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  1. AU="Lia, Andrea"
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  1. Article: Erratum to "Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?"

    Tax, Gabor / Lia, Andrea / Santino, Angelo / Roversi, Pietro

    Journal of oncology

    2020  Volume 2020, Page(s) 1396429

    Abstract: This corrects the article DOI: 10.1155/2019/8384913.]. ...

    Abstract [This corrects the article DOI: 10.1155/2019/8384913.].
    Language English
    Publishing date 2020-07-09
    Publishing country Egypt
    Document type Published Erratum
    ZDB-ID 2461349-6
    ISSN 1687-8469 ; 1687-8450
    ISSN (online) 1687-8469
    ISSN 1687-8450
    DOI 10.1155/2020/1396429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?

    Tax, Gábor / Lia, Andrea / Santino, Angelo / Roversi, Pietro

    Journal of oncology

    2019  Volume 2019, Page(s) 8384913

    Abstract: Endoplasmic reticulum glycoprotein folding quality control (ERQC) and ER-associated degradation (ERAD) preside over cellular glycoprotein secretion and maintain steady glycoproteostasis. When cells turn malignant, cancer cell plasticity is affected and ... ...

    Abstract Endoplasmic reticulum glycoprotein folding quality control (ERQC) and ER-associated degradation (ERAD) preside over cellular glycoprotein secretion and maintain steady glycoproteostasis. When cells turn malignant, cancer cell plasticity is affected and supported either by point mutations, preferential isoform selection, altered expression levels, or shifts to conformational equilibria of a secreted glycoprotein. Such changes are crucial in mediating altered extracellular signalling, metabolic behavior, and adhesion properties of cancer cells. It is therefore conceivable that interference with ERQC and/or ERAD can be used to selectively damage cancers. Indeed, inhibitors of the late stages of ERAD are already in the clinic against cancers such as multiple myeloma. Here, we review recent advances in our understanding of the complex relationship between glycoproteostasis and cancer biology and discuss the potential of ERQC and ERAD modulators for the selective targeting of cancer cell plasticity.
    Language English
    Publishing date 2019-10-01
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2461349-6
    ISSN 1687-8469 ; 1687-8450
    ISSN (online) 1687-8469
    ISSN 1687-8450
    DOI 10.1155/2019/8384913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Partial catalytic Cys oxidation of human GAPDH to Cys-sulfonic acid.

    Lia, Andrea / Dowle, Adam / Taylor, Chris / Santino, Angelo / Roversi, Pietro

    Wellcome open research

    2020  Volume 5, Page(s) 114

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2020-08-25
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.15893.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells.

    Tax, Gabor / Guay, Kevin P / Pantalone, Ludovica / Ceci, Martina / Soldà, Tatiana / Hitchman, Charlie J / Hill, Johan C / Vasiljević, Snežana / Lia, Andrea / Modenutti, Carlos P / Straatman, Kees R / Santino, Angelo / Molinari, Maurizio / Zitzmann, Nicole / Hebert, Daniel N / Roversi, Pietro / Trerotola, Marco

    Traffic (Copenhagen, Denmark)

    2024  Volume 25, Issue 1, Page(s) e12927

    Abstract: Endoplasmic reticulum (ER) retention of misfolded glycoproteins is mediated by the ER-localized eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognizes a misfolded glycoprotein and flags ... ...

    Abstract Endoplasmic reticulum (ER) retention of misfolded glycoproteins is mediated by the ER-localized eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognizes a misfolded glycoprotein and flags it for ER retention by re-glucosylating one of its N-linked glycans. In the background of a congenital mutation in a secreted glycoprotein gene, UGGT-mediated ER retention can cause rare disease, even if the mutant glycoprotein retains activity ("responsive mutant"). Using confocal laser scanning microscopy, we investigated here the subcellular localization of the human Trop-2-Q118E, E227K and L186P mutants, which cause gelatinous drop-like corneal dystrophy (GDLD). Compared with the wild-type Trop-2, which is correctly localized at the plasma membrane, these Trop-2 mutants are retained in the ER. We studied fluorescent chimeras of the Trop-2 Q118E, E227K and L186P mutants in mammalian cells harboring CRISPR/Cas9-mediated inhibition of the UGGT1 and/or UGGT2 genes. The membrane localization of the Trop-2 Q118E, E227K and L186P mutants was successfully rescued in UGGT1
    MeSH term(s) Animals ; Humans ; Rare Diseases/metabolism ; Protein Folding ; Glycoproteins/genetics ; Glycoproteins/metabolism ; Endoplasmic Reticulum/metabolism ; Mutation ; Mammals/metabolism ; Glucosyltransferases/metabolism
    Chemical Substances Glycoproteins ; UGGT1 protein, human (EC 2.4.1.-) ; Glucosyltransferases (EC 2.4.1.-)
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483852-7
    ISSN 1600-0854 ; 1398-9219
    ISSN (online) 1600-0854
    ISSN 1398-9219
    DOI 10.1111/tra.12927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: EFR-Mediated Innate Immune Response in

    Lia, Andrea / Gallo, Antonia / Marti, Lucia / Roversi, Pietro / Santino, Angelo

    Genes

    2018  Volume 10, Issue 1

    Abstract: Plants offer a simpler and cheaper alternative to mammalian animal models for the study of endoplasmic reticulum glycoprotein folding quality control (ERQC). In particular, ... ...

    Abstract Plants offer a simpler and cheaper alternative to mammalian animal models for the study of endoplasmic reticulum glycoprotein folding quality control (ERQC). In particular, the
    Language English
    Publishing date 2018-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes10010015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in

    Tax, Gábor / Guay, Kevin P / Soldà, Tatiana / Hitchman, Charlie J / Hill, Johan C / Vasiljević, Snežana / Lia, Andrea / Modenutti, Carlos P / Straatman, Kees R / Santino, Angelo / Molinari, Maurizio / Zitzmann, Nicole / Hebert, Daniel N / Roversi, Pietro / Trerotola, Marco

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Endoplasmic reticulum (ER) retention of mis-folded glycoproteins is mediated by the ERlocalised eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognises a mis-folded glycoprotein and flags ... ...

    Abstract Endoplasmic reticulum (ER) retention of mis-folded glycoproteins is mediated by the ERlocalised eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognises a mis-folded glycoprotein and flags it for ER retention by reglucosylating one of its N-linked glycans. In the background of a congenital mutation in a secreted glycoprotein gene, UGGT-mediated ER retention can cause rare disease even if the mutant glycoprotein retains activity ("responsive mutant"). Here, we investigated the subcellular localisation of the human Trop-2 Q118E variant, which causes gelatinous droplike corneal dystrophy (GDLD). Compared with the wild type Trop-2, which is correctly localised at the plasma membrane, the Trop-2-Q118E variant is found to be heavily retained in the ER. Using Trop-2-Q118E, we tested UGGT modulation as a rescue-of-secretion therapeutic strategy for congenital rare disease caused by responsive mutations in genes encoding secreted glycoproteins. We investigated secretion of a EYFP-fusion of Trop-2-Q118E by confocal laser scanning microscopy. As a limiting case of UGGT inhibition, mammalian cells harbouring CRISPR/Cas9-mediated inhibition of the
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.30.542711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In Planta Preliminary Screening of ER Glycoprotein Folding Quality Control (ERQC) Modulators.

    Marti, Lucia / Lia, Andrea / Reca, Ida-Barbara / Roversi, Pietro / Santino, Angelo / Zitzmann, Nicole

    International journal of molecular sciences

    2018  Volume 19, Issue 7

    Abstract: Small molecule modulators of the Endoplasmic Reticulum glycoprotein folding quality control (ERQC) machinery have broad-spectrum antiviral activity against a number of enveloped viruses and have the potential to rescue secretion of misfolded but active ... ...

    Abstract Small molecule modulators of the Endoplasmic Reticulum glycoprotein folding quality control (ERQC) machinery have broad-spectrum antiviral activity against a number of enveloped viruses and have the potential to rescue secretion of misfolded but active glycoproteins in rare diseases. In vivo assays of candidate inhibitors in mammals are expensive and cannot be afforded at the preliminary stages of drug development programs. The strong conservation of the ERQC machinery across eukaryotes makes transgenic plants an attractive system for low-cost, easy and fast proof-of-concept screening of candidate ERQC inhibitors. The
    MeSH term(s) Arabidopsis/drug effects ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Endoplasmic Reticulum-Associated Degradation/drug effects ; Glycoproteins/metabolism ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Recombinant Proteins/metabolism ; alpha-Glucosidases/metabolism
    Chemical Substances Arabidopsis Proteins ; Glycoproteins ; Glycoside Hydrolase Inhibitors ; Recombinant Proteins ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2018-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19072135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Explicit instructions and consolidation promote rewiring of automatic behaviors in the human mind

    Emese Szegedi-Hallgató / Karolina Janacsek / Teodóra Vékony / Lia Andrea Tasi / Leila Kerepes / Emőke Adrienn Hompoth / Anna Bálint / Dezső Németh

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Volume 7

    Abstract: Abstract One major challenge in human behavior and brain sciences is to understand how we can rewire already existing perceptual, motor, cognitive, and social skills or habits. Here we aimed to characterize one aspect of rewiring, namely, how we can ... ...

    Abstract Abstract One major challenge in human behavior and brain sciences is to understand how we can rewire already existing perceptual, motor, cognitive, and social skills or habits. Here we aimed to characterize one aspect of rewiring, namely, how we can update our knowledge of sequential/statistical regularities when they change. The dynamics of rewiring was explored from learning to consolidation using a unique experimental design which is suitable to capture the effect of implicit and explicit processing and the proactive and retroactive interference. Our results indicate that humans can rewire their knowledge of such regularities incidentally, and consolidation has a critical role in this process. Moreover, old and new knowledge can coexist, leading to effective adaptivity of the human mind in the changing environment, although the execution of the recently acquired knowledge may be more fluent than the execution of the previously learned one. These findings can contribute to a better understanding of the cognitive processes underlying behavior change, and can provide insights into how we can boost behavior change in various contexts, such as sports, educational settings or psychotherapy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 501
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book ; Thesis: Eine erste Evaluation des neuen Hamburger Glücksspielinventars (HGI)

    Cordes, Lia Andrea

    intrapsychische und interaktionelle Funktionalitäten des Glückspielens

    2004  

    Author's details von: Lia Andrea Cordes
    Language German
    Size 87, 12 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diplomarbeit--Hamburg, 2004
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Explicit instructions and consolidation promote rewiring of automatic behaviors in the human mind.

    Szegedi-Hallgató, Emese / Janacsek, Karolina / Vékony, Teodóra / Tasi, Lia Andrea / Kerepes, Leila / Hompoth, Emőke Adrienn / Bálint, Anna / Németh, Dezső

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 4365

    Abstract: One major challenge in human behavior and brain sciences is to understand how we can rewire already existing perceptual, motor, cognitive, and social skills or habits. Here we aimed to characterize one aspect of rewiring, namely, how we can update our ... ...

    Abstract One major challenge in human behavior and brain sciences is to understand how we can rewire already existing perceptual, motor, cognitive, and social skills or habits. Here we aimed to characterize one aspect of rewiring, namely, how we can update our knowledge of sequential/statistical regularities when they change. The dynamics of rewiring was explored from learning to consolidation using a unique experimental design which is suitable to capture the effect of implicit and explicit processing and the proactive and retroactive interference. Our results indicate that humans can rewire their knowledge of such regularities incidentally, and consolidation has a critical role in this process. Moreover, old and new knowledge can coexist, leading to effective adaptivity of the human mind in the changing environment, although the execution of the recently acquired knowledge may be more fluent than the execution of the previously learned one. These findings can contribute to a better understanding of the cognitive processes underlying behavior change, and can provide insights into how we can boost behavior change in various contexts, such as sports, educational settings or psychotherapy.
    MeSH term(s) Adult ; Behavior ; Brain/physiology ; Executive Function ; Female ; Humans ; Knowledge ; Learning ; Male ; Memory, Short-Term ; Motor Skills ; Psychomotor Performance ; Young Adult
    Language English
    Publishing date 2017-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-04500-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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