Article: Effects of human umbilical cord blood mononuclear cells on ovalbumin-induced asthma in mice.
2023 Volume 15, Issue 10, Page(s) 5454–5465
Abstract: Background: Umbilical cord blood mononuclear cells (UCMNCs) show broad immune-modulation effects, which may be helpful for treating asthma. Effects of UCMNCs on asthma were investigated with mouse model in present study.: Methods: Asthma was induced ... ...
| Abstract | Background: Umbilical cord blood mononuclear cells (UCMNCs) show broad immune-modulation effects, which may be helpful for treating asthma. Effects of UCMNCs on asthma were investigated with mouse model in present study. Methods: Asthma was induced in BALB/c mice by ovalbumin (OVA) immunization and challenge. Asthmatic mice were then treated on days 7 and 20 with intravenous injections of UCMNCs in doses of 4×10 Results: Compared with the model group, AHR in the UCMNC Conclusions: UCMNCs can modulate AHR, T-helper (Th)2 inflammation, and airway injury in experimental asthma at appropriate dose. |
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| Language | English |
| Publishing date | 2023-09-15 |
| Publishing country | China |
| Document type | Journal Article |
| ZDB-ID | 2573571-8 |
| ISSN | 2077-6624 ; 2072-1439 |
| ISSN (online) | 2077-6624 |
| ISSN | 2072-1439 |
| DOI | 10.21037/jtd-22-1669 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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