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  1. AU="Li-Feng Han"
  2. AU="Jennifer Tremblay-Mercier"
  3. AU=Abouzied Mohei M
  4. AU="Eckardstein, Arnold von"
  5. AU="Häberle, Ramona"
  6. AU="Tsikari, Theano"
  7. AU="Mawutorli Nyarku"
  8. AU="Dene R. Littler"
  9. AU="Zamai, Loris"
  10. AU=Kato Takashi
  11. AU=Haase Michael
  12. AU="Ingrams, Duncan"
  13. AU=Liu Rong
  14. AU="Musselman, Kristin E"
  15. AU=Abrams M J
  16. AU="Paul, Archi Sundar"
  17. AU=Yoon Hyuk
  18. AU="Gonzalez, Emily"
  19. AU="Dunnill, M S"
  20. AU=Kuo Chih-Hung
  21. AU=Geronimo Carly L.
  22. AU=Stafforini D M
  23. AU="Sytse J. Piersma"
  24. AU="Peng, Hongke"
  25. AU="Kelly, Geoffrey"
  26. AU=Schwartzenburg Joshua AU=Schwartzenburg Joshua
  27. AU="Deshpande, Sneha Satish"
  28. AU="Ganhewa, Aparna D" AU="Ganhewa, Aparna D"
  29. AU="Flanagan, T L"
  30. AU=Davila Eduardo
  31. AU="Miroli, Augusto"
  32. AU="Stahl, B"
  33. AU="Dehari, Hironari"
  34. AU="Pinheiro, Silviane Bezerra"
  35. AU="Jamal Al Deen Alkoteesh"
  36. AU="Chen, Dingqiang"
  37. AU="Jeremy C. Ganz"
  38. AU="Lee, Ta-Sheng"
  39. AU="Shi, Jin-Ming"
  40. AU=Kristoffersen K B
  41. AU=Du Chao
  42. AU="Anton I. Skaro"

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  1. Artikel ; Online: Polyphenols from the Peels of Punica granatum L. and Their Bioactivity of Suppressing Lipopolysaccharide-Stimulated Inflammatory Cytokines and Mediators in RAW 264.7 Cells via Activating p38 MAPK and NF-κB Signaling Pathways

    Hui-Min Li / Ongher Kouye / Ding-Shan Yang / Ya-Qi Zhang / Jing-Ya Ruan / Li-Feng Han / Yi Zhang / Tao Wang

    Molecules, Vol 27, Iss 14, p

    2022  Band 4622

    Abstract: Punica granatum L. (Punicaceae) is a popular fruit all over the world. Owning to its enriched polyphenols, P. granatum has been widely used in treating inflammation-related diseases, such as cardiovascular diseases and cancer. Twenty polyphenols, ... ...

    Abstract Punica granatum L. (Punicaceae) is a popular fruit all over the world. Owning to its enriched polyphenols, P. granatum has been widely used in treating inflammation-related diseases, such as cardiovascular diseases and cancer. Twenty polyphenols, containing nine unreported ones, named punicagranins A–I ( 1 – 9 ), along with eleven known isolates ( 10 – 20 ), were obtained from the peels. Their detailed structures were elucidated based on UV, IR, NMR, MS, optical rotation, ECD analyses and chemical evidence. The potential anti-inflammatory activities of all polyphenols were examined on a lipopolysaccharide (LPS)-induced inflammatory macrophages model, which indicated that enhancing nitric oxide (NO) production in response to inflammation stimulated in RAW 264.7 cells was controlled by compounds 1 , 3 , 5 – 8 , 10 , 11 , 14 and 16 – 20 in a concentration-dependent manner. The investigation of structure–activity relationships for tannins 6 – 8 and 12 – 20 suggested that HHDP, flavogallonyl and/or gallagyl were key groups for NO production inhibitory activity. Western blotting indicated that compounds 6 – 8 could down-regulate the phosphorylation levels of proteins p38 MAPK, IKKα/β, IκBα and NF-κB p65 as well as inhibit the levels of inflammation-related cytokines and mediators, such as IL-6, TNF-α, iNOS and COX-2, at the concentration of 30 μM. In conclusion, polyphenols are proposed to be the potential anti-inflammatory active ingredients in P. granatum peels, and their molecular mechanism is likely related to the regulation of the p38 MAPK and NF-κB signaling pathways.
    Schlagwörter Punica granatum L ; polyphenols ; anti-inflammation ; RAW 264.7 cells ; p38 MAPK ; NF-κB signaling pathway ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  2. Artikel: Prenylated flavonoids and dihydrophenanthrenes from the leaves of Epimedium brevicornu and their cytotoxicity against HepG2 cells

    Pang, Xu / Hai-Yang Yu / Li-Feng Han / Li-Min Hu / Shuang-Shuang Yin / Tao Wang / Yi Zhang

    Natural product research. 2018 Oct. 2, v. 32, no. 19

    2018  

    Abstract: Phytochemical study on the leaves of Epimedium brevicornu finally led to the isolation of four prenylated flavonoids (1–4) and three dihydrophenanthrenes (5–7), of which 1, 2, 5 and 7 were new compounds. The structures of these compounds were established ...

    Abstract Phytochemical study on the leaves of Epimedium brevicornu finally led to the isolation of four prenylated flavonoids (1–4) and three dihydrophenanthrenes (5–7), of which 1, 2, 5 and 7 were new compounds. The structures of these compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry. These isolates exhibited the cytotoxic activities against HepG2 cells with the IC50 values of 32.8–87.3 μM.
    Schlagwörter cytotoxicity ; Epimedium brevicornu ; flavonoids ; human cell lines ; inhibitory concentration 50 ; leaves ; mass spectrometry ; nuclear magnetic resonance spectroscopy
    Sprache Englisch
    Erscheinungsverlauf 2018-1002
    Umfang p. 2253-2259.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2017.1405410
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  3. Artikel ; Online: Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum

    He-Shui Yu / Lin-Lin Wang / Ying He / Li-Feng Han / Hui Ding / Xin-Bo Song / Xiu-Mei Gao / Nai-Ru Yun / Zheng Li

    Evidence-Based Complementary and Alternative Medicine, Vol

    2020  Band 2020

    Abstract: The roots of Polygonum multiflorum (PM) (He Shou Wu in Chinese) are one of the most commonly used tonic traditional Chinese medicines (TCMs) in China. PM is traditionally valued for its antiaging, liver- and kidney-tonifying, and hair-blackening effects. ...

    Abstract The roots of Polygonum multiflorum (PM) (He Shou Wu in Chinese) are one of the most commonly used tonic traditional Chinese medicines (TCMs) in China. PM is traditionally valued for its antiaging, liver- and kidney-tonifying, and hair-blackening effects. However, an increasing number of hepatotoxicity cases induced by PM attract the attention of scholars worldwide. Thus far, the potential liver injury compounds and the mechanism are still uncertain. The aim of this review is to provide comprehensive information on the potential hepatotoxic components and mechanism of PM based on the scientific literature. Moreover, perspectives for future investigations of hepatotoxic components are discussed. This study will build a new foundation for further study on the hepatotoxic components and mechanism of PM.
    Schlagwörter Other systems of medicine ; RZ201-999
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Simultaneously targeted and untargeted multicomponent characterization of Erzhi Pill by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry

    Fu, Ling-ling / Hui Ding / Li-feng Han / Li Jia / Wen-zhi Yang / Chun-xia Zhang / Ying Hu / Tian-tian Zuo / Xiu-mei Gao / De-an Guo

    Journal of chromatography. 2019 Jan. 11, v. 1584

    2019  

    Abstract: Large-scale targeted and untargeted metabolites characterization can be achieved by feat of different liquid chromatography/mass spectrometry (LC–MS) platforms by multiple MS experiments or using data-independent acquisition followed by precursor-product ...

    Abstract Large-scale targeted and untargeted metabolites characterization can be achieved by feat of different liquid chromatography/mass spectrometry (LC–MS) platforms by multiple MS experiments or using data-independent acquisition followed by precursor-product ions matching based on certain algorithms. The resulting insufficiency in efficiency and availability greatly restricts the applicability of these strategies in large-scale profiling and identification of various metabolites. A strategy simultaneously enabling both the targeted and untargeted metabolites characterization is established on a Q Exactive hybrid quadrupole-Orbitrap mass spectrometer, by integrating precursor ions list-triggered data-dependent MS2 acquisition (PIL/dd-MS2) of the targeted components and using the “If idle-pick others” (IIPO) function to induce untargeted metabolites fragmentation. A compounds-specific mass defect filter (MDF) algorithm is proposed as a method to generate the PIL. As a proof of concept, this strategy coupled with offline two-dimensional liquid chromatography (2D-LC) was applied to identify the multicomponents of a traditional Chinese medicine formula Erzhi Pill (EZP). A rigid MDF vehicle was elaborated by orthogonal screening of the integer mass and integer mass-dependent dynamic mass defects considering a variation of 20 ppm. The Full MS/dd-MS2 method enabling PIL and IIPO exhibited better performance than Full MS/dd-MS2 and Targeted SIM/dd-MS2 (selected ion monitoring) in respect of the sensitivity in identifying the targeted components and the ability to characterize more untargeted ones. As a consequence, 270 components were separated from EZP, and 146 thereof were selectively characterized. In conclusion, it is a practical, multifaced strategy facilitating the in-depth metabolites profiling and characterization of complex herbal and biological samples.
    Schlagwörter Oriental traditional medicine ; algorithms ; ions ; liquid chromatography ; mass spectrometry ; metabolites ; monitoring ; screening ; spectrometers
    Sprache Englisch
    Erscheinungsverlauf 2019-0111
    Umfang p. 87-96.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 218139-3
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    DOI 10.1016/j.chroma.2018.11.024
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  5. Artikel: Xanthine oxidase inhibitory effects of the constituents of Chrysanthemum morifolium stems

    Qu, Lu / Jing-Ya Ruan / Li-Feng Han / Li-Jun Jin / Tao Wang / Wen-Zhong Shi / Xiao-Xia Li / Yi Zhang

    Phytochemical Society of Europe Phytochemistry letters. 2017 Mar., v. 19

    2017  

    Abstract: The flowers of Chrysanthemum morifolium Ramat. (family: Asteraceae) are used in Traditional Chinese Medicine to treat fever, cold and swelling. However the aerial part is considered as agriculture waste and the chemical and pharmacological information is ...

    Abstract The flowers of Chrysanthemum morifolium Ramat. (family: Asteraceae) are used in Traditional Chinese Medicine to treat fever, cold and swelling. However the aerial part is considered as agriculture waste and the chemical and pharmacological information is scanty. From the stems of this plant, four new compounds named as morineoliganosides A (1), B (2), C (3) and heterophyllol-1-O-β-d-glucopyranoside A (4) together with 27 known isolates (5–31), including flavonoids and caffeoylquinic acids were isolated. Their structures were elucidated by chemical and spectroscopic methods The inhibitory effects on xanthine oxidase of these compounds have been determined. This research provided a scientific development and utilization of C. morifolium stems.
    Schlagwörter aerial parts ; agricultural wastes ; chlorogenic acid ; Chrysanthemum morifolium ; fever ; flavonoids ; flowers ; Oriental traditional medicine ; spectroscopy ; stems ; xanthine oxidase
    Sprache Englisch
    Erscheinungsverlauf 2017-03
    Umfang p. 39-45.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2016.11.007
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  6. Artikel: Rearranged oleanane type saponins, astraisoolesaponins A1–A3 and B, from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

    Zhang, Yi / Hai-Yang Yu / Jian Li / Jing-Ya Ruan / Li-Feng Han / Tao Wang / Ting-Ting Wang / Xiao-Xia Li / Yuan-Qiang Guo

    Tetrahedron. 2016 Nov. 03, v. 72

    2016  

    Abstract: Four novel saponins, astraisoolesaponins A1–A3 and B (1–4) were isolated from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Spectroscopic analysis indicated that 1–4 are the first example of saponins possessing a ...

    Abstract Four novel saponins, astraisoolesaponins A1–A3 and B (1–4) were isolated from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Spectroscopic analysis indicated that 1–4 are the first example of saponins possessing a 28-methyl-rearranged carbon skeleton. Their absolute configurations were determined by electronic circular dichroism (ECD) calculations. Both 3 and 4 displayed triglyceride accumulation inhibitory effects in HepG2 cells and glucose uptake increase effects on L6 cells.
    Schlagwörter Astragalus membranaceus ; carbon ; chemical reactions ; chemical structure ; circular dichroism spectroscopy ; glucose ; human cell lines ; saponins ; stems ; triacylglycerols
    Sprache Englisch
    Erscheinungsverlauf 2016-1103
    Umfang p. 7008-7013.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2016.09.034
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  7. Artikel: Synergistic photocatalysis of Cr(VI) reduction and 4-Chlorophenol degradation over hydroxylated α-Fe2O3 under visible light irradiation

    Wang, Ji-Chao / Juan Ren / Hong-Chang Yao / Lin Zhang / Jian-She Wang / Shuang-Quan Zang / Li-Feng Han / Zhong-Jun Li

    Journal of hazardous materials. 2016 July 05, v. 311

    2016  

    Abstract: A series of Fe2O3 materials with hydroxyl are synthesized in different monohydric alcohol (C2–C5) solvents by solvothermal method and characterized by XRD, BET, XPS, TG and EA. The amount of hydroxyl is demonstrated to be emerged on the surface of the ... ...

    Abstract A series of Fe2O3 materials with hydroxyl are synthesized in different monohydric alcohol (C2–C5) solvents by solvothermal method and characterized by XRD, BET, XPS, TG and EA. The amount of hydroxyl is demonstrated to be emerged on the surface of the as-synthesized Fe2O3 particles and their contents are determined to be from 7.99 to 3.74wt%. The Cr(VI) reduction experiments show that the hydroxyl content of Fe2O3 samples exacts great influence on the photocatalytic activity under visible light irradiation (λ>400nm) and that the Fe2O3 sample synthesized in n-butyl alcohol exhibits the optimal photocatalytic activity. The synergistic photocatalysis for 4-Chlorophenol (4-CP) degradation and Cr(VI) reduction over above Fe2O3 sample is further investigated. The photocatalytic ratio of Cr(VI) reduction are enhanced from 24.8% to 70.2% while that of 4-CP oxidation are increased from 13.5% to 47.8% after 1h visible light irradiation. The Fe2O3 sample keeps good degradation rates of mixed pollutants after 9 runs. The active oxygen intermediates O2−, OH and H2O2 formed in the photoreaction process are discovered by ESR measurement and UV–vis test. The photocatalytic degradation mechanism is proposed accordingly.
    Schlagwörter X-ray diffraction ; X-ray photoelectron spectroscopy ; alcohols ; chromium ; ferric oxide ; hydrogen peroxide ; hydroxyl radicals ; irradiation ; oxidation ; oxygen ; photocatalysis ; pollutants ; solvents ; superoxide anion
    Sprache Englisch
    Erscheinungsverlauf 2016-0705
    Umfang p. 11-19.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2016.02.055
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  8. Artikel ; Online: Rare Syringyl Acylated Flavonol Glycosides from the Aerial Parts of Leonurus japonicus Houtt.

    Tao Wang / Xiu-Mei Gao / Li-Feng Han / Chun-Hua Wu / Lu Qu / Ya-Ting An / Yi Zhang / Shen Deng

    Molecules, Vol 18, Iss 3, Pp 2967-

    2013  Band 2977

    Abstract: Five new syringyl acylated flavonol glycosides, named leonurusoides A (1), B (2), C (3), D (4), and E (5), together with one known one 6 were obtained from the aerial parts of Leonurus japonicus. Their structures were elucidated by chemical and ... ...

    Abstract Five new syringyl acylated flavonol glycosides, named leonurusoides A (1), B (2), C (3), D (4), and E (5), together with one known one 6 were obtained from the aerial parts of Leonurus japonicus. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Compounds 1-6 showed triglyceride (TG) accumulation inhibitory effects in free fatty acid-induced HepG2 cells.
    Schlagwörter Leonurus japonicus ; syringyl acylated flavonol glycosides ; TG accumulation inhibitory effects ; HepG2 cells ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2013-03-01T00:00:00Z
    Verlag MDPI AG
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  9. Artikel ; Online: Analysis of the Constituents in “Zhu She Yong Xue Shuan Tong” by Ultra High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry Combined with Preparative High Performance Liquid Chromatography

    Lin-Lin Wang / Li-Feng Han / He-Shui Yu / Mang-Mang Sang / Er-Wei Liu / Yi Zhang / Shi-Ming Fang / Tao Wang / Xiu-Mei Gao

    Molecules, Vol 20, Iss 11, Pp 20518-

    2015  Band 20537

    Abstract: Zhu She Yong Xue Shuan Tong” lyophilized powder (ZSYXST), consists of a series of saponins extracted from Panax notoginseng, which has been widely used in China for the treatment of strokes. In this study, an ultra-high performance liquid chromatography ...

    Abstract “Zhu She Yong Xue Shuan Tong” lyophilized powder (ZSYXST), consists of a series of saponins extracted from Panax notoginseng, which has been widely used in China for the treatment of strokes. In this study, an ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) combined with preparative high performance liquid chromatography (PHPLC) method was developed to rapidly identify both major and minor saponins in ZSYXST. Some high content components were removed through PHPLC in order to increase the sensitivity of the trace saponins. Then, specific characteristic fragment ions in both positive and negative mode were utilized to determine the types of aglycone, saccharide, as well as the saccharide chain linkages. As a result, 94 saponins, including 20 pairs of isomers and ten new compounds, which could represent higher than 98% components in ZSYXST, were identified or tentatively identified in commercial ZSYXST samples.
    Schlagwörter ZSYXST ; saponins ; UHPLC-Q-TOF/MS ; Organic chemistry ; QD241-441 ; Chemistry ; QD1-999 ; Science ; Q
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2015-11-01T00:00:00Z
    Verlag MDPI AG
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  10. Artikel ; Online: Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen

    Tao Wang / Xiu-Mei Gao / Kojo Agyemang / Li-Li Liu / Kaunda Joseph Sakah / Zhi-Zhen Wu / Yi Zhang / Li-Feng Han

    Molecules, Vol 18, Iss 9, Pp 10352-

    2013  Band 10366

    Abstract: Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which ... ...

    Abstract Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.
    Schlagwörter Panax notoginseng ; root ; protopanaxatriol type saponins ; L6 cell ; mitochondrial oxidative stress ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2013-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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