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  1. AU="Li, Zhongmei"
  2. AU="Tal Noy-Porat"
  3. AU="Via, Jeremy"
  4. AU="Farshad Moradi Kashkooli"
  5. AU="Doaa Ebrahim"
  6. AU="Rangarajan, Amith"
  7. AU="Alonso-Sánchez, Jesús"
  8. AU="Zhuo, J C"
  9. AU="Pazurek, Angelica" AU="Pazurek, Angelica"
  10. AU=Sundararaman T
  11. AU="Singla, Amit Kumar"
  12. AU="Shu, Ran"
  13. AU="Kim, Jiha"
  14. AU="MacDonald, Suzanne E."
  15. AU="Heather Limburg"
  16. AU="Gross, Boris"
  17. AU="Perkins, George H"
  18. AU="Jormanainen, J"
  19. AU="Pichardo-González, Priamo A"
  20. AU="Cannegieter, Suzanne"
  21. AU="Trocino, Giuseppe"
  22. AU="Emiliano, Thais Moura"
  23. AU=Sinelli Mariateresa
  24. AU="De-guo LÜ"
  25. AU="Benoit-Pilven, Clara"
  26. AU="Lanza, Stefania"
  27. AU="Chilingarian, A"
  28. AU="Baldovini, Nicolas"
  29. AU="López Rodríguez, David"
  30. AU="Alexander König"
  31. AU="Jakobsen, Henrik L"
  32. AU="Yong-Zhao Dai"
  33. AU="Tara L. Pukala"
  34. AU="Addo‐Danso, Shalom D."
  35. AU=Ficheux Q.
  36. AU="Tomoyo Sawada"
  37. AU="Mohammad Kawsar Sharif Siam"
  38. AU=Kushnareva Yulia
  39. AU="Canova, Christopher T"
  40. AU="Hasnaoui, Naoual"
  41. AU="Maradana, Jhansi"
  42. AU="Raggini, Elisa"
  43. AU="Baxter, A."
  44. AU="Jackson, Shirnae"
  45. AU="Schenzle, Lisa"
  46. AU="Veronica Phillips"
  47. AU="Braun, Jörg"
  48. AU="Cassandra E. Holbert"
  49. AU="Trevisan Alexandra"

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  1. Artikel ; Online: A Distributed Proximal Consensus Algorithm for Energy Saving in Ethylene Production.

    Nie, Rong / Du, Wenli / Wang, Ting / Li, Zhongmei / He, Shuping

    IEEE transactions on neural networks and learning systems

    2024  Band 35, Heft 3, Seite(n) 3052–3061

    Abstract: This article presents a distributed optimization framework in order to solve the plant-wide energy-saving problem of an ethylene plant. First, the ethylene production process is abstracted into a distributed network, and then, a new distributed consensus ...

    Abstract This article presents a distributed optimization framework in order to solve the plant-wide energy-saving problem of an ethylene plant. First, the ethylene production process is abstracted into a distributed network, and then, a new distributed consensus algorithm is proposed, which is called adaptive step-size-based distributed proximal consensus algorithm (ASS-DPCA). This algorithm can dynamically adjust the step size and automatically abandon the irrational evolutionary route while eliminating the dependence of optimization algorithms on model gradient information. Moreover, the designed algorithm is able to converge to an optimal solution for any convex cost functions and approach to a convex constraint set of agents over an undirected connected graph. Finally, the results of numerical simulation and industrial experiments show that the algorithm can reduce the total energy consumption of an ethylene plant with less computing time and assured consensus.
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2023.3320691
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  2. Artikel ; Online: Research Progress in Mathematical Analysis of Map Projection by Computer Algebra

    BIAN Shaofeng / LI Houpu / LI Zhongmei

    Acta Geodaetica et Cartographica Sinica, Vol 46, Iss 10, Pp 1557-

    2017  Band 1569

    Abstract: Map projection is an important component of modern cartography, and involves many fussy mathematical analysis processes, such as the power series expansions of elliptical functions, differential of complex and implicit functions, elliptical integral and ... ...

    Abstract Map projection is an important component of modern cartography, and involves many fussy mathematical analysis processes, such as the power series expansions of elliptical functions, differential of complex and implicit functions, elliptical integral and the operation of complex numbers. The derivation of these problems by hand not only consumes much time and energy but also makes mistake easily, and sometimes can not be realized at all because of the impossible complexity. The research achievements in mathematical analysis of map projection by computer algebra are systematically reviewed in five aspects, i.e., the symbolic expressions of forward and inverse solution of ellipsoidal latitudes, the direct transformations between map projections with different distortion properties, expressions of Gauss projection by complex function, mathematical analysis of oblique Mercator projection, polar chart projection with its transformation. Main problems that need to be further solved in this research field are analyzed. It will be helpful to promote the development of map projection.
    Schlagwörter map projection ; projection transformation ; Gauss projection ; polar projection ; computer algebra ; Mathematical geography. Cartography ; GA1-1776
    Sprache Chinesisch
    Erscheinungsdatum 2017-10-01T00:00:00Z
    Verlag Surveying and Mapping Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Robust Total Least Squares Estimation of Space Intersection Appropriate for Multi-images

    LI Zhongmei / BIAN Shaofeng / QU Yong

    Acta Geodaetica et Cartographica Sinica, Vol 46, Iss 5, Pp 593-

    2017  Band 604

    Abstract: In order to take full advantage of available observation resources, based on theory of space intersection with stereo images, by conducting weighted quadratic sum of spatial distance from the target point to multiple space lines as the objective function ...

    Abstract In order to take full advantage of available observation resources, based on theory of space intersection with stereo images, by conducting weighted quadratic sum of spatial distance from the target point to multiple space lines as the objective function and carrying out its first as well as second derivatives, robust total least squares estimation of space intersection appropriate for multi-images was realized. Compared to stereopair, more observed information and theories of robust estimation were considered in the process of space intersection with multi-images, bringing about higher intersection accuracy and robustness. Finally, correctness and robustness of the method was verified though example analysis, which can enrich the space intersection theory in photogrammetry to some degree.
    Schlagwörter photogrammetry ; multi-images ; space intersection ; spatial distance ; total least squares method ; reweighting iteration method ; Mathematical geography. Cartography ; GA1-1776
    Sprache Chinesisch
    Erscheinungsdatum 2017-05-01T00:00:00Z
    Verlag Surveying and Mapping Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Investigation of Renalase gene rs2576178 polymorphism in patients with coronary artery disease.

    Hu, Ning / Wang, Jun / Hu, Pengfei / Li, Zhongmei

    Bioscience reports

    2018  Band 38, Heft 5

    Abstract: Renalase gene rs2576178 polymorphism has been demonstrated to be a risk factor of ischemic stroke, essential hypertension, and end-stage renal disease, but the association Renalase with risk of coronary artery disease (CAD) has been less reported. ... ...

    Abstract Renalase gene rs2576178 polymorphism has been demonstrated to be a risk factor of ischemic stroke, essential hypertension, and end-stage renal disease, but the association Renalase with risk of coronary artery disease (CAD) has been less reported. Therefore, we detected Renalase rs2576178 polymorphism in 449 CAD patients and 507 healthy controls using matrix-assisted laser-desorption ionization (MALDI)/time of flight (TOF)-mass spectrometry (MS). It was found that GG genotype or G allele of rs2576178 polymorphism was associated with the risk of CAD. Stratified analysis indicated that Renalase polymorphism significantly increased the risk of CAD in females, smokers, and alcoholics. However, there was no significant association between different genotypes of rs2576178 polymorphism and clinical parameters. In summary, Renalase rs2576178 polymorphism is associated with increased risk of CAD, but this finding should be confirmed by larger studies with more diverse ethnic populations.
    Mesh-Begriff(e) Alleles ; Asian Continental Ancestry Group/genetics ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics ; Coronary Artery Disease/physiopathology ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Kidney Failure, Chronic/genetics ; Kidney Failure, Chronic/physiopathology ; Male ; Middle Aged ; Monoamine Oxidase/genetics ; Polymorphism, Single Nucleotide/genetics ; Risk Factors ; Stroke/epidemiology ; Stroke/genetics ; Stroke/physiopathology
    Chemische Substanzen Monoamine Oxidase (EC 1.4.3.4) ; renalase (EC 1.4.3.4.)
    Sprache Englisch
    Erscheinungsdatum 2018-09-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20180839
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  5. Artikel ; Online: Experimental Study on Nano-Parameters of Styrene-Butadiene-Styrene Block Copolymer Modified Bitumen Based on Atomic Force Microscopy.

    Zhang, Wengang / Wang, Fang / Shi, Jun / Li, Zhongmei / Liang, Xiaofei

    Polymers

    2019  Band 11, Heft 6

    Abstract: In this paper, an atomic force microscope (AFM) was used to study the nano-morphology characteristics of styrene-butadiene-styrene block copolymer (SBS) modified bitumen. The effects of SBS content and short-term aging on the nano-morphology parameters ... ...

    Abstract In this paper, an atomic force microscope (AFM) was used to study the nano-morphology characteristics of styrene-butadiene-styrene block copolymer (SBS) modified bitumen. The effects of SBS content and short-term aging on the nano-morphology parameters of bitumen were studied. The correlation between nano-morphology parameters and main pavement performances of SBS modified bitumen was analyzed. The results show that with the increase of SBS content, the average area of bee-like structure and the proportions of bee-like structure area of SBS modified bitumen increases gradually, the roughness of the whole image and the roughness of the lightweight component region decreases gradually, but the increasing or decreasing trend is no longer obvious when the content of SBS is more than 4%. The maximum height difference of SBS modified bitumen is linear with the content of SBS. The larger the content of SBS, the smaller the influence of short-term aging on the nano-morphology of SBS modified bitumen. The penetration degree will decrease and the softening point will increase with the increase of the proportion of bee-like structure area of SBS modified bitumen. The ductility will decrease with the increase of the roughness of the lightweight component region. The ductility and the Brookfield viscosity will increase with the increase of the maximum height difference. The research results provided a reference for defining quantifiable nano-parameters of SBS modified bitumen and establishing the relationship between nano-parameters and pavement performances.
    Sprache Englisch
    Erscheinungsdatum 2019-06-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym11060989
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  6. Artikel ; Online: Forward and Inverse Expressions of Polar Gauss Projection without Zoning Limitations

    LI Zhongmei / BIAN Shaofeng / JIN Lixin / CHEN Cheng / LIU Qiang

    Acta Geodaetica et Cartographica Sinica, Vol 46, Iss 6, Pp 780-

    2017  Band 788

    Abstract: As traditional formulae of Gauss projection could not be used in polar regions, strict equation of complex conformal colatitude was derived with relationship between conformal colatitude and isometric latitude introduced, and then strict forward ... ...

    Abstract As traditional formulae of Gauss projection could not be used in polar regions, strict equation of complex conformal colatitude was derived with relationship between conformal colatitude and isometric latitude introduced, and then strict forward expressions of Gauss projection suit for polar regions were carried out. Based on relationship between exponential and trigonometric functions, inverse expressions of polar Gauss projection were derived by means of symbol iteration method. With reference to the forward expressions, corresponding equations of length ratio and meridian convergence for polar Gauss projection were achieved. Finally, Taking CGCS2000 ellipsoid for example, by comparing with results calculated by formulae of Gauss projection in power series forms, correctness of the proposed expressions was verified. Expressions in this paper are all free from bandwidth, and can be used in the entire poles, which could provide important references for polar mapping and navigation.
    Schlagwörter Gauss projection ; polar region ; forward and inverse solution ; length ratio ; meridian convergence angle ; Mathematical geography. Cartography ; GA1-1776
    Thema/Rubrik (Code) 400
    Sprache Chinesisch
    Erscheinungsdatum 2017-06-01T00:00:00Z
    Verlag Surveying and Mapping Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: The lncRNA

    Wheeler, Benjamin D / Gagnon, John D / Zhu, Wandi S / Muñoz-Sandoval, Priscila / Wong, Simon K / Simeonov, Dimitre S / Li, Zhongmei / DeBarge, Rachel / Spitzer, Matthew H / Marson, Alexander / Ansel, K Mark

    eLife

    2023  Band 12

    Abstract: Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers. Through biochemical analysis of RNA:protein interactions, we ... ...

    Abstract Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers. Through biochemical analysis of RNA:protein interactions, we uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA
    Mesh-Begriff(e) Animals ; Mice ; CD28 Antigens ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; T-Lymphocytes, Cytotoxic ; Memory T Cells
    Chemische Substanzen CD28 Antigens ; MicroRNAs ; RNA, Long Noncoding ; Malat1 long non-coding RNA, mouse ; Mirn15 microRNA, mouse ; Mirn16 microRNA, mouse
    Sprache Englisch
    Erscheinungsdatum 2023-12-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.87900
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  8. Artikel: Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk.

    Simeonov, Dimitre R / Park, Kyemyung / Cortez, Jessica T / Young, Arabella / Li, Zhongmei / Nguyen, Vinh / Umhoefer, Jennifer / Indart, Alyssa C / Woo, Jonathan M / Anderson, Mark S / Tsang, John S / Germain, Ronald N / Wong, Harikesh S / Marson, Alexander

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Genetic variants associated with human autoimmune diseases commonly map to non-coding control regions, particularly enhancers that function selectively in immune cells and fine-tune gene expression within a relatively narrow range of values. How such ... ...

    Abstract Genetic variants associated with human autoimmune diseases commonly map to non-coding control regions, particularly enhancers that function selectively in immune cells and fine-tune gene expression within a relatively narrow range of values. How such modest, cell-type-selective changes can meaningfully shape organismal disease risk remains unclear. To explore this issue, we experimentally manipulated species-conserved enhancers within the disease-associated
    Sprache Englisch
    Erscheinungsdatum 2023-06-18
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.06.17.545426
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation.

    Wheeler, Benjamin D / Gagnon, John D / Zhu, Wandi S / Muñoz-Sandoval, Priscila / Wong, Simon K / Simeonov, Dimitre R / Li, Zhongmei / Debarge, Rachel / Spitzer, Matthew H / Marson, Alexander / Ansel, K Mark

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, many intracellular bacteria and cancers. Through biochemical analysis of RNA:protein interactions, we ... ...

    Abstract Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, many intracellular bacteria and cancers. Through biochemical analysis of RNA:protein interactions, we uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) and the microRNA family miR-15/16. miR-15/16 is a widely and highly expressed tumor suppressor miRNA family important for cell proliferation and survival. miR-15/16 also play important roles in T cell responses to viral infection, including the regulation of antigen-specific T cell expansion and T cell memory. Comparative Argonaute-2 high throughput sequencing of crosslinking immunoprecipitation (Ago2 HITS-CLIP, or AHC) combined with gene expression profiling in normal and miR-15/16-deficient T cells revealed a large network of several hundred direct miR-15/16 target mRNAs, many with functional relevance for T cell activation, survival and memory formation. Among these targets, the long non-coding RNA Malat1 contained the largest absolute magnitude miR-15/16-dependent AHC peak in T cells. This binding site was also among the strongest lncRNA:miRNA interactions detected in the T cell transcriptome. We used CRISPR targeting with homology directed repair to generate mice with a 5-nucleotide mutation in the miR-15/16 binding site in Malat1. This mutation interrupted Malat1:miR-15/16 interaction, and enhanced the repression of other miR-15/16 target genes, including CD28. Interrupting Malat1 interaction with miR-15/16 decreased cytotoxic T cell activation, including the expression of IL-2 and a broader CD28-responsive gene program. Accordingly, Malat1 mutation diminished memory cell persistence following LCMV Armstrong and
    Sprache Englisch
    Erscheinungsdatum 2023-07-29
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.04.14.536843
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.

    Lo, Wan-Lin / Kuhlmann, Miriam / Rizzuto, Gabrielle / Ekiz, H Atakan / Kolawole, Elizabeth M / Revelo, Monica P / Andargachew, Rakieb / Li, Zhongmei / Tsai, Yuan-Li / Marson, Alexander / Evavold, Brian D / Zehn, Dietmar / Weiss, Arthur

    Nature immunology

    2023  Band 24, Heft 4, Seite(n) 676–689

    Abstract: Mature T cells must discriminate between brief interactions with self-peptides and prolonged binding to agonists. The kinetic proofreading model posits that certain T-cell antigen receptor signaling nodes serve as molecular timers to facilitate such ... ...

    Abstract Mature T cells must discriminate between brief interactions with self-peptides and prolonged binding to agonists. The kinetic proofreading model posits that certain T-cell antigen receptor signaling nodes serve as molecular timers to facilitate such discrimination. However, the physiological significance of this regulatory mechanism and the pathological consequences of disrupting it are unknown. Here we report that accelerating the normally slow phosphorylation of the linker for activation of T cells (LAT) residue Y136 by introducing an adjacent Gly135Asp alteration (LAT
    Mesh-Begriff(e) Mice ; Animals ; Adaptor Proteins, Signal Transducing/metabolism ; Amino Acid Substitution ; T-Lymphocytes ; Receptors, Antigen, T-Cell/metabolism ; Lymphocyte Activation ; Phosphorylation ; Phosphoproteins/genetics
    Chemische Substanzen Adaptor Proteins, Signal Transducing ; Receptors, Antigen, T-Cell ; Phosphoproteins
    Sprache Englisch
    Erscheinungsdatum 2023-03-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01444-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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