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  1. Article ; Online: Association with controlling nutritional status score and disease activity of ulcerative colitis.

    Lian, Ziyu / Hu, Jingyi / Cheng, Cheng / Liu, Yajun / Zhu, Lei / Shen, Hong

    The Journal of international medical research

    2023  Volume 51, Issue 8, Page(s) 3000605231184046

    Abstract: Objective: To explore the association between the controlling nutritional status (CONUT) score and disease activity in patients with ulcerative colitis (UC).: Methods: This retrospective study enrolled patients with UC. Demographic, clinical and ... ...

    Abstract Objective: To explore the association between the controlling nutritional status (CONUT) score and disease activity in patients with ulcerative colitis (UC).
    Methods: This retrospective study enrolled patients with UC. Demographic, clinical and laboratory data were collected and compared. The CONUT score was obtained for each patient. The association between the CONUT score and laboratory parameters was analysed and the ability of the score to assess disease activity was evaluated.
    Results: A total of 182 patients with UC were enrolled. Patients with active disease showed significantly increased inflammatory biomarkers and decreased nutritional biomarkers compared with patients in remission. Malnourished individuals had significantly elevated inflammatory biomarkers and significantly reduced haemoglobin, prealbumin and retinol-binding protein. The CONUT score was inversely correlated with haemoglobin, prealbumin, retinol-binding protein and was positively correlated with faecal calprotectin, C-reactive protein, erythrocyte sedimentation rate, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. The area under the receiver operating characteristic curve was 0.655 (95% confidence interval, 0.557-0.752). The optimal cut-off value was 1.5 points, with a sensitivity of 75.7% and a specificity of 50.0%.
    Conclusion: The CONUT score may evaluate the inflammatory response and nutritional status of UC patients, so it could be a potential biomarker to assess disease activity in UC.
    MeSH term(s) Humans ; Nutritional Status ; Colitis, Ulcerative ; Retrospective Studies ; Prealbumin/metabolism ; Biomarkers ; Retinol-Binding Proteins
    Chemical Substances Prealbumin ; Biomarkers ; Retinol-Binding Proteins
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605231184046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 925: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effect of ligustrazine nanoparticles on Th1/Th2 balance by TLR4/MyD88/NF-κB pathway in rats with postoperative peritoneal adhesion.

    Yang, Lili / Lian, Ziyu / Zhang, Bin / Li, Zhengjun / Zeng, Li / Li, Wenlin / Bian, Yaoyao

    BMC surgery

    2021  Volume 21, Issue 1, Page(s) 211

    Abstract: Background: Postoperative peritoneal adhesion (PPA) is regarded as fibrous bands connecting both injured abdominal wall and organs or adjacent tissues. It is associated with T helper (Th)1 and Th2 differentiation. However, the critical role of the ... ...

    Abstract Background: Postoperative peritoneal adhesion (PPA) is regarded as fibrous bands connecting both injured abdominal wall and organs or adjacent tissues. It is associated with T helper (Th)1 and Th2 differentiation. However, the critical role of the immunopathogenesis of adhesion formation was precisely unknown. The aim of this study was to investigate the effect of a new agent polylactic acid (PLA) nanoparticles loaded with ligustrazine, that is, ligustrazine nanoparticles (LN) on PPA and identify the potential mechanism.
    Methods: Twenty-four Sprague-Dawley rats were randomly divided into the sham, model, LN, and sodium hyaluronate (SH) groups. The structure of LN, including entrapment efficiency (EE) and loading capacity (LC), and in vitro drug release were calculated. Adhesions were scored and the Masson's trichrome staining was used to determine the collagen deposition. The expressions of TLR4, MyD88, and NF-κB were measured by qRT-PCR, immunohistochemistry, and western blot assay. Moreover, Th1-related cytokines (IFN-γ, IL-12), Th2-related cytokines (IL-4, IL-6) in the cecum tissue and serum were conducted by ELISA.
    Results: LN had good EE, LC, and control-release delivery characters with fairly uniform diameter and spherical morphology. It could effectively prevent adhesion formation after surgery. Besides, it could reduce collagen fibers accumulation, downregulate the expression levels of TLR4, MyD88, and NF-κB, and maintain Th1/Th2 balance.
    Conclusions: Ligustrazine nanoparticles had effective effects on Th1/Th2 balance by regulating TLR4/MyD88/NF-κB pathway in PPA rats. It may be served as a promising therapy on postoperative adhesion formation.
    MeSH term(s) Animals ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Nanoparticles ; Pyrazines/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Th1-Th2 Balance ; Tissue Adhesions/drug therapy ; Tissue Adhesions/immunology ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism
    Chemical Substances Myd88 protein, rat ; Myeloid Differentiation Factor 88 ; NF-kappa B ; Pyrazines ; Tlr4 protein, rat ; Toll-Like Receptor 4 ; tetramethylpyrazine (V80F4IA5XG)
    Language English
    Publishing date 2021-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-021-01201-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Qing-Chang-Hua-Shi granule ameliorates DSS-induced colitis by activating NLRP6 signaling and regulating Th17/Treg balance.

    Cheng, Cheng / Hu, Jingyi / Li, Yanan / Ji, Yuejin / Lian, Ziyu / Au, Ryan / Xu, Feng / Li, Weiyang / Shen, Hong / Zhu, Lei

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 107, Page(s) 154452

    Abstract: Background: Chinese herbal medicine Qing-Chang-Hua-Shi granule (QCHS) is widely used to treat ulcerative colitis in China. However, the molecular mechanisms of QCHS remains largely unknown.: Purpose: To assess the therapeutic effects of QCHS on ... ...

    Abstract Background: Chinese herbal medicine Qing-Chang-Hua-Shi granule (QCHS) is widely used to treat ulcerative colitis in China. However, the molecular mechanisms of QCHS remains largely unknown.
    Purpose: To assess the therapeutic effects of QCHS on colitis and to reveal its mechanisms of action.
    Methods: The main components of QCHS were identified using a UHPLC-QTOF-MS method and the efficacy of QCHS was evaluated using an DSS-induced mice model. The inflammatory responses and mucosal integrity in colon were comprehensively assessed. Flow cytometry was used to analysis the proportion of Th17 and Treg cells. Detect the signal transduction of the NOD-like receptor family pyrin domain containing 6 (NLRP6) both in vitro and in vivo. Furthermore, siNLRP6 transfection was used to validate the functional targets of QCHS.
    Results: QCHS treatment significantly alleviated colitis in mice by improving symptoms and pathological damage. Moreover, QCHS treatment suppressed the inflammatory response and preserved the integrity of colon tissue. Most importantly, QCHS balanced the Th17/Treg response of UC mice. Mechanistically, by activating NLRP6 inflammasome pathway, QCHS regulated the maturation of interleukin (IL)-1β and IL-18 to affect inflammation and drive Th17 cell differentiation.
    Conclusions: The effect of QCHS on UC mice is dose-dependent, with high-dose QCHS being superior to 5-Aminosalicylic acid (200 mg/kg/day). QCHS acts through the NLRP6 signaling pathway to modulate Th17/Treg balance, resulting in the protective effects against colitis. This study investigated the relevant pharmacological mechanisms of QCHS, providing further evidence for the application of QCHS in UC treatment.
    MeSH term(s) Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/pathology ; Colon/pathology ; Dextran Sulfate/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Inflammasomes/metabolism ; Interleukin-18/metabolism ; Interleukin-18/pharmacology ; Interleukin-18/therapeutic use ; Mesalamine/adverse effects ; Mice ; Mice, Inbred C57BL ; NLR Proteins/metabolism ; Signal Transduction ; T-Lymphocytes, Regulatory ; Th17 Cells
    Chemical Substances Drugs, Chinese Herbal ; Inflammasomes ; Interleukin-18 ; NLR Proteins ; qing-chang-hua-shi granules ; Mesalamine (4Q81I59GXC) ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2022-09-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Qing-Chang-Hua-Shi granule ameliorates DSS-induced colitis by activating NLRP6 signaling and regulating Th17/Treg balance

    Cheng, Cheng / Hu, Jingyi / Li, Yanan / Ji, Yuejin / Lian, Ziyu / Au, Ryan / Xu, Feng / Li, Weiyang / Shen, Hong / Zhu, Lei

    Phytomedicine. 2022 Dec., v. 107

    2022  

    Abstract: Chinese herbal medicine Qing-Chang-Hua-Shi granule (QCHS) is widely used to treat ulcerative colitis in China. However, the molecular mechanisms of QCHS remains largely unknown. To assess the therapeutic effects of QCHS on colitis and to reveal its ... ...

    Abstract Chinese herbal medicine Qing-Chang-Hua-Shi granule (QCHS) is widely used to treat ulcerative colitis in China. However, the molecular mechanisms of QCHS remains largely unknown. To assess the therapeutic effects of QCHS on colitis and to reveal its mechanisms of action. The main components of QCHS were identified using a UHPLC-QTOF-MS method and the efficacy of QCHS was evaluated using an DSS-induced mice model. The inflammatory responses and mucosal integrity in colon were comprehensively assessed. Flow cytometry was used to analysis the proportion of Th17 and Treg cells. Detect the signal transduction of the NOD-like receptor family pyrin domain containing 6 (NLRP6) both in vitro and in vivo. Furthermore, siNLRP6 transfection was used to validate the functional targets of QCHS. QCHS treatment significantly alleviated colitis in mice by improving symptoms and pathological damage. Moreover, QCHS treatment suppressed the inflammatory response and preserved the integrity of colon tissue. Most importantly, QCHS balanced the Th17/Treg response of UC mice. Mechanistically, by activating NLRP6 inflammasome pathway, QCHS regulated the maturation of interleukin (IL)-1β and IL-18 to affect inflammation and drive Th17 cell differentiation. The effect of QCHS on UC mice is dose-dependent, with high-dose QCHS being superior to 5-Aminosalicylic acid (200 mg/kg/day). QCHS acts through the NLRP6 signaling pathway to modulate Th17/Treg balance, resulting in the protective effects against colitis. This study investigated the relevant pharmacological mechanisms of QCHS, providing further evidence for the application of QCHS in UC treatment.
    Keywords cell differentiation ; colon ; dose response ; flow cytometry ; herbal medicines ; inflammasomes ; inflammation ; interleukin-18 ; models ; signal transduction ; therapeutics ; transfection ; ulcerative colitis ; China
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154452
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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