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  1. Article: The Cell Cycle-Associated Protein CDKN2A May Promotes Colorectal Cancer Cell Metastasis by Inducing Epithelial-Mesenchymal Transition.

    Shi, Wei-Kun / Li, Yun-Hao / Bai, Xue-Shan / Lin, Guo-Le

    Frontiers in oncology

    2022  Volume 12, Page(s) 834235

    Abstract: Colorectal cancer (CRC) is a common gastrointestinal malignancy, and recurrence and metastasis contribute considerably to its high mortality. It is well known that the epithelial-mesenchymal transition (EMT) accelerates the rate of cancer cell ... ...

    Abstract Colorectal cancer (CRC) is a common gastrointestinal malignancy, and recurrence and metastasis contribute considerably to its high mortality. It is well known that the epithelial-mesenchymal transition (EMT) accelerates the rate of cancer cell dissemination and migration, thus promoting cancer metastasis. Targeted therapy is a common modality for cancer treatment, and it can play a role in inhibiting cancer progression. In this study, bioinformatics was used to search for genes associated with the prognosis of CRC. First, differential analysis was performed on colon and rectal cancer samples to obtain 2,840 and 3,177 differentially expressed genes (DEGs), respectively. A Venn diagram was then used to identify 262 overlapping genes from the two groups of DEGs and EMT-related genes. The overlapping genes were subjected to batch survival analysis and batch expression analysis successively, and nine genes were obtained whose high expression in CRC led to a poor prognosis. The least absolute shrinkage and selection operator (LASSO) prognostic model was then constructed to obtain the risk score formula. A nomogram was constructed to seek prognostic independent factors to obtain CDKN2A. Finally, CCK-8 assay, flow cytometry and western blotting assays were performed to analyze the cellular biological function of CDKN2A. The results showed that knockdown of CDKN2A expression inhibited HT-29 cell proliferation, promoted apoptosis and cell cycle progression, and affected the EMT process in CRC.
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.834235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Potential Role of Virus Infection in the Progression of Thyroid Cancer.

    Wu, Yong Ke / Jiang, Tian Tian / Su, Yuan Hao / Mei, Lin / Sun, Ting Kai / Li, Yun Hao / Wang, Zhi Dong / Ji, Yuan Yuan

    World journal of oncology

    2024  Volume 15, Issue 3, Page(s) 382–393

    Abstract: Multiple factors have engaged in the progression of thyroid cancer (TC). Recent studies have shown that viral infection can be a critical factor in the pathogenesis of TC. Viruses, such as Epstein-Barr virus (EBV), hepatitis C virus (HCV), human ... ...

    Abstract Multiple factors have engaged in the progression of thyroid cancer (TC). Recent studies have shown that viral infection can be a critical factor in the pathogenesis of TC. Viruses, such as Epstein-Barr virus (EBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may play an essential role in the occurrence, development, and even prognosis in TC. This review mainly explored the potential role of viral infection in the progress of TC. The possible mechanisms could be recognizing the host cell, binding to the receptors, affecting oncogenes levels, releasing viral products to shape a beneficial environment, interacting with immune cells to induce immune evasion, and altering the pituitary-thyroid axis. Thus, comprehensive knowledge may provide insights into finding molecular targets for diagnosing and treating virus-related TC.
    Language English
    Publishing date 2024-04-15
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to the letter «Discrepancies in analysis of frequency, type of complications and economic costs of outlying patients in general and digestive surgery».

    Gomez-Rosado, Juan-Carlos / Li, Yun-Hao / Valdés-Hernández, Javier / Capitán-Morales, Luis-Cristobal

    Cirugia espanola

    2019  Volume 97, Issue 7, Page(s) 422–423

    Title translation Réplica a la carta al director «Discrepancias en el análisis de la frecuencia, tipos de complicación y costes económicos en los pacientes ectópicos de cirugía general y digestiva».
    MeSH term(s) Costs and Cost Analysis ; Digestive System Surgical Procedures ; Humans
    Language Spanish
    Publishing date 2019-06-11
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2019.05.007
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  4. Article ; Online: Long-term outcomes of transanal endoscopic microsurgery for the treatment of rectal neuroendocrine tumors.

    Shi, Wei-Kun / Hou, Rui / Li, Yun-Hao / Qiu, Xiao-Yuan / Liu, Yu-Xin / Wu, Bin / Xiao, Yi / Zhou, Jiao-Lin / Lin, Guo-Le

    BMC surgery

    2022  Volume 22, Issue 1, Page(s) 43

    Abstract: Background: Transanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess the efficacy and safety of TEM in the treatment of rectal neuroendocrine tumors (RNET).: Methods: A ... ...

    Abstract Background: Transanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess the efficacy and safety of TEM in the treatment of rectal neuroendocrine tumors (RNET).
    Methods: A retrospective study of patients who had undergone TEM for RNET at our institution between December 2006 and June 2019 was performed. Demographic and tumor characteristics, operative and pathological details, complications, anal function questionnaires, and follow-up data were included.
    Results: A total of 144 patients was included. TEM was performed as primary excision in 54 patients, after endoscopic forceps biopsy in 57 patients, and after incomplete resection by endoscopic excision in 33 patients. The median size of all primary tumors was 0.6 cm (range, 0.3-2.0 cm), and the negative resection margin was achieved in 142 (98.6%) patients. Postoperative complications (referring to only bleeding) occurred in 3 (2.1%) patients and was successfully managed with conservative method. After a median follow-up of 75.5 months after surgery, 3 patients died of other causes, and 2 patients suffered metastasis. An anal function questionnaire was posted 24 months after TEM. Among the results, 3 (2.1%) patients complained of major low anterior resection syndrome (LARS), including 1 (0.7%) who suffered from complete incontinence, while 6 (4.2%) patients had minor LARS.
    Conclusions: TEM has satisfying long-term outcomes and relatively low anal function disturbance as for the treatment of small RNET. TEM also acts as a preferred salvage treatment for incomplete endoscopic excision.
    MeSH term(s) Humans ; Microsurgery ; Neuroendocrine Tumors/surgery ; Postoperative Complications/epidemiology ; Rectal Neoplasms/surgery ; Retrospective Studies ; Syndrome ; Transanal Endoscopic Microsurgery ; Treatment Outcome
    Language English
    Publishing date 2022-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-022-01494-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Implementation of sodium alginate-Fe

    Zhang, Zhi-Xuan / Lv, Lu / Shi, Ai-Hua / Li, Yun-Hao / Wang, Tian-Ren / Guo, Yuan-Hang / Hu, Bao-Juan / Yan, Xiao-Peng / Fu, Jun-Ke / Ma, Feng / Wang, Hao-Hua / Lv, Yi / Zhang, Yong

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 9979

    Abstract: Many methods are used to locate preoperative small pulmonary nodules. However, deficiencies of complications and success rates exist. We introduce a novel magnetic gel for small pulmonary nodules localization in rabbit model, and furtherly evaluate its ... ...

    Abstract Many methods are used to locate preoperative small pulmonary nodules. However, deficiencies of complications and success rates exist. We introduce a novel magnetic gel for small pulmonary nodules localization in rabbit model, and furtherly evaluate its safety and feasibility. Rabbits were used as the experimental objects. A magnetic gel was used as a tracer magnet, mixed as sodium alginate-Fe
    MeSH term(s) Alginates ; Animals ; Lung Neoplasms/pathology ; Multiple Pulmonary Nodules/pathology ; Rabbits ; Retrospective Studies ; Solitary Pulmonary Nodule/pathology ; Thoracic Surgery, Video-Assisted ; Tomography, X-Ray Computed/methods
    Chemical Substances Alginates
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-13884-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Analysis of frequency, type of complications and economic costs of outlying patients in general and digestive surgery.

    Gomez-Rosado, Juan-Carlos / Li, Yun-Hao / Valdés-Hernández, Javier / Oliva-Mompeán, Fernando / Capitán-Morales, Luis-Cristobal

    Cirugia espanola

    2019  Volume 97, Issue 5, Page(s) 282–288

    Abstract: Introduction: The shortage of available beds and the increase in Emergency Department pressure can cause some patients to be admitted in wards with available beds assigned to other services (outlying patients). The aim of this study is to assess the ... ...

    Title translation Análisis de la frecuencia, tipos de complicación y costes económicos en los pacientes ectópicos de cirugía general y digestiva.
    Abstract Introduction: The shortage of available beds and the increase in Emergency Department pressure can cause some patients to be admitted in wards with available beds assigned to other services (outlying patients). The aim of this study is to assess the frequency, types of complications and costs of outlying patients.
    Methods: Using a retrospective cohort model, we analysed the 2015 general and digestive surgery records (source: Minimum Basic Data Set and economic database). After selecting all outlying patients, we compared the complications, length of stay, costs and consequences of complications against a randomized sample of non-outlying patients with the same DRG and date of episode for every outlying patient, obtaining one non-outlying patient for each selected outlying patient. Thirteen outlying patients with no non-outlying patient pair were excluded from the study.
    Results: From a total of 2,915 patients, 363 (12.45%) were outlying patients. A total of 350 outlying patients were analysed versus 350 non-outlying patients. There were no significant differences in complications (9.4 vs. 8.3%), length of stay (4.33 vs. 4.65 days) or costs (€3,034.12 vs. €3,223.27). Outlying patients men presented a significantly higher risk of complications compared to women (RR=2.10). Outlying patients presented complications after 2.5 or more days.
    Conclusions: When outlying admissions become necessary, the selection of patients with less complex pathologies does not increase complications or their consequences (ICU admissions, readmissions, reoperations or mortality), hospital stays or costs. Only in cases of prolonged outlying stays of more than 2.5 days, or in males, may more complications appear. Therefore, male outliers should be avoided in general, and patients should be transferred to the proper ward if a length of stay beyond 2.5 days is foreseen.
    MeSH term(s) Bed Occupancy/statistics & numerical data ; Digestive System Surgical Procedures/adverse effects ; Digestive System Surgical Procedures/economics ; Digestive System Surgical Procedures/statistics & numerical data ; Female ; Health Services Research/methods ; Hospital Costs/statistics & numerical data ; Humans ; Length of Stay/economics ; Length of Stay/statistics & numerical data ; Male ; Patient Admission/statistics & numerical data ; Postoperative Complications/economics ; Postoperative Complications/epidemiology ; Retrospective Studies ; Spain/epidemiology ; Specialties, Surgical/organization & administration ; Surgical Procedures, Operative/adverse effects ; Surgical Procedures, Operative/economics ; Surgical Procedures, Operative/statistics & numerical data
    Language Spanish
    Publishing date 2019-02-10
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2019.01.001
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  7. Article: Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis.

    He, Xiao-Li / He, Yan-Ming / Zhang, Dan / Li, Hong-Shan / Zhang, Qiang / Yuan, Sha-Sha / Zhang, Zeng / Wang, Yan-Yan / Liu, Cheng-Hao / Fan, Chao-Hua / Li, Yun-Hao / Zheng, Min / Yang, Hong-Jie / Zhou, Ping

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 8888040

    Abstract: Yueju, a famous classic Chinese prescription, has been extensively used in treating depression syndromes for hundreds of years. Recent studies have reported that Yueju showed good effects in treating metabolic diseases, such as obesity and hyperlipidemia. ...

    Abstract Yueju, a famous classic Chinese prescription, has been extensively used in treating depression syndromes for hundreds of years. Recent studies have reported that Yueju showed good effects in treating metabolic diseases, such as obesity and hyperlipidemia. Nonalcoholic steatohepatitis (NASH), which leads to cirrhosis and severe cardiovascular diseases, is closely linked to obesity and abnormal lipid metabolism. In this study, Yueju could decrease the levels of alanine aminotransferase, aspartate transaminase, triglyceride, cholesterol, and low-density lipoprotein-C but increase the high-density lipoprotein-C in the serum of the NASH rat model induced by high-fat and high-cholesterol diet. Yueju could alleviate hepatosteatosis by increasing the phosphorylation of acetyl-CoA carboxylase and inhibiting the expression of fatty acid synthase and stearoyl-CoA desaturase 1. Yueju downregulated the expression of
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/8888040
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    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Protective effects of a G. lucidum proteoglycan on INS-1 cells against IAPP-induced apoptosis via attenuating endoplasmic reticulum stress and modulating CHOP/JNK pathways.

    He, Yan-Ming / Zhang, Qiang / Zheng, Min / Fan, Zhao-Hua / Li, Yun-Hao / Zhang, Dan / Zhang, Zeng / Yuan, Sha-Sha / Wang, Yan-Yan / Zhou, Ping / Yang, Hong-Jie

    International journal of biological macromolecules

    2017  Volume 106, Page(s) 893–900

    Abstract: Fudan-Yueyang-G. lucidum (FYGL) is a water-soluble macromolecular proteoglycan extracted from Ganoderma lucidum which has been used for health promotion for a long time in China. The aim of this study was to investigate the protective effects of FYGL on ... ...

    Abstract Fudan-Yueyang-G. lucidum (FYGL) is a water-soluble macromolecular proteoglycan extracted from Ganoderma lucidum which has been used for health promotion for a long time in China. The aim of this study was to investigate the protective effects of FYGL on INS-1 rat insulinoma beta cells against IAPP-induced cell apoptosis, as well as the underlying mechanisms. The results showed that apoptotic cells were significantly increased when incubated with islet amyloid polypeptide (IAPP). However, cytotoxicity of IAPP was significantly attenuated by co-incubation of the cells with FYGL. The results of RT-PCR showed that mRNA expression of caspase-3, caspase-12 and C/EBP homologous protein (CHOP) in IAPP-treated cells were inhibited by FYGL. Moreover, FYGL significantly prevented the IAPP-induced abnormal expression of inositol-requiring protein-1α (IRE1α), protein kinase RNA (PKR)-like ER kinase (PERK), activating transcription factor 6 (ATF6), as well as suppressed the activation of CHOP and c-Jun N-terminal kinase (JNK). Taken together, our results suggest that FYGL protects INS-1 pancreatic beta cells against IAPP-induced apoptosis through attenuating endoplasmic reticulum stress (ERS) and modulating CHOP/JNK pathways.
    MeSH term(s) Activating Transcription Factor 6/genetics ; Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/genetics ; Endoribonucleases/genetics ; Humans ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/pathology ; Insulinoma/drug therapy ; Insulinoma/genetics ; Insulinoma/pathology ; Islet Amyloid Polypeptide/administration & dosage ; MAP Kinase Signaling System/drug effects ; Medicine, Chinese Traditional ; Multienzyme Complexes/genetics ; Protein-Serine-Threonine Kinases/genetics ; Proteoglycans/administration & dosage ; Proteoglycans/chemistry ; Rats ; Reishi/chemistry ; Transcription Factor CHOP/genetics ; eIF-2 Kinase/genetics
    Chemical Substances Activating Transcription Factor 6 ; Atf6 protein, rat ; DDIT3 protein, human ; Ern1 protein, rat ; Islet Amyloid Polypeptide ; Multienzyme Complexes ; Proteoglycans ; Transcription Factor CHOP (147336-12-7) ; PERK kinase (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; eIF-2 Kinase (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
    Language English
    Publishing date 2017-09-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2017.08.089
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    Zs.B 2374: Show issues Location:
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