LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 425

Search options

  1. Article ; Online: Dilemma of immunosuppression and infection risk in systemic lupus erythematosus.

    He, Jing / Li, Zhanguo

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue Suppl 1, Page(s) i22–i29

    Abstract: Patients with SLE are at high risk of various infections as evidenced by a number of studies. The main determinants of infection in SLE are disease activity, organ damage, and often inevitable medication. The molecular and cellular mechanisms underlying ... ...

    Abstract Patients with SLE are at high risk of various infections as evidenced by a number of studies. The main determinants of infection in SLE are disease activity, organ damage, and often inevitable medication. The molecular and cellular mechanisms underlying infection remain unclear. Impaired immunity, immunosuppressants and corticosteroids clearly increase the risk of infection, whereas some medications, such as low-dose IL-2, hydroxychloroquine and IVIG are safe in SLE patients with substantial evidence. It is important to balance the immunosuppression and infection risks in practice. This article focuses on medication-related infections in SLE and discusses the therapeutic options for the disease in clinical practice.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/chemically induced ; Immunosuppressive Agents/adverse effects ; Hydroxychloroquine/adverse effects ; Immunosuppression Therapy/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Infections/chemically induced
    Chemical Substances Immunosuppressive Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac678
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: A New EWM-FCM Approach to Optimize the Allocation of Water Ecology Compensation Funds

    Lu, Yali / Ding, Wenwen / Li, Zhanguo

    Water resources management. 2022 Aug., v. 36, no. 10

    2022  

    Abstract: In compensation events in some parts of China, funds for water and ecological compensation are usually allocated using the factor allocation method, which often fails to satisfy all stakeholders and affects the overall efficiency of ecological ... ...

    Abstract In compensation events in some parts of China, funds for water and ecological compensation are usually allocated using the factor allocation method, which often fails to satisfy all stakeholders and affects the overall efficiency of ecological compensation Managers need to rethink the effectiveness of the fund allocation method in order to reduce stakeholder complaints and maintain the stability of the ecological protection system. In addition, the dynamic adjustment of the weights in the funding allocation process is an important means of satisfying stakeholders in real time. This paper is based on the entropy weight method (EWM), which has an objective weighting process, introduces fuzzy cognitive map (FCM) theory, integrates objective entropy weights with the state values in FCM, and uses the advantages of the objective assignment of EWM to compensate for the subjective nature of the initial assignment of FCM. At the same time the correlation weights of FCM provide a feedback mechanism for EWM allocation, which makes EWM dynamically adjustable and enhances the practicality of EWM allocation, resulting in an EWM-FCM integration method. The feedback function of the method was used to calculate the case of water ecological compensation funds allocated for the Yellow River (Henan section) in China, and a variety of options for the allocation ratio of water ecological compensation funds were calculated. Stakeholders could choose the appropriate option according to the agreement, which improved the efficiency and satisfaction of the allocation.
    Keywords administrative management ; ecology ; entropy ; fuzzy logic ; stakeholders ; water ; China ; Yellow River
    Language English
    Dates of publication 2022-08
    Size p. 3779-3795.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 59924-4
    ISSN 1573-1650 ; 0920-4741
    ISSN (online) 1573-1650
    ISSN 0920-4741
    DOI 10.1007/s11269-022-03230-0
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 6155: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy.

    Xie, Yang / Jia, Yuan / Li, Zhanguo / Hu, Fanlei

    Expert opinion on therapeutic targets

    2022  Volume 26, Issue 5, Page(s) 461–477

    Abstract: Introduction: Scavenger receptor A (SR-A) is reported to be involved in innate and adaptive immunity and in recent years, the soluble form of SR-A has also been identified. Intriguingly, SR-A displays double-edged sword features in different diseases. ... ...

    Abstract Introduction: Scavenger receptor A (SR-A) is reported to be involved in innate and adaptive immunity and in recent years, the soluble form of SR-A has also been identified. Intriguingly, SR-A displays double-edged sword features in different diseases. Moreover, targeted therapy on SR-A, including genetic modulation, small molecule inhibitor, inhibitory peptides, fucoidan, and blocking antibodies, provides potential strategies for treatment. Currently, therapeutics targeting SR-A are in preclinical studies and clinical trials, revealing great perspectives in future immunotherapy.
    Areas covered: Through searching PubMed (January 1979-March 2022) and clinicaltrials.gov, we review most of the research and clinical trials involving SR-A. This review briefly summarizes recent study advances on SR-A, with particular concern on its role in immunity and autoimmune diseases.
    Expert opinion: Given the emerging evidence of SR-A in immunity, its targeted therapy has been studied in various diseases, especially autoimmune diseases. However, many challenges still remain to be overcome, such as the double-sworded effects and the specific isoform targeting. For further clinical success of SR-A targeted therapy, the crystal structure illustration and the dual function discrimination of SR-A should be further investigated. Nevertheless, although challenging, targeting SR-A would be a potential effective strategy in the treatment of autoimmune diseases and other immune-related diseases.
    MeSH term(s) Adaptive Immunity ; Autoimmune Diseases/drug therapy ; Humans ; Immunotherapy ; Receptors, Scavenger
    Chemical Substances Receptors, Scavenger
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2022.2072729
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Low-dose interleukin-2 therapy in autoimmune and inflammatory diseases: facts and hopes.

    Li, Zhan-Guo / He, Jing / Miao, Miao

    Science bulletin

    2022  Volume 68, Issue 1, Page(s) 10–13

    MeSH term(s) Humans ; Interleukin-2/therapeutic use ; Autoimmune Diseases/drug therapy ; Interleukin-6/therapeutic use ; Immunotherapy ; Hope
    Chemical Substances Interleukin-2 ; Interleukin-6
    Language English
    Publishing date 2022-12-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2022.12.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: A Rare Case of Neurosarcoidosis Overlapped with Sjogren's Syndrome.

    Cai, Wenxin / Li, Ru / He, Jing / Shao, Miao / Li, Zhanguo

    Journal of clinical medicine

    2022  Volume 11, Issue 19

    Abstract: The coexisting of sarcoidosis and Sjögren's syndrome (SS) has long been neglected since sarcoidosis is considered as an exclusion criterion for SS. We described a 55-year-old woman, who was diagnosed with coexisting neurosarcoidosis and Sjögren's ... ...

    Abstract The coexisting of sarcoidosis and Sjögren's syndrome (SS) has long been neglected since sarcoidosis is considered as an exclusion criterion for SS. We described a 55-year-old woman, who was diagnosed with coexisting neurosarcoidosis and Sjögren's syndrome for 16 years. She presented with erythema nodosum, progressive sensory and motor impairment of the extremities, dry mouth, and dry eyes. High-resolution computed tomography (HRCT) of the chest showed symmetrical pulmonary micronodules, interstitial changes, and enlarged mediastinal lymph nodes. Spine magnetic resonance imaging (MRI) showed syringomyelia and thickening of the T3-9 spinal cord. She was with positive ANA and anti-SSA antibodies, impaired function of the lacrimal, salivary gland and renal tubules. Biopsy of skin and lung nodules revealed non-caseous granuloma. Salivary gland biopsy showed focal lymphocyte infiltration. Classification criteria for sarcoidosis and Sjogren's syndrome were fulfilled in this patient based on clinical and laboratory features. This case extends our understanding of overlapped Sjogren's syndrome with sarcoidosis and provides a referential value for clinical diagnosis.
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11195709
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A new look at rheumatology in China--opportunities and challenges.

    Li, Zhan-Guo

    Nature reviews. Rheumatology

    2015  Volume 11, Issue 5, Page(s) 313–317

    Abstract: In the past two decades, Chinese rheumatology has developed rapidly in terms of both clinical practice and basic research. Many rheumatology departments and divisions have been established, creating positions for more residents to join rheumatology ... ...

    Abstract In the past two decades, Chinese rheumatology has developed rapidly in terms of both clinical practice and basic research. Many rheumatology departments and divisions have been established, creating positions for more residents to join rheumatology practices. Numerous studies of rheumatic diseases have been published in recent years by Chinese rheumatologists and immunologists, supported by government funding that has dramatically increased over the past few years. These studies are focused mainly on epidemiology, mechanisms, early diagnosis and interventions of rheumatic diseases. Increasing numbers of national and international scientific activities in China, including research collaborations, education programmes and conferences have greatly helped the development of rheumatology. In this APLAR series article, the major, high-impact studies and latest developments in Chinese rheumatology are reviewed.
    MeSH term(s) Biological Factors/therapeutic use ; China/epidemiology ; Cooperative Behavior ; Humans ; Rheumatic Diseases/epidemiology ; Rheumatic Diseases/pathology ; Rheumatic Diseases/therapy ; Rheumatology/education ; Rheumatology/organization & administration ; Rheumatology/trends
    Chemical Substances Biological Factors
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2014.218
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6338: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The challenges of early diagnosis and therapeutic prediction in rheumatoid arthritis.

    Zhao, Jinxia / Li, Zhan-Guo

    International journal of rheumatic diseases

    2019  Volume 21, Issue 12, Page(s) 2059–2062

    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Biomarkers/blood ; Early Diagnosis ; Humans ; Precision Medicine ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; Severity of Illness Index
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-01-25
    Publishing country England
    Document type Editorial ; Review
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.13459
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6098: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Double-negative (DN) B cells: an under-recognized effector memory B cell subset in autoimmunity.

    Li, Yuzi / Li, Zhanguo / Hu, Fanlei

    Clinical and experimental immunology

    2021  Volume 205, Issue 2, Page(s) 119–127

    Abstract: Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studied subsets, ... ...

    Abstract Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studied subsets, CD27
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; B-Lymphocyte Subsets/immunology ; Humans ; Immunoglobulin D/immunology ; Immunologic Memory/immunology
    Chemical Substances Immunoglobulin D
    Language English
    Publishing date 2021-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1111/cei.13615
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Effects of Different Types of Stabilizers on the Properties of Foam Detergent Used for Radioactive Surface Contamination.

    Zhang, Hao / Liang, Lili / Xi, Hailing / Lin, Xiaoyan / Li, Zhanguo / Jiao, Yu

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 16

    Abstract: Compared with high-pressure water and reagent washing decontamination, foam decontamination has a promising application due to its ability to significantly reduce the volume of radioactive waste liquids and effectively decontaminate the inner surface of ... ...

    Abstract Compared with high-pressure water and reagent washing decontamination, foam decontamination has a promising application due to its ability to significantly reduce the volume of radioactive waste liquids and effectively decontaminate the inner surface of the pipes, the interior of the large cavities, and the vertical walls. However, the foam is less stable, leading to a low decontamination rate. Currently, three main types of stabilizers with different stabilizing mechanisms, namely nanoparticles, polymers, and cosurfactants, are used to improve foam stability and thus increase the decontamination rate. Nanosilica (NS), xanthan gum (XG), and n-tetradecanol (TD) were used as typical representatives of nanoparticles, polymers, and cosurfactants, respectively, to improve the stability of the foam detergent with pH < 2 and chelating agents. The differences in the effects of these three types of stabilizers on foam properties were investigated. Although NS, XG, and TD all increase the half-life of the foam from 7.2 min to about 40 min, the concentration of TD is much lower than that of NS and XG in the foaming solution, and TD foaming solution has the highest foaming ratio. Moreover, TD can markedly lower the surface tension, resulting in a significant reduction of the wetting contact angle on the surfaces of glass, ceramic tile, stainless steel, and paint, while NS and XG cannot signally change the surface tension and have no obvious effect on the wetting contact angle. At low shear rates, TD can increase the apparent viscosity of foam by two orders of magnitude, and the wall-hanging time of the foam on the vertical wall is more than 30 min. In contrast, NS and XG cause a limited increase in the apparent viscosity of the foam, and the wall-hanging times are both less than 5 min. In addition, TD foaming solution has excellent storage stability, and the storage time has no obvious effect on the performance of the foam. And after only three days of storage, NS undergoes severe agglomeration and precipitation in the foaming solution, resulting in a complete loss of the stabilizing effect. After 90 days of storage, the half-life of XG foam decreases by 26%. For simulated radioactive uranium contamination on both horizontal and vertical surfaces, TD can significantly improve the decontamination rate, especially for vertical surfaces, where TD can increase the single decontamination rate by more than 50%.
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28166107
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Tritium and Carbon-14 Contamination Reshaping the Microbial Community Structure, Metabolic Network, and Element Cycle in the Seawater Environment.

    Lai, Jin-Long / Li, Zhan-Guo / Wang, Yi / Xi, Hai-Ling / Luo, Xue-Gang

    Environmental science & technology

    2023  Volume 57, Issue 13, Page(s) 5305–5316

    Abstract: The potential ecological risks caused by entering radioactive wastewater containing tritium and carbon-14 into the sea require careful evaluation. This study simulated seawater's tritium and carbon-14 pollution and analyzed the effects on the seawater ... ...

    Abstract The potential ecological risks caused by entering radioactive wastewater containing tritium and carbon-14 into the sea require careful evaluation. This study simulated seawater's tritium and carbon-14 pollution and analyzed the effects on the seawater and sediment microenvironments. Tritium and carbon-14 pollution primarily altered nitrogen and phosphorus metabolism in the seawater environment. Analysis by 16S rRNA sequencing showed changes in the relative abundance of microorganisms involved in carbon, nitrogen, and phosphorus metabolism and organic matter degradation in response to tritium and carbon-14 exposure. Metabonomics and metagenomic analysis showed that tritium and carbon-14 exposure interfered with gene expression involving nucleotide and amino acid metabolites, in agreement with the results seen for microbial community structure. Tritium and carbon-14 exposure also modulated the abundance of functional genes involved in carbohydrate, phosphorus, sulfur, and nitrogen metabolic pathways in sediments. Tritium and carbon-14 pollution in seawater adversely affected microbial diversity, metabolic processes, and the abundance of nutrient-cycling genes. These results provide valuable information for further evaluating the risks of tritium and carbon-14 in marine environments.
    MeSH term(s) Carbon Radioisotopes/metabolism ; Tritium/metabolism ; Bacteria/genetics ; Bacteria/metabolism ; RNA, Ribosomal, 16S/genetics ; Microbiota/genetics ; Seawater ; Metabolic Networks and Pathways ; Carbon/metabolism ; Nitrogen/metabolism ; Phosphorus/metabolism ; Geologic Sediments/chemistry
    Chemical Substances Carbon-14 (7V68J5677O) ; Carbon Radioisotopes ; Tritium (10028-17-8) ; RNA, Ribosomal, 16S ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c00422
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top