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  1. Article ; Online: A case report on Rubinsein-Taybi syndrome associated with a de novo CREBBP gene mutation.

    Li, Zheng / Li, Zi-Jin / Hao, Li-Hong

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-04-29
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.033
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    Zs.B 2831: Show issues Location:
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  2. Article ; Online: Nano-Engineering Strategies for Tumor-Specific Therapy.

    Li, Zijin / Xie, Hai-Yan / Nie, Weidong

    ChemMedChem

    2024  Volume 19, Issue 10, Page(s) e202300647

    Abstract: Nanodelivery systems (NDSs) provide promising prospects for decreasing drug doses, reducing side effects, and improving therapeutic effects. However, the bioapplications of NDSs are still compromised by their fast clearance, indiscriminate ... ...

    Abstract Nanodelivery systems (NDSs) provide promising prospects for decreasing drug doses, reducing side effects, and improving therapeutic effects. However, the bioapplications of NDSs are still compromised by their fast clearance, indiscriminate biodistribution, and limited tumor accumulation. Hence, engineering modification of NDSs aiming at promoting tumor-specific therapy and avoiding systemic toxicity is usually needed. An NDS integrating various functionalities, including flexible camouflage, specific biorecognition, and sensitive stimuli-responsiveness, into one sequence would be "smart" and highly effective. Herein, we systematically summarize the related principles, methods, and progress. At the end of the review, we predict the obstacles to precise nanoengineering and prospects for the future application of NDSs.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/therapy ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Nanoparticles/chemistry ; Animals ; Drug Delivery Systems ; Nanotechnology
    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202300647
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  3. Article ; Online: Editorial: Human-centred computer audition: sound, music, and healthcare.

    Qian, Kun / Fazekas, Gyorgy / Li, Shengchen / Li, Zijin / Schuller, Björn W

    Frontiers in digital health

    2023  Volume 5, Page(s) 1340517

    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-253X
    ISSN (online) 2673-253X
    DOI 10.3389/fdgth.2023.1340517
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  4. Article: Case report and literature review: Orally ingested toothpick perforating the lower rectum.

    Zhang, Xingliang / Xing, Mei / Lei, Shaoyang / Li, Wentao / Li, Zijin / Xie, Yibing / Zhu, Chenyu / Zhang, Shuqian

    Frontiers in surgery

    2024  Volume 11, Page(s) 1368762

    Abstract: Introduction: Most foreign bodies (FBs) can spontaneously pass through the gastrointestinal tract. Sharp FBs are believed to be able to puncture any part of the gastrointestinal tract, causing perforation and potentially secondary damage to adjacent ... ...

    Abstract Introduction: Most foreign bodies (FBs) can spontaneously pass through the gastrointestinal tract. Sharp FBs are believed to be able to puncture any part of the gastrointestinal tract, causing perforation and potentially secondary damage to adjacent organs.
    Case description: A 44-year-old man complained of having persistent dull pain in the perianal region. He was diagnosed with a toothpick impacted into the wall of the lower rectum after accepting a digital rectal examination of the lower rectum and a pelvic computed tomography (CT). The surgeon extracted the FB using vascular forceps guided by the operator's index finger. The patient was discharged after intravenous ceftriaxone was given for 6 days. A follow-up pelvic CT performed 2 weeks after surgery revealed that the perirectal fat and muscles had already normalized.
    Conclusion: A systematic review of relevant literature from the past decade was performed to summarize the imaging features of an orally ingested toothpick perforating the gastrointestinal tract. The location of abdominal pain is an important clue for the diagnosis of toothpick perforation, and a CT examination is recommended as the first option for the detection of an ingested toothpick. Determining the location of the toothpick perforation and assessing the severity of local inflammation are important bases for the selection of treatment.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1368762
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  5. Article: Optimal futures hedging strategies based on an improved kernel density estimation method.

    Yu, Xing / Wang, Xinxin / Zhang, Weiguo / Li, Zijin

    Soft computing

    2021  Volume 25, Issue 23, Page(s) 14769–14783

    Abstract: In this paper, we study the hedging effectiveness of crude oil futures on the basis of the lower partial moments (LPMs). An improved kernel density estimation method is proposed to estimate the optimal hedge ratio. We investigate crude oil price hedging ... ...

    Abstract In this paper, we study the hedging effectiveness of crude oil futures on the basis of the lower partial moments (LPMs). An improved kernel density estimation method is proposed to estimate the optimal hedge ratio. We investigate crude oil price hedging by contributing to the literature in the following twofold: First, unlike the existing studies which focus on univariate kernel density method, we use bivariate kernel density to calculate the estimated LPMs, wherein the two bandwidths of the bivariate kernel density are not limited to the same, which is our main innovation point. According to the criterion of minimizing the mean integrated square error, we derive the conditions that the optimal bandwidths satisfy. In the process of derivation, we make a distribution assumption locally in order to simplify calculation, but this type of local distribution assumption is far better than global distribution assumption used in parameter method theoretically and empirically. Second, in order to meet the requirement of bivariate kernel density for independent random variables, we adopt ARCH models to obtain the independent noises with related to the returns of crude oil spot and futures. Genetic algorithm is used to tune the parameters that maximize quasi-likelihood. Empirical results reveal that, at first, the hedging strategy based on the improved kernel density estimation method is of highly efficiency, and then it achieves better performance than the hedging strategy based on the traditional parametric method. We also compare the risk control effectiveness of static hedge ratio vs. time-varying hedge ratio and find that static hedging has a better performance than time-varying hedging.
    Language English
    Publishing date 2021-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1476598-6
    ISSN 1433-7479 ; 1432-7643
    ISSN (online) 1433-7479
    ISSN 1432-7643
    DOI 10.1007/s00500-021-06185-3
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  6. Article ; Online: Effects of one-week bilateral cerebellar iTBS on resting-state functional brain network and multi-task attentional performance in healthy individuals: A randomized, sham-controlled trial.

    Liu, Meiliang / Yu, Chao / Shi, Jinping / Xu, Yunfang / Li, Zijin / Huang, Junhao / Si, Zhengye / Yao, Li / Yin, Kuiying / Zhao, Zhiwen

    NeuroImage

    2024  , Page(s) 120648

    Abstract: Background: Cerebellar intermittent theta burst stimulation (iTBS) modulates the excitability of the cerebral cortex and may enhance attentional performance. To date, few studies have conducted iTBS on healthy subjects for one week and used ... ...

    Abstract Background: Cerebellar intermittent theta burst stimulation (iTBS) modulates the excitability of the cerebral cortex and may enhance attentional performance. To date, few studies have conducted iTBS on healthy subjects for one week and used electroencephalography (EEG) to investigate the effect of multiple stimulation sessions on resting-state functional brain networks and the daily stimulation effect on attentional performance.
    Methods: 16 healthy subjects participated in a one-week experiment, receiving bilateral cerebellar iTBS or sham stimulation and engaging in multi-task attentional training. The primary measures were the one-week attentional performance and pre- and post-experiment resting-state EEG activities. Amplitude Envelope Correlation (AEC) was used to construct the functional connectivity in the eye-open (EO) and eye-closed (EC) phases.
    Results: At least three sessions of iTBS were required to enhance multi-task performance significantly, whereas only one or two sessions failed to elicit the improvement. Compared with the control group, iTBS induced significant changes in PSD, AEC functional connectivity, and AEC network properties during the EO phase, while it had little effect during the EC phase. During the EO phase, the network property changes of the iTBS subject were correlated with improved attentional performance.
    Conclusion: The multi-task performance requires multiple stimulations to enhance. iTBS affects the resting-state alpha band brain activities during the EO rather than the EC phase. The AEC network properties may serve as a biomarker to assess the attentional potential of healthy subjects.
    Language English
    Publishing date 2024-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2024.120648
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  7. Book ; Online: A Holistic Evaluation of Piano Sound Quality

    Zhou, Monan / Wu, Shangda / Ji, Shaohua / Li, Zijin / Li, Wei

    2023  

    Abstract: This paper aims to develop a holistic evaluation method for piano sound quality to assist in purchasing decisions. Unlike previous studies that focused on the effect of piano performance techniques on sound quality, this study evaluates the inherent ... ...

    Abstract This paper aims to develop a holistic evaluation method for piano sound quality to assist in purchasing decisions. Unlike previous studies that focused on the effect of piano performance techniques on sound quality, this study evaluates the inherent sound quality of different pianos. To derive quality evaluation systems, the study uses subjective questionnaires based on a piano sound quality dataset. The method selects the optimal piano classification models by comparing the fine-tuning results of different pre-training models of Convolutional Neural Networks (CNN). To improve the interpretability of the models, the study applies Equivalent Rectangular Bandwidth (ERB) analysis. The results reveal that musically trained individuals are better able to distinguish between the sound quality differences of different pianos. The best fine-tuned CNN pre-trained backbone achieves a high accuracy of 98.3\% as the piano classifier. However, the dataset is limited, and the audio is sliced to increase its quantity, resulting in a lack of diversity and balance, so we use focal loss to reduce the impact of data imbalance. To optimize the method, the dataset will be expanded, or few-shot learning techniques will be employed in future research.
    Keywords Computer Science - Sound ; Computer Science - Artificial Intelligence ; Electrical Engineering and Systems Science - Audio and Speech Processing
    Subject code 780
    Publishing date 2023-10-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The role of UGT1A1 (c.-3279 T > G) gene polymorphisms in neonatal hyperbilirubinemia susceptibility.

    Li, Zijin / Song, Li / Hao, Lihong

    BMC medical genetics

    2020  Volume 21, Issue 1, Page(s) 218

    Abstract: Background: Neonatal hyperbilirubinemia (NNH) is a common disease in newborns. This research study aimed to assess the associations between uridine diphospho-glucuronate-glucuronosyltransferase 1A1 (UGT1A1, c.-3279 T > G) polymorphisms and NNH risk.: ... ...

    Abstract Background: Neonatal hyperbilirubinemia (NNH) is a common disease in newborns. This research study aimed to assess the associations between uridine diphospho-glucuronate-glucuronosyltransferase 1A1 (UGT1A1, c.-3279 T > G) polymorphisms and NNH risk.
    Methods: We searched PubMed, the Cochrane Library, and the Embase electronic databases. All published eligible studies before July 1, 2019, were searched for this meta-analysis.
    Results: We identified 7 independent studies including 1560 cases. The data showed that in the general population, compared with the GT + GG vs TT and GG vs TT, c.-3279 T > G (rs4124874) was significantly related to a higher NNH risk (GG vs TT: OR = 1.865, 95% CI: 1.031-3.373, P = 0.039; GT + GG vs TT: OR = 1.331, 95% CI: 1.055-1.679, P = 0.016). Although not statistically significant, the data showed that c.3279 T > G had a tendency to be associated with NNH under the allele model and GG vs GT + TT in the overall population (G vs T: OR = 1.288, 95% CI: 0.982-1.689, P = 0.067; GG vs TT + GT: OR = 1.583, 95% CI: 0.947-2.647, P = 0.080).
    Conclusion: The UGT1A1 gene c.-3279 T > G (rs4124874) polymorphism increased susceptibility to NNH, especially for the comparison of GT + GG vs TT and GG vs TT. In the future, we can use homozygous state of the UGT1A1 gene c.-3279 T > G (rs4124874) polymorphism for the diagnosis and screening of molecular biomarkers in NNH patients.
    MeSH term(s) African Continental Ancestry Group ; Asian Continental Ancestry Group ; Case-Control Studies ; European Continental Ancestry Group ; Gene Expression ; Genetic Predisposition to Disease ; Glucuronosyltransferase/genetics ; Humans ; Hyperbilirubinemia, Neonatal/diagnosis ; Hyperbilirubinemia, Neonatal/ethnology ; Hyperbilirubinemia, Neonatal/genetics ; Hyperbilirubinemia, Neonatal/pathology ; Infant, Newborn ; Odds Ratio ; Polymorphism, Single Nucleotide
    Chemical Substances UGT1A1 enzyme (EC 2.4.1.-) ; Glucuronosyltransferase (EC 2.4.1.17)
    Language English
    Publishing date 2020-11-06
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ISSN 1471-2350
    ISSN (online) 1471-2350
    DOI 10.1186/s12881-020-01155-2
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  9. Article ; Online: Color-changing fluorescent DNA probe containing solvatochromic Dansyl-nucleoside surrogate for sensing local variation of DNA duplex.

    Cui, Haonan / Fang, Jiaobing / Sun, Minglei / Liu, Ziqi / Li, Zijin / Liu, Kaifu / Liu, Mingzhe

    Bioorganic & medicinal chemistry letters

    2022  Volume 59, Page(s) 128551

    Abstract: A novel Dansyl-nucleoside surrogate (Dns) based on (±)-trans-4-(hydroxymethyl) piperidin-3-ol was designed and synthesized. The Dns exhibited excellent solvatochromic properties. About 90 nm of red-shift accompanied color change from green to orange ... ...

    Abstract A novel Dansyl-nucleoside surrogate (Dns) based on (±)-trans-4-(hydroxymethyl) piperidin-3-ol was designed and synthesized. The Dns exhibited excellent solvatochromic properties. About 90 nm of red-shift accompanied color change from green to orange could be achieved with an increase of solvent polarity. The Dns was incorporated into oligodeoxynucleotide by phosphoroamidite chemistry. Two kinds of Dns-incorporated fluorescent DNA probes were designed and synthesized for sensing variation of DNA duplexes based on color-changing manner. As a result, the color-changing DNA probe not only can detect complementary oligonucleotide, but also can distinguish mismatch flanked in Dansyl/nucleobase pair by naked eye. Moreover, the change of fluorescence color of sample solutions could be captured by smartphone, and the photographs could be digitalized by image-processing software. Thus, the Dns-incorporated fluorescent DNA probe is expected to open the way to point-of-care assays in the future.
    MeSH term(s) Color ; DNA/chemistry ; DNA Probes/chemical synthesis ; DNA Probes/chemistry ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Molecular Structure ; Nucleosides/chemistry ; Piperidines/chemistry
    Chemical Substances DNA Probes ; Fluorescent Dyes ; Nucleosides ; Piperidines ; DNA (9007-49-2)
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2022.128551
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  10. Article: Distant Metastasis is the Dominant Cause of Treatment Failure after Lateral Lymph Node Dissection in Patients with Lateral Lymph Node Metastasis: Results of the Large Multicenter Lateral Node Study in China.

    Li, Kan / Wang, Feng / Jiang, Yujuan / Hong, Gong / Li, Zijin / Liang, Jianwei / Wu, Weinan / Xing, Wei / Liu, Qian

    Journal of Cancer

    2023  Volume 14, Issue 17, Page(s) 3227–3237

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-10-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.88009
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