drugs.
    MeSH term(s) Animals ; Mice ; Anxiety/drug therapy ; Anxiety/etiology ; Cognition ; Molecular Docking Simulation ; NF-E2-Related Factor 2/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Sleep Deprivation/complications ; Sleep Deprivation/drug therapy
    Chemical Substances NF-E2-Related Factor 2 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Nfe2l2 protein, mouse ; 8-O-acetyl shanzhiside methyl ester (57420-46-9)
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-022-01132-z
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    Zs.A 2155: Show issues Location:
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  7. Article: Effects of Levistilide A on Hemorheology and Endothelial Cell Injury in Rats with Blood Stasis.

    Liu, XiaoTong / Zhang, MiJia / Li, YuJiao / He, WenLu / Lu, GuangHua / Wang, Qiong / Wang, QiaoZhi

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 6595383

    Abstract: Background: Vascular endothelial cell injury is not only the initiating factor of cardiovascular and cerebrovascular diseases but also the essence of blood stasis. Levistilide A (LA), a natural component isolated from the traditional Chinese herb, : ... ...

    Abstract Background: Vascular endothelial cell injury is not only the initiating factor of cardiovascular and cerebrovascular diseases but also the essence of blood stasis. Levistilide A (LA), a natural component isolated from the traditional Chinese herb,
    Materials and methods: In this experiment, the effects of LA on the model of acute blood stasis in rats were explored. The blood samples were collected for the measurement of coagulation and hemorheological indices, and the carotid arteries were also excised from rats for hematoxylin-eosin (HE) staining and immunohistochemistry (IHC). In addition, the improvement effects of LA on the H
    Results: In vivo
    Conclusion: These findings demonstrated that LA has the ability to improve blood hypercoagulation and blood viscosity, and enhance the viability of cells. It is more likely that it exerts a protective effect on the endothelial cell through the PI3K-AKT-eNOs pathway. These results indicate LA will be a potential candidate to cure blood stasis with endothelial cell injury.
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/6595383
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  8. Article ; Online: The effects of endodontic access cavity design on dentine removal and effectiveness of canal instrumentation in maxillary molars.

    Wang, Dan / Wang, Wei / Li, Yu-Jiao / Wang, Yi-Rong / Hong, Tao / Bai, Shi-Zhu / Tian, Yu

    International endodontic journal

    2021  Volume 54, Issue 12, Page(s) 2290–2299

    Abstract: Aim: To evaluate in a laboratory setting, the impact of three designs of endodontic access cavities on dentine removal and effectiveness of canal instrumentation in extracted maxillary first molars using micro-computed tomography (micro-CT).: ... ...

    Abstract Aim: To evaluate in a laboratory setting, the impact of three designs of endodontic access cavities on dentine removal and effectiveness of canal instrumentation in extracted maxillary first molars using micro-computed tomography (micro-CT).
    Methodology: A total of 30 extracted intact maxillary first molars were selected and scanned by micro-CT with a voxel size of 24 µm and randomly distributed into three groups: the traditional endodontic cavity (TEC) group, the conservative endodontic cavity (CEC) group and the guided endodontic cavity (GEC) group. The pulp chambers of teeth in the groups were accessed accordingly. After root canal preparation, the teeth were rescanned. The volume of dentine removed after canal preparation, the noninstrumented canal areas, canal transportation and centring ratio were analysed. Data were analysed statistically using one-way analysis of variance. Tukey's post hoc test was used for multiple comparisons. The significance level was set at p < .05.
    Results: The total volume of dentine removed was significantly greater in the TEC group after root canal preparation (p < .05). No significant differences in the volume of dentine removed occurred between the CEC and GEC groups (p > .05). The volume of dentine removed in the crown, pericervical dentine and coronal third of the canal was significantly lower in CEC and GEC groups when compared to that in the TEC group (p < .05), no difference was observed in the middle third of the canal and apical third of the canal amongst the three groups (p > .05). There was no significant difference in noninstrumented canal area, canal transportation and centring ratio amongst the TEC, CEC and GEC groups (p > .05).
    Conclusions: In extracted maxillary molars tested in a laboratory setting, CEC and GEC preserved more tooth tissue in the crown, pericervical dentine and coronal third of the canal compared with TEC after root canal preparation. The design of the endodontic access cavity did not impact on the effectiveness of canal instrumentation in terms of noninstrumented canal area, canal transportation and centring ratio.
    MeSH term(s) Dental Pulp Cavity/diagnostic imaging ; Dental Pulp Cavity/surgery ; Dentin ; Molar/diagnostic imaging ; Molar/surgery ; Root Canal Preparation ; X-Ray Microtomography
    Language English
    Publishing date 2021-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 603734-3
    ISSN 1365-2591 ; 0143-2885
    ISSN (online) 1365-2591
    ISSN 0143-2885
    DOI 10.1111/iej.13621
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  9. Article: [Adsorption, Reclaim, and Regeneration of Cd by Magnetic Calcium Dihydrogen Phosphate Nanoparticles].

    Li, Yu-Jiao / Yang, Zhi-Min / Chen, Yu-Cheng / Huang, Lei / Tang, Hai-Yan

    Huan jing ke xue= Huanjing kexue

    2019  Volume 40, Issue 4, Page(s) 1849–1856

    Abstract: In order to improve the adsorption-separation of ... ...

    Abstract In order to improve the adsorption-separation of Cd
    Language Chinese
    Publishing date 2019-05-14
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.201808020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Cognitive-Enhancing Effects of

    Jiang, Ning / Li, Yu-Jiao / Wang, Meng-di / Huang, Hong / Chen, Shanguang / Li, Yinghui / Qu, Lina / Wang, Fengzhong / Liu, Xinmin / Wang, Qiong

    Frontiers in psychiatry

    2022  Volume 12, Page(s) 596017

    Abstract: Chronic sleep deprivation (SD) causes neurological and neurodegenerative dysfunction including learning and memory deficit. The ... ...

    Abstract Chronic sleep deprivation (SD) causes neurological and neurodegenerative dysfunction including learning and memory deficit. The orchid
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.596017
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