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Article ; Online: Unveiling the mystery of ILC3s: Their functions and interactions in mucosal immunity.

Liang, Bing / Xing, Dongming

2023 Volume 123, Page(s) 110772

Abstract: Innate lymphoid cells (ILCs) are a recently discovered subset of immune cells that play a crucial role in preserving tissue health and combating infections. Among these, ILC3s are particularly vital in regulating mucosal immunity across multiple organs ... ...

Abstract	Innate lymphoid cells (ILCs) are a recently discovered subset of immune cells that play a crucial role in preserving tissue health and combating infections. Among these, ILC3s are particularly vital in regulating mucosal immunity across multiple organs such as the gut, lungs, and skin. The purpose of this article is to present a comprehensive and detailed overview of current knowledge on ILC3s, with a specific emphasis on their intricate interactions with various components of the intestinal microenvironment. Recent research on the complex, bidirectional communication pathways between ILC3s and intestinal epithelial cells, stromal cells, immune cells, microbiota, their metabolites, and diet are highlighted. Furthermore, this review comprehensively examines the diverse functions of ILC3s, which include lymphoid tissue development, tissue repair, infection, inflammation, and metabolic diseases, as well as the effector molecules that facilitate these functions. Overall, this review provides valuable insights into the biological and functional aspects of ILC3s and underscores their potential for developing innovative therapies for immune-mediated disorders, while also acknowledging the remaining knowledge gaps and challenges that need to be addressed.
MeSH term(s)	Humans ; Lymphocytes ; Immunity, Innate ; Immunity, Mucosal ; Lymphoid Tissue ; Inflammation/metabolism
Language	English
Publishing date	2023-08-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110772
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Article ; Online: The Current and Future Perspectives of Postbiotics.

Liang, Bing / Xing, Dongming

Probiotics and antimicrobial proteins

2023 Volume 15, Issue 6, Page(s) 1626–1643

Abstract: With the emphasis on intestinal health, probiotics have exploded into a vast market potential. However, new scientific evidence points out that the beneficial health benefits of probiotics are not necessarily directly related to viable bacteria. However, ...

Abstract	With the emphasis on intestinal health, probiotics have exploded into a vast market potential. However, new scientific evidence points out that the beneficial health benefits of probiotics are not necessarily directly related to viable bacteria. However, the metabolites or bacterial components of the live bacteria are the driving force behind health promotion. Therefore, scientists gradually noticed that the beneficial effects of probiotics are based on bacteria itself, metabolites, or cell lysates, and these factors are officially named "postbiotics" by the ISAPP. Postbiotic components are diverse and outperform live probiotics in terms of technology, safety, and cost due to their good absorption, metabolism, and organismal distribution. Postbiotics have been shown to have bioactivities such as antimicrobial, antioxidant, anti-inflammatory, anti-proliferative, and immunomodulation. Moreover, numerous studies have revealed the significant potential of postbiotics for disease treatment. This paper first presents the production and classification of postbiotics with examples from lactic acid bacteria (LAB), followed by the mechanisms of action with the most recent pre-clinical and clinical studies and the wide range of non-clinical and clinical applications of postbiotics. Furthermore, the current and future prospects of the postbiotic market with commercial available products are discussed. Finally, we comment on the knowledge gaps and future clinical applications with several examples.
MeSH term(s)	Antioxidants ; Immunomodulation ; Lactobacillales ; Probiotics
Chemical Substances	Antioxidants
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-023-10045-x
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Article ; Online: A preliminary research on the periodic characteristics of a ventilation system with fluid oscillator

Liang Bing / Wang Haidong

E3S Web of Conferences, Vol 356, p

2022 Volume 01068

Abstract: The fluid oscillator is a device that produces periodic alternating jets by supplying a certain pressure of the fluid. In this paper, the fluid oscillator is applied to the field of building ventilation. The supply air direction will change periodically ... ...

Abstract	The fluid oscillator is a device that produces periodic alternating jets by supplying a certain pressure of the fluid. In this paper, the fluid oscillator is applied to the field of building ventilation. The supply air direction will change periodically and create a vortex shedding effect in the ventilated environment. By establishing a three-dimensional model of the double feedback fluid oscillator, CFD numerical simulation technology was used to study the indoor flow field characteristics when the fluid oscillator was used for ventilation and the slit air supply. The results show that the influence area of slotted air is small, and the energy is concentrated and distributed. Only a few eddies are generated on both sides of the main jet, and many stagnation zones are generated indoors. Fluid oscillator ventilation into the indoor airflow has a broader range of influence. The flow field distribution is uniform, and the jet energy dissipates quickly. The fluid oscillator will generate many eddy currents inside the room, effectively reducing the airflow stagnation zone in the room. Because the fluid oscillator can accelerate the disturbance of the flow field inside the room, it has a particular reference value to optimize the indoor air distribution.
Keywords	Environmental sciences ; GE1-350
Subject code	532
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: rL-RVG inhibits the proliferation and migration of human small cell lung cancer cell line NCI-H446

LIANG Bing, YAN Yu-lan

Jichu yixue yu linchuang, Vol 42, Iss 10, Pp 1549-

2022 Volume 1554

Abstract: Objective To investigate the effect and potential mechanism of recombinant Newcastle disease virus rL-RVG on proliferation and migration of human small cell lung cancer cell line NCI-H446. Methods NCI-H446 cells were divided into 3 groups: incubated with ...

Abstract	Objective To investigate the effect and potential mechanism of recombinant Newcastle disease virus rL-RVG on proliferation and migration of human small cell lung cancer cell line NCI-H446. Methods NCI-H446 cells were divided into 3 groups: incubated with PBS, Newcastle disease virus(NDV) and rL-RVG, respectively. Immunofluorescence assay was used to detect the expression of RVG and NDV protein. MTT assay was used to determine the anti-proliferation of the virus. The cell migration was detected by scratch test and Transwell method. Immuno-fluorescence assay was used to detect the expression of E-cadherin and MMP2 proteins. Results After infection, rL-RVG stably expressed in NCI-H446 cell with high infection efficiency.The scratch distance in rL-RVG group was significantly shorter than that in NDV group and control group(P＜0.05). In the Transwell experiment, the number of cells crossing the compartment in the rL-RVG group were significantly less than that in the control group(P＜0.05). MMP2 protein expression was down-regulated in rL-RVG group, while E-cadherin protein expression was up-regulated(P＜0.05), compared with NDV group and control group. Conclusions rL-RVG could inhibit the proliferation of NCI-H446 cell with the potential mechanism of effects on cell migration through regulating E-cadherin and MMP2.
Keywords	small cell lung cancer\|newcastle disease virus\|migration ; Medicine ; R
Subject code	570
Language	Chinese
Publishing date	2022-10-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
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Article ; Online: Study on the strength deterioration characteristic and damage model of coal pillar dams with repeated water immersion in underground reservoirs.

Wang, Beifang / Zhou, Duo / Zhang, Jing / Liang, Bing

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6338

Abstract: The continuous operation of coal mine underground reservoirs exposes the coal pillar dams to mining disturbances and prolonged water immersion, resulting in the deterioration of coal pillars' mechanical properties and posing a serious threat to the dam ... ...

Abstract	The continuous operation of coal mine underground reservoirs exposes the coal pillar dams to mining disturbances and prolonged water immersion, resulting in the deterioration of coal pillars' mechanical properties and posing a serious threat to the dam stability. To this end, coal samples from the proposed pillar dam in the 5-2 coal seam of Daliuta Mine in Shendong Mining Area were selected for conducting water absorption tests and triaxial compression tests under conditions of repeated water immersion, in order to study the deterioration of the mechanical properties and acoustic emission damage characteristic of coal samples as well as the mechanism behind the deterioration of coal samples under the water-rock interaction. The results indicated that: (1) the saturated water content of coal samples exhibited a progressive increase as the water immersion times increased, but with a diminishing rate of growth. (2) As the water immersion times increased, the compressive strength, cohesive force, and internal friction angle of coal samples gradually decreased. Notably, the deterioration effect was more pronounced in compressive strength and cohesive force, while the decline in internal friction angle was relatively minor, and the total deterioration degree and the stage deterioration degree of the above three had evident cumulativity and non-uniformity. The progressive rise in water immersion times led to a gradual attenuation of the deterioration effect. Meanwhile, the confining pressure exhibited a certain inhibitory impact on the strength deterioration of coal samples. (3) Compared to the dry coal samples, the average AE count rate of coal samples subjected to a single water immersion exhibited a significant decrease, and subsequent water immersion for two, three, and four times resulted in a very minor decrease in the average AE count rate. (4) The AE cumulative ringing counts in coal samples exhibited varying degrees of reduction as water immersion times increased. Specifically, the most significant decrease in AE cumulative ringing counts occurred after the initial water immersion, followed by a gradual decrease thereafter. The energy-releasing capacity of coal samples decreased, while their plasticity exhibited a gradual increase. (5) A damage model was developed for coal samples based on the water immersion times. The model indicated that the damage to coal samples increased as the water immersion times increased, and the damage rate gradually decreased and eventually stabilized. (6) The deterioration mechanism of coals under the water-rock interaction was explained. Through repeated water immersion, the physical, chemical, and mechanical interactions between water and coal induced alterations in the internal microstructure of coal samples, resulting in the deterioration of mechanical properties such as compressive strength, cohesive force, and internal friction angle, which was a cumulative damage process from the microscopic to the macroscopic level.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56741-8
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Article ; Online: Synergistic advantages of volcanic ash weathering in saline soils: CO

Liang, Bing / Wei, Jianbing / Wu, Shangyu / Hao, Heyang

The Science of the total environment

2024 Volume 925, Page(s) 171825

Abstract: Carbon dioxide ( ... ...

Abstract	Carbon dioxide (CO
MeSH term(s)	Humans ; Soil/chemistry ; Carbon Dioxide/analysis ; Volcanic Eruptions ; Agriculture ; Weather ; Edible Grain/chemistry ; Sorghum ; Carbon Sequestration ; Silicates
Chemical Substances	Soil ; Carbon Dioxide (142M471B3J) ; Silicates
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171825
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Article ; Online: Therapeutic effect and mechanism of celecoxib on bladder cancer cell implanted mice

LIANG Bing, LUO Hou-zhou

Jichu yixue yu linchuang, Vol 41, Iss 2, Pp 240-

2021 Volume 244

Abstract: Objective To explore the therapeutic effect of celecoxib on mice implanted with bladder cancer cells and its related mechanism. Methods Sixty male BALB/c nude mice were randomly divided into three groups: control group, model group and observation group. ...

Abstract	Objective To explore the therapeutic effect of celecoxib on mice implanted with bladder cancer cells and its related mechanism. Methods Sixty male BALB/c nude mice were randomly divided into three groups: control group, model group and observation group. The model group and the observation group were implanted with human bladder cancer cell line 5637 to establish a mouse bladder cancer model. The mice in the observation group were treated with celecoxib, while the mice in the control group and the model group were injected with the same dose of 0.9% sodium chloride solution. After 4 weeks of treatment, the tumor tissue of model group and experimental group and normal tissue of control group were taken to detect the expression of CD4+, CD8+, and the ratio of CD4+/CD8+ in the tissues of three groups. Western blot was performed to test the positive expression of COX-2, VEGF and cPLA2.TUNEL method was used to test the apoptotic rate of bladder cancer cells in model group and observation group. Results The mice in the control group grew normally without tumor under the skin. The tumorigenesis rate of model group and observation group was 100%. The tumor mass of the model group and the observation group were (2.08±0.36)g and (1.18±0.21)g. Compared with the model group, the tumor mass of mice in the observation group decreased significantly (P＜0.05). The tumor inhibition rate of mice in the observation group was 43.33%. The levels of CD4+, CD4+/CD8+ in tissue of model group and observation group was significantly lower than that of control group, and the level of CD8+ was significantly higher than that of control group (P＜0.05). The levels of CD4+, CD4+/CD8+ in tumor tissue of mice in the observation group were significantly higher than those in the model group, and the level of CD8+ was significantly lower than that in the model group (P＜0.05). COX-2 and cPLA2 protein levels were not expressed in tissues of mice in control group, the expression of VEGF protein was positive in all three groups. The expression levels of ...
Keywords	celecoxib\|human bladder cancer cell line 5637\|bladder cancer\|immune cells\|apoptosis ; Medicine ; R
Subject code	616
Language	Chinese
Publishing date	2021-02-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Influence of perceived social support on detection of social norm violation: evidence from N1 and N400.

Liang, Bing / Li, Bingbing / Fan, Xiaoyue / Mu, Yan / Wang, Juan

Frontiers in psychology

2024 Volume 15, Page(s) 1336186

Abstract: Introduction: The perceived social support individuals receive from their others plays a crucial role in shaping conformity with social norms. However, the specific mechanism underlying perceived social support and the detection of social norms remains ... ...

Abstract	Introduction: The perceived social support individuals receive from their others plays a crucial role in shaping conformity with social norms. However, the specific mechanism underlying perceived social support and the detection of social norms remains unclear. Methods: In this study, college students with high and low levels of perceived social support were asked to judge the appropriateness of stranger's behaviors (e.g., singing) in different situations (e.g., library). The participants' electroencephalography activities were analyzed aiming to uncover the neural mechanism underlying how perceived social support influences the detection of others' normative behavior. Results: The ERP results indicate that, for individuals with a lower level of perceived social support, larger amplitudes of the N1 component (related to primary processing) and the N400 component (related to cognitive conflict) were observed when detecting others' social norm violation compared to the conformity condition. However, for individuals with a higher level of perceived social support, no significant differences were found in detecting others' conformity or violation of social norms. Discussion: The results indicate that, when the perceived social support level of the individual is low, detecting others' social norm violation elicits deeper primary processing and stronger cognitive conflict compared to conformity condition.
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1336186
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Article ; Online: High-Precision Carton Detection Based on Adaptive Image Augmentation for Unmanned Cargo Handling Tasks.

Liang, Bing / Wang, Xin / Zhao, Wenhao / Wang, Xiaobang

Sensors (Basel, Switzerland)

2023 Volume 24, Issue 1

Abstract: Unattended intelligent cargo handling is an important means to improve the efficiency and safety of port cargo trans-shipment, where high-precision carton detection is an unquestioned prerequisite. Therefore, this paper introduces an adaptive image ... ...

Abstract	Unattended intelligent cargo handling is an important means to improve the efficiency and safety of port cargo trans-shipment, where high-precision carton detection is an unquestioned prerequisite. Therefore, this paper introduces an adaptive image augmentation method for high-precision carton detection. First, the imaging parameters of the images are clustered into various scenarios, and the imaging parameters and perspectives are adaptively adjusted to achieve the automatic augmenting and balancing of the carton dataset in each scenario, which reduces the interference of the scenarios on the carton detection precision. Then, the carton boundary features are extracted and stochastically sampled to synthesize new images, thus enhancing the detection performance of the trained model for dense cargo boundaries. Moreover, the weight function of the hyperparameters of the trained model is constructed to achieve their preferential crossover during genetic evolution to ensure the training efficiency of the augmented dataset. Finally, an intelligent cargo handling platform is developed and field experiments are conducted. The outcomes of the experiments reveal that the method attains a detection precision of 0.828. This technique significantly enhances the detection precision by 18.1% and 4.4% when compared to the baseline and other methods, which provides a reliable guarantee for intelligent cargo handling processes.
Language	English
Publishing date	2023-12-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24010012
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Article ; Online: Research on the dynamic evolution law of fissures in shallow-buried and short-distance coal seam mining in Lijiahao Coal Mine.

Wang, Beifang / Zhou, Duo / Zhang, Jing / Liang, Bing

Scientific reports

2023 Volume 13, Issue 1, Page(s) 5625

Abstract: Aiming at the problem of spontaneous combustion of coal relics caused by the overburden fracture network penetrating the upper and lower coal seams in the process of shallow-buried and short-distance coal seam mining, the 31114 working face of Lijiahao ... ...

Abstract	Aiming at the problem of spontaneous combustion of coal relics caused by the overburden fracture network penetrating the upper and lower coal seams in the process of shallow-buried and short-distance coal seam mining, the 31114 working face of Lijiahao coal mine was used as the research background to study the characteristics of overburden transport and fracture development in shallow-buried and short-distance coal seam mining by using physical similar simulation test; the fractal dimension and image processing techniques were used to quantify the overburden fractures; the classical mechanical models of "solid support beam" and "masonry beam" were combined to analyze the causes of fracture dynamic evolution. The results show that: (1) Before the key seam fracture, the stress in the upper rock seam only changes in a small amount, and the stress in the lower rock seam evolves similarly to the single coal seam mining; when the key seam fracture is broken, the stress in the upper and lower rock seams will change by jumps. (2) The fractal dimension of the fissures rised from 1.4 to 1.5, the total area of fissures is increased from 16,638 pixels to 17,707 pixels, and the total length is increased from 2217 to 3071 pixels; after the main key layer of the overlying rock is broken, the fractal dimension of the fissures is reduced from 1.56 to 1.5, and the total area of fissures is reduced from 31,451 pixels to 29,089 pixels, the total length has increased from 5657 to 6619 pixels. (3) Before the key layer between the coal seams is broken, it will be suspended to form a "fixed beam". After the first break, the broken rock above it will settle synchronously until the rock blocks form a hinged structure and then collapse. After the fall stops, the key layer periodically breaks to form a "masonry beam" structure, and the overlying stratum settles synchronously.
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-32849-1
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