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  1. Article ; Online: Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration.

    Qin, Meng-Chen / Li, Jun-Jie / Zheng, Yan-Tao / Li, Yun-Jia / Zhang, Yu-Xue / Ou, Rou-Xuan / He, Wei-Yi / Zhao, Jia-Min / Liu, Su-Tong / Liu, Ming-Hao / Lin, Hai-Yan / Gao, Lei

    Food & function

    2023  Volume 14, Issue 23, Page(s) 10347–10361

    Abstract: Liver fibrosis (LF) is an important reparative process in response to acute or chronic hepatic injury, which has the potential to advance towards cirrhosis and hepatocellular carcinoma. Dietary naringin consumption contributes to protection against LF in ...

    Abstract Liver fibrosis (LF) is an important reparative process in response to acute or chronic hepatic injury, which has the potential to advance towards cirrhosis and hepatocellular carcinoma. Dietary naringin consumption contributes to protection against LF in animal studies, while the exact protective mechanism of naringin remains unclear. This study aimed to investigate the molecular mechanisms behind the potential protective effect of naringin against TAA-induced LF in zebrafish. In this study, we utilized zebrafish to create the LF model and investigate the therapeutic mechanism of naringin. Firstly, we evaluated the changes in hepatic fibrosis and lipid accumulation in the liver following naringin treatment with oil red O, Nile red, and Sirius red and immunohistochemistry. In addition, we employed an ROS probe to directly measure oxidative stress and monitor inflammatory cell migration in a zebrafish transgenic line. Morpholino was used in the knockdown of IDO1 in order to verify its vital role in LF. Our findings demonstrated that naringin exhibited anti-inflammatory and anti-fibrotic action in conjunction with a reversal in lipid accumulation, oxidative stress and suppression of macrophage infiltration and activation of hepatic stellate cells. Furthermore, the results showed that the antifibrotic effect of naringin was removed upon IDO1 knockdown, proving that naringin exerts a protective effect by regulating IDO1. Naringin demonstrates remarkable protective effects against LF, effectively counteracting inflammation and hepatic steatosis in zebrafish liver. These findings suggest that naringin may function as an effective IDO1 inhibitor, holding the potential for clinical translation as a therapeutic agent for the treatment of LF.
    MeSH term(s) Animals ; Zebrafish ; Lipid Metabolism ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Liver/metabolism ; Fibrosis ; Hepatic Stellate Cells/metabolism ; Lipids/pharmacology
    Chemical Substances naringin (N7TD9J649B) ; Lipids
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo03858k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease.

    Deng, Guang-Hui / Wu, Chao-Feng / Li, Yun-Jia / Shi, Hao / Zhong, Wei-Chao / Hong, Mu-Keng / Li, Jun-Jie / Zhao, Jia-Min / Liu, Chang / Qin, Meng-Chen / Zeng, Zhi-Yun / Zhang, Wei-Min / Yung, Ken Kin Lam / Lv, Zhi-Ping / Gao, Lei

    Military Medical Research

    2023  Volume 10, Issue 1, Page(s) 53

    Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) in protecting hepatocytes and mediating iron metabolism in the ... ...

    Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) in protecting hepatocytes and mediating iron metabolism in the liver. This study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in NAFLD.
    Methods: Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this study. Cav-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in vitro. Moreover, a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro, respectively, while a high-iron diet was used to construct an in vivo iron overload model. Besides, iron concentration, the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit, Prussian blue staining, Western blotting, immunofluorescence staining, immunohistochemical staining and ELISA. The related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and staining.
    Results: Significant disorder of lipid and iron metabolism occurred in NAFLD. The expression of Cav-1 was decreased in NAFLD hepatocytes (P < 0.05), accompanied by iron metabolism disorder. Cav-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD, subsequently alleviating the oxidative stress induced by excess ferrous ions in the liver. Further, CD68
    Conclusions: These findings confirm that Cav-1 is an essential target protein that regulates iron and lipid metabolic homeostasis. It is a pivotal molecule for predicting and protecting against the development of NAFLD.
    MeSH term(s) Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Iron/metabolism ; Caveolin 1/metabolism ; Lipids
    Chemical Substances Iron (E1UOL152H7) ; Caveolin 1 ; Lipids
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2768940-2
    ISSN 2054-9369 ; 2054-9369
    ISSN (online) 2054-9369
    ISSN 2054-9369
    DOI 10.1186/s40779-023-00487-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Allele-specific expression analyses reveal immune divergences between ibex and goat species.

    Yang, Zhi-Rui / Li, Jia-Xin / Zheng, Zhu-Qing / Zhao, Chen / Wang, Yu / Li, Ming / Nanaei, Hojjat Asadollahpour / Dai, Xue-Lei / Li, Yun-Jia / Li, Ran / Cao, Chun-Na / Li, Mao / Jiang, Yu / Zheng, Wen-Xin / Wang, Xi-Hong

    Zoological research

    2022  Volume 43, Issue 4, Page(s) 671–674

    MeSH term(s) Alleles ; Animals ; Gene Expression/immunology ; Gene Expression Profiling ; Goats/genetics ; Goats/immunology
    Language English
    Publishing date 2022-07-05
    Publishing country China
    Document type Letter
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2022.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats

    An-hui Yao / Li-yun Jia / Yu-kai Zhang / Quan-rui Ma / Peng Cheng / Ling Liu / Gong Ju / Fang Kuang

    Evidence-Based Complementary and Alternative Medicine, Vol

    2012  Volume 2012

    Abstract: To determine the role of toll-like receptors (TLRs) myeloid differentiation factor 88 (MyD88) dependent pathway in the spinal cord secondary injury, compression injury was made at T8 segment of the spinal cord in adult male Sprague-Dawley rats. Shown by ... ...

    Abstract To determine the role of toll-like receptors (TLRs) myeloid differentiation factor 88 (MyD88) dependent pathway in the spinal cord secondary injury, compression injury was made at T8 segment of the spinal cord in adult male Sprague-Dawley rats. Shown by RT-PCR, TLR4 mRNA in the spinal cord was quickly elevated after compression injury. Intramedullary injection of MyD88 inhibitory peptide (MIP) resulted in significant improvement in locomotor function recovery at various time points after surgery. Meanwhile, injury area, p38 phosphorylation, and proinflammation cytokines in the injured spinal cord were significantly reduced in MIP-treated animals, compared with control peptide (CP) group. These data suggest that TLRs MyD88-dependent pathway may play an important role in the development of secondary spinal cord injury, and inhibition of this pathway at early time after primary injury could effectively protect cells from inflammation and apoptosis and therefore improve the functional recovery.
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Beneficial Effect of the Traditional Chinese Drug Shu-Xue-Tong on Recovery of Spinal Cord Injury in the Rat

    Li-Yun Jia / An-Hui Yao / Fang Kuang / Yu-Kai Zhang / Xue-Feng Shen / Gong Ju

    Evidence-Based Complementary and Alternative Medicine, Vol

    2011  Volume 2011

    Abstract: Shu-Xue-Tong (SXT) is a traditional Chinese drug widely used to ameliorate stagnation of blood flow, such as brain or myocardial infarction. Whether SXT may have therapeutic value for spinal cord injury (SCI), during which ischemia plays an important ... ...

    Abstract Shu-Xue-Tong (SXT) is a traditional Chinese drug widely used to ameliorate stagnation of blood flow, such as brain or myocardial infarction. Whether SXT may have therapeutic value for spinal cord injury (SCI), during which ischemia plays an important role in its pathology, remains to be elucidated. We hypothesized that SXT may promote SCI healing by improving spinal cord blood flow (SCBF), and a study was thus designed to explore this possibility. Twenty-five male Sprague-Dawley rats were used. SCI was induced by compression, and SXT was administrated 24 h postinjury for 14 successive days. The effects of SXT were assessed by means of laser-Doppler flowmetry, motor functional analysis (open-field walking and footprint analysis), and histological analysis (hematoxylin-eosin and thionin staining and NeuN immunohistochemistry). SXT significantly promoted SCBF of the contused spinal cord and enhanced the recovery of motor function. Histological analysis indicated that the lesion size was reduced, the pathological changes were ameliorated, and more neurons were preserved. Based on these results we conclude that SXT can effectively improve SCI.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 572
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Effect of the matrix crystallinity on the percolation threshold and dielectric behavior in percolative composites

    Li, Yun-Jia / Xu, Man / Feng, Jun-Qiang / Cao, Xiao-Long / Yu, Yan-Fei / Dang, Zhi-Min

    Journal of applied polymer science. 2007 Dec. 05, v. 106, no. 5

    2007  

    Abstract: Through the use of polyethylenes with different crystallinities as matrices, the effects of the matrix crystallinity on the percolation threshold and dielectric behavior of percolative composites have been investigated. The results suggest that the ... ...

    Abstract Through the use of polyethylenes with different crystallinities as matrices, the effects of the matrix crystallinity on the percolation threshold and dielectric behavior of percolative composites have been investigated. The results suggest that the percolation threshold is negatively related to the matrix crystallinity, whereas the enhancement of the dielectric constant is positively related to the matrix crystallinity. A two-dimensional diagram is proposed to illustrate such relationships. In addition, it has been found that the insulator-conductor transition is much flatter in low-crystallinity-matrix-based composites, and this may be favorable for preparing threshold composites with a high dielectric constant and a low loss tangent. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
    Language English
    Dates of publication 2007-1205
    Size p. 3359-3365.
    Publishing place Wiley Subscription Services, Inc., A Wiley Company
    Document type Article
    ZDB-ID 1491105-x
    ISSN 1097-4628 ; 0021-8995
    ISSN (online) 1097-4628
    ISSN 0021-8995
    DOI 10.1002/app.26988
    Database NAL-Catalogue (AGRICOLA)

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