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  1. Book ; Online: Non-Coding RNAs and Human Diseases

    Li, Yujing / Shan, Ge / Teng, Zhao-Qian / Wingo, Thomas S.

    2020  

    Keywords Science: general issues ; Medical genetics ; miRNA ; ncRNAs ; lncRNA ; circRNA ; piRNA ; cancer biology ; neurologcial disorders
    Size 1 electronic resource (346 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230526
    ISBN 9782889638321 ; 2889638324
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial: baseline hepatitis B virus haplotype number may help predict a functional cure in patients with chronic hepatitis B treated with nucleotide analogues.

    Li, Yu-Jing / Chen, En-Qiang

    Alimentary pharmacology & therapeutics

    2023  Volume 57, Issue 5, Page(s) 581–582

    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/genetics ; Nucleotides/therapeutic use ; Haplotypes ; Antiviral Agents/therapeutic use ; Hepatitis B Surface Antigens
    Chemical Substances Nucleotides ; Antiviral Agents ; Hepatitis B Surface Antigens
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
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  3. Article: Stem Cell-Derived Organoids.

    Li, Yujing / Li, Xuekun / Kang, Yunhee / Jiang, Shu

    Stem cells international

    2024  Volume 2024, Page(s) 9798375

    Language English
    Publishing date 2024-01-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2024/9798375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comprehensive transcriptional analysis of early dorsal skin development in pigs.

    Zhang, Xinyue / Zhang, Mei / Li, Yujing / Jiang, Yanzhi

    Gene

    2024  Volume 899, Page(s) 148141

    Abstract: Porcine skin is similar to human skin in physiology, anatomy and histology and is often used as a model animal for human skin research. There are few studies on the transcriptome aspects of pig skin during the embryonic period. In this study, RNA ... ...

    Abstract Porcine skin is similar to human skin in physiology, anatomy and histology and is often used as a model animal for human skin research. There are few studies on the transcriptome aspects of pig skin during the embryonic period. In this study, RNA sequencing was performed on the dorsal skin of Chenghua sows at embryonic day 56 (E56), embryonic day 76 (E76), embryonic day 105 (E105), and 3 days after birth (D3) to explore RNA changes in pig dorsal skin at four ages. A number of skin-related differential genes were identified by intercomparison between RNAs at four time points, and KEGG functional analysis showed that these differential genes were mainly enriched in metabolic and developmental, immune, and disease pathways, and the pathways enriched in GO analysis were highly overlapping. Collagen is an important part of the skin, with type I collagen making up the largest portion. In this study, collagen type I alpha 1 (COL1A1) and collagen type I alpha 2 (COL1A2) were significantly upregulated at four time points. In addition, lncRNA-miRNA-mRNA and miRNA-circRNA coexpression networks were constructed. The data obtained may help to explain age-related changes in transcriptional patterns during skin development and provide further references for understanding human skin development at the molecular level.
    MeSH term(s) Humans ; Animals ; Swine/genetics ; Female ; Collagen Type I/genetics ; Gene Expression Profiling ; Gene Regulatory Networks ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Messenger/genetics ; RNA, Long Noncoding/genetics
    Chemical Substances Collagen Type I ; MicroRNAs ; RNA, Messenger ; RNA, Long Noncoding
    Language English
    Publishing date 2024-01-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2024.148141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Establishment and analysis of artificial neural network diagnosis model for coagulation-related molecular subgroups in coronary artery disease.

    Zheng, Biwei / Li, Yujing / Xiong, Guoliang

    Frontiers in genetics

    2024  Volume 15, Page(s) 1351774

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2024.1351774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recent Advances in Dissecting the Function of Ethylene in Interaction between Host and Pathogen.

    Shu, Pan / Li, Yujing / Sheng, Jiping / Shen, Lin

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 9, Page(s) 4552–4563

    Abstract: Pathogens influence the growth and development of plants, resulting in detrimental damage to their yields and quality. Ethylene, a gaseous phytohormone, serves a pivotal function in modulating diverse physiological processes in plants, including defense ... ...

    Abstract Pathogens influence the growth and development of plants, resulting in detrimental damage to their yields and quality. Ethylene, a gaseous phytohormone, serves a pivotal function in modulating diverse physiological processes in plants, including defense mechanisms against pathogen invasion. Ethylene biosynthesis is involved in both plants and pathogens. Recent empirical research elucidates the intricate interactions and regulatory mechanisms between ethylene and pathogens across various plant species. In this review, we provide a comprehensive overview of the latest findings concerning ethylene's role and its regulatory networks in host-pathogen interactions. Additionally, we explore the crosstalk between ethylene and other phytohormones. Points regarding ethylene emission and its modulation by pathogens are also emphasized. Moreover, we also discuss potential unresolved issues in the field that warrant further investigation.
    MeSH term(s) Ethylenes ; Plant Growth Regulators ; Plants/genetics
    Chemical Substances ethylene (91GW059KN7) ; Ethylenes ; Plant Growth Regulators
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c07978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Tomato

    Shu, Pan / Li, Yujing / Sheng, Jiping / Shen, Lin

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 10, Page(s) 5185–5196

    Abstract: Mitogen-activated protein kinase (MAPK) cascades and raffinose have been observed to increase in plants exposed to cold. However, it remains elusive whether and how MAPK regulates raffinose synthesis under cold stress. Here, overexpression ... ...

    Abstract Mitogen-activated protein kinase (MAPK) cascades and raffinose have been observed to increase in plants exposed to cold. However, it remains elusive whether and how MAPK regulates raffinose synthesis under cold stress. Here, overexpression of
    MeSH term(s) Raffinose/metabolism ; Solanum lycopersicum ; Plant Proteins/metabolism ; Cold Temperature ; Mitogen-Activated Protein Kinases/genetics ; Gene Expression Regulation, Plant ; Plants, Genetically Modified/metabolism
    Chemical Substances Raffinose (N5O3QU595M) ; Plant Proteins ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c09066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Cell-based therapies for rheumatoid arthritis: opportunities and challenges.

    Li, Yu-Jing / Chen, Zhu

    Therapeutic advances in musculoskeletal disease

    2022  Volume 14, Page(s) 1759720X221100294

    Abstract: Rheumatoid arthritis (RA) is the most common immune-mediated inflammatory disease characterized by chronic synovitis that hardly resolves spontaneously. The current treatment of RA consists of nonsteroidal anti-inflammatory drugs (NSAIDs), ... ...

    Abstract Rheumatoid arthritis (RA) is the most common immune-mediated inflammatory disease characterized by chronic synovitis that hardly resolves spontaneously. The current treatment of RA consists of nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, conventional disease-modifying antirheumatic drugs (cDMARDs), biologic and targeted synthetic DMARDs. Although the treat-to-target strategy has been intensively applied in the past decade, clinical unmet needs still exist since a substantial proportion of patients are refractory or even develop severe adverse effects to current therapies. In recent years, with the deeper understanding of immunopathogenesis of the disease, cell-based therapies have exhibited effective and promising interventions to RA. Several cell-based therapies, such as mesenchymal stem cells (MSC), adoptive transfer of regulatory T cells (Treg), and chimeric antigen receptor (CAR)-T cell therapy as well as their beneficial effects have been documented and verified so far. In this review, we summarize the current evidence and discuss the prospect as well as challenges for these three types of cellular therapies in RA.
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X221100294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Physiological, transcriptome and co-expression network analysis of chlorophyll-deficient mutants in flue-cured tobacco.

    Feng, Yuqing / Li, Yujing / Zhao, Yuanyuan / Shi, Hongzhi

    BMC plant biology

    2023  Volume 23, Issue 1, Page(s) 153

    Abstract: Background: Photosynthetic pigments in higher plants, including chlorophyll (Chl) and carotenoids, are crucial for photosynthesis and photoprotection. Chl-deficient tobacco seedlings generally have a lower photosynthesis rate and higher nitrate-nitrogen ...

    Abstract Background: Photosynthetic pigments in higher plants, including chlorophyll (Chl) and carotenoids, are crucial for photosynthesis and photoprotection. Chl-deficient tobacco seedlings generally have a lower photosynthesis rate and higher nitrate-nitrogen (NO
    Results: The results showed that, when compared to the WT, the Chl content and biomass of mutant plants were considerably lower while the NO
    Conclusion: Our results demonstrated that differences in chlorophyll and nitrate content were caused by the combined effects of chloroplast development, photosynthesis, as well as related biological activity. In addition, transcriptome results provide a bioinformatics resource for further functional identification of key pathways and genes responsible for differences in chlorophyll and nitrate content in tobacco plants.
    MeSH term(s) Chlorophyll/metabolism ; Nicotiana/genetics ; Nicotiana/metabolism ; Transcriptome ; Nitrates/metabolism ; Photosynthesis/genetics ; Nitrogen/metabolism ; Plant Leaves/metabolism
    Chemical Substances Chlorophyll (1406-65-1) ; Nitrates ; Nitrogen (N762921K75)
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059868-3
    ISSN 1471-2229 ; 1471-2229
    ISSN (online) 1471-2229
    ISSN 1471-2229
    DOI 10.1186/s12870-023-04169-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comprehensive transcriptional analysis of pig facial skin development.

    Li, Yujing / Shi, Rui / Yuan, Rong / Jiang, Yanzhi

    PeerJ

    2023  Volume 11, Page(s) e15955

    Abstract: Background: Skin development is a complex process that is influenced by many factors. Pig skin is used as an ideal material for xenografts because it is more anatomically and physiologically similar to human skin. It has been shown that the skin ... ...

    Abstract Background: Skin development is a complex process that is influenced by many factors. Pig skin is used as an ideal material for xenografts because it is more anatomically and physiologically similar to human skin. It has been shown that the skin development of different pig breeds is different, and some Chinese pig breeds have the characteristics of skin thickness and facial skin folds, but the specific regulatory mechanism of this skin development is not yet clear.
    Methods: In this study, the facial skin of Chenghua sows in the four developmental stages of postnatal Day 3 (D3) , Day 90 (D90) , Day 180 (D180), and Year 3 (Y3) were used as experimental materials, and RNA sequencing (RNA-seq) analysis was used to explore the changes in RNA expression in skin development at the four developmental stages, determine the differentially expressed messenger RNAs (mRNAs), long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), and perform functional analysis of related genes by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.
    Results: A pairwise comparison of the four developmental stages identified several differentially expressed genes (DEGs) and found that the number of differentially expressed RNAs (DE RNAs) increased with increasing developmental time intervals. Elastin (ELN) is an important component of the skin. Its content affects the relaxation of the epidermis and dermal connection, and its expression is continuously downregulated during the four developmental stages. The functions of DEGs at different developmental stages were examined by performing GO and KEGG analyses, and the GO terms and enrichment pathways of mRNAs, lncRNAs, miRNAs, and circRNAs highly overlapped, among which the PPAR signaling pathway, a classical pathway for skin development, was enriched by DEGs of D3 vs. D180, D90 vs. D180 and D180 vs. Y3. In addition, we constructed lncRNA-miRNA-mRNA and circRNA-miRNA interaction networks and found genes that may be associated with skin development, but their interactions need further study.
    Conclusions: We identified a number of genes associated with skin development, performed functional analyses on some important DEGs and constructed interaction networks that facilitate further studies of skin development.
    MeSH term(s) Humans ; Swine/genetics ; Animals ; Female ; RNA, Circular ; RNA, Long Noncoding/genetics ; Skin ; MicroRNAs/genetics ; Epidermis
    Chemical Substances RNA, Circular ; RNA, Long Noncoding ; MicroRNAs
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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