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  1. Book ; Online ; E-Book: Perinatal stem cells

    Han, Zhong Chao / Takahashi, Tsuneo A. / Han, Zhibo / Li, Zongjin

    biology, manufacturing and translational medicine

    2019  

    Author's details Zhong Chao Han, Tsuneo A. Takahashi, Zhibo Han, Zongjin Li editors
    Language English
    Size 1 Online-Ressource (vi, 173 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020019201
    ISBN 978-981-13-2703-2 ; 9789811327025 ; 981-13-2703-3 ; 9811327025
    DOI 10.1007/978-981-13-2703-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial.

    Li, Zongjin

    Pharmaceutical nanotechnology

    2022  Volume 10, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2022-05-12
    Publishing country United Arab Emirates
    Document type Editorial
    ISSN 2211-7393
    ISSN (online) 2211-7393
    DOI 10.2174/221173851001220328150618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapeutic trends of priming mesenchymal stem cells: A bibliometric analysis.

    Hezam, Kamal / Fu, Enze / Zhang, Jun / Li, Zongjin

    Biochemistry and biophysics reports

    2024  Volume 38, Page(s) 101708

    Abstract: Mesenchymal stem cells (MSCs) have gained substantial attention in regenerative medicine due to their multilineage differentiation potential and immunomodulatory capabilities. MSCs have demonstrated therapeutic promise in numerous preclinical and ... ...

    Abstract Mesenchymal stem cells (MSCs) have gained substantial attention in regenerative medicine due to their multilineage differentiation potential and immunomodulatory capabilities. MSCs have demonstrated therapeutic promise in numerous preclinical and clinical studies across a variety of diseases, including neurodegenerative disorders, cardiovascular diseases, and autoimmune conditions. Recently, priming MSCs has emerged as a novel strategy to enhance their therapeutic efficacy by preconditioning them for optimal survival and function in challenging in vivo environments. This study presented a comprehensive bibliometric analysis of research activity in the field of priming mesenchymal stem cells (MSCs) from 2003 to 2023. Utilizing a dataset of 585 documents, we explored research trends, leading authors and countries, productive journals, and frequently used keywords. We also explored priming strategies to augment the therapeutic efficacy of MSCs. Our findings show increasing research productivity with a peak in 2019, identified the United States as the leading contributor, and highlighted WANG JA as the most prolific author. The most published journal was Stem Cell Research & Therapy. Keyword analysis revealed core research areas emerging hotspots, while coword and cited sources visualizations elucidated the conceptual framework and key information sources. Further studies are crucial to advance the translation of primed MSCs from bench to bedside, potentially revolutionizing the landscape of regenerative medicine.
    Language English
    Publishing date 2024-04-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2024.101708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advances and Perspectives of Pharmaceutical Nanotechnology in mRNA therapy.

    Cheng, Hui / Li, Zongjin

    Pharmaceutical nanotechnology

    2022  

    Language English
    Publishing date 2022-08-25
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 2211-7393
    ISSN (online) 2211-7393
    DOI 10.2174/2211738510666220825145124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In vivo tracking of mesenchymal stem cell dynamics and therapeutics in LPS-induced acute lung injury models.

    Wang, Chen / Hezam, Kamal / Fu, Enze / Pan, Kai / Liu, Yue / Li, Zongjin

    Experimental cell research

    2024  Volume 437, Issue 2, Page(s) 114013

    Abstract: Mesenchymal stem cells (MSCs) have been widely used to treat various inflammatory and immune-related diseases in preclinical and clinical settings. Intravital microscopy (IVM) is considered the gold standard for investigating pathophysiological ... ...

    Abstract Mesenchymal stem cells (MSCs) have been widely used to treat various inflammatory and immune-related diseases in preclinical and clinical settings. Intravital microscopy (IVM) is considered the gold standard for investigating pathophysiological conditions in living animals. However, the potential for real-time monitoring of MSCs in the pulmonary microenvironment remains underexplored. In this study, we first constructed a lung window and captured changes in the lung at the cellular level under both inflammatory and noninflammatory conditions with a microscope. We further investigated the dynamics and effects of MSCs under two different conditions. Meanwhile, we assessed the alterations in the adhesive capacity of vascular endothelial cells in vitro to investigate the underlying mechanisms of MSC retention in an inflammatory environment. This study emphasizes the importance of the "lung window" for live imaging of the cellular behavior of MSCs by vein injection. Moreover, our results revealed that the upregulation of vascular cell adhesion molecule 1 (VCAM1) in endothelial cells post-inflammatory injury could enhance MSC retention in the lung, further ameliorating acute lung injury. In summary, intravital microscopy imaging provides a practical method to investigate the therapeutic effects of MSCs in acute lung injury.
    MeSH term(s) Animals ; Lipopolysaccharides/pharmacology ; Endothelial Cells/metabolism ; Acute Lung Injury/chemically induced ; Lung/metabolism ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cell Transplantation
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2024.114013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Molecular Imaging of Tumor Progression and Angiogenesis by Dual Bioluminescence.

    Liu, Yue / Huang, Ziyu / Li, Zongjin

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2524, Page(s) 457–469

    Abstract: Angiogenesis is a prerequisite for tumor growth and invasion, and anti-angiogenesis has become a highlight in tumor treatment research. However, so far, there is no reliable solution for how to simultaneously visualize the relationship between tumor ... ...

    Abstract Angiogenesis is a prerequisite for tumor growth and invasion, and anti-angiogenesis has become a highlight in tumor treatment research. However, so far, there is no reliable solution for how to simultaneously visualize the relationship between tumor progression and angiogenesis. Bioluminescence imaging (BLI) has been broadly utilized and is a very promising non-invasive imaging technique with the advantages of low cost, high sensitivity, and robust specificity. In this chapter, we describe a dual bioluminescence imaging BLI protocol for tumor progression and angiogenesis through implanting murine breast cancer cell line 4T1 which stably expressing Renilla luciferase (RLuc) into the transgenic mice with angiogenesis-induced firefly luciferase (FLuc) expression. This modality enables us to synchronously monitor the tumor progression and angiogenesis in the same mouse, which has broad applicability in oncology studies.
    MeSH term(s) Animals ; Luciferases, Firefly ; Luminescent Measurements/methods ; Mice ; Mice, Transgenic ; Molecular Imaging ; Neovascularization, Pathologic/metabolism
    Chemical Substances Luciferases, Firefly (EC 1.13.12.7)
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2453-1_34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Molecular Imaging of Therapeutic Effect of Mesenchymal Stem Cell-Derived Exosomes for Hindlimb Ischemia Treatment.

    Zhang, Kaiyue / Li, Zongjin

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2150, Page(s) 213–225

    Abstract: Critical limb ischemia is a major cause of morbidity and mortality worldwide. Recently, many studies confirmed that MSC-derived exosomes (MSC-exosomes) had potential therapeutic effect to treat hindlimb ischemia through pro-angiogenesis. The therapeutic ... ...

    Abstract Critical limb ischemia is a major cause of morbidity and mortality worldwide. Recently, many studies confirmed that MSC-derived exosomes (MSC-exosomes) had potential therapeutic effect to treat hindlimb ischemia through pro-angiogenesis. The therapeutic angiogenesis is a critical measurement to judge the beneficial effect of MSC-exosomes treatment. Formerly, the therapeutic effect of MSC-exosomes was usually evaluated through clinical assessment and histopathological examination. Here, we describe a strategy to evaluate the therapeutic effect of MSC-exosomes by monitoring the therapeutic angiogenesis with bioluminescent imaging in hindlimb ischemia mice models.
    MeSH term(s) Animals ; Cells, Cultured ; Disease Models, Animal ; Exosomes/metabolism ; Firefly Luciferin/metabolism ; Hindlimb/blood supply ; Hindlimb/pathology ; Humans ; Ischemia/diagnostic imaging ; Ischemia/pathology ; Ischemia/therapy ; Luminescent Measurements ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Mice ; Molecular Imaging/methods ; Vascular Endothelial Growth Factor Receptor-2/metabolism
    Chemical Substances Firefly Luciferin (5TBB02N29K) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
    Language English
    Publishing date 2019-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/7651_2019_221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ab initio mechanism revealing for tricalcium silicate dissolution.

    Li, Yunjian / Pan, Hui / Liu, Qing / Ming, Xing / Li, Zongjin

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1253

    Abstract: Dissolution of minerals in water is ubiquitous in nature and industry, especially for the calcium silicate species. However, the behavior of such a complex chemical reaction is still unclear at atomic level. Here, we show that the ab initio molecular ... ...

    Abstract Dissolution of minerals in water is ubiquitous in nature and industry, especially for the calcium silicate species. However, the behavior of such a complex chemical reaction is still unclear at atomic level. Here, we show that the ab initio molecular dynamics and metadynamics simulations enable quantitative analyses of reaction pathways, thermodynamics and kinetics of the calcium ion dissolution from the tricalcium silicate (Ca
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28932-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Surface Engineering of Migratory Corrosion Inhibitors: Controlling the Wettability of Calcium Silicate Hydrate in the Nanoscale.

    Wang, Muhan / Sun, Huiwen / Zhou, Xiangming / Wang, Pan / Li, Zongjin / Hou, Dongshuai

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 48, Page(s) 17110–17121

    Abstract: Migratory corrosion inhibitors (MCIs) are regarded as effective additives to prevent harmful ion transmission and improve concrete durability, but their behavior in the porosity of concrete is still unclarified. This paper proposes a unique perspective ... ...

    Abstract Migratory corrosion inhibitors (MCIs) are regarded as effective additives to prevent harmful ion transmission and improve concrete durability, but their behavior in the porosity of concrete is still unclarified. This paper proposes a unique perspective to evaluate the effects of surfactant-like MCIs in calcium silicate hydrate (C-S-H) nanoporosity through molecular and electronic structural information. Advanced enhanced sampling methods and perturbation theory methods were applied to evaluate the role of different MCIs. The reduced density gradient of MCI molecules was obtained by using quantum chemical calculations. This calculation is instrumental in elucidating the intensity of interactions among distinct MCI molecule head groups and the C-S-H matrix. It is found that MCIs can effectively improve the interfacial tension (IFT) between C-S-H and water, which corresponds to the inhibitory ability of transmission. Free energy indicates that the MCI has the properties of strong adsorption and weak dissolution, facilitating the improvement of IFT. The relationship between the MCI functional group and the ability of adsorption and dissolution is revealed. This study suggests that MCIs work as surface controllers of C-S-H pores and that their properties can be assessed on the nanoscale.
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c01953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: STW-MD: a novel spatio-temporal weighting and multi-step decision tree method for considering spatial heterogeneity in brain gene expression data.

    Mao, Shanjun / Huang, Xiao / Chen, Runjiu / Zhang, Chenyang / Diao, Yizhu / Li, Zongjin / Wang, Qingzhe / Tang, Shan / Guo, Shuixia

    Briefings in bioinformatics

    2024  Volume 25, Issue 2

    Abstract: Gene expression during brain development or abnormal development is a biological process that is highly dynamic in spatio and temporal. Previous studies have mainly focused on individual brain regions or a certain developmental stage. Our motivation is ... ...

    Abstract Gene expression during brain development or abnormal development is a biological process that is highly dynamic in spatio and temporal. Previous studies have mainly focused on individual brain regions or a certain developmental stage. Our motivation is to address this gap by incorporating spatio-temporal information to gain a more complete understanding of brain development or abnormal brain development, such as Alzheimer's disease (AD), and to identify potential determinants of response. In this study, we propose a novel two-step framework based on spatial-temporal information weighting and multi-step decision trees. This framework can effectively exploit the spatial similarity and temporal dependence between different stages and different brain regions, and facilitate differential gene analysis in brain regions with high heterogeneity. We focus on two datasets: the AD dataset, which includes gene expression data from early, middle and late stages, and the brain development dataset, spanning fetal development to adulthood. Our findings highlight the advantages of the proposed framework in discovering gene classes and elucidating their impact on brain development and AD progression across diverse brain regions and stages. These findings align with existing studies and provide insights into the processes of normal and abnormal brain development.
    MeSH term(s) Humans ; Brain ; Alzheimer Disease/genetics ; Gene Expression ; Decision Trees
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbae051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6262: Show issues Location:
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