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  1. Article ; Online: Editorial Comment: Dark-Blood Dual-Energy CT for Pancreatic Cancer-A New Approach for Assessment of Vascular Involvement.

    Li, Zhen

    AJR. American journal of roentgenology

    2023  Volume 220, Issue 6, Page(s) 849

    MeSH term(s) Humans ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/surgery ; Tomography, X-Ray Computed/methods ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.22.28952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.57: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Online: Fortgeschrittene Methoden zur Beschreibung der Wirbelschicht-Sprühgranulation

    Li, Zhen

    2013  

    Abstract: A multiscale simulation model is developed by combining the CFD Simulation and the population balance equations to describe a transient process of fluidized bed spray granulation. In this model, the CFD simulation generates the particle growth and ... ...

    Abstract A multiscale simulation model is developed by combining the CFD Simulation and the population balance equations to describe a transient process of fluidized bed spray granulation. In this model, the CFD simulation generates the particle growth and nucleation rates in consideration of fluid dynamics, drying and multiple interactions, such as drops deposition, dust integration and nucleation between different particles (drops, dust and granules)
    Keywords Chemical engineering
    Size 1 electronic resource (VIII, 216 p. p.)
    Publisher KIT Scientific Publishing
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note GERMAN ; Open Access
    HBZ-ID HT020197748
    ISBN 9783731500872 ; 3731500876
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Effects of processing technology on tea quality analyzed using high-resolution mass spectrometry-based metabolomics.

    Wang, Jie / Li, Zhen

    Food chemistry

    2024  Volume 443, Page(s) 138548

    Abstract: Fixation is a crucial step in green tea processing that can impact quality. In this study, we explored the differences in the chemical components of steamed and fried green teas made from the same batch of fresh tea leaves using different fixing methods. ...

    Abstract Fixation is a crucial step in green tea processing that can impact quality. In this study, we explored the differences in the chemical components of steamed and fried green teas made from the same batch of fresh tea leaves using different fixing methods. Results showed that concentrations of sucrose and free amino acids were significantly higher in steamed green tea. Abundances of 12 compounds including purine nucleoside, pyrimidine nucleoside derivatives, and catechins were higher in fried green tea, while 34 compounds such as amino acids and their derivatives, benzofurans and flavonoids were higher in steamed green tea. Thus, steaming retained more compounds associated with sweet and fresh tastes, such as free amino acids, while frying produced more compounds with bitter tastes, such as catechin. This might explain why steamed green tea is mellower than fried tea.
    MeSH term(s) Flavonoids/analysis ; Tea/chemistry ; Catechin/chemistry ; Mass Spectrometry ; Amino Acids/analysis ; Metabolomics ; Plant Leaves/chemistry ; Camellia sinensis/chemistry
    Chemical Substances Flavonoids ; Tea ; Catechin (8R1V1STN48) ; Amino Acids
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  4. Article ; Online: Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice.

    Zhuang, Wei / Li, Zhen

    European cytokine network

    2024  Volume 34, Issue 4, Page(s) 46–53

    Abstract: There is currently no safe or effective treatment for inflammatory bowel disease (IBD), which is defined as recurrent and persistent intestinal inflammation. Thymic stromal lymphopoietin (TSLP) has been shown to be associated with the pathogenesis of IBD, ...

    Abstract There is currently no safe or effective treatment for inflammatory bowel disease (IBD), which is defined as recurrent and persistent intestinal inflammation. Thymic stromal lymphopoietin (TSLP) has been shown to be associated with the pathogenesis of IBD, and the JAK2/STAT5 signalling pathway has demonstrated much promise as a novel therapeutic target for IBD. In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 μg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change, intestinal inflammation, and integrity of the mucosal barrier. In addition, the effect of DSS and/or tezepelumab on the phosphorylation of the JAK/STAT pathway was investigated. TSLP expression levels were elevated in DSS-induced IBD mice, whereas TSLP antibody treatment suppressed the pathological features associated with IBD and alleviated intestinal inflammation and mucosal barrier disruption. Moreover, level of phosphorylated JAK2/STAT5 were increased in DSS-induced IBD mice, but were strongly decreased in the presence of tezepelumab. Our findings suggest that targeting TSLP via the JAK2/STAT5 signalling pathway may be an effective approach for the treatment of IBD.
    MeSH term(s) Animals ; Mice ; Thymic Stromal Lymphopoietin ; STAT5 Transcription Factor ; Janus Kinases ; STAT Transcription Factors ; Signal Transduction ; Cytokines ; Colitis/chemically induced ; Colitis/drug therapy ; Inflammatory Bowel Diseases ; Inflammation
    Chemical Substances Thymic Stromal Lymphopoietin (GT0IL38SP4) ; STAT5 Transcription Factor ; Janus Kinases (EC 2.7.10.2) ; STAT Transcription Factors ; Cytokines
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 1118857-1
    ISSN 1952-4005 ; 1148-5493
    ISSN (online) 1952-4005
    ISSN 1148-5493
    DOI 10.1684/ecn.2023.0489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3447: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Ganglioside GD2 is a potential candidate marker for lung cancer stem cells

    LI Zhen, DUAN Zhaojun, LUO Yunping

    Jichu yixue yu linchuang, Vol 43, Iss 5, Pp 777-

    2023  Volume 784

    Abstract: Objective To explore the feasibility of ganglioside GD2 as a marker for lung cancer stem cells (LCSCs). Methods Cancer stem cells (CSCs) of lung cancer cell lines were enriched by spheroid culturing in vitro; The expression of stemness-related genes and ... ...

    Abstract Objective To explore the feasibility of ganglioside GD2 as a marker for lung cancer stem cells (LCSCs). Methods Cancer stem cells (CSCs) of lung cancer cell lines were enriched by spheroid culturing in vitro; The expression of stemness-related genes and GD3 synthase (GD3S) in LCSCs were detected by RT-qPCR and Western blot; The expression of GD2 and other stemness phenotypes in lung cancer cell line A549 were detected by flow cytometry; Cell proliferation was detected by CCK8 assay; Cell invasion and migration in vitro were examined by Transwell and wound healing assays; The oncogenicity of different subpopulations in cell line A549 was compared with tumor xenograft model. Results CSCs of A549 cell were successfully enriched by and the percentage of GD2+ cells was 0.57% in adherent cell, but the percentage of GD2+ cells was able to increase to 20.4% after spheroid culturing. In comparison with GD2- A549 cells, GD2+ A549 cells showed significantly enhanced cell proliferation (P＜0.05),invasion (P＜0.05) and migration ability (P＜0.01) in vitro. There was a close association between GD2 and two other LCSCs phenotypes, and the expression level of GD2 was positively correlated with the expression of CD44 (P＜0.01) and EpCAM (P＜0.001). The results in vivo indicated that tumors formed by GD2+ A549 cells grew faster (P＜0.001) and were more malignant (P＜0.01) as compared to GD2- A549 cells. Conclusions Ganglioside GD2 is a potential marker for LCSCs to identify cancer stem cells, providing a novel strategy of GD2-targeted lung cancer immunothearapy.
    Keywords lung cancer stem cells|ganglioside gd2|tumor-associated antigen|immunotherapy ; Medicine ; R
    Language Chinese
    Publishing date 2023-05-01T00:00:00Z
    Publisher Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book: International standard Chinese-English basic nomenclature of Chinese medicine

    Li, Zhen-ji

    = Zhong yi ji ben ming ci shu yu zhong ying dui zhao guo ji biao zhun

    2008  

    Title variant Zhong yi ji ben ming ci shu yu zhong ying dui zhao guo ji biao zhun
    Institution World Federation of Chinese Medicine Societies
    Author's details World Federation of Chinese Medicine Societies. Ed.-in-chief: Li Zhen-ji
    Keywords Medicine, Chinese Traditional
    Language English
    Size XXXVI, 789 S.
    Publisher People’s Medical Publ. House
    Publishing place Beijing
    Publishing country China
    Document type Book
    HBZ-ID HT015685492
    ISBN 978-7-117-09356-9 ; 7-117-09356-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 6959 order for loan Magazin

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  7. Article ; Online: Imaging of hydrogen peroxide (H

    Li, Zhen

    Talanta

    2020  Volume 212, Page(s) 120804

    Abstract: Hydrogen peroxide ( ... ...

    Abstract Hydrogen peroxide (H
    MeSH term(s) Boronic Acids/chemical synthesis ; Boronic Acids/chemistry ; Boronic Acids/toxicity ; Cell Survival ; Ferroptosis/physiology ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/toxicity ; Hep G2 Cells ; Humans ; Hydrogen Peroxide/analysis ; Limit of Detection ; Microscopy, Confocal/methods ; Microscopy, Fluorescence/methods
    Chemical Substances Boronic Acids ; Fluorescent Dyes ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2020-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2020.120804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Successful cardiopulmonary resuscitation of cardiac arrest induced by massive pulmonary embolism under general anesthesia: a case report.

    Li, Zhen / Cai, Ning

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1164076

    Abstract: Background: While pulmonary embolism (PE) is a common occurrence, a large life-threatening PE is not. Herein, we discuss the case of a patient with a life-threatening PE that occurred under general anesthesia.: Case presentation: We present the case ... ...

    Abstract Background: While pulmonary embolism (PE) is a common occurrence, a large life-threatening PE is not. Herein, we discuss the case of a patient with a life-threatening PE that occurred under general anesthesia.
    Case presentation: We present the case of a 59-year-old male patient who was at bed rest for several days due to trauma, which resulted in femoral and rib fractures and a lung contusion. The patient was scheduled for femoral fracture reduction and internal fixation under general anesthesia. After disinfection and surgical towel laying, there was a sudden occurrence of severe PE and cardiac arrest; the patient was successfully resuscitated. Computed tomography pulmonary angiography (CTPA) was performed to confirm the diagnosis, and the patient's condition improved after thrombolytic therapy. Unfortunately, the patient's family eventually discontinued treatment.
    Discussion: Massive PE frequently occurs suddenly, may endanger a patient's life at any point in time, and cannot be diagnosed quickly on the basis of clinical manifestations. Although the vital signs fluctuate greatly and there is insufficient time to conduct more tests, some factors such as special disease history, electrocardiography, end-tidal carbon dioxide, and blood gas analysis may help us determine the preliminary diagnosis; however, the final diagnosis is made using CTPA. Current treatment options include thrombectomy, thrombolysis, and early anticoagulation, of which thrombolysis and early anticoagulation are the most feasible.
    Conclusion: Massive PE is a life-threatening disease that requires early diagnosis and timely treatment to save patients' lives.
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1164076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Universality and Approximation Bounds for Echo State Networks With Random Weights.

    Li, Zhen / Yang, Yunfei

    IEEE transactions on neural networks and learning systems

    2023  Volume PP

    Abstract: We study the uniform approximation of echo state networks (ESNs) with randomly generated internal weights. These models, in which only the readout weights are optimized during training, have made empirical success in learning dynamical systems. Recent ... ...

    Abstract We study the uniform approximation of echo state networks (ESNs) with randomly generated internal weights. These models, in which only the readout weights are optimized during training, have made empirical success in learning dynamical systems. Recent results showed that ESNs with ReLU activation are universal. In this article, we give an alternative construction and prove that the universality holds for general activation functions. Specifically, our main result shows that, under certain condition on the activation function, there exists a sampling procedure for the internal weights so that the ESN can approximate any continuous casual time-invariant operators with high probability. In particular, for ReLU activation, we give explicit construction for these sampling procedures. We also quantify the approximation error of the constructed ReLU ESNs for sufficiently regular operators.
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2023.3339512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Thermodynamic efficiency of atmospheric motion governed by the Lorenz system.

    Li, Zhen / Izumida, Yuki

    Physical review. E

    2023  Volume 108, Issue 4-1, Page(s) 44201

    Abstract: The Lorenz system was derived on the basis of a model of convective atmospheric motions and may serve as a paradigmatic model for considering a complex climate system. In this study we formulated the thermodynamic efficiency of convective atmospheric ... ...

    Abstract The Lorenz system was derived on the basis of a model of convective atmospheric motions and may serve as a paradigmatic model for considering a complex climate system. In this study we formulated the thermodynamic efficiency of convective atmospheric motions governed by the Lorenz system by treating it as a nonequilibrium thermodynamic system. Based on the fluid conservation equations under the Oberbeck-Boussinesq approximation, the work necessary to maintain atmospheric motion and heat fluxes at the boundaries were calculated. Using these calculations, the thermodynamic efficiency was formulated for stationary and chaotic dynamics. The numerical results show that for both stationary and chaotic dynamics, the efficiency tends to increase as the atmospheric motion is driven out of thermodynamic equilibrium when the Rayleigh number increases. However, it is shown that the efficiency is upper bounded by the maximum efficiency, which is expressed in terms of the parameters characterizing the fluid and the convective system. The analysis of the entropy generation rate was also performed for elucidating the difference between the thermodynamic efficiency of conventional heat engines and the present atmospheric heat engine. It is also found that there exists an abrupt drop in efficiency at the critical Hopf bifurcation point, where the dynamics change from stationary to chaotic. These properties are similar to those found previously in the Malkus-Lorenz waterwheel system.
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.108.044201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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