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Article ; Online: Biomarkers for detecting and improving AKI after liver transplantation: From diagnosis to treatment.

Liu, Jing / Zhao, Yi / Li, Zhen-Qiong / Chen, Qing / Luo, Chang-Qing / Su, Jin-Xuan / Wang, Yu-Mei

2021 Volume 35, Issue 2, Page(s) 100612

Abstract: Orthotopic liver transplantation (OLT) is a well-established treatment for patients with liver failure. The shortage of donor organs and postoperative complications remain major obstacles for improving patient survival. Among these complications, acute ... ...

Abstract	Orthotopic liver transplantation (OLT) is a well-established treatment for patients with liver failure. The shortage of donor organs and postoperative complications remain major obstacles for improving patient survival. Among these complications, acute kidney injury (AKI) is one of the most frequent types, contributing to graft loss. The timely detection and reversal of AKI can reduce its adverse influences on graft and patient outcomes. Traditional markers for detecting AKI are often limited with regard to their accuracy and specificity, and the discovery of better AKI markers and therapeutic targets assumes great importance. During past decades, studies directed toward early detection and treatment of AKI in OLT have been available. This review summarizes the evidence of these biomarkers for the prediction, diagnosis, treatment and prognosis stratification of AKI associated with OLT.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Biomarkers ; Humans ; Liver Transplantation/adverse effects ; Postoperative Complications/diagnosis ; Prognosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639400-0
ISSN	1557-9816 ; 0955-470X
ISSN (online)	1557-9816
ISSN	0955-470X
DOI	10.1016/j.trre.2021.100612
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Article ; Online: Efficacy and safety of tacrolimus vs. cyclophosphamide for idiopathic membranous nephropathy: A meta-analysis of Chinese adults.

Li, Zhen-Qiong / Hu, Man-Li / Zhang, Chun / Wang, Yu-Mei

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

2015 Volume 35, Issue 5, Page(s) 623–628

Abstract: The efficacy and safety of tacrolimus (TAC) and cyclophosphamide (CTX) in the treatment of idiopathic membranous nephropathy (IMN) were compared in Chinese adult patients using a meta- analysis of the available literatures. Randomized controlled clinical ...

Abstract	The efficacy and safety of tacrolimus (TAC) and cyclophosphamide (CTX) in the treatment of idiopathic membranous nephropathy (IMN) were compared in Chinese adult patients using a meta- analysis of the available literatures. Randomized controlled clinical trials (RCTs) of the treatment of primary IMN with TAC or CTX combined with corticosteroids in the English databases PubMed, Embase and Cochrane, as well as Chinese databases, were searched. Qualified studies were subjected to quality assessment and meta-analysis. A total of 8 RCTs, including 359 Chinese patients, were included in the meta-analysis. The complete remission rate and overall remission rate in the TAC treatment group after 6 months of treatment were higher than those in the CTX treatment group. No significant difference in remission rate was found after 12 months of treatment. There was no significant difference in the adverse reaction between the two groups at the 6th or 12th months. TAC-based treatment was associated with a faster response than CTX at the 6th month, but there was no significant difference between the two groups at 12th month in Chinese adults. Further study is needed to evaluate the long-term efficacy and safety of this treatment regimen.
MeSH term(s)	Adult ; Asian Continental Ancestry Group ; Cyclophosphamide/therapeutic use ; Female ; Glomerular Basement Membrane/drug effects ; Glomerular Basement Membrane/immunology ; Glomerular Basement Membrane/pathology ; Glomerulonephritis, Membranous/drug therapy ; Glomerulonephritis, Membranous/ethnology ; Glomerulonephritis, Membranous/immunology ; Glomerulonephritis, Membranous/pathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Patient Safety ; Randomized Controlled Trials as Topic ; Tacrolimus/therapeutic use ; Treatment Outcome
Chemical Substances	Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2015-10
Publishing country	China
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2090603-1
ISSN	1993-1352 ; 1672-0733 ; 0257-716X
ISSN (online)	1993-1352
ISSN	1672-0733 ; 0257-716X
DOI	10.1007/s11596-015-1480-8
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Article: Clinicopathological features of renal amyloidosis: a single-center study on 47 cases.

Luo, Chang-Qing / Zhang, Yu-An / Li, Zhen-Qiong / Wang, Yu-Mei

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

2015 Volume 35, Issue 1, Page(s) 48–53

Abstract: The correlations between the clinicopathological features and the long-term outcomes of renal amyloidosis (RA) were analyzed with a view to develop strategies for improving diagnosis and prognosis of RA. We retrospectively reviewed the ... ...

Abstract	The correlations between the clinicopathological features and the long-term outcomes of renal amyloidosis (RA) were analyzed with a view to develop strategies for improving diagnosis and prognosis of RA. We retrospectively reviewed the clinicopathological characteristics of 47 patients diagnosed with RA between 2004 and 2014 at the Wuhan Union Hospital. The data on the renal histology, clinical manifestations, and prognosis of RA patients were retrieved from the hospital records and characteristic patterns were identified. The histological changes in the kidneys were correlated with the clinical manifestations of RA. Additionally, most RA patients in this study had decreased serum levels of κ light chain and increased urine levels of κ and λ light chains as well as presence of M-protein in the urine and serum. Patients with early RA showed no specific pathognomonic symptoms. Bleeding associated with diagnostic renal biopsy was rare. We recommend that the routine work-up of patients aged over 40 years and presenting with non-diabetic nephropathy includes the non-invasive tests for the measurement of serum and urine levels of κ and λ light chains as well as protein electrophoresis tests for the presence of urinary and serum M-protein. Additionally, such patients should undergo renal biopsy screening with Cong-red staining to ensure early diagnosis of RA and improve their survival, since the risk of hemorrhage related to renal biopsy screening is low at early stages of RA.
MeSH term(s)	Amyloidosis/diagnosis ; Amyloidosis/pathology ; Biopsy ; Humans ; Immunoglobulins/blood ; Immunoglobulins/urine ; Kidney Diseases/diagnosis ; Kidney Diseases/pathology ; Prognosis
Chemical Substances	Immunoglobulins
Language	English
Publishing date	2015-02
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2090603-1
ISSN	1993-1352 ; 1672-0733 ; 0257-716X
ISSN (online)	1993-1352
ISSN	1672-0733 ; 0257-716X
DOI	10.1007/s11596-015-1387-4
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Article: SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules.

Chen, Zhaohui / Hu, Junyi / Liu, Lilong / Chen, Rong / Wang, Miao / Xiong, Ming / Li, Zhen-Qiong / Zhao, Yi / Li, Hong / Guan, Chuhuai / Zhang, Jie / Liu, Liang / Chen, Ke / Wang, Yu-Mei

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 664868

Abstract: Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk factors, and outcomes of AKI in COVID-19 patients. We found that ... ...

Abstract	Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk factors, and outcomes of AKI in COVID-19 patients. We found that angiotensin-converting enzyme II (ACE2) and transmembrane protease serine 2 (TMPRSS2) were mainly expressed by different cell types in the human kidney. However, in autopsy kidney samples, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoprotein was detected in ACE2
Language	English
Publishing date	2021-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.664868
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Article ; Online: Angiopoietin-Tie signaling in kidney diseases: an updated review.

He, Fang-Fang / Zhang, Di / Chen, Qing / Zhao, Yi / Wu, Liang / Li, Zhen-Qiong / Zhang, Chun / Jiang, Zhao-Hua / Wang, Yu-Mei

FEBS letters

2019 Volume 593, Issue 19, Page(s) 2706–2715

Abstract: Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang- ... ...

Abstract	Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang-Tie signaling pathway participates in the developmental and tumor-induced angiogenesis and is also involved in many disease settings, such as vascular diseases, systemic inflammation, and cancers. Since Angs are widely expressed in the kidney, an enormous amount of research focuses on their roles in the kidney. In this review, we describe the biological functions of the Ang-Tie signaling pathway and summarize their roles in kidney development and maturation, acute and chronic kidney diseases, diabetic nephropathy, lupus nephropathy, hemolytic uremic syndrome, end-stage renal diseases, and renal cell carcinoma. Understanding the molecular mechanisms of Ang-Tie signaling may reveal potential therapeutic targets for preventing or alleviating kidney diseases.
MeSH term(s)	Angiopoietins/metabolism ; Animals ; Humans ; Kidney Diseases/metabolism ; Receptors, TIE/metabolism ; Signal Transduction
Chemical Substances	Angiopoietins ; Receptors, TIE (EC 2.7.10.1)
Language	English
Publishing date	2019-08-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.13568
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Article: Angiopoietin‐Tie signaling in kidney diseases: an updated review

He, Fang‐Fang / Zhang, Di / Chen, Qing / Zhao, Yi / Wu, Liang / Li, Zhen‐Qiong / Zhang, Chun / Jiang, Zhao‐Hua / Wang, Yu‐Mei

FEBS letters. 2019 Oct., v. 593, no. 19

2019

Abstract	Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang‐Tie signaling pathway participates in the developmental and tumor‐induced angiogenesis and is also involved in many disease settings, such as vascular diseases, systemic inflammation, and cancers. Since Angs are widely expressed in the kidney, an enormous amount of research focuses on their roles in the kidney. In this review, we describe the biological functions of the Ang‐Tie signaling pathway and summarize their roles in kidney development and maturation, acute and chronic kidney diseases, diabetic nephropathy, lupus nephropathy, hemolytic uremic syndrome, end‐stage renal diseases, and renal cell carcinoma. Understanding the molecular mechanisms of Ang‐Tie signaling may reveal potential therapeutic targets for preventing or alleviating kidney diseases.
Keywords	angiogenesis ; angiopoietins ; cell viability ; diabetic nephropathy ; hemolytic uremic syndrome ; inflammation ; kidneys ; renal cell carcinoma ; therapeutics ; tyrosine
Language	English
Dates of publication	2019-10
Size	p. 2706-2715.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.13568
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A New Pathogenesis of Albuminuria: Role of Transcytosis.

He, Fang-Fang / Gong, Yi / Li, Zhen-Qiong / Wu, Liang / Jiang, Hua-Jun / Su, Hua / Zhang, Chun / Wang, Yu-Mei

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

2018 Volume 47, Issue 3, Page(s) 1274–1286

Abstract: Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to basolateral membranes without disrupting cellular homeostasis. In kidney, macromolecular components in the serum, such ... ...

Abstract	Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to basolateral membranes without disrupting cellular homeostasis. In kidney, macromolecular components in the serum, such as albumin, low-density lipoprotein and immunoglobulins, pass through the glomerular filtration barrier (GFB) and proximal tubular cells (PTCs) by transcytosis. Protein transcytosis plays a vital role in the pathology of albuminuria, which causes progressive destruction of the GFB structure and function. However, the pathophysiological consequences of protein transcytosis in the kidney remain largely unknown. This article summarizes recent researches on the regulation of albumin transcytosis across the GFB and PTCs in both physiological and pathological conditions. Understanding the mechanism of albumin transcytosis may reveal potential therapeutic targets for prevention or alleviation of the pathological consequences of albuminuria.
MeSH term(s)	Albuminuria/metabolism ; Albuminuria/pathology ; Animals ; Glomerular Filtration Barrier/metabolism ; Glomerular Filtration Barrier/pathology ; Humans ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Transcytosis
Language	English
Publishing date	2018-06-15
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000490223
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Article: A New Pathogenesis of Albuminuria: Role of Transcytosis

He, Fang-Fang / Gong, Yi / Li, Zhen-Qiong / Wu, Liang / Jiang, Hua-Jun / Su, Hua / Zhang, Chun / Wang, Yu-Mei

Cellular Physiology and Biochemistry

2018 Volume 47, Issue 3, Page(s) 1274–1286

Institution	Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Abstract	Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to basolateral membranes without disrupting cellular homeostasis. In kidney, macromolecular components in the serum, such as albumin, low-density lipoprotein and immunoglobulins, pass through the glomerular filtration barrier (GFB) and proximal tubular cells (PTCs) by transcytosis. Protein transcytosis plays a vital role in the pathology of albuminuria, which causes progressive destruction of the GFB structure and function. However, the pathophysiological consequences of protein transcytosis in the kidney remain largely unknown. This article summarizes recent researches on the regulation of albumin transcytosis across the GFB and PTCs in both physiological and pathological conditions. Understanding the mechanism of albumin transcytosis may reveal potential therapeutic targets for prevention or alleviation of the pathological consequences of albuminuria.
Keywords	Transcytosis ; Albuminuria ; Glomerular filtration barrier ; Proximal tubular cell
Language	English
Publishing date	2018-06-15
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Review ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000490223
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Article: [Relationship between CD36 expression, foamy cell aggregates in renal interstitium and serum cholesterol level].

Su, Hua / Zhu, Hong-yan / Liu, Jian-she / Deng, An-guo / Li, Zhen-qiong

Zhonghua bing li xue za zhi = Chinese journal of pathology

2011 Volume 40, Issue 1, Page(s) 42–43

MeSH term(s)	CD36 Antigens/metabolism ; Cell Aggregation ; Cholesterol/blood ; Foam Cells/pathology ; Glomerulonephritis, IGA/blood ; Glomerulonephritis, IGA/metabolism ; Glomerulonephritis, IGA/pathology ; Glomerulonephritis, Membranoproliferative/blood ; Glomerulonephritis, Membranoproliferative/metabolism ; Glomerulonephritis, Membranoproliferative/pathology ; Glomerulonephritis, Membranous/blood ; Glomerulonephritis, Membranous/metabolism ; Glomerulonephritis, Membranous/pathology ; Glomerulosclerosis, Focal Segmental/blood ; Glomerulosclerosis, Focal Segmental/metabolism ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Nephritis/blood ; Nephritis/metabolism ; Nephritis/pathology ; Nephritis, Hereditary/blood ; Nephritis, Hereditary/metabolism ; Nephritis, Hereditary/pathology
Chemical Substances	CD36 Antigens ; Cholesterol (97C5T2UQ7J)
Language	Chinese
Publishing date	2011-01
Publishing country	China
Document type	Journal Article
ZDB-ID	784533-9
ISSN	0529-5807
ISSN	0529-5807
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