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Article ; Online: Constructing a 3D Ion Transport Channel-Based CNF Composite Film with an Intercalated Structure for Superior Performance Flexible Supercapacitors.

Yan, Chunxia / Cheng, Fangyue / Guan, Jie / Li, Zhimao / Wang, Can / Chen, Nannan / Cheng, Chunzu / Wang, Feijun / Shao, Ziqiang

ACS applied materials & interfaces

2024

Abstract: The weak stiffness, huge thickness, and low specific capacitance of commonly utilized flexible supercapacitors hinder their great electrochemical performance. Learning from a biomimetic interface strategy, we design flexible film electrodes based on ... ...

Abstract	The weak stiffness, huge thickness, and low specific capacitance of commonly utilized flexible supercapacitors hinder their great electrochemical performance. Learning from a biomimetic interface strategy, we design flexible film electrodes based on functional intercalated structures with excellent electrochemical properties and mechanical flexibility. A composite film with high strength and flexibility is created using graphene (reduced graphene oxide (rGO)) as the plane layer, layered double metal hydroxide (LDH) as the support layer, and cellulose nanofiber (CNF) as the connection agent and flexible agent. The interlayer height can be adjusted by the ion concentration. The highly interconnected network enables excellent electron and ion transport channels, facilitating rapid ion diffusion and redox reactions. Moreover, the high flexibility and mechanical properties of the film achieve multiple folding and bending. The CNF-rGO-NiCoLDH film electrode exhibits high capacitance performance (3620.5 mF cm
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c19037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hydrophobic modification of cellulose nanofibers by gallic acid and the application in pressure sensing.

Li, Zhimao / Yan, Chunxia / Xu, Wenjing / Shang, Yanlong / Wu, Qian / Mehmood, Saqib / Wang, Feijun / Cheng, Chunzu / Liu, Qiong / Shao, Ziqiang

International journal of biological macromolecules

2024 Volume 261, Issue Pt 2, Page(s) 129770

Abstract: Via rational molecular structure design and using gallic acid (GA) for hydrophobic modification of cellulose nanofibers (CNF), the "polymer dipole" CNF-GA with hydrophilic main chains and hydrophobic side chains was prepared, which improved the poor ... ...

Abstract	Via rational molecular structure design and using gallic acid (GA) for hydrophobic modification of cellulose nanofibers (CNF), the "polymer dipole" CNF-GA with hydrophilic main chains and hydrophobic side chains was prepared, which improved the poor piezoelectric properties of CNF used for preparing pressure sensors. Due to the appearance of the side chains, the elongation at break of the CNF-GA-2, compared with CNF, was enhanced by 186 %, and the excellent tensile strength, puncture load, and tearing strength were displayed. Moreover, the significant glass transition temperature (T
MeSH term(s)	Humans ; Cellulose/chemistry ; Nanofibers/chemistry ; Polymers ; Tensile Strength ; Hydrophobic and Hydrophilic Interactions ; Nitrites ; Transition Elements
Chemical Substances	Cellulose (9004-34-6) ; MXene ; Polymers ; Nitrites ; Transition Elements
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129770
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Article ; Online: Construction and validation of classification models for predicting the response to concurrent chemo-radiotherapy of patients with esophageal squamous cell carcinoma based on multi-omics data.

Li, Zhi-Mao / Liu, Wei / Chen, Xu-Li / Wu, Wen-Zhi / Xu, Xiu-E / Chu, Man-Yu / Yu, Shuai-Xia / Li, En-Min / Huang, He-Cheng / Xu, Li-Yan

Clinics and research in hepatology and gastroenterology

2024 Volume 48, Issue 4, Page(s) 102318

Abstract: Background: Concurrent chemo-radiotherapy (CCRT) is the preferred non-surgical treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC). Unfortunately, some patients respond poorly, which leads to inappropriate or excessive ...

Abstract	Background: Concurrent chemo-radiotherapy (CCRT) is the preferred non-surgical treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC). Unfortunately, some patients respond poorly, which leads to inappropriate or excessive treatment and affects patient survival. To accurately predict the response of ESCC patients to CCRT, we developed classification models based on the clinical, serum proteomic and radiomic data. Methods: A total of 138 ESCC patients receiving CCRT were enrolled in this study and randomly split into a training cohort (n = 92) and a test cohort (n = 46). All patients were classified into either complete response (CR) or incomplete response (non-CR) groups according to RECIST1.1. Radiomic features were extracted by 3Dslicer. Serum proteomic data was obtained by Olink proximity extension assay. The logistic regression model with elastic-net penalty and the R-package "rms" v6.2-0 were applied to construct classification and nomogram models, respectively. The area under the receiver operating characteristic curves (AUC) was used to evaluate the predictive performance of the models. Results: Seven classification models based on multi-omics data were constructed, of which Model-COR, which integrates five clinical, five serum proteomic, and seven radiomic features, achieved the best predictive performance on the test cohort (AUC = 0.8357, 95 % CI: 0.7158-0.9556). Meanwhile, patients predicted to be CR by Model-COR showed significantly longer overall survival than those predicted to be non-CR in both cohorts (Log-rank P = 0.0014 and 0.027, respectively). Furthermore, two nomogram models based on multi-omics data also performed well in predicting response to CCRT (AUC = 0.8398 and 0.8483, respectively). Conclusion: We developed and validated a multi-omics based classification model and two nomogram models for predicting the response of ESCC patients to CCRT, which achieved the best prediction performance by integrating clinical, serum Olink proteomic, and radiomic data. These models could be useful for personalized treatment decisions and more precise clinical radiotherapy and chemotherapy for ESCC patients.
MeSH term(s)	Humans ; Esophageal Neoplasms/therapy ; Esophageal Squamous Cell Carcinoma/therapy ; Multiomics ; Proteomics ; Pathologic Complete Response ; Chemoradiotherapy ; Retrospective Studies
Language	English
Publishing date	2024-03-11
Publishing country	France
Document type	Journal Article
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2024.102318
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Article: Engineering two nitrogen-containing polyhedral oligomeric silsesquioxanes (N-POSSs) to enhance the fire safety of epoxy resin endowed with superior thermal stability

Ye, Xinming / Feng, Yu / Tian, Panpan / Li, Zhimao / Li, Yingchun / Wang, Wensheng / Li, Jie / Qiao, Liang / Wang, Kun / Zhang, Wenchao / Pan, Ye-Tang / Yang, Rongjie

Polymer degradation and stability. 2022 Apr. 17,

2022

Abstract: Despite remarkable advances in developing flame retardants and smoke suppressants for epoxy resin (EP), engineering nitrogen-containing polyhedral oligomeric silsesquioxane (N-POSS) to impart superior fire safety properties to EP has remained an ... ...

Abstract	Despite remarkable advances in developing flame retardants and smoke suppressants for epoxy resin (EP), engineering nitrogen-containing polyhedral oligomeric silsesquioxane (N-POSS) to impart superior fire safety properties to EP has remained an intractable challenge. In this work, two nitrogen-containing polyhedral oligomeric silsesquioxanes (N-POSSs), namely, aminoethyl-aminopropyl-hepta-phenyl polyhedral oligomeric silsesquioxane (AEAP-POSS) and aminopropyl-hepta-phenyl polyhedral oligomeric silsesquioxane (AP-POSS), were synthesized through the “corner-capping” reaction. The molecular structures of N-POSSs were fully characterized by FTIR, ¹H NMR, ²⁹Si NMR and MALDI-TOF MS, and the synthesized AEAP-POSS and AP-POSS were introduced into EP to solve the shortcomings of flammability. TGA results showed that the incorporation of 4 wt% N-POSS nanoparticles distinctly improved the char residue at 800 °C, which significantly enhanced the thermal stability of the EP composites. When 4 wt% of AP-POSS was introduced into EP, reductions in the peak of heat release rate (p-HRR), fire growth index (FGI), peak of smoke production rate (p-SPR), and the peak of CO production rate (p-COP) reached to 60.6%, 70.2%, 52.3% and 60.4%, respectively. Subsequently, TG-FTIR and XPS were utilized to investigate the flame retardancy and smoke suppression mechanism. Our work presented a considerable advancement for the facile fabrication of flame retardants based on nitrogen-containing polyhedral oligomeric silsesquioxane compounds.
Keywords	degradation ; epoxides ; fire safety ; flammability ; heat ; silsesquioxanes ; smoke ; thermal stability
Language	English
Dates of publication	2022-0417
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	1502217-1
ISSN	0141-3910
ISSN	0141-3910
DOI	10.1016/j.polymdegradstab.2022.109946
Database	NAL-Catalogue (AGRICOLA)

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Article: Clinical differences between small and large pheochromocytomas and paragangliomas.

Zhao, Lin / Li, ZhiMao / Meng, Xu / Fan, Hua / Zhang, ZengLei / Zhang, ZhaoCai / Liu, YeCheng / Zhou, XianLiang / Zhu, HuaDong

Frontiers in endocrinology

2023 Volume 14, Page(s) 1087506

Abstract: Background: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors, most of which are characterized by the release of catecholamine, and range in diameters from less than 1 cm to 10 cm or more. However, knowledge of the differences in ... ...

Abstract	Background: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors, most of which are characterized by the release of catecholamine, and range in diameters from less than 1 cm to 10 cm or more. However, knowledge of the differences in clinical features between small and large PPGLs is insufficient. Methods: A retrospective analysis of patients with PPGLs treated at our institution between January 2018 and June 2020 was performed. The clinical characteristics of patients were investigated, and comparisons were made between patients with large and small PPGLs. The logistic regression analysis was used to confirm the risk factors, and the receiver operating characteristic curve was used to evaluate the diagnostic performance of the variables. Results: Totally 263 patients were included, including 110 patients in small tumor group and 153 patients in large tumor group. There were more male patients in the large tumor group (p=0.009). More patients had hypertension (p<0.001) and diabetes (p=0.002) in the large tumor group. The 24-h urinary epinephrine (24hU-E) (p < 0.001) and 24-h urinary norepinephrine (24hU-NE) (p=0.002) concentrations were higher in the large tumor group. In terms of tumor location, adrenal-PPGLs were more frequent in the large tumor group (p<0.001). Multivariate logistic regression analysis showed that male sex [odds ratio (OR): 2.871, 95% confidence interval (CI): 1.444-5.711, p=0.003], 24hU-E concentrations (OR: 1.025, 95% CI:1.004-1.047, p=0.020), 24hU-NE concentrations (OR: 1.002, 95%CI: 1.001-1.004, p=0.045), and adrenal-PPGLs (OR: 2.510, 95% CI:1.256-5.018, p=0.009) were positive risk factors for large tumors. Taking above variables into the same model, the area under the receiver operating characteristic curve of the model for predicting the large tumor was 0.772 (95% CI: 0.706-0.834). After the short-term follow-up, there was no significant difference in tumor recurrence between the two groups (p=0.681). Conclusions: Significant differences in numerous clinical characteristics exist between large and small PPGLs. The male patients were more likely to be with large tumors, and such tumors were more likely to reside on the adrenal glands. Catecholamine measurements also help predict tumor size of PPGLs. Clinical decision-making will benefit from this information.
MeSH term(s)	Humans ; Male ; Pheochromocytoma/diagnosis ; Pheochromocytoma/epidemiology ; Pheochromocytoma/pathology ; Retrospective Studies ; Neoplasm Recurrence, Local ; Paraganglioma/diagnosis ; Paraganglioma/pathology ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/epidemiology ; Adrenal Gland Neoplasms/pathology ; Catecholamines
Chemical Substances	Catecholamines
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1087506
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Article ; Online: Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.

Heng, Jinghua / Li, Zhimao / Liu, Luxin / Zheng, Zhenyuan / Zheng, Yaqi / Xu, Xiue / Liao, Liandi / Xu, Hongyao / Huang, Hecheng / Li, Enmin / Xu, Liyan

International journal of radiation oncology, biology, physics

2023 Volume 117, Issue 4, Page(s) 966–978

Abstract: Purpose: The overall survival of patients with esophageal squamous cell carcinoma (ESCC) is not high due to the lack of markers to evaluate concurrent chemoradiation therapy (CCRT) resistance. The aim of this study is to use proteomics to identify a ... ...

Abstract	Purpose: The overall survival of patients with esophageal squamous cell carcinoma (ESCC) is not high due to the lack of markers to evaluate concurrent chemoradiation therapy (CCRT) resistance. The aim of this study is to use proteomics to identify a protein related to radiation therapy resistance and explore its molecular mechanisms. Methods and materials: Proteomic data for pretreatment biopsy tissues from 18 patients with ESCC who underwent CCRT (complete response [CR] group, n = 8; incomplete response [<CR] group, n = 10) were collected and combined with ESCC proteomic data from iProx (n = 124) to identify candidate proteins that confer resistance to CCRT. Subsequently, 125 paraffin-embedded biopsies were used for immunohistochemical validation. Colony formation assays, after ionizing radiation (IR), of acetyl-CoA acetyltransferase 2 (ACAT2)-overexpressing, -knockdown or knockout ESCC cells were used to determine the effects of ACAT2 on radioresistance. reactive oxygen species, C11-BODIPY, and Western blotting were employed to reveal the potential mechanism of ACAT2-mediated radioresistance after IR.<br />Results: Enrichment analysis of differentially expressed proteins (<CR vs CR) showed that the pathways of molecules conferring CCRT resistance in ESCC were related to lipid metabolism, whereas molecules conferring CCRT sensitivity were mainly related to immunity pathways. ACAT2 was selected from proteomics and validated by immunohistochemistry as a risk factor for reduced overall survival and CCRT or radiation therapy resistance among ESCC patients. ACAT2 overexpression conferred resistance to IR treatment, whereas ACAT2 knockdown or knockout conferred IR sensitivity. ACAT2 knockout cells were prone to have elevated reactive oxygen species production, enhanced lipid peroxidation, and reduced levels of glutathione peroxidase 4 after IR compared with irradiated wild-type cells. ACAT2 knockout cells could be rescued from IR-mediated toxicity by ferrostatin-1 and liproxstatin.<br />Conclusion: ACAT2 overexpression confers radioresistance by inhibiting ferroptosis in ESCC, suggesting ACAT2 could be a potential biomarker of poor radiotherapeutic response and a therapeutic target for enhancing the radiosensitivity of ESCC.
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2023.05.031
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Article: Synthesis and characterization of 2,5-furandicarboxylic acid poly(butanediol sebacate-butanediol) terephthalate (PBSeT) segment copolyesters with excellent water vapor barrier and good mechanical properties

Feng, Yu / Li, Yingchun / Ye, Xinming / Li, Zhimao / Wang, Wensheng / Liu, Tong / Azab, Islam H. El / Mersal, Gaber A. M. / Ibrahim, Mohamed M. / El-Bahy, Zeinhom M. / Huang, Mina / Guo, Zhanhu

Journal of materials science. 2022 June, v. 57, no. 24

2022

Abstract: In order to improve the performance of biodegradable materials, aliphatic–aromatic copolyesters were synthesized from sebacic acid, terephthalic acid, 1,4-butanediol and 2,5-furandicarboxylic acid via two-step esterification and polycondensation. ... ...

Abstract	In order to improve the performance of biodegradable materials, aliphatic–aromatic copolyesters were synthesized from sebacic acid, terephthalic acid, 1,4-butanediol and 2,5-furandicarboxylic acid via two-step esterification and polycondensation. Copolyesters were characterized by intrinsic viscosity, gel permeation chromatography, X-ray diffraction, Fourier infrared spectroscopy, nuclear magnetic resonance, differential scanning calorimetry, thermogravimetric analysis, lipase biodegradation, tensile and cup method testing. All the copolyesters had a weight-averaged molecular weight over 61,000 g/mol or intrinsic viscosity over 1.1 dL/g when the 2,5-furandicarboxylic acid content was in the range from 2 to 10% of terephthalic acid content. Particularly, the tensile strength, yield strength, elongation at break, molecular weight and water vapor barrier of copolyesters were improved to different extents. Obviously, the addition of 2,5-furandicarboxylic acid did not significantly affect the glass transition temperature and thermal stability of polyesters. When the addition amount of 2,5-furandicarboxylic acid was 10%, the water vapor barrier of copolyester reached the highest, which was increased by 89% compared with PBAT. On the whole, the copolyesters with the addition of 6% of 2,5-furandicarboxylic acid had the best comprehensive performance, which was conducive to promoting the application of biodegradable agricultural mulching and food packaging film.
Keywords	X-ray diffraction ; biodegradability ; biodegradation ; butanediol ; carboxylic ester hydrolases ; condensation reactions ; esterification ; gel chromatography ; glass transition temperature ; infrared spectroscopy ; molecular weight ; nuclear magnetic resonance spectroscopy ; polyesters ; tensile strength ; thermal stability ; thermogravimetry ; viscosity ; water vapor
Language	English
Dates of publication	2022-06
Size	p. 10997-11012.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-022-07269-7
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Article ; Online: Development and Validation of a New Staging System for Esophageal Squamous Cell Carcinoma Patients Based on Combined Pathological TNM, Radiomics, and Proteomics.

Zheng, Shao-Jun / Zheng, Chun-Peng / Zhai, Tian-Tian / Xu, Xiu-E / Zheng, Ya-Qi / Li, Zhi-Mao / Li, En-Min / Liu, Wei / Xu, Li-Yan

Annals of surgical oncology

2022 Volume 30, Issue 4, Page(s) 2227–2241

Abstract: Objective: This study aimed to construct a new staging system for patients with esophageal squamous cell carcinoma (ESCC) based on combined pathological TNM (pTNM) stage, radiomics, and proteomics.: Methods: This study collected patients with ... ...

Abstract	Objective: This study aimed to construct a new staging system for patients with esophageal squamous cell carcinoma (ESCC) based on combined pathological TNM (pTNM) stage, radiomics, and proteomics. Methods: This study collected patients with radiomics and pTNM stage (Cohort 1, n = 786), among whom 103 patients also had proteomic data (Cohort 2, n = 103). The Cox regression model with the least absolute shrinkage and selection operator, and the Cox proportional hazards model were used to construct a nomogram and predictive models. Concordance index (C-index) and the integrated area under the time-dependent receiver operating characteristic (ROC) curve (IAUC) were used to evaluate the predictive models. The corresponding staging systems were further assessed using Kaplan-Meier survival curves. Results: For Cohort 1, the RadpTNM4c staging systems, constructed based on combined pTNM stage and radiomic features, outperformed the pTNM4c stage in both the training dataset 1 (Train1; IAUC 0.711 vs. 0.706, p < 0.001) and the validation dataset 1 (Valid1; IAUC 0.695 vs. 0.659, p < 0.001; C-index 0.703 vs. 0.674, p = 0.029). For Cohort 2, the ProtRadpTNM2c staging system, constructed based on combined pTNM stage, radiomics, and proteomics, outperformed the pTNM2c stage in both the Train2 (IAUC 0.777 vs. 0.610, p < 0.001; C-index 0.898 vs. 0.608, p < 0.001) and Valid2 (IAUC 0.746 vs. 0.608, p < 0.001; C-index 0.889 vs. 0.641, p = 0.009) datasets. Conclusions: The ProtRadpTNM2c staging system, based on combined pTNM stage, radiomic, and proteomic features, improves the predictive performance of the classical pTNM staging system.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/diagnostic imaging ; Esophageal Squamous Cell Carcinoma/therapy ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/therapy ; Esophageal Neoplasms/pathology ; Proteomics ; Neoplasm Staging ; Nomograms
Language	English
Publishing date	2022-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-13026-6
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Article ; Online: Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer.

Li, Rong-Yao / Zheng, Zhen-Yuan / Li, Zhi-Mao / Heng, Jing-Hua / Zheng, Ya-Qi / Deng, Dan-Xia / Xu, Xiu-E / Liao, Lian-Di / Lin, Wan / Xu, Hong-Yao / Huang, He-Cheng / Li, En-Min / Xu, Li-Yan

Chemico-biological interactions

2022 Volume 361, Page(s) 109967

Abstract: Esophageal cancer is the seventh most common cancer globally. Chemotherapy resistance remains a significant challenge in the treatment of esophageal cancer patients. Cisplatin can damage tumor cells by inducing pyroptosis. However, the underlying ... ...

Abstract	Esophageal cancer is the seventh most common cancer globally. Chemotherapy resistance remains a significant challenge in the treatment of esophageal cancer patients. Cisplatin can damage tumor cells by inducing pyroptosis. However, the underlying molecular mechanisms remain unclear. In this work, we aim to investigate pyroptosis-dependent molecular mechanisms underlying cisplatin sensitivity and find potential biomarkers to predict response to cisplatin-based chemotherapy for esophageal cancer patients. Pyroptosis-associated proteins were screened via proteomics for esophageal cancer (n = 124) and bioinformatics analysis. We observed that high calpain-1 (CAPN1) and calpain-2 (CAPN2) expression were associated with favorable clinical outcomes and prolonged survival in esophageal cancer patients. We employed immunohistochemistry to evaluate the expression of CAPN1 and CAPN2 in pretreatment tumor biopsies from 108 patients with esophageal cancer who received concurrent chemoradiotherapy (CCRT). These results suggested that esophageal cancer patients with high expression of both CAPN1 and CAPN2 are likely to experience a complete response to CCRT and have significantly better survival. Western blotting, LDH release, calpain activity and cell viability assays indicated that cisplatin could activate calpain activity, while calpain inhibition or knockout suppressed cisplatin-induced pyroptosis. Mechanistically, we uncovered a novel mechanism whereby cisplatin induced pyroptosis via activation of a CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME signaling axis in esophageal cancer cells. Collectively, this study is the first to explore the effects of calpain on cisplatin-induced pyroptosis in esophageal cancer cells. Further, our findings also imply that the combination of CAPN1 and CAPN2 could be considered as a promising biomarker of cisplatin sensitivity and prognosis in patients with esophageal cancer, providing a possibility to guide individualized treatment.
MeSH term(s)	Calpain/metabolism ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cisplatin/metabolism ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/metabolism ; Humans ; Pyroptosis ; bcl-2-Associated X Protein/metabolism
Chemical Substances	bcl-2-Associated X Protein ; Calpain (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; CAPN1 protein, human (EC 3.4.22.52) ; CAPN2 protein, human (EC 3.4.22.53) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-05-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2022.109967
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Article ; Online: Simple and rapid nicotine analysis using a disposable silica nanochannel-assisted electrochemiluminescence sensor.

Xiao, Yi / Chen, Suhua / Zhang, Guocan / Li, Zhimao / Xiao, Han / Chen, Chuanpin / He, Chunlian / Zhang, Ran / Yang, Xiaoping

The Analyst

2020 Volume 145, Issue 14, Page(s) 4806–4814

Abstract: Nicotine analysis is essential to medicine, toxicology and the tobacco industry. However, no simple, portable and disposable method was developed to meet their demands. Here, we report a simple, rapid and disposable silica nanochannel (SAN)-based ... ...

Abstract	Nicotine analysis is essential to medicine, toxicology and the tobacco industry. However, no simple, portable and disposable method was developed to meet their demands. Here, we report a simple, rapid and disposable silica nanochannel (SAN)-based electrochemiluminescence (ECL) sensor for nicotine analysis by simply assembling a SAN electrode with a paper cover. The sensing principle of the disposable sensor is based on the size exclusion effect and charge selectivity, which obviously prolong the sensor service time. We find that the sensor exhibits good specificity to nicotine, and most of the complex matrices are unlikely to impact the detection. The performance of the disposable sensor in cigarettes, e-cigarettes, nicotine gums, and lozenges is fully validated, showing satisfactory linearity, sensitivity (a limit of detection of 27.82 nM), and accuracy (a recovery between 96.00% and 106.51%). The disposable sensor can be potentially applied for on-site nicotine analysis.
MeSH term(s)	Electrodes ; Electronic Nicotine Delivery Systems ; Luminescent Measurements ; Nicotine ; Silicon Dioxide
Chemical Substances	Nicotine (6M3C89ZY6R) ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2020-06-26
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d0an00588f
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