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Article ; Online: A New Phenothiazine-Based Fluorescent Sensor for Detection of Cyanide.

Li, Yulei / Zhou, Chen / Li, Jiaxin / Sun, Jing

2024 Volume 14, Issue 1

Abstract: A new fluorescent sensor for the detection of ... ...

Abstract	A new fluorescent sensor for the detection of CN
MeSH term(s)	Animals ; Cyanides ; Zebrafish ; Fluorescent Dyes ; Phenothiazines
Chemical Substances	Cyanides ; Fluorescent Dyes ; phenothiazine (GS9EX7QNU6) ; Phenothiazines
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios14010051
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Article ; Online: Safety and Efficacy of the Modified Vaccinia Ankara-Bavaria Nordic Vaccine Against Mpox in the Real World: Systematic Review and Meta-Analysis.

Pang, Yi / Cao, Demin / Zhu, Xiaoying / Long, Qinqin / Tian, Fengqin / Long, Xidai / Li, Yulei

Viral immunology

2024 Volume 37, Issue 4, Page(s) 216–219

Abstract: In May 2022, mpox began to spread worldwide, posing a serious threat to human public health. Modified Vaccinia Ankara-Bavaria Nordic (MVA-BN) is a live attenuated orthopoxvirus vaccine that has been authorized by the U.S. Food and Drug Administration as ... ...

Abstract	In May 2022, mpox began to spread worldwide, posing a serious threat to human public health. Modified Vaccinia Ankara-Bavaria Nordic (MVA-BN) is a live attenuated orthopoxvirus vaccine that has been authorized by the U.S. Food and Drug Administration as the vaccine of choice for the prevention of mpox. In this study, we conducted a meta-analysis of all currently published literature on the efficacy and safety of the MVA-BN vaccine in the real world, showing that the MVA-BN vaccine is effective and safe, with efficacy of up to 75% with a single dose and up to 80% with a two-dose vaccine. Meanwhile, we found that subcutaneous injection has lower local and systemic adverse events than intradermal injection, regardless of single- or two-dose vaccination, and subcutaneous injection is better tolerated in children, the elderly, or people with underlying medical conditions. These results have important reference value for clinical practice.
MeSH term(s)	Humans ; Vaccine Efficacy ; Vaccines, Attenuated/immunology ; Vaccines, Attenuated/administration & dosage ; Vaccines, Attenuated/adverse effects ; Poxviridae Infections/prevention & control ; Poxviridae Infections/immunology ; Vaccinia virus/immunology ; Vaccinia virus/genetics ; Vaccination ; Injections, Subcutaneous ; Injections, Intradermal ; Viral Vaccines/adverse effects ; Viral Vaccines/immunology ; Viral Vaccines/administration & dosage ; Orthopoxvirus/immunology ; Orthopoxvirus/genetics ; Child
Chemical Substances	Vaccines, Attenuated ; Viral Vaccines
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	639075-4
ISSN	1557-8976 ; 0882-8245
ISSN (online)	1557-8976
ISSN	0882-8245
DOI	10.1089/vim.2023.0147
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Article ; Online: Robust and flexible polyester fiber membrane with under-liquid dual superlyophobicity for efficient on-demand oil-water separation.

Li, Yulei / Jia, Mengke / Shi, Baoying / Wang, Songlin / Luan, Xiayu / Hao, Zhanhua / Wang, Yufeng

International journal of biological macromolecules

2024 Volume 262, Issue Pt 2, Page(s) 130138

Abstract: Functional materials with under-liquid dual superlyophobicity have generated a great deal of concern from researchers due to their switchable separation ability oil-water mixtures and emulsions. Conceptually, under-liquid dual superlyophobicity is a ... ...

Abstract	Functional materials with under-liquid dual superlyophobicity have generated a great deal of concern from researchers due to their switchable separation ability oil-water mixtures and emulsions. Conceptually, under-liquid dual superlyophobicity is a Cassie state achievable under-liquid through the synergy of an under-liquid double lyophobic surface and the construction of a highly rough surface. However, obtaining an under-liquid dual superlyophobic surface remains difficult due to its thermodynamic contradiction and complex surface composition. Herein, we successfully prepared a functional coating by modifying the mixture of cellulose nanocrystals (CNCs) and nano-TiO
MeSH term(s)	Cellulose ; Fabaceae ; Nanoparticles ; Polyesters ; Thermodynamics
Chemical Substances	Cellulose (9004-34-6) ; Polyesters
Language	English
Publishing date	2024-02-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130138
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Article ; Online: Truncated FRMD7 proteins in congenital Nystagmus: novel frameshift mutations and proteasomal pathway implications.

Su, Yuqing / Zhang, Juntao / Gao, Jiahui / Ding, Guoqing / Jiang, Heng / Liu, Yang / Li, Yulei / Yang, Guohua

BMC medical genomics

2024 Volume 17, Issue 1, Page(s) 36

Abstract: Idiopathic congenital nystagmus (ICN) manifests as involuntary and periodic eye movements. To identify the genetic defect associated with X-linked ICN, Whole Exome Sequencing (WES) was conducted in two affected families. We identified two frameshift ... ...

Abstract	Idiopathic congenital nystagmus (ICN) manifests as involuntary and periodic eye movements. To identify the genetic defect associated with X-linked ICN, Whole Exome Sequencing (WES) was conducted in two affected families. We identified two frameshift mutations in FRMD7, c.1492dupT/p.(Y498Lfs15) and c.1616delG/p.(R539Kfs2). Plasmids harboring the mutated genes and qPCR analysis revealed mRNA stability, evading degradation via the NMD pathway, and corroborated truncated protein production via Western-blot analysis. Notably, both truncated proteins were degraded through the proteasomal (ubiquitination) pathway, suggesting potential therapeutic avenues targeting this pathway for similar mutations. Moreover, we conducted a comprehensive analysis, summarizing 140 mutations within the FRMD7 gene. Our findings highlight the FERM and FA structural domains as mutation-prone regions. Interestingly, exons 9 and 12 are the most mutated regions, but 90% (28/31) mutations in exon 9 are missense while 84% (21/25) mutations in exon 12 are frameshift. A predominant occurrence of shift code mutations was observed in exons 11 and 12, possibly associated with the localization of premature termination codons (PTCs), leading to the generation of deleterious truncated proteins. Additionally, our conjecture suggests that the loss of FRMD7 protein function might not solely drive pathology; rather, the emergence of aberrant protein function could be pivotal in nystagmus etiology. We propose a dependence of FRMD7 protein normal function primarily on its anterior domain. Future investigations are warranted to validate this hypothesis.
MeSH term(s)	Humans ; Frameshift Mutation ; Nystagmus, Congenital/genetics ; Base Sequence ; Membrane Proteins/genetics ; Cytoskeletal Proteins/genetics ; Pedigree ; DNA Mutational Analysis ; Mutation
Chemical Substances	Membrane Proteins ; Cytoskeletal Proteins ; FRMD7 protein, human
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2411865-5
ISSN	1755-8794 ; 1755-8794
ISSN (online)	1755-8794
ISSN	1755-8794
DOI	10.1186/s12920-024-01817-7
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Article: Contraction and expansion dynamics: deciphering genomic underpinnings of growth rate and pathogenicity in

Zhu, Xiaoying / Lu, Qunfeng / Li, Yulei / Long, Qinqin / Zhang, Xinyu / Long, Xidai / Cao, Demin

Frontiers in microbiology

2023 Volume 14, Page(s) 1292897

Abstract: Background: Mycobacterium: Methods: Here, We conducted a comprehensive comparative genomics study involving 53 : Results: Our core/pan-genome analysis highlighted 1,307 shared gene families, revealing an open pan-genome structure. A phylogenetic ... ...

Abstract	Background: Mycobacterium Methods: Here, We conducted a comprehensive comparative genomics study involving 53 Results: Our core/pan-genome analysis highlighted 1,307 shared gene families, revealing an open pan-genome structure. A phylogenetic tree highlighted clear boundaries between SGM and RGM, as well as TP and other species. Gene family contraction emerged as the primary alteration associated with growth and pathogenicity transitions. Specifically, ABC transporters for amino acids and inorganic ions, along with quorum sensing genes, exhibited significant contractions in SGM species, potentially influencing their distinct traits. Conversely, TP strains displayed contraction in lipid and secondary metabolite biosynthesis and metabolism-related genes. Across the 53 species, we identified 26 core and 64 accessory virulence factors. Remarkably, TP and OP strains stood out for their expanded mycobactin biosynthesis and type VII secretion system gene families, pivotal for their pathogenicity. Conclusion: Our findings underscore the importance of gene family contraction in nucleic acids, ions, and substance metabolism for host adaptation, while emphasizing the significance of virulence gene family expansion, including type VII secretion systems and mycobactin biosynthesis, in driving mycobacterial pathogenicity.
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1292897
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Article: High Prevalence of Respiratory Co-Infections and Risk Factors in COVID-19 Patients at Hospital Admission During an Epidemic Peak in China.

Zhu, Xiaoying / Tian, Fengqin / Li, Yulei / Lu, Qunfeng / Long, Qinqin / Long, Xidai / Cao, Demin

Infection and drug resistance

2023 Volume 16, Page(s) 6781–6793

Abstract: Background: Recent research highlights the contribution of co-infections to elevated disease severity and mortality among COVID-19 patients. Given China's decision to ease epidemic prevention policies in December 2022, a comprehensive exploration of the ...

Abstract	Background: Recent research highlights the contribution of co-infections to elevated disease severity and mortality among COVID-19 patients. Given China's decision to ease epidemic prevention policies in December 2022, a comprehensive exploration of the risks and characteristics of co-infections with respiratory pathogens becomes imperative. Methods: We conducted a retrospective analysis of 716 COVID-19 patients admitted to a primary hospital in China. The detection of twelve respiratory pathogens was conducted using qPCR, and the potential risk factors were analyzed through Cox regression analysis. Results: Within this cohort, 76.82% of cases exhibited co-infection involving eleven distinct pathogens. Among these, bacterial co-infections were observed in 74% of cases, with Conclusion: Our findings underscore a significant occurrence of co-infections among COVID-19 patients during the epidemic, emphasizing the need for enhanced antibiotic stewardship. Effective management strategies should encompass respiratory status, nutritional aspects, and vigilance towards co-infections involving
Language	English
Publishing date	2023-10-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S435143
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Article ; Online: Efficacy, immunogenicity and safety of respiratory syncytial virus prefusion F vaccine: systematic review and meta-analysis.

Pang, Yi / Lu, Haishan / Cao, Demin / Zhu, Xiaoying / Long, Qinqin / Tian, Fengqin / Long, Xidai / Li, Yulei

BMC public health

2024 Volume 24, Issue 1, Page(s) 1244

Abstract: Objective: A notable research gap exists in the systematic review and meta-analysis concerning the efficacy, immunogenicity, and safety of the respiratory syncytial virus (RSV) prefusion F vaccine.: Methods: We conducted a comprehensive search across ...

Abstract	Objective: A notable research gap exists in the systematic review and meta-analysis concerning the efficacy, immunogenicity, and safety of the respiratory syncytial virus (RSV) prefusion F vaccine. Methods: We conducted a comprehensive search across PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov to retrieve articles related to the efficacy, immunogenicity, and safety of RSV prefusion F vaccines, published through September 8, 2023. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: A total of 22 randomized controlled trials involving 78,990 participants were included in this systematic review and meta-analysis. The RSV prefusion F vaccine exhibited a vaccine effectiveness of 68% (95% CI: 59-75%) against RSV-associated acute respiratory illness, 70% (95% CI: 60-77%) against medically attended RSV-associated lower respiratory tract illness, and 87% (95% CI: 71-94%) against medically attended severe RSV-associated lower respiratory tract illness. Common reported local adverse reactions following RSV prefusion F vaccination include pain, redness, and swelling at the injection site, and systemic reactions such as fatigue, headache, myalgia, arthralgia, nausea, and chills. Conclusions: Our meta-analysis suggests that vaccines using the RSV prefusion F protein as antigen exhibit appears broadly acceptable efficacy, immunogenicity, and safety in the population. In particular, it provides high protective efficiency against severe RSV-associated lower respiratory tract disease.
MeSH term(s)	Humans ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines/immunology ; Vaccine Efficacy ; Respiratory Syncytial Virus, Human/immunology ; Immunogenicity, Vaccine ; Randomized Controlled Trials as Topic
Chemical Substances	Respiratory Syncytial Virus Vaccines
Language	English
Publishing date	2024-05-06
Publishing country	England
Document type	Journal Article ; Systematic Review ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18748-8
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Article ; Online: All-hydrocarbon stapling enables improvement of antimicrobial activity and proteolytic stability of peptide Figainin 2.

Xue, Jingwen / Fu, Yinxue / Li, Huang / Zhang, Ting / Cong, Wei / Hu, Honggang / Lu, Zhiyuan / Yan, Fang / Li, Yulei

Journal of peptide science : an official publication of the European Peptide Society

2024 Volume 30, Issue 6, Page(s) e3566

Abstract: Figainin 2 is a cationic, hydrophobic, α-helical host-defense peptide with 28 residues, which was isolated from the skin secretions of the Chaco tree frog. It shows potent inhibitory activity against both Gram-negative and Gram-positive pathogens and has ...

Abstract	Figainin 2 is a cationic, hydrophobic, α-helical host-defense peptide with 28 residues, which was isolated from the skin secretions of the Chaco tree frog. It shows potent inhibitory activity against both Gram-negative and Gram-positive pathogens and has garnered considerable interest in developing novel classes of natural antibacterial agents. However, as a linear peptide, conformational flexibility and poor proteolytic stability hindered its development as antibacterial agent. To alleviate its susceptibility to proteolytic degradation and improve its antibacterial activity, a series of hydrocarbon-stable analogs of Figainin 2 were synthesized and evaluated for their secondary structure, protease stability, antimicrobial, and hemolytic activities. Among them, F2-12 showed significant improvement in protease resistance and antimicrobial activity compared to that of the template peptide. This study provides a promising strategy for the development of antimicrobial drugs.
MeSH term(s)	Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/chemical synthesis ; Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/chemical synthesis ; Animals ; Proteolysis ; Hemolysis/drug effects ; Gram-Positive Bacteria/drug effects ; Humans ; Structure-Activity Relationship ; Protein Structure, Secondary ; Gram-Negative Bacteria/drug effects ; Protein Stability
Chemical Substances	Anti-Bacterial Agents ; Antimicrobial Cationic Peptides
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1234416-3
ISSN	1099-1387 ; 1075-2617
ISSN (online)	1099-1387
ISSN	1075-2617
DOI	10.1002/psc.3566
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Article ; Online: A self-supported porous NiMo electrocatalyst to boost the catalytic activity in the hydrogen evolution reaction.

Kong, Qingxiang / Li, Yulei / Zhao, Qin / Liu, Zhenwei / Wu, Song / Tong, Xiaoning / Wang, Junli / Huang, Bangfu / Xu, Ruidong / Yang, Linjing

Dalton transactions (Cambridge, England : 2003)

2024

Abstract: To develop hydrogen energy production and address the issues of global warming, inexpensive, effective, and long-lasting transition metal-based electrocatalysts for the synthesis of hydrogen are crucial. Herein, a porous electrocatalyst NiMo/Ni/NF was ... ...

Abstract	To develop hydrogen energy production and address the issues of global warming, inexpensive, effective, and long-lasting transition metal-based electrocatalysts for the synthesis of hydrogen are crucial. Herein, a porous electrocatalyst NiMo/Ni/NF was successfully constructed by a two-step electrodeposition process, and was used in the hydrogen evolution reaction (HER) of electrocatalytic water decomposition. NiMo nanoparticles were coated on porous Ni/NF grown on nickel foam (NF), leading to a resilient porous structure with enhanced conductivity for efficient charge transfer, as well as distinctive three-dimensional channels for quick electrolyte diffusion and gas release. Notably, the low overpotential (42 mV) and fast kinetics (Tafel slope of 44 mV dec
Language	English
Publishing date	2024-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d4dt00508b
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Article ; Online: Genetic characteristics and pathogenicity of novel reassortant H6 viruses isolated from wild birds in China.

Li, Yulei / Li, Minghui / Tian, Jingman / Bai, Xiaoli / Li, Yanbing

Veterinary microbiology

2021 Volume 254, Page(s) 108978

Abstract: During our routine surveillance, we isolated seven H6 avian influenza virus (AIV) strains, including three H6N1 strains, three H6N2 strains, and one H6N8 strain, from 3667 fresh fecal samples that were collected from wild bird habitats in China from ... ...

Abstract	During our routine surveillance, we isolated seven H6 avian influenza virus (AIV) strains, including three H6N1 strains, three H6N2 strains, and one H6N8 strain, from 3667 fresh fecal samples that were collected from wild bird habitats in China from March 2017 and May 2019. Phylogenetic analysis revealed that these viruses formed five different genotypes and have undergone complicate reassortment during their evolution by acquiring genes from AIVs of both Eurasian and North American lineages that have been previously detected in migrating waterfowl and poultry. Viral pathogenesis in mice showed that these H6 viruses replicated efficiently in both the nasal turbinates and lungs of mice without pre-adaptation, but none of them were lethal for mice. We studied the genetic characteristic and biological property of novel reassortant H6 viruses isolated from wild birds in China. It also highlights the need for continued surveillance of H6 AIVs circulating in nature.
MeSH term(s)	Animals ; Animals, Wild/virology ; Birds/virology ; Chick Embryo ; China ; Feces/virology ; Female ; Genome, Viral ; Genotype ; Humans ; Influenza A virus/classification ; Influenza A virus/genetics ; Influenza A virus/pathogenicity ; Influenza in Birds/virology ; Lung/virology ; Mice ; Mice, Inbred BALB C ; Phylogeny ; RNA, Viral/genetics ; Reassortant Viruses/classification ; Reassortant Viruses/genetics ; Reassortant Viruses/pathogenicity ; Sequence Analysis, DNA ; Virulence ; Virus Replication
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-01-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2021.108978
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