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  1. Article ; Online: Characteristics of water flooded layer in Minghuazhen Formation

    Li Zhonglin

    E3S Web of Conferences, Vol 375, p

    2023  Volume 01016

    Abstract: In the process of oilfield exploitation, the water-flooded layer in the Minghuazhen Formation cannot be accurately identified, which has a great impact on the oilfield exploitation efficiency. If the water-flooded layer marker in the Minghuazhen ... ...

    Abstract In the process of oilfield exploitation, the water-flooded layer in the Minghuazhen Formation cannot be accurately identified, which has a great impact on the oilfield exploitation efficiency. If the water-flooded layer marker in the Minghuazhen Formation cannot be fundamentally defined, the oilfield may not be able to carry out normal exploitation operation. Based ON this, THIS PAPER expounds the basic characteristics of oil accumulation in the water-flooded layer of Minghuazhen Formation, puts forward the characteristics of the water-flooded layer, and analyzes the factors of low resistance for reference.
    Keywords oilfield minghuazhen formation ; water flooded layer ; characteristics analysis ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Current status of producing autologous hematopoietic stem cells.

    Li, Zhonglin / Yang, Ling

    Current research in translational medicine

    2023  Volume 71, Issue 1, Page(s) 103377

    Abstract: Hematopoietic stem cells (HSCs) transplantation is an established therapy for many diseases of the hematopoietic system, for example aplastic anemia, acute myeloid leukemia and acute lymphoblastic leukemia. With the development of the HSCs research, HSCs ...

    Abstract Hematopoietic stem cells (HSCs) transplantation is an established therapy for many diseases of the hematopoietic system, for example aplastic anemia, acute myeloid leukemia and acute lymphoblastic leukemia. With the development of the HSCs research, HSCs provide an attractive method for treating hereditary blood disorders and immunotherapy of cancer by introducing gene modification. Compared with allogenic HSCs transplantation, using autologous HSCs or HSCs from induced pluripotent stem cells (iPSCs) would eliminate the probability of alloimmunization and transfusion-transmitted infectious diseases. The methods for obtaining autologous HSCs include amplifying patients' HSCs or inducing patients' somatic cells to HSCs (graph abstract). However, the biggest problem is inducing HSCs to proliferate in vitro and maintaining their stemness at the same time. Although many tests have been made to transform iPSCs to HSCs, the artificially generated HSCs still have substantial disparity compared with physiological HSCs. This review summarized the application status and obstacles to implantation of autologous HSCs and iPSC-derived HSCs. Meanwhile, we summarized the latest research progress in HSCs amplification and iPSCs reprogramming methods, which will help to solve the problems mentioned above.
    MeSH term(s) Humans ; Cell Differentiation/genetics ; Hematopoietic Stem Cells ; Induced Pluripotent Stem Cells ; Hematopoietic Stem Cell Transplantation/methods ; Leukemia, Myeloid, Acute
    Language English
    Publishing date 2023-01-05
    Publishing country France
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2023.103377
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  3. Article: The Crosstalk between Gut Microbiota and Bile Acids Promotes the Development of Non-Alcoholic Fatty Liver Disease.

    Li, Zhonglin / Yuan, Hang / Chu, Huikuan / Yang, Ling

    Microorganisms

    2023  Volume 11, Issue 8

    Abstract: Recently the roles of gut microbiota are highly regarded in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The intestinal bacteria regulate the metabolism of bile acids depending on bile salt hydrolase (BSH), 7-dehydroxylation, ... ...

    Abstract Recently the roles of gut microbiota are highly regarded in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The intestinal bacteria regulate the metabolism of bile acids depending on bile salt hydrolase (BSH), 7-dehydroxylation, hydroxysteroid dehydrogenase (HSDH), or amide conjugation reaction, thus exerting effects on NAFLD development through bile acid receptors such as farnesoid X receptor (FXR), Takeda G-protein-coupled bile acid protein 5 (TGR5), and vitamin D receptor (VDR), which modulate nutrient metabolism and insulin sensitivity via interacting with downstream molecules. Reversely, the composition of gut microbiota is also affected by the level of bile acids in turn. We summarize the mutual regulation between the specific bacteria and bile acids in NAFLD and the latest clinical research based on microbiota and bile acids, which facilitate the development of novel treatment modalities in NAFLD.
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11082059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fission cross-section measurements for the

    Han, Yafei / Qiao, Yujie / Li, Zhonglin / Han, Xueyan / Wang, Qiang / Fang, Kaihong / Zhang, Shuo

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2024  Volume 205, Page(s) 111177

    Abstract: In this study, we conducted measurements of the independent fission cross-sections ... ...

    Abstract In this study, we conducted measurements of the independent fission cross-sections of
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2024.111177
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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.279: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Dual Strategies of Metal Preintercalation and In Situ Electrochemical Oxidization Operating on MXene for Enhancement of Ion/Electron Transfer and Zinc-Ion Storage Capacity in Aqueous Zinc-Ion Batteries.

    Li, Zhonglin / Wei, Yifan / Liu, Yongyao / Yan, Shuai / Wu, Mingyan

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 8, Page(s) e2206860

    Abstract: As an emerging two-dimensional material, MXenes exhibit enormous potentials in the fields of energy storage and conversion, due to their superior conductivity, effective surface chemistry, accordion-like layered structure, and numerous ordered ... ...

    Abstract As an emerging two-dimensional material, MXenes exhibit enormous potentials in the fields of energy storage and conversion, due to their superior conductivity, effective surface chemistry, accordion-like layered structure, and numerous ordered nanochannels. However, interlayer accumulation and chemical sluggishness of structural elements have hampered the demonstration of the superiorities of MXenes. By metal preintercalation and in situ electrochemical oxidization strategies on V
    Language English
    Publishing date 2023-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206860
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  6. Article: Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database.

    Li, Zhonglin / Yang, Ling

    Frontiers in genetics

    2020  Volume 11, Page(s) 558557

    Abstract: Background: The coronavirus disease 2019 (COVID-19) has become a worldwide public health crisis. At present, there are no effective antiviral drugs to treat COVID-19. Although some vaccines have been developed, late-stage clinical trials that allow ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) has become a worldwide public health crisis. At present, there are no effective antiviral drugs to treat COVID-19. Although some vaccines have been developed, late-stage clinical trials that allow licensure by regulatory agencies are still needed. Previous reports have indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV are highly homologous and both use angiotensin-converting enzyme 2 (ACE2) as the receptor to enter cells, and SARS-CoV infection reduces the ACE2 expression in the lung. Therefore, the analysis of genes co-expressed with ACE2 in the lung may uncover the underlying mechanism of COVID-19. Finally, we used the Connectivity map (Cmap) database to search for candidate drugs using transcriptome profiles of patients with COVID-19.
    Method: Based on the differentially expressed genes (DEGs), indicated by the expression of RNAs isolated from bronchoalveolar lavage fluid (BALF) cells of patients with COVID-19, we performed functional enrichment analysis and hub gene cluster analysis. Furthermore, we identified genes co-expressed with ACE2 in healthy lung samples and analyzed the significant genes. Additionally, to identify several candidate drugs for the treatment of COVID-19, we queried Cmap using DEGs and genes co-expressed with ACE2.
    Results and conclusion: The up-regulated genes in the BALF cells of patients with COVID-19 are related to viral mRNA translation. The down-regulated genes are related to immune response functions. Genes positively correlated with ACE2 are related to immune defense and those negatively correlated are enriched in synaptic transmission functions. The results reflected prosperous viral proliferation and immune dysfunction in patients. Furthermore, ACE2 may not only mediate viral entrance, but also play an important role in immune defense. By using Cmap with transcriptome profiles of patients with COVID-19, we identified candidate drugs for the treatment of COVID-19, such as amantadine and acyclovir.
    Keywords covid19
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.558557
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  7. Article ; Online: A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis.

    Villeneuve, Judith / Tremblay, Élody / Gaudreault, Nathalie / Saavedra Armero, Victoria / Boudreau, Dominique K / Li, Zhonglin / Renaut, Sébastien / Dion, Geneviève / Bossé, Yohan

    American journal of respiratory cell and molecular biology

    2024  

    Abstract: The recent European Respiratory Society statement on familial pulmonary fibrosis (FPF) supports the need of genetic testing in the care of patients and their relatives. However, no solution (i.e., a concrete test) was provided to implemented genetic ... ...

    Abstract The recent European Respiratory Society statement on familial pulmonary fibrosis (FPF) supports the need of genetic testing in the care of patients and their relatives. However, no solution (i.e., a concrete test) was provided to implemented genetic testing in daily practice. Herein, we tabulated and standardized the nomenclature of 128 genetic variants in 20 genes implicated in adult-onset pulmonary fibrosis. The objective was to develop a laboratory developed test (LDT) based on standard Sanger sequencing in order to capture all known FPF-associated variants. Targeted DNA fragments were amplified with harmonized PCR conditions to perform the LDT in a single 96-well plate. The new genetic test was evaluated in 62 sporadic cases of idiopathic pulmonary fibrosis (IPF). As expected in this population, we observed a low yield of disease-causing mutations. More importantly, 100% of targeted variants by the LDT were successfully evaluated. Furthermore, four variants of uncertain significance with
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2024-0009MA
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Interpretable-ADMET: a web service for ADMET prediction and optimization based on deep neural representation.

    Wei, Yu / Li, Shanshan / Li, Zhonglin / Wan, Ziwei / Lin, Jianping

    Bioinformatics (Oxford, England)

    2022  Volume 38, Issue 10, Page(s) 2863–2871

    Abstract: Motivation: In the process of discovery and optimization of lead compounds, it is difficult for non-expert pharmacologists to intuitively determine the contribution of substructure to a particular property of a molecule.: Results: In this work, we ... ...

    Abstract Motivation: In the process of discovery and optimization of lead compounds, it is difficult for non-expert pharmacologists to intuitively determine the contribution of substructure to a particular property of a molecule.
    Results: In this work, we develop a user-friendly web service, named interpretable-absorption, distribution, metabolism, excretion and toxicity (ADMET), which predict 59 ADMET-associated properties using 90 qualitative classification models and 28 quantitative regression models based on graph convolutional neural network and graph attention network algorithms. In interpretable-ADMET, there are 250 729 entries associated with 59 kinds of ADMET-associated properties for 80 167 chemical compounds. In addition to making predictions, interpretable-ADMET provides interpretation models based on gradient-weighted class activation map for identifying the substructure, which is important to the particular property. Interpretable-ADMET also provides an optimize module to automatically generate a set of novel virtual candidates based on matched molecular pair rules. We believe that interpretable-ADMET could serve as a useful tool for lead optimization in drug discovery.
    Availability and implementation: Interpretable-ADMET is available at http://cadd.pharmacy.nankai.edu.cn/interpretableadmet/.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Algorithms ; Drug Discovery ; Neural Networks, Computer
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btac192
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    Zs.A 2374: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The Compatibility of COFs Cathode and Optimized Electrolyte for Ultra-Long Lifetime Rechargeable Aqueous Zinc-Ion Battery.

    Wei, Yifan / Li, Zhonglin / Liu, Yongyao / Ji, Zhenyu / Zou, Shuixiang / Zhou, Yuzhe / Yan, Shuai / Chen, Cheng / Wu, Mingyan

    ChemSusChem

    2024  Volume 17, Issue 8, Page(s) e202301851

    Abstract: Rechargeable aqueous zinc-ion batteries (RAZIBs) are attractive due to their affordability, safety, and eco-friendliness. However, their potential is limited by the lack of high-capacity cathodes and compatible electrolytes needed for reliable ... ...

    Abstract Rechargeable aqueous zinc-ion batteries (RAZIBs) are attractive due to their affordability, safety, and eco-friendliness. However, their potential is limited by the lack of high-capacity cathodes and compatible electrolytes needed for reliable performance. Herein, we have presented a compatibility strategy for the development of a durable and long-lasting RAZIBs. The covalent organic frameworks (COFs) based on anthraquinone (DAAQ-COF) is created and utilized as the cathode, with zinc metal serving as the anode. The electrolyte is made up of an aqueous solution containing zinc salts at various concentrations. The COF cathode has been designed to be endowed with a rich array of redox-active groups, enhancing its electrochemical properties. Meanwhile, the electrolyte is formulated using triflate anions, which have exhibited superiority over sulfate anions. This strategy lead to the development of an optimized COF cathode with fast charging capability, high Coulombic efficiency (nearly 100 %) and long-term cyclability (retention rate of nearly 100 % at 1 A g
    Language English
    Publishing date 2024-03-22
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202301851
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  10. Article ; Online: Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database

    Li, Zhonglin / Yang, Ling

    Frontiers in Genetics

    2020  Volume 11

    Keywords Genetics(clinical) ; Molecular Medicine ; Genetics ; covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.558557
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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