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  1. Article ; Online: Assessing the financial impact of cancer drug list (CDL) implementation on patients receiving chemotherapy in an ambulatory cancer centre in Singapore

    Darren Lee / Li Qing Lim / Jo Lene Leow / Lita Chew

    Proceedings of Singapore Healthcare, Vol

    2024  Volume 33

    Abstract: Background On 1 st September 2022, the Cancer Drug List (CDL) was implemented to ensure the long-term affordability of chemotherapy and insurance premiums. This project aimed to determine the financial impact of CDL on out-of-pocket expenses (OOPE), ... ...

    Abstract Background On 1 st September 2022, the Cancer Drug List (CDL) was implemented to ensure the long-term affordability of chemotherapy and insurance premiums. This project aimed to determine the financial impact of CDL on out-of-pocket expenses (OOPE), acceptability and financial toxicity (FT) after CDL implementation. Methods A cross-sectional study was conducted at National Cancer Center Singapore. We analyzed OOPE before and after implementation of CDL by reviewing billing transactions in Aug-Sept 2022. Acceptability and FT were determined using theoretical framework of acceptability (TFA) and COmprehensive Score for financial Toxicity (COST) tool respectively via survey. Results Of the 314 patients finalized bills examined, majority (68.8%) experienced no change in their OOPE, and 69.1% had no OOPE. Most patients (72.6%) were unaware of implementation of CDL. Among patients aware of CDL, majority (61.9%) were accepting, but unsure on how it benefits them. FT was reported as low (mean COST score = 22.4 ± 9.9), and patients ≥65 years old or have at least pre-university education were less likely to experience FT. Conclusion Despite best efforts from policymakers, it is challenging to achieve a one-size fits funding or subsidy framework that can cater to the needs of all patients. Some groups of patients would inevitably still experience high OOPE and FT due to their personal or clinical circumstances. Patients can be better empowered to seek financial assistance or resources.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: 4-Alkylcoumarins and a phloroglucinol from the stem bark of Calophyllum gracilentum

    Lim, Chan Kiang / Li Qing Lim / Vivien Yi Mian Jong / Yenn Pinn Ham

    Phytochemical Society of Europe Phytochemistry letters. 2019 Apr., v. 30

    2019  

    Abstract: Three new 4-alkylcoumarins, gracilenins A–C (1-3) and a new phloroglucinol, gracilenol (4), along with two known compounds, euxanthone and friedelin were isolated from the stem bark of Calophyllum gracilentum. Their structures were established on the ... ...

    Abstract Three new 4-alkylcoumarins, gracilenins A–C (1-3) and a new phloroglucinol, gracilenol (4), along with two known compounds, euxanthone and friedelin were isolated from the stem bark of Calophyllum gracilentum. Their structures were established on the basis of 1D and 2D NMR spectroscopic data and HRESIMS analysis. This is the first report of 4-(butan-2-yl)coumarin derivatives in this genus.
    Keywords bark ; Calophyllum ; coumarin ; nuclear magnetic resonance spectroscopy ; spectral analysis
    Language English
    Dates of publication 2019-04
    Size p. 99-102.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2019.01.022
    Database NAL-Catalogue (AGRICOLA)

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