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  1. AU="Liñares, J"
  2. AU="Valle, Valentina"
  3. AU="Tóth, András"
  4. AU="Pawar, Atul Darasing"
  5. AU="Semper, Chelsea"
  6. AU="Kraus, Joanne F"

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  1. Artikel ; Online: Contaminants in Dietary Supplements: Toxicity, Doping Risk, and Current Regulation.

    Zapata-Linares, Jesús / Gervasini, Guillermo

    International journal of sport nutrition and exercise metabolism

    2024  , Seite(n) 1–10

    Abstract: Athletes, both amateur and professional, often resort to the consumption of nutritional supplements without professional supervision and without being aware of the risks they may entail. We conducted an exhaustive literature search to determine the most ... ...

    Abstract Athletes, both amateur and professional, often resort to the consumption of nutritional supplements without professional supervision and without being aware of the risks they may entail. We conducted an exhaustive literature search to determine the most common substances found as contaminants in dietary supplements. For each substance, we analyzed its mechanism of action, clinical indication, health risk, and putative use as doping agent. In addition, we evaluated the current regulation of these supplements. Contamination of nutritional supplements (accidental or intentional), especially with steroids and stimulants, is a hazardous situation. The prolonged consumption of these products without being aware of their composition can cause serious health risks and, in the case of professional athletes, a possible sanction for doping.
    Sprache Englisch
    Erscheinungsdatum 2024-04-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1101115-4
    ISSN 1543-2742 ; 1050-1606 ; 1526-484X
    ISSN (online) 1543-2742
    ISSN 1050-1606 ; 1526-484X
    DOI 10.1123/ijsnem.2023-0263
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Decolonising money: learning from collective struggles for self-determination.

    Cabaña, Gabriela / Linares, Julio

    Sustainability science

    2022  Band 17, Heft 4, Seite(n) 1159–1170

    Abstract: As a reflection of our politically engaged research, this paper addresses the multiple challenges of transforming money for the emergence of the Pluriverse, arguing that practical efforts of emancipation and autonomy need to dismantle the colonial nature ...

    Abstract As a reflection of our politically engaged research, this paper addresses the multiple challenges of transforming money for the emergence of the Pluriverse, arguing that practical efforts of emancipation and autonomy need to dismantle the colonial nature of our current monetary system: the flip side of the colonial state. On the one hand, we look into Chiloé, a territory marked by long-term relations of colonialism, dependency and extraction, where the arrival of monetised forms of work in extractive industries has meant the destruction of former ways of inhabiting the territory. On the other, we explore the emergence of the Circles project, in Berlin, that aims at creating a basic income from the bottom-up, whereby people in different communities issue money equally and exchange with each other without the need for state cash. More than assuming that money in itself is 'bad', we suggest that a recovery of the social and ecological fabric of life could be done through local money systems, designed and managed by the communities themselves, delivered and redistributed as a basic income. Moving to a plural monetary system based on relations of care would lead to a recovery of history as a project of collective self-determination.
    Sprache Englisch
    Erscheinungsdatum 2022-03-31
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2260333-5
    ISSN 1862-4057 ; 1862-4065
    ISSN (online) 1862-4057
    ISSN 1862-4065
    DOI 10.1007/s11625-022-01104-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Cell death as a defense strategy against pathogens in plants and animals.

    Salguero-Linares, Jose / Coll, Nuria S

    PLoS pathogens

    2023  Band 19, Heft 4, Seite(n) e1011253

    Abstract: Eukaryotes are endowed with sophisticated innate immune systems to recognize non-self and halt pathogen proliferation. Activation of cell death at the site of attempted pathogen ingress is a common strategy used by plants and animals to restrict pathogen ...

    Abstract Eukaryotes are endowed with sophisticated innate immune systems to recognize non-self and halt pathogen proliferation. Activation of cell death at the site of attempted pathogen ingress is a common strategy used by plants and animals to restrict pathogen proliferation and trigger immune responses in the surrounding tissues. As such, immunogenic cell death shares several features in both plants and animals that will be discussed in this article, namely: (i) it is triggered by activation of NLR immune receptors-often through oligomerization; (ii) it results in disruption of the plasma membrane (PM)/endomembrane integrity driving an imbalance in ion fluxes; and (iii) it results in the release of signaling molecules from dying cells.
    Mesh-Begriff(e) Animals ; Plants ; Signal Transduction ; Cell Death ; Receptors, Immunologic/metabolism ; Protein Binding ; Plant Immunity
    Chemische Substanzen Receptors, Immunologic
    Sprache Englisch
    Erscheinungsdatum 2023-04-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011253
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  4. Artikel: Unveiling acquired resistance to anti-EGFR therapies in colorectal cancer: a long and winding road.

    Ríos-Hoyo, Alejandro / Monzonís, Xavier / Vidal, Joana / Linares, Jenniffer / Montagut, Clara

    Frontiers in pharmacology

    2024  Band 15, Seite(n) 1398419

    Abstract: Emergence of acquired resistance limits the efficacy of the anti-EGFR therapies cetuximab and panitumumab in metastatic colorectal cancer. In the last decade, preclinical and clinical cohort studies have uncovered genomic alterations that confer a ... ...

    Abstract Emergence of acquired resistance limits the efficacy of the anti-EGFR therapies cetuximab and panitumumab in metastatic colorectal cancer. In the last decade, preclinical and clinical cohort studies have uncovered genomic alterations that confer a selective advantage to tumor cells under EGFR blockade, mainly downstream re-activation of RAS-MEK signaling and mutations in the extracellular domain of EGFR (EGFR-ECD). Liquid biopsies (genotyping of ctDNA) have been established as an excellent tool to easily monitor the dynamics of genomic alterations resistance in the blood of patients and to select patients for rechallenge with anti-EGFR therapies. Accordingly, several clinical trials have shown clinical benefit of rechallenge with anti-EGFR therapy in genomically-selected patients using ctDNA. However, alternative mechanisms underpinning resistance beyond genomics -mainly related to the tumor microenvironment-have been unveiled, specifically relevant in patients receiving chemotherapy-based multi-drug treatment in first line. This review explores the complexity of the multifaceted mechanisms that mediate secondary resistance to anti-EGFR therapies and potential therapeutic strategies to circumvent acquired resistance.
    Sprache Englisch
    Erscheinungsdatum 2024-04-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1398419
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Why is my anaesthesia machine detecting halothane after bronchodilator administration? A curious fact.

    López-Baamonde, Manuel / López-Hernández, Antonio / Perdomo Linares, Juan / Rivas, Eva

    Revista espanola de anestesiologia y reanimacion

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-02-10
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redare.2024.02.009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Computer session 2 on DFT

    Linares J.

    EPJ Web of Conferences, Vol 14, p

    2011  Band 02006

    Schlagwörter Physics ; QC1-999 ; Science ; Q ; DOAJ:Physics (General) ; DOAJ:Physics and Astronomy
    Sprache Englisch
    Erscheinungsdatum 2011-05-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: Clinical note on photophthalmia predominantly conjunctival; On the occasion of three clinical cases.

    LINARES, J

    Archivos de la Sociedad Oftalmologica Hispano-Americana

    2007  Band 8, Heft 10, Seite(n) 1002

    Titelübersetzung Nota clänica sobre fotoftalmäa de predominio conjuntival; con motivo de tres casos clänicos.
    Mesh-Begriff(e) Eye Injuries ; Humans ; Infant, Newborn ; Ophthalmia Neonatorum
    Sprache Spanisch
    Erscheinungsdatum 2007-12-15
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 603351-9
    ISSN 0365-7051
    ISSN 0365-7051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: ncRNAs Orchestrate Chemosensitivity Induction by Neddylation Blockades.

    Pérez-González, Andrea / Ramírez-Díaz, Ivonne / Guzmán-Linares, Josué / Sarvari, Pouya / Sarvari, Pourya / Rubio, Karla

    Cancers

    2024  Band 16, Heft 4

    Abstract: We performed an integrative transcriptomic in silico analysis using lung adenocarcinoma A549 cells treated with the neddylation inhibitor MLN4924 and the gefitinib-resistant PC9 cell line (PC9GR). We focused on the transcriptional effects of the top ... ...

    Abstract We performed an integrative transcriptomic in silico analysis using lung adenocarcinoma A549 cells treated with the neddylation inhibitor MLN4924 and the gefitinib-resistant PC9 cell line (PC9GR). We focused on the transcriptional effects of the top differentially expressed ncRNA biotypes and their correlating stemness factors. Interestingly, MLN4924-treated cells showed a significant upregulation of mRNAs involved in carcinogenesis, cell attachment, and differentiation pathways, as well as a parallel downregulation of stemness maintenance and survival signaling pathways, an effect that was inversely observed in PC9GR cells. Moreover, we found that stemness factor expression could be contrasted by selected up-regulated ncRNAs upon MLN4924 treatment in a dose and time-independent manner. Furthermore, upregulated miRNAs and lncRNA-targeted mRNAs showed an evident enrichment of proliferation, differentiation, and apoptosis pathways, while downregulated ncRNA-targeted mRNAs were implicated in stem cell maintenance. Finally, our results proved that stemness (
    Sprache Englisch
    Erscheinungsdatum 2024-02-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040825
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Ectopic recurrence of craniopharyngioma in the posterior fossa: Case report and review of the literature.

    Selfa, Antonio / Arráez, Cinta / Ros, Ángela / Linares, Jorge / Cerro, Laura / Arráez, Miguel Ángel

    Neurocirugia (English Edition)

    2023  Band 34, Heft 1, Seite(n) 32–39

    Abstract: Craniopharyngiomas are benign epithelial tumors which may very occasionally recur in ectopic locations. We present two cases of ectopic recurrence, both in the posterior fossa, and provide a review of the literature with basic statistics. Two patients ... ...

    Abstract Craniopharyngiomas are benign epithelial tumors which may very occasionally recur in ectopic locations. We present two cases of ectopic recurrence, both in the posterior fossa, and provide a review of the literature with basic statistics. Two patients admitted to our institution with posterior fossa lesions underwent gross total resection. Pathological studies showed adamantinomatous craniopharyngiomas (ACP). Both patients had a prior history of suprasellar tumor surgery. We also reviewed the related data and undertook a basic statistical analysis. We found 67 cases of ectopic recurrent craniopharyngioma (including the present cases): 51 cases were adamantinomatous (76%), 6 papillary (9%) and 10 unknown (15%). 18 cases occurred in the posterior fossa, all of them diagnosed as the ACP subtype. The intervals until recurrence were 15.15 years for posterior fossa recurrences and 5.75 years for supratentorial cases. Student t test showed significant differences in time to recurrence (p 0.002). Gross total resection was performed in 53 cases (79%), subtotal resection+radiotherapy in 3 (5%) and 11 (16%) cases were treated with other options. Ectopic recurrence is a rare but possible event. Those in the posterior fossa may appear later than in the supratentorial space. ACP is likely to be the most common subtype in these cases, possibly due to its more aggressive behavior compared to the papillary subtype. Long term follow-up should be performed to detect ectopic recurrences. Ectopic recurrences are often surgically accessible and gross total resection should be achieved.
    Mesh-Begriff(e) Humans ; Craniopharyngioma/diagnostic imaging ; Craniopharyngioma/surgery ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery ; Brain Neoplasms ; Recurrence
    Sprache Englisch
    Erscheinungsdatum 2023-01-09
    Erscheinungsland Spain
    Dokumenttyp Case Reports ; Journal Article ; Review
    ISSN 2529-8496
    ISSN (online) 2529-8496
    DOI 10.1016/j.neucie.2022.11.001
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  10. Artikel ; Online: Development of a biorefinery from olive mill leaves: Comparison of different process configurations

    López-Linares, J.C. / Romero-García, J.M. / Romero, I. / Ruiz, E. / Castro, E.

    Industrial Crops & Products. 2023 Sept., v. 200 p.116813-

    2023  

    Abstract: In this work, three process configurations were studied to advance the biorefinery of olive oil mill leaves (OL), whose main products comprise natural antioxidants, lignin and bioethanol, so far never studied. Configuration 1 includes an organosolvent ... ...

    Abstract In this work, three process configurations were studied to advance the biorefinery of olive oil mill leaves (OL), whose main products comprise natural antioxidants, lignin and bioethanol, so far never studied. Configuration 1 includes an organosolvent pretreatment, followed by a simultaneous saccharification and fermentation (SSF). This process scheme is the simplest but it resulted in a poor fractionation of the biomass. In configuration 2, a previous extraction with ethanol is included in the process, to boost the recovery of natural antioxidants (45 mg/g OL expressed as gallic acid equivalent). Configuration 3 consists of an acid extraction, organosolv pretreatment, SSF and co-fermentation stages, which achieved a better fractionation, presenting the highest bioethanol production with a yield of 71% of the theoretical yield (with respect to the sugars in raw material, 102 mg/g OL). This configuration generated a liquid stream from the organosolv pretreatment, with a higher lignin content (70 mg/g OL), and this makes it easier to obtain high purity lignin.
    Schlagwörter bioethanol ; biomass ; biorefining ; ethanol ; ethanol production ; fermentation ; fractionation ; gallic acid ; lignin ; lignin content ; liquids ; olive oil mills ; olives ; raw materials ; saccharification ; streams ; Olive leaves ; Biorefinery ; Natural antioxidants
    Sprache Englisch
    Erscheinungsverlauf 2023-09
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Use and reproduction
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2023.116813
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 5577: Hefte anzeigen

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